• The Transactions of the Korea Information Processing Society
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• v.7 no.9
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• pp.2797-2806
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• 2000

Recently, DDSs(Distributed Database Systems) have been implemented on V AN(V alue Added Network) as we know the amazing expansion of information network. DDS can yield significant cost and response time advantages over centralized systems for geographically distributed organizations. However, inappropriate design can result in high cost and poor response time to maintain the database at each site. In a DDS design, the main problem is how to select proper computer and how to allocate data fragment into a proper site. In this paper, we address DDS design problem of selecting the proper class of computers and the allocating data files on VAN. Also, the formulated model includes two objectives, the waited response time and the investment cost to include their relationship. Specially, the formulation of waited response time is based on M/M/1 queueing system to evaluate more precisely. GA(Genetic Algorithm), a kind of heuristic search method, is developed to search an optimal solution in the proposed design model and we show the simulation result to examine the algorithm performance.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2157-2162
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• 2012

Objective: The PI3K/PTEN/AKT/mTOR signaling pathway has been implicated in resistance to cisplatin. In the current study, we determined whether common genetic variations in this pathway are associated with platinum-based chemotherapy response and clinical outcome in advanced non-small cell lung cancer (NSCLC) patients. Methods: Seven common single nucleotide polymorphisms (SNPs) in core genes of this pathway were genotyped in 199 patients and analyzed for associations with chemotherapy response, progression-free survival (PFS) and overall survival (OS). Results: Logistic regression analysis revealed an association between AKT1 rs2494752 and response to treatment. Patients carrying heterozygous AG had an increased risk of disease progression after two cycles of platinum-based chemotherapy compared to those with AA genotype (Adjusted odds ratio (OR)=2.18, 95% confidence interval (CI): 1.00-4.77, which remained significant in the stratified analyses). However, log-rank test and cox regression detected no association between these polymorphisms in the PI3K pathway genes and survival in advanced NSCLC patients. Conclusions: Our findings suggest that genetic variants in the PI3K/PTEN/AKT/mTOR pathway may predict platinum-based chemotherapy response in advanced NSCLC patients in a Chinese population.

• 제어로봇시스템학회:학술대회논문집
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• 1996.10b
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• pp.956-959
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• 1996

In this study, we propose a neuro-genetic controller combined with a linear controller in parallel to improve the tracking performance of the Line of Sight(LOS) stabilization system and reject the effect of disturbances. A Genetic Algorithm(GA) is used to optimize weights of the neuro-genetic controller since this algorithm can search a global minimum without derivatives or other auxiliary knowledge. The LOS system is very complex and has limited measurable output data. Under these specific circumstances GA solves many problems that other training methods have. Computer simulation results show that the, proposed controller makes better tracking response and rejection of disturbance than a linear controller.

• International Journal of Control, Automation, and Systems
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• v.5 no.1
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• pp.79-85
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• 2007

In this paper, a real-coded genetic algorithm is proposed for identification of time delay systems from step responses. FOPDT(First-Order Plus Dead-Time) and SOPDT(Second-Order Plus Dead-Time) systems, which are the most useful processes in this field, but are difficult for system identification because of a long dead-time problem and a model mismatch problem. Genetic algorithms have been successfully applied to a variety of complex optimization problems where other techniques have often failed. Thus, the modified crossover operator of a real-code genetic algorithm is proposed to effectively search the system parameters. The proposed method, using a real-coding genetic algorithm, shows better performance characteristics when compared to the usual area-based identification method and the directed identification method that uses step responses.

• Animal cells and systems
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• v.16 no.5
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• pp.425-430
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• 2012

The southwestern Australian frog Crinia georgiana (Anura; Myobatrachidae) inhabits ephemeral pools in which the tadpoles often face desiccation. Under these conditions selection on tadpoles can be severe and can directly affect fitness during the aquatic as well as the terrestrial developmental stages. A quantitative genetic study using a half-sib breeding design was conducted to understand the genetic effects on larval life-history traits. We found no significant additive genetic variance in any of larval traits. Except for hatching period, heritability estimates based on females were high in egg size, larval period, snout-vent length, and weight at metamorphosis, suggesting non-additive genetic effects. These results indicate that any response to selection during hatching and larval periods should be predominately governed by non-additive genetic effects in C. georgiana.

• Journal of Institute of Control, Robotics and Systems
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• v.9 no.1
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• pp.57-62
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• 2003

It is difficult to determine the feeding rate of coagulant in the water treatment plant, due to nonlinearity, multivariables and slow response characteristics etc. To deal with this difficulty, the genetic-fuzzy system genetic-equation system and the neural network system were used in determining the feeding rate of the coagulant. Fuzzy system and neural network system are excellently robust in multivariables and nonlinear problems. but fuzzy system is difficult to construct the fuzzy parameter such as the rule table and the membership function. Therefore we made the genetic-fuzzy system by the fusion of genetic algorithms and fuzzy system, and also made the feeding rate equation by genetic algorithms. To train fuzzy system, equation parameter and neural network system, the actual operation data of the water treatment plant was used. We determined optimized feeding rates of coagulant by the fuzzy system, the equation and the neural network and also compared them with the feeding rates of the actual operation data.

• International Journal of Industrial Entomology and Biomaterials
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• v.10 no.2
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• pp.95-99
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• 2005

A breeding plan was carried out on four commercial strains of silkworm (Bombyx mori L.) 101, 102, 103 and 104 to improve some important traits. Genetic gain or response to selection $({\Delta}G)$, heritability of cocoon shell weight (CSW) and specific combining ability effects were estimated to determine the strains that can be improved. Strain 101 had lowest heritabitity, ${\Delta}G$ and viability. Strain 102 was acceptable in selection response but its viability was low. Therefore these two strains were not suitable for more selection. As a result, only lines 103 and 104 were chosen for further improvement. Intra population selection based on independent culling level method practiced from third to sixth generation for both productive and viability traits simultaneously. While CSW and CW had increasingly enhanced during primary generations, they went slightly up after third generation. According to negative genetic correlation, viability decreased during primary generations, but after third generation that paid attention to balanced development of both productive and viability traits, viability increased so that the pupation rate reached to $91\%$ in 103 and $97\%$ in 104 for last generation $(G_8)$.

• Journal of Advanced Marine Engineering and Technology
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• v.35 no.2
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• pp.271-277
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• 2011

An identification method of the structural damping matrix for a steel bar by the genetic algorithm is proposed. Supposing the damping matrix were in proportion to the stiffness matrix, the proportional factors can be identified from the curve fitting of the experimental frequency response function(FRF) by the genetic algorithm. Applying the identified damping matrix to FEM of a beam model, the values of the objective function could be reduced to about 1/60 in comparison with conventional FEM model without damping. The damping matrices of some sub-structures which have large damping partly could be identified by the algorithm, and they could be used as some parts of the FEM model for a whole structure.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.20 no.10
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• pp.946-952
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• 2010

A method for the identification of structural characteristic parameters of a steel bar in the matrices form such as stiffness matrices and mass matrices from frequency response function(FRF) by genetic algorithm is proposed. As the method is based on the finite element method(FEM), the obtained matrices have perfect physical meanings if the FRFs got from the analysis and the FRFs from the experiments were well coincident each other. The identified characteristic matrices from the FRFs with maximun 40 % of random errors by the genetic algorithm are coincident with the characteristic matrices from exact FEM FRFs well each other. The fitted element diameters by using only 2 points experimental FRFs are similar to the actual diameters of the bar. The fitted FRFs are good accordance with the experimental FRFs on the graphs. FRFs of the rest 9 points not used for calculating could be fitted even well.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.32 no.7
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• pp.13-18
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• 2004

This paper describes an efficient and robust optimization method for helicopter rotor airfoil design in forward flight. Navier-Stokes analysis was employed to compute the dynamic response of an airfoil, which simulates the unsteady rotor flow-field in forward flight. The optimization system consists of two categories; Response Surface Method to construct the response surface model based on D-optimal 3-level factorial design, and Genetic Algorithm to obtain the optimum solution of a defined objective function including penalty terms of constraints. The influence of design variables and their interactions on the aerodynamic performance was examined through the optimization process.