• Biomolecules & Therapeutics
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• v.14 no.1
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• pp.1-10
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• 2006

Drug dependence deals a heavy socioeconomic burden to the society. For adolescents, the damage from drug dependence is greater than adults considering their higher susceptibility to drug effect and increasing chance for violence leading to criminal punishment process. Habitual drug use depends on genetic and environmental factors and the complex interactions between the two. Mammalian model systems have been useful in understanding the neurochemical and cellular impacts of abused drugs on specific regions of the brain, and in identifying the molecular targets of drugs. More elucidation is required whether biological effects of drugs actually cause the habitual dependence at the cellular level. Although there is much insight available on the nature of drug abuse problems, none of the systems designed to help drug dependent individuals is efficient in screening functional ingredients of the drug, and thus resulting in the failure of helping drug dependent individuals recover from drug dependence. Alternative model systems draw the attention of researchers, such as the invertebrate model systems of nematodes (Caenorhabditis elegans) and fruit flies (Drosophila melanogaster). These models should provide new insight into the mechanisms leading to the behavior of drug users (even functional studies analyzing molecular mechanism), and screening useful components to help remove drug dependence among drug users. The relatively simple anatomy and gene expression of the invertebrate model systems should enable researchers to coordinate current knowledge on drug abuse. Furthermore, the invertebrate model systems should facilitate advance in experiments on the susceptibility of specific genetic backgrounds and the interaction between genetic factors to drug dependence.

• Current Research on Agriculture and Life Sciences
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• v.1
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• pp.27-34
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• 1983

This study was conducted to obtain the basic informations on the selection for the early and high-yielding lines in $F_2$ populations of wheat. Two combinations such as Olmil-Saemil cross and Naphal-Cheonggemil cross and their eight populations were used and genetic parameters of genetic variances and path-coefficients for agronomic traits mainly in $F_2$ populations were analyzed. Genetic coefficient of variability in Olmil-Saemil cross was higher in harvest index, grain number, grain yield and plant height in decreasing order, but in Naphal-Cheonggemil cross harvest index, plant height, and 1,000-grain weight were higher in order. Heading and maturing dates, plant height, and harvest index showed high hertability (0.525-0.808) in both crosses, but very low heritabilities were observed in grain numbers per panicle and yield. In both crosses, genetic advances(%) was higher in heading and maturing stage, but lowest in yield. High genetic advance was obtained in 1,000-grain weight of Naphal-Cheonggemil cross. The highly significant correlations between yield and panicle number, yield and grain number per panicle were obtained, and the highest direct effect on yield was obtained in panicle number followed by grain number per panicle number.

• Proceedings of the KIEE Conference
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• 2006.07a
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• pp.502-503
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• 2006

If the fault occurs on the underground Power cable system, the fault current on the sheath has the influence on all sections because it's returned through earth at the directly grounded point and operation point of SVL(Sheath Voltage Limiter) at joint box. Therefore, the earth resistance and the operation of SVL have an effect on the zero-sequence current. Then the impedance between relaying point and fault point is Increased. That causes the overreach of distance relay. For these reasons, the distance relay algorithm for protecting of the underground power cable systems was developed. It effectively advance the errors using ACI(Advanced Computing Intelligence) technique. In this algorithm, the optimization was performed by fuzzy inference system and genetic algorithm.

• Korean Journal of Plant Resources
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• v.10 no.2
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• pp.200-210
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• 1997

The understanding on the plant genome is accelerated with the fast advance of molecular biological techniques. The molecular dissecting of the plant genome has made possible the precise genotyping the plants, which can be utilized for molecular breeding program. As well, the molecular cloning of genes interested can facilitate the process of gene transfer between intra-and inter-generic taxa. Moreover, the manipulation of the agronomically important QTL genes, which can be rarely performed by the conventional genetic methods, is also possible by the utilization of molecular markers. In addition to these genetical applications, molecular markers are useful in the areas of plant taxonomy and management of germplasm by fingerprinting analysis. This paper describes the theoretical aspects marker technologies and practical applications of each marker technique.

• The Journal of the Korean dental association
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• v.55 no.12
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• pp.862-869
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• 2017

Cleft lip and palate is the most common teratologic condition of oromaxillofacial units, probably associated with genetic and environmental causes. The goal of cleft surgery is to optimize facial esthetics and stomatognathic function while minimizing growth disturbances from surgical intervention. In this article, the author suggests the recent surgical strategies that minimize cleft nasal deformity and midfacial skeletal constriction. From the author's surgical experiences and literature reviews, only considerate surgeries would achieve functional improvement and facial esthetics in patients with cleft lip and palate.

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.428-429
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• 2008

In a previous paper, the distance relay algorithm for protecting of the underground power cable system was introduced. It effectively advance the errors using ACI(Advanced Computing Intelligence) technique. In this algorithm, the optimization was performed by fuzzy inference system and genetic algorithm. In this paper, hardware system based on ACI technique is introduced and tested by hardware test.

• Journal of the Korean Society of Visualization
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• v.5 no.2
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• pp.26-32
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• 2007

Stereoscopic PTV and Stereoscopic-PIV measurements have been carried out for the studies of the wake of a ship's propeller. Stereoscopic photogrammetry based on a 3D-PTV principle was introduced using two high-definition cameras(1k x 1k, 30Hz). The arrangement of the two cameras was based on angular position. The pair-matching of the three-dimensional velocity vectors were based on Genetic Algorithm based 3D-PTV technique. The results obtained by both measurement systems have been compared at the advance ratio J=0.88(290 rpm, d=54 mm). Turbulent properties have also been compared each other at the same condition.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1998.04a
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• pp.199-209
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• 1998

Since most engineering problems have had open-ended and ill-defined characteristics, design process is in advance attended with determination of alternatives based on realistic constraints after definition of appropriate problem. And it is completed with selection of best alternative through their comparison and investigation, and with performance of selected-alternative's detail design. As the process of structural design compared with that of general design, this paper presents a paradigm which can generate structural design alternatives, select optimum structure among them and simultaneously set its optimum design variables in reference of several objective as a result in more extended design region. For this purpose, specialized genetic algorithms which can handle design alternatives and multicriteria problems is used.

• Korean Journal of Biological Psychiatry
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• v.28 no.1
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• pp.1-6
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• 2021

Pharmacogenetics is opening a new era of precision medicine in psychiatry. Drug-metabolizing enzymes are characterized by genetic polymorphisms, which render a large portion of variability in individual drug metabolism. Dose adjustment based on pharmacogenetics knowledge is a first step to translate pharmacogenetics into clinical practice. However, diverse factors including cost-effectiveness should be addressed to provide clinical recommendation. To address current challenges in pharmacogenetics testing in psychiatry, this review provides an update regarding genotyping (SNP analysis, array, and next-generation sequencing), genotype-phenotype correlations, and cost-effectiveness. The current updates on pharmacogenetics in psychiatry will provide guidance for both clinician and researchers to have a consensus in harmonizing efforts to advance the pharmacogenetics field in a part of precision medicine in psychiatry.

• 제어로봇시스템학회:학술대회논문집
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• 2002.10a
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• pp.78.5-78
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• 2002

We propose an evolutionary reinforcement learning (RL) system with time-varying parameters that can deal with a dynamic environment. The proposed system has three characteristics: 1) It can deal easily with a dynamic environment by using time-varying parameters; 2) The division of state space is acquired evolutionarily by genetic algorithm (GA); 3) One does not have to design the rules constructing an agent in advance. So far many RL systems have been proposed. These systems adjust constant or non time-varying parameters; by those systems it is difficult to realize appropriate behavior in complex and dynamic environment. Hence, we propose the RL system whose parameters can vary temporally. T...