• Steel and Composite Structures
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• 제28권6호
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• pp.719-734
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• 2018

Prior to the introduction of modern seismic guidelines, it was a common practice to provide straight bar anchorage for beam bottom reinforcement of gravity load designed building. Exterior joints with straight bar anchorages for beam bottom reinforcements are susceptible to sudden anchorage failure under load reversals and hence require systematic seismic upgradation. Hence in the present study, an attempt is made to upgrade exterior beam-column sub-assemblage of a three storied gravity load designed (GLD) building with single steel haunch. Analytical formulations are presented for evaluating the haunch forces in single steel haunch retrofit. Influence of parameters that affect the efficacy and effectiveness of the single haunch retrofit are also discussed. The effectiveness of the single haunch retrofit for enhancing seismic performance of GLD beam-column specimen is evaluated through experimental investigation under reverse cyclic loading. The single steel haunch retrofit had succeeded in preventing the anchorage failure of beam bottom bars of GLD specimen, delaying the joint shear damage and partially directing the damage towards the beam. A remarkable improvement in the load carrying capacity of the upgraded GLD beam-column sub-assemblage is observed. Further, a tremendous improvement in the energy dissipation of about 2.63 times that of GLD specimen is observed in the case of upgraded GLD specimen. The study also underlines the efficacy of single steel haunch retrofit for seismic upgradation of deficient GLD structures.

• Earthquakes and Structures
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• 제16권2호
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• pp.235-251
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• 2019

Corrosion of reinforcement is the greatest threat to the safety of existing reinforced concrete (RC) structures. Most of the olden structures are gravity load designed (GLD) and are seismically deficient. In present study, investigations are carried out on corrosion damaged GLD beam-column sub-assemblages under reverse cyclic loading, in order to evaluate their seismic performance. Five GLD beam-column sub-assemblage specimens comprising of i) One uncorroded ii) Two corroded iii) One uncorroded strengthened with steel bracket and haunch iv) One corroded strengthened with steel bracket and haunch, are tested under reverse cyclic loading. The performances of these specimens are assessed in terms of hysteretic behaviour, energy dissipation and strength degradation. It is noted that the nature of corrosion i.e. uniform or pitting corrosion and its location have significant influence on the behaviour of corrosion damaged GLD beam-column sub-assemblages. The corroded specimens with localised corrosion pits showed in-cyclic strength degradation. The study also reveals that external strengthening which provides an alternate force path but depends on the strength of the existing reinforcement bars, is able to mitigate the seismic risk of corroded GLD beam-column sub-assemblages to the level of control uncorroded GLD specimen.

• Structural Engineering and Mechanics
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• 제73권3호
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• pp.239-257
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• 2020

In the present study, an innovative steel bracket and haunch hybrid scheme is devised, for retrofitting of earthquake damaged deficient beam-column sub-assemblages. Formulations are presented for evaluating haunch force factor under combined load case of lateral and gravity loads for the design of double haunch retrofit. The strength hierarchies of control and retrofitted beam-column sub-assemblages are established to showcase the efficacy of the retrofit in reversing the undesirable strength hierarchy. Further, the efficacy of the proposed retrofit scheme is demonstrated through experimental investigations carried out on gravity load designed (GLD), non-ductile and ductile detailed beam-column sub-assemblages which were damaged under reverse cyclic loading. The maximum load carried by repaired and retrofitted GLD specimen in positive and negative cycle is 12% and 28% respectively higher than that of the control GLD specimen. Further, the retrofitted GLD specimen sustained load up to drift ratio of 5.88% compared with 2.94% drift sustained by control GLD specimen. Repaired and retrofitted non-ductile specimen, could attain the displacement ductility of three during positive cycle of loading and showed improved ductility well above the expected displacement ductility of three during negative cycle. The hybrid haunch retrofit restored the load carrying capacity of damaged ductile specimen to the original level of control specimen and improved the ductility closer to the expected displacement ductility of five. The total cumulative energy dissipated by repaired and retrofitted GLD, non-ductile and ductile specimens are respectively 6.5 times, 2.31 times, 1.21 times that of the corresponding undamaged control specimens. Further, the damage indices of the repaired and retrofitted specimens are found to be lower than that of the corresponding control specimens. The novel and innovative steel bracket and haunch hybrid retrofit scheme proposed in the present study demonstrated its effectiveness by attaining the required displacement ductility and load carrying capacity and would be an excellent candidate for post-earthquake retrofit of damaged existing RC structures designed according to different design evolutions.

• Radiation Oncology Journal
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• 제21권3호
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• pp.222-226
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• 2003

목적: 변이를 보이는 lpr 마우스와 Fas ligand 변이를 보이는 gld 마우스를 이용하여 in vivo에서 Fas와 Fas ligand의 발현이 전리 방사선에 의해 유도되는 apoptosis에서 어떤 역할을 하는지 조사하고자 하였다. 대상 및 방법: Fas의 변이를 보이는 $C57BL/6J-Fas^{lpr}$ 마우스와 대조군인 C57BL/6J 마우스, Fas ligand 변이를 보이는 $C3H/HeJ-Fas^{gld}$ 마우스와 대조군인 C3H/HeJ 마우스를 대상으로 하였다. 마우스는 8주령 웅성으로서 전신 방사선 조사하여 일정 시간 후 비장을 적출하였다. 조직을 hematoxylin-eosin 염색하여 apoptosis 유도 수준을 비교 분석하였다. 또한 apoptosis 조절 물질인 p53, Bcl-2, Bax, Bcl-X_L,\;Bcl-X_S$에 대하여 Western Western blotting을 시행하고 발현수준을 densitometry로 분석하여 관련된 기전을 연구하였다. 결과: 2.5 Gydh k10 Gy 조사시에 $C57BL/6J-Fas^{lpr}$ 마우스와 $C3H/HeJ-Fas^{gld}$ 마우스에서 대조군 비하여 방사선에 의한 apoptosis가 유의하게 감소되는 것으로 나타났다(p<0.05). C57BL/6J 마우스와, C3H/HeJ 마우스에서 10 Gy 방사선 조사 후 Bax가 8시간 째에 각각 3배, 3.3배의 증가를 보였으나 $C57BL/6J-Fas^{lpr}$ 마우스와, $C3H/HeJ-Fas^{gld}$ 마우스에서는 뚜렷한 발현증가가 관찰되지 않았다. 결과: Fas의 변이가 있는 lpr 마우스와 Fas ligand의 변이가 있는 gld 마우스에서 방사선에 의한 apoptosis가 대조군 보다 현저하게 낮으며 이는 방사선에 의한 Bax의 유도가 미약한 것과 연관된 것으로 나타났다. 방사선에 의한 apoptosis 유도에 Fas의 역할이 매우 중요한 것으로 보인다.

• 영재교육연구
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• 제24권5호
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• pp.851-876
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• 2014

이 논문은 학습장애영재 모델(Song & Porath, 2011)의 실증적 검증 차원으로, 읽기, 쓰기, 수학에서 학습장애가 없는 영재와 학습장애영재가 보이는 영역적 사고를 조사하였다. 두 그룹의 영재들로부터 인터뷰 자료를 수집하였고 분야적 사고 측면에서 분석하였다. 그 결과 영재는 읽기, 쓰기, 수학에서 비교적 균형 잡힌 영역적 사고를 나타낸 반면 학습장애영재는 특정 분야에서 약한 영역적 사고를 보였다. 뿐만 아니라 오직 학습장애영재만이 읽기, 쓰기, 수학의 각각의 분야 내에서 서로 상반된 태도를 보였는데 그들은 같은 분야 내에서 긍정과 부정의 감정을 동시에 드러냈다. 이 논문은 학습장애영재 모델에서 제시하고 있는 인지 메커니즘을 통해 두 영재집단의 차이점들을 설명하고 영재 선발과 교육에 대한 새로운 접근 방법을 제안하고 있다.

• BMB Reports
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• 제49권2호
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• pp.93-98
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• 2016

Germline stem cells (GSCs) are the best understood adult stem cell types in the nematode Caenorhabditis elegans, and have provided an important model system for studying stem cells and their cell fate in vivo, in mammals. In this review, we propose a mechanism that controls GSCs and their cell fate through selective activation, repression and mobilization of the specific mRNAs. This mechanism is acutely controlled by known signal transduction pathways (e.g., Notch signaling and Ras-ERK MAPK signaling pathways) and P granule (analogous to mammalian germ granule)-associated mRNA regulators (FBF-1, FBF-2, GLD-1, GLD-2, GLD-3, RNP-8 and IFE-1). Importantly, all regulators are highly conserved in many multi-cellular animals. Therefore, GSCs from a simple animal may provide broad insight into vertebrate stem cells (e.g., hematopoietic stem cells) and their cell fate specification.

• 한국지열·수열에너지학회논문집
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• 제10권1호
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• pp.14-19
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• 2014

This paper presents a preliminary experimental and computational study on the evaluation of thermal performance and initial cost of U, W and coil type ground heat exchangers (GHEs). Heat exchange rate of the individual GHE was evaluated from the thermal resperformance test (TPT) results, and the construction cost was also calculated. For more information, GLD (ground loop design) simulations of various piping size are carried out. From simulation results, the optimized GHE was suggested based on the thermal performance and construction cost as well. Besides, the required borehole length of U and W type GHEs was calculated considering a real construction condition using GLD program.

• Journal of Microbiology and Biotechnology
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• 제18권11호
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• pp.1797-1802
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• 2008

Saccharomyces cerevisiae was metabolically engineered to improve 1,2-propanediol production. Deletion of the tpil (triosephosphate isomerase) gene in S. cerevisiae increased the carbon flux to DHAP (dihydroxylacetone phosphate) in glycolysis, resulting in increased glycerol production. Then, the mgs and gldA genes, the products of which convert DHAP to l,2-propanediol, were introduced to the tpil-deficient strain using a multicopy plasmid. As expected, the intracellular level of methylglyoxal was increased by introduction of the mgs gene in S. cerevisiae and that of 1,2-propanediol by introduction of both the mgs and gldA genes. As a result, 1.11 g/l of 1,2-propanediol was achieved in flask culture.

• Nonlinear Functional Analysis and Applications
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• 제28권3호
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• pp.793-800
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• 2023

In this paper, we propose a generalization of Lindley distribution (GLD) via a special structure that is concern with progressively Type-II right censoring and time failure data. We study the modern properties that we have built by such combination, for example, survival function, hazard function, moments, and estimation by non-Bayesian methods. Application on some selected data related to Lindley distribution (LD) and (ED) have been employed to find out the best distribution that can fit data comparing with the GLD.

• 신재생에너지
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• 제10권3호
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• pp.6-13
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• 2014

This paper presents a computational study of thermal performance and construction cost of horizontal ground heat exchangers (GHEs). GLD (ground loop design) simulations of various type of GHEs were carried out. Construction costs were also calculated based on standard estimating, and compared with vertical type GHE system. Besides that, dummy regression analysis was conducted to study the influence of design parameters on the simulation results in horizontal ground heat exchanger system.