• Journal of Animal Science and Technology
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• 제48권1호
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• pp.9-14
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• 2006

본 시험은 유질에 영향을 미치는 체세포수에 대하여 영향을 미칠 것으로 생각되는 면역물질에 대한 환경효과와 유전모수를 추정하고자 축산연구소에서 사육하고 있는 착유우를 공시하여 이들의 혈액과 우유 시료를 채취하여 조사 분석하였다. 분만산차는 체세포수와 호중구에 영향을 미치는 것으로 나타났고(p<0.01), 비유기는 체세포수와 IgG, 호중구에 영향을 미치는 것으로 나타났다. 하지만 코티솔과 림프구는 산차와 유기에 의하여 영향을 받지 않는 것으로 나타났다. 체세포수의 산차간 비교에서 1, 2, 3 산차간에는 차이가 없었으나 4산차 이상에서는 높아지는 경향이 있어 3산차 이하와 비교 할 시에 유의적인 차이가 있었고 유기별 비교에서는 비유초기(90일 이하)와 비유후기(181일 이후)가 비유중기(91～180) 보다 높게 나타났다. 코티솔은 체세포수의 산차 성적과 마찬가지로 3산차 이하와 4산차 이상 간에 차이가 있었고 비유기별 성적에서는 높아지는 것처럼 보이나 차이는 없었다. 면역물질인 IgG는 1산차와 4산차 이상의 비교에서만 차이가 있었고 유기에서는 비유 초기가 비유 중기와 후기에 비하여 높은 결과를 보였고 림프구는 1산차와 4산차 이상 간에 차이가 있었으나 유기간에는 차이가 없었다. 호중구는 산차가 증가할수록 감소하는 경향으로 2산차 이하와 3산차 이상간에 차이가 있었으며 비유중기 까지는 차이가 없었고 비유 후기에는 높게 나타났다. 체세포수의 유전력은 낮은 수준이지만 유질 개량을 위하여 의미 있을 정도로 높게 추정되었으며 코티솔, 림프구와 부의 높은 유전상관을 보였다. 코티솔의 유전력은 비교적 낮은 수준이었고 림프구, 호중구간의 정의 상관관계를 보였다. IgG의 유전력은 중 정도를 보였으며 림프구와 호중구와는 높은 부의 유전상관을 보였다. 림프구는 높은 유전력을 보였고 호중구와도 높은 유전적 상관을 보였다. 호중구는 체세포수와 비슷한 수준의 유전력을 나타내었다. 이상의 연구 결과에서 코티솔, IgG, 림프구, 호중구가 체세포수와 유전적으로 높은 상관관계를 가지고 있어 우유 품질 개선에 중요한 형질임을 알 수 있었다. 또한 농가의 사육규모가 증가하고 두 당 생산성이 더욱 증가함에 따라 생산성과 질병을 동시에 고려하는 젖소개량 관련 연구가 수행되어야 할 것으로 사료된다.

• Journal of Animal Science and Technology
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• 제54권2호
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• pp.83-87
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• 2012

본 연구에서는 18,668두의 자가검정 및 입회검정된 돼지 자료를 이용하여 유전모수를 추정하였다. 2007년부터 2011년 4월까지 전라남도 영광 소재 N 종돈장에서 검정된 Duroc, Berkshire, Landrace 및 Yorkshire종 18,668두에 대한 자료를 근거로 하여 돼지의 주요 산육형질인 일당증체량, 체고 및 체장에 대한 유전력, 유전상관 및 표현형상관을 다형질 Animal model을 이용하여 추정하였다. 본 연구에서 추정된 Duroc종에 대한 일당증체량, 체고 및 체장에 대한 유전력은 0.22, 0.37, 0.4로 추정되었으며 Berkshire종의 유전력은 0.58, 0.34 및 0.48로 나타났고 Landrace종의 각 형질의 유전력은 0.26, 0.41 및 0.52이었으며 Yorkshire종의 유전력은 0.28, 0.39 및 0.43을 나타내었다. 본 연구에서 추정된Duroc의 주요 경제 형질간의 유전 상관 및 표현형 상관은 일당 증체량과, 체고, 체장, 체고와 체장간에 각각 유전, 표현형 상관 0.33, 0.47과 0.42, 0.48 그리고 0.57 및 0.41로 추정되었으며 Berkshire종 유전 상관 및 표현형 상관은 0.75, 0.70 및 0.53, 0.58 그리고 체고의 대한 체장은 0.69 및 0.57을 나타내었다. Landrace종의 경우 유전 상관 및 표현형 상관이 일당증체량과, 체고, 체장, 체고와 체장간에 각각 유전, 표현형 상관 0.17, 0.38과 0.34, 0.46 그리고 0.61 및 0.52로 추정 되었으며 Yorkshire종은 0.50, 0.53 및 0.47, 0.56 그리고 0.71, 0.59로 추정되었다.

• Clinical and Experimental Pediatrics
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• 제50권9호
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• pp.835-840
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• 2007

Any infant noted to be jaundiced at 2 weeks of age should be evaluated for cholestasis with measurement of total and direct serum bilirubin. With the insight into the clinical phenotype and the genotype-phenotype correlations, it is now possible to evaluate more precisely the neonate who presents with conjugated hyperbilirubinemia. Testing should be performed for the specific treatable causes of neonatal cholestasis, specifically sepsis, galactosemia, tyrosinemia, citrin deficiency and endocrine disorders. Biliary atresia must be excluded. Low levels of serum gamma-glutamyl transferase in the presence of cholestasis should suggest progressive familial intrahepatic cholestasis type 1, 2, or arthrogryposis- renal dysfunction-cholestasis syndrome. If the serum bile acid level is low, a bile acid synthetic defect should be considered. Molecular genetic testing and molecular-based diagnostic strategies are in evolution.

• Asian-Australasian Journal of Animal Sciences
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• 제28권10호
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• pp.1388-1393
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• 2015

Genetic parameters of Berkshire pigs for reproduction, carcass and meat quality traits were estimated using the records from a breeding farm in Korea. For reproduction traits, 2,457 records of the total number of piglets born (TNB) and the number of piglets born alive (NBA) from 781 sows and 53 sires were used. For two carcass traits which are carcass weight (CW) and backfat thickness (BF) and for 10 meat quality traits which are pH value after 45 minutes (pH45m), pH value after 24 hours (pH24h), lightness in meat color (LMC), redness in meat color (RMC), yellowness in meat color (YMC), moisture holding capacity (MHC), drip loss (DL), cooking loss (CL), fat content (FC), and shear force value (SH), 1,942 pig records were used to estimate genetic parameters. The genetic parameters for each trait were estimated using VCE program with animal model. Heritability estimates for reproduction traits TNB and NBA were 0.07 and 0.06, respectively, for carcass traits CW and BF were 0.37 and 0.57, respectively and for meat traits pH45m, pH24h, LMC, RMC, YMC, MHC, DL, CL, FC, and SH were 0.48, 0.15, 0.19, 0.36, 0.28, 0.21, 0.33, 0.45, 0.43, and 0.39, respectively. The estimate for genetic correlation coefficient between CW and BF was 0.27. The Genetic correlation between pH24h and meat color traits were in the range of -0.51 to -0.33 and between pH24h and DL and SH were -0.41 and -0.32, respectively. The estimates for genetic correlation coefficients between reproductive and meat quality traits were very low or zero. However, the estimates for genetic correlation coefficients between reproductive traits and drip and cooking loss were in the range of 0.12 to 0.17 and -0.14 to -0.12, respectively. As the estimated heritability of meat quality traits showed medium to high heritability, these traits may be applicable for the genetic improvement by continuous measurement. However, since some of the meat quality traits showed negative genetic correlations with carcass traits, an appropriate breeding scheme is required that carefully considers the complexity of genetic parameters and applicability of data.

• Asian-Australasian Journal of Animal Sciences
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• 제30권12호
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• pp.1718-1723
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• 2017

Objective: The study explored the dynamics of shearing force and its correlation with chemical compositions and in vitro dry matter digestibility (IVDMD) of stylo. Methods: The shearing force, diameter, linear density, chemical composition, and IVDMD of different height stylo stem were investigated. Linear regression analysis was done to determine the relationships between the shearing force and cut height, diameter, chemical composition, or IVDMD. Results: The results showed that shearing force of stylo stem increased with plant height increasing and the crude protein (CP) content and IVDMD decreased but fiber content increased over time, resulting in decreased forage value. In addition, tall stem had greater shearing force than short stem. Moreover, shearing force is positively correlated with stem diameter, linear density and fiber fraction, but negatively correlated with CP content and IVDMD. Conclusion: Overall, shearing force is an indicator more direct, easier and faster to measure than chemical composition and digestibility for evaluation of forage nutritive value related to animal performance. Therefore, it can be used to evaluate the nutritive value of stylo.

• The Plant Pathology Journal
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• 제30권2호
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• pp.117-124
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• 2014

The plant pathogenic bacterial genus Pectobacteirum consists of heterogeneous strains. The P. carotovorum species is a complex strain showing divergent characteristics, and a new subspecies named P. carotovorum subsp. brasiliensis has been identified recently. In this paper, we re-identified the P. carotovorum subsp. brasiliensis isolates from those classified under the subspecies carotovorum and newly isolated P. carotovorum subsp. brasiliensis strains. All isolates were able to produce plant cell-wall degrading enzymes such as pectate lyase, polygalacturonase, cellulase and protease. We used genetic and biochemical methods to examine the diversity of P. carotovorum subsp. brasiliensis isolates, and found genetic diversity within the brasiliensis subsp. isolates in Korea. The restriction fragment length polymorphism analysis based on the recA gene revealed a unique pattern for the brasiliensis subspecies. The Korean brasiliensis subsp. isolates were divided into four clades based on pulsed-field gel electrophoresis. However, correlations between clades and isolated hosts or year could not be found, suggesting that diverse brasiliensis subsp. isolates existed.

• 한국자원식물학회지
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• 제11권3호
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• pp.264-271
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• 1998

This study was conducted to investigate morphological characteristics of Korean local garlic varieties and to define the genetic variability and the correlations amongthe characters associated with yield. The plant height, the leaf sheath diameter, the nubmer of leaves, and bulb weight were significantly increased in the garlic plants from heavier seed bulbs. The proportation of six clove bulbs was more than 60% in Seosan variety and this was not realted with the number of cloves in seed bulb. While more than 70% bulbs in Jeoksung and Danyang varieties cultivated in paddy field were composed of 6 or 7 cloves, majority of the bulbs of Euisung and Danyang varieties cultivated in upland were composed of bulbs with 7 cloves or more. The highest genotypic coefficient of variation (GCV) and phenotypic coefficient of variation (PCV) were observed in bulb weight. GCV and PCV also showed high value in leaf sheath diameter. Thus, there is a greater scope for selection of these characters. The small difference between PCV and GCV values in plant height indicates that the environmental influence would be limited in this character. High heritability was observed of plant height (56.76%) and bulb weight (45.95%). And the weight per bulb (34.24%) exhibited highest genitic advance followed by leaf sheath diameter (18.8%) and plant height (9.61%), and those would be the ideal characters for selelction.

• Animal Bioscience
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• 제34권7호
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• pp.1100-1104
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• 2021

Objective: The objective of present study was to estimate heritability of non-return rate (NRR) and success of first insemination (SFI) by using the Bayesian approach with Gibbs sampling. Methods: Heifer Traits were denoted as NRR-h and SFI-h, and cow traits as NRR-c and SFI-c. The variance covariance components were estimated using threshold model under Bayesian procedures THRGIBBS1F90. Results: The SFI was more relevant to evaluating success of insemination because a high percentage of animals that demonstrated no return did not successfully conceive in NRR. Estimated heritability of NRR and SFI in heifers were 0.032 and 0.039 and the corresponding estimates for cows were 0.020 and 0.027. The model showed low values of Geweke (p-value ranging between 0.012 and 0.018) and a low Monte Carlo chain error, indicating that the amount of a posteriori for the heritability estimate was valid for binary traits. Genetic correlation between the same traits among heifers and cows by using the two-trait threshold model were low, 0.485 and 0.591 for NRR and SFI, respectively. High genetic correlations were observed between NRR-h and SFI-h (0.922) and between NRR-c and SFI-c (0.954). Conclusion: SFI showed slightly higher heritability than NRR but the two traits are genetically correlated. Based on this result, both two could be used for early indicator for evaluate the capacity of cows to conceive.

• Childhood Kidney Diseases
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• 제27권2호
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• pp.70-75
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• 2023

Dent disease is a rare inherited kidney tubulopathy caused by mutations in either the CLCN5 (Dent disease 1) or OCRL1 (Dent disease 2) genes, and which is often underdiagnosed in practice. A diagnosis is clinically suspected in patients with low-molecular-weight proteinuria, hypercalciuria, and one of the following: hematuria, nephrolithiasis, nephrocalcinosis, hypophosphatemia, or chronic kidney disease. Inheritance is X-linked recessive, meaning, these symptoms are generally only found in males; female carriers may have mild phenotypes. Genetic testing is only a method to confirm the diagnosis, approximately 25% to 35% of patients have neither the CLCN5 nor OCRL1 pathogenic variants (Dent disease 3), making diagnosis more challenging. The genotype-phenotype correlations are not evident with the limited clinical data available. As with many other genetic diseases, the management of patients with Dent disease concentrates on symptom relief rather than any causative process. The current treatments are mainly supportive to reduce hypercalciuria and prevent nephrolithiasis. Chronic kidney disease progresses to end-stage between the ages of the third to fifth decades in 30% to 80% of affected males. In this review, we aimed to summarize the literature on Dent disease and reveal the clinical characteristics and molecular basis of Korean patients with Dent disease.

• 한국산학기술학회논문지
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• 제18권11호
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• pp.350-356
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• 2017

국내에서는 우리 고유의 재래돼지가 보존되고 있으나 성장 및 번식능력이 낮고 등지방두께가 두꺼워 경제성이 떨어진다는 이유로 농가에서 사육을 기피하고 있다. 하지만, 나고야의정서 발효 등에 따라 고유 유전자원의 중요성은 커지고 있으며 따라서, 고유 유전자원인 재래돼지를 활용한 신 계통 개발의 중요성은 점차 커지고 있다. 본 연구는 개체모형을 이용하여 돼지의 경제적 형질에 대한 유전모수 및 유전적 변화의 추정을 통해 모체유전효과가 돼지의 경제 형질에 미치는 영향을 알아보기 위해 수행되었다. 자료는 국립축산과학원으로부터 2000년부터 2015년까지 수집한 두록종, 재래돼지 그리고 합성종(재래돼지${\times}$두록종)의 자료를 사용하였다. 본 연구에 사용된 경제형질은 일당증체량과 등지방두께를 이용하였으며 분석에 사용된 Model식은 개체효과만을 고려한 Model 1과 모체효과를 추가한 Model 2 그리고 모체 영구환경효과가 포함된 Model 3을 사용하여 분석에 이용하였다. 분석 결과 상가적 유전력이 모체효과 유전력보다 높은 유전력을 나타냈으며 상가적 유전분산과 모체 유전분산 간의 유전상관은 모든 품종에서 강한 부(-)의 상관관계를 가지는 것을 확인할 수 있었다. 따라서, 좀 더 효율적인 개량 효과를 거두기 위해서는 품종 및 형질 또는 개량 방향에 따라 개체 효과와 모체유전효과 그리고 유전상관을 적절히 고려해야 할 것으로 사료된다.