• Steel and Composite Structures
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• v.28 no.6
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• pp.719-734
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• 2018

Prior to the introduction of modern seismic guidelines, it was a common practice to provide straight bar anchorage for beam bottom reinforcement of gravity load designed building. Exterior joints with straight bar anchorages for beam bottom reinforcements are susceptible to sudden anchorage failure under load reversals and hence require systematic seismic upgradation. Hence in the present study, an attempt is made to upgrade exterior beam-column sub-assemblage of a three storied gravity load designed (GLD) building with single steel haunch. Analytical formulations are presented for evaluating the haunch forces in single steel haunch retrofit. Influence of parameters that affect the efficacy and effectiveness of the single haunch retrofit are also discussed. The effectiveness of the single haunch retrofit for enhancing seismic performance of GLD beam-column specimen is evaluated through experimental investigation under reverse cyclic loading. The single steel haunch retrofit had succeeded in preventing the anchorage failure of beam bottom bars of GLD specimen, delaying the joint shear damage and partially directing the damage towards the beam. A remarkable improvement in the load carrying capacity of the upgraded GLD beam-column sub-assemblage is observed. Further, a tremendous improvement in the energy dissipation of about 2.63 times that of GLD specimen is observed in the case of upgraded GLD specimen. The study also underlines the efficacy of single steel haunch retrofit for seismic upgradation of deficient GLD structures.

• Earthquakes and Structures
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• v.16 no.2
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• pp.235-251
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• 2019

Corrosion of reinforcement is the greatest threat to the safety of existing reinforced concrete (RC) structures. Most of the olden structures are gravity load designed (GLD) and are seismically deficient. In present study, investigations are carried out on corrosion damaged GLD beam-column sub-assemblages under reverse cyclic loading, in order to evaluate their seismic performance. Five GLD beam-column sub-assemblage specimens comprising of i) One uncorroded ii) Two corroded iii) One uncorroded strengthened with steel bracket and haunch iv) One corroded strengthened with steel bracket and haunch, are tested under reverse cyclic loading. The performances of these specimens are assessed in terms of hysteretic behaviour, energy dissipation and strength degradation. It is noted that the nature of corrosion i.e. uniform or pitting corrosion and its location have significant influence on the behaviour of corrosion damaged GLD beam-column sub-assemblages. The corroded specimens with localised corrosion pits showed in-cyclic strength degradation. The study also reveals that external strengthening which provides an alternate force path but depends on the strength of the existing reinforcement bars, is able to mitigate the seismic risk of corroded GLD beam-column sub-assemblages to the level of control uncorroded GLD specimen.

• Structural Engineering and Mechanics
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• v.73 no.3
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• pp.239-257
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• 2020

In the present study, an innovative steel bracket and haunch hybrid scheme is devised, for retrofitting of earthquake damaged deficient beam-column sub-assemblages. Formulations are presented for evaluating haunch force factor under combined load case of lateral and gravity loads for the design of double haunch retrofit. The strength hierarchies of control and retrofitted beam-column sub-assemblages are established to showcase the efficacy of the retrofit in reversing the undesirable strength hierarchy. Further, the efficacy of the proposed retrofit scheme is demonstrated through experimental investigations carried out on gravity load designed (GLD), non-ductile and ductile detailed beam-column sub-assemblages which were damaged under reverse cyclic loading. The maximum load carried by repaired and retrofitted GLD specimen in positive and negative cycle is 12% and 28% respectively higher than that of the control GLD specimen. Further, the retrofitted GLD specimen sustained load up to drift ratio of 5.88% compared with 2.94% drift sustained by control GLD specimen. Repaired and retrofitted non-ductile specimen, could attain the displacement ductility of three during positive cycle of loading and showed improved ductility well above the expected displacement ductility of three during negative cycle. The hybrid haunch retrofit restored the load carrying capacity of damaged ductile specimen to the original level of control specimen and improved the ductility closer to the expected displacement ductility of five. The total cumulative energy dissipated by repaired and retrofitted GLD, non-ductile and ductile specimens are respectively 6.5 times, 2.31 times, 1.21 times that of the corresponding undamaged control specimens. Further, the damage indices of the repaired and retrofitted specimens are found to be lower than that of the corresponding control specimens. The novel and innovative steel bracket and haunch hybrid retrofit scheme proposed in the present study demonstrated its effectiveness by attaining the required displacement ductility and load carrying capacity and would be an excellent candidate for post-earthquake retrofit of damaged existing RC structures designed according to different design evolutions.

• Radiation Oncology Journal
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• v.21 no.3
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• pp.222-226
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• 2003

Purpose: The interaction of the Fas: Fas ligand has been recognized to play an important role in radiation induced apoptosis. The purpose of this study was to investigate the role of Fas and Fas ligand mutations, in radiation-induced apoptosis in vivo. Materials and Methods: Mice with a mutation in the Fas ($C57BL/6J-Fas^{lpr}$) and its normal control (C57BL/6J) and the Fas ligand ($C3H/HeJ-Fas^{gld}$) and its normal control (C3H/HeJ), were used in this study. Eight-week old male mice were given whole body radiation. After irradiation, the mice were killed at various time intervals, and their spleens collected. Tissue sample was stained with hematoxylin-eosin, and the numbers of apoptotic cells scored. The regulating molecules of apoptosis including the p53, Bcl-2, Bax, $Bcl-X_L\;and\;Bcl-X_s$ genes were also analyzed by Western blotting. Results: With 2.5 Gy and 10 Gy of irradiation, the levels of apoptosis were lower in the $C57BL/6J-Fas^{lpr}\;and\;C3H/HeJ-Fas^{gld}$ mice than in the control mice (p<0.05). With the expression of apoptosis regulating molecules, the Bax was increased in both the C57BL/6J and C3H/HeJ mice in response to radiation; the peak levels of Bax in the C57BL6J and C3H/HeJ were 3 and 3.3-fold higher after 8hr, respectively. However the Bax was not increased in either the $C57BL/6J-Fas^{lpr}\;or\;C3H/HeJ-Fas^{gld}$mice. The p53, Bcl-X_L,\;Bcl-X_S$and Bcl-2 showed no significant changes in the $C57BL/6J-Fas^{lpr},\;C3H/HeJ-Fas^{gld}$, C57BL/6J and C3H/HeJ mice. Conclusion: The levels of radiation-induced apoptosis were lower in the lpr and gld, than the control mice, which seemed to be related to the level of Bax activation due to the radiation in the lpr and gld mice. This result suggests that Fas/Fas L plays an important role in radiation-induced apoptosis in vivo.

• Journal of Gifted/Talented Education
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• v.24 no.5
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• pp.851-876
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• 2014

As an empirical test of a model of giftedness with learning disabilities (Song & Porath, 2011), this paper investigated domain thoughts of gifted students without learning disabilities and gifted students with learning disabilities (GLD) in reading, writing, and math. Gifted students in each group were interviewed and the data were analyzed for domain thoughts. The results showed that the former group of gifted students exhibited domain thoughts in a more balanced manner, whereas GLD students showed large discrepancies between domain thoughts; they showed weak specific domain thoughts in contrast to strong other domain thoughts. They also showed ambivalent attitudes even in a domain activity; they presented positive and negative thoughts at the same time. With a comprehensive explanation of the differences between the two groups of gifted students through a cognitive mechanism presented in the model of GLD model, this paper provides new approaches for identification and education of gifted students and GLD students.

• BMB Reports
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• v.49 no.2
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• pp.93-98
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• 2016

Germline stem cells (GSCs) are the best understood adult stem cell types in the nematode Caenorhabditis elegans, and have provided an important model system for studying stem cells and their cell fate in vivo, in mammals. In this review, we propose a mechanism that controls GSCs and their cell fate through selective activation, repression and mobilization of the specific mRNAs. This mechanism is acutely controlled by known signal transduction pathways (e.g., Notch signaling and Ras-ERK MAPK signaling pathways) and P granule (analogous to mammalian germ granule)-associated mRNA regulators (FBF-1, FBF-2, GLD-1, GLD-2, GLD-3, RNP-8 and IFE-1). Importantly, all regulators are highly conserved in many multi-cellular animals. Therefore, GSCs from a simple animal may provide broad insight into vertebrate stem cells (e.g., hematopoietic stem cells) and their cell fate specification.

• Journal of the Korean Society for Geothermal and Hydrothermal Energy
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• v.10 no.1
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• pp.14-19
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• 2014

This paper presents a preliminary experimental and computational study on the evaluation of thermal performance and initial cost of U, W and coil type ground heat exchangers (GHEs). Heat exchange rate of the individual GHE was evaluated from the thermal resperformance test (TPT) results, and the construction cost was also calculated. For more information, GLD (ground loop design) simulations of various piping size are carried out. From simulation results, the optimized GHE was suggested based on the thermal performance and construction cost as well. Besides, the required borehole length of U and W type GHEs was calculated considering a real construction condition using GLD program.

• Journal of Microbiology and Biotechnology
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• v.18 no.11
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• pp.1797-1802
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• 2008

Saccharomyces cerevisiae was metabolically engineered to improve 1,2-propanediol production. Deletion of the tpil (triosephosphate isomerase) gene in S. cerevisiae increased the carbon flux to DHAP (dihydroxylacetone phosphate) in glycolysis, resulting in increased glycerol production. Then, the mgs and gldA genes, the products of which convert DHAP to l,2-propanediol, were introduced to the tpil-deficient strain using a multicopy plasmid. As expected, the intracellular level of methylglyoxal was increased by introduction of the mgs gene in S. cerevisiae and that of 1,2-propanediol by introduction of both the mgs and gldA genes. As a result, 1.11 g/l of 1,2-propanediol was achieved in flask culture.

• Nonlinear Functional Analysis and Applications
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• v.28 no.3
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• pp.793-800
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• 2023

In this paper, we propose a generalization of Lindley distribution (GLD) via a special structure that is concern with progressively Type-II right censoring and time failure data. We study the modern properties that we have built by such combination, for example, survival function, hazard function, moments, and estimation by non-Bayesian methods. Application on some selected data related to Lindley distribution (LD) and (ED) have been employed to find out the best distribution that can fit data comparing with the GLD.

• New & Renewable Energy
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• v.10 no.3
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• pp.6-13
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• 2014

This paper presents a computational study of thermal performance and construction cost of horizontal ground heat exchangers (GHEs). GLD (ground loop design) simulations of various type of GHEs were carried out. Construction costs were also calculated based on standard estimating, and compared with vertical type GHE system. Besides that, dummy regression analysis was conducted to study the influence of design parameters on the simulation results in horizontal ground heat exchanger system.