• 한국정보과학회논문지:소프트웨어및응용
• /
• 제29권9호
• /
• pp.676-683
• /
• 2002

XML(extensible Markup Language)문서가 웹 문서의 표준으로 자리 매김 할 수 있는 가장 큰 성공요인은 사용자가 문서 타입을 기술할 수 있는 유연성(flexibility)이다. 그러나 XML의 유연성으로 야기되는 문제점은 동일한 의미를 표현하기 위해 XML문서 작성자마다 서로 다른 태그명과 구조를 사용한다는 점이다. 즉 서로 다른 태그 집합, 요소(element), 속성(attribute)에 대한 서로 다른 이름 또는 다른 문서 구조로 인해 다른 태그로 표현된 문서는 서로 다른 부류의 문서로 간주되기 쉽다. 따라서 본 논문은 XML태그에 내재된 의미 정보(semantic information)와 구조 정보(structured information)를 추출하여 의미적으로 최대한 유사한 동의어로 확장하고, XML문서의 확장된 태그간의 의미적 유사도를 비교 분석할 수 있는 개념 기반의 태그 패턴 매처(Tag Pattern Matcher)를 설계 구현하였다. 두 XML문서의 태그간의 의미적 유사도에 가중치를 부여하여 기존의 비구조적인(semi-structured) 문서를 위한 벡터 스페이스 모델(vector space model)을 확장함으로써 두 XML문서가 유사한지를 파악할 수 있다.

• 한국토양비료학회지
• /
• 제44권4호
• /
• pp.591-596
• /
• 2011

The applications of chemical fertilizers and various types of organic materials may cause heavy metal accumulation in soil. In this study, we conducted to investigate the relationship between the different chemical forms of heavy metals such as Cr, Cd, Pb, Cu, Ni, and Zn retained in soil and the metal concentrations in Korean raspberry plant. Forty five soil samples were collected from 2 to 6 years old Korean raspberry cultivation fields (RCFs), Gochang, Korea, to determine total, exchangeable (1.0 M $MgCl_2$-extractable), DTPA-extractable metal contents. The leaves and fruits of raspberry plant were sampled at harvest stage. Total metal contents in soils ranged from $0.87mg\;kg^{-1}$ to $66.82mg\;kg^{-1}$. Exchangeable and DTPA-extractable metals ranged between 0.02 and $0.67mg\;kg^{-1}$ and between $0.05mg\;kg^{-1}$ and $7.07mg\;kg^{-1}$, respectively. The metal concentrations in the plant leaf and fruit determined on a dry-basis were between $1.30mg\;kg^{-1}$ and $38.82mg\;kg^{-1}$ and between $0.05mg\;kg^{-1}$ and $21.51mg\;kg^{-1}$, respectively, but Cd and Pb were not detected in the leaf. The total, exchangeable, and DTPA-extractable contents of the metal ions in soil were directly correlated one another, but the contents of different metals in the different fractions were inversely correlated in general. Most of total and DTPA-extractable metals in the soil were directly correlated with the contents of the same metals in the plant, whereas exchangeable metals in the soil were not statistically correlated with the same metals in plants. Thus, we concluded that the metal contents in the raspberry field soils were much lower thanthe levels of Soil Contamination Warning Standard (SCWS), and the plant metal concentrations were also less than the maximum permissible limits. The total and DTPA-extractable metals in the soil were closely related to the metal concentrations in the plant.

• 동의생리병리학회지
• /
• 제20권6호
• /
• pp.1678-1727
• /
• 2006

This study was perfromed to develop the assessment guideline and endpoints for clinical trial with anticancer herbal medicine. The botanical products used to humans for long time may be applied to phase 3 clinical trial after submitting the evidences for safety and efficacy of them or completion of basic requirement of phase 1 and phase 2 for safety confirmation and dose determination. Syndrome improvement was chiefly evaluated by Zubrod and karnofsky(%) methods. We suggest the general clinical trial assessment with botanical products, by following assessment points, that is, tumor size for 50 points, survival fate for 10 points, major syndromes for 40 points. It is recommendable that the each symptom of Qi deficiency syndrome, blood deficiency syndrome and Qi stagnation syndrome was allocated by assessment points, Similarly, the each symptom was given the assessment points according to the severity of symptom, for example, slight for 3 points, moderate for 2 points and severe for 1 point in hepatocelluar carcinoma and lung cancer. Then, the efficacy of botanical products was evaluated by the difference between pre-treatment and post-treatment. Asking the neoplastic patients of questionnaire on physical, emotional, cognitive, social and role subjects availability, three more syndromes (Fatigue, Pain and Nausea/Vomit), quality of life(QOL) will be evaluated by GLM statistics. In addition, in case of lung cancer, 13 questions will be asked by the EORTC QLQ-C13 forms. As the assessment of endpoints for efficacy to reduce side effects induced by chemotherapy and radiotherapy, the data of image scanning and hemato-urinalysis can be usefully applied on immune response, weight loss, indigestion, hemopoietic damage and injury of liver and kidney, while the changes of syndromes of side effect can be evaluated by differentiation methods of Qi and blood and five viscera. However, it is still necessary to determine the ratio between scientific analytical method and Oriental differentiation method as well as confirm the Oriental assessment endpoints by clinical trial. In addition, we suggest the continuous development of assessment endpoints on other carcinomas except of hepatocelluar carcinoma and lung cancer in future.

• Toxicological Research
• /
• 제33권4호
• /
• pp.265-272
• /
• 2017

Aryl hydrocarbons such as 3-nitrobenzanthrone (NBA), 4-aminobiphenyl (ABP), acetylaminofluorene (AAF), benzo(a)pyrene (BaP), and 1-nitropyrene (NP) form bulky DNA adducts when absorbed by mammalian cells. These chemicals are metabolically activated to reactive forms in mammalian cells and preferentially get attached covalently to the $N^2$ or C8 positions of guanine or the $N^6$ position of adenine. The proportion of $N^2$ and C8 guanine adducts in DNA differs among chemicals. Although these adducts block DNA replication, cells have a mechanism allowing to continue replication by bypassing these adducts: translesion DNA synthesis (TLS). TLS is performed by translesion DNA polymerases-Pol ${\eta}$, ${\kappa}$, ${\iota}$, and ${\zeta}$ and Rev1-in an error-free or error-prone manner. Regarding the NBA adducts, namely, 2-(2'-deoxyguanosin-$N^2$-yl)-3-aminobenzanthrone (dG-$N^2$-ABA) and N-(2'-deoxyguanosin-8-yl)-3-aminobenzanthrone (dG-C8-ABA), dG-$N^2$-ABA is produced more often than dG-C8-ABA, whereas dG-C8-ABA blocks DNA replication more strongly than dG-$N^2$-ABA. dG-$N^2$-ABA allows for a less error-prone bypass than dG-C8-ABA does. Pol ${\eta}$ and ${\kappa}$ are stronger contributors to TLS over dG-C8-ABA, and Pol ${\kappa}$ bypasses dG-C8-ABA in an error-prone manner. TLS efficiency and error-proneness are affected by the sequences surrounding the adduct, as demonstrated in our previous study on an ABP adduct, N-(2'-deoxyguanosine-8-yl)-4-aminobiphenyl (dG-C8-ABP). Elucidation of the general mechanisms determining efficiency, error-proneness, and the polymerases involved in TLS over various adducts is the next step in the research on TLS. These TLS studies will clarify the mechanisms underlying aryl hydrocarbon mutagenesis and carcinogenesis in more detail.

• Journal of Genetic Medicine
• /
• 제4권1호
• /
• pp.22-37
• /
• 2007

The autosomal dominant spinocerebellar ataxias (SCAs) are a group of neurodegenerative diseases, clinically and genetically heterogeneous, characterized by degeneration of spinocerebellar pathways with variable involvement of other neural systems. At present, 27 distinct genetic forms of SCAs are known: SCA1-8, SCA10-21, SCA23, SCA25-28, DRPLA (dentatorubral-pallidoluysian atrophy), and 16q-liked ADCA (autosomal dominant cerebellar ataxia). Epidemiological data about the prevalence of SCAs are restricted to a few studies of isolated geographical regions, and most do not reflect the real occurrence of the disease. In general a prevalence of about 0.3-2 cases per 100,000 people is assumed. As SCA are highly heterogeneous, the prevalence of specific subtypes varies between different ethnic and continental populations. Most recent data suggest that SCA3 is the commonest subtype worldwide; SCA1, SCA2, SCA6, SCA7, and SCA8 have a prevalence of over 2%, and the remaining SCAs are thought to be rare (prevalence <1%). In this review, we highlight and discuss the SCA7. The hallmark of SCA7 is the association of hereditary ataxia and visual loss caused by pigmentary macular degeneration. Visual failure is progressive, bilateral and symmetrical, and leads irreversibly to blindness. This association represents a distinct disease entity classified as autosomal dominant cerebellar ataxia (ADCA) type II by Harding. The disease affectsprimarily the cerebellum and the retina by the moderate to severe neuronal loss and gliosis, but also many other central nervous system structures as the disease progresses. SCA7 is caused by expansion of an unstable trinucleotide CAG repeat in the ATXN7 gene encoding a polyglutamine (polyQ) tract in the corresponding protein, ataxin-7. Normal ATXN7 alleles contain 4-35 CAG repeats, whereas pathological alleles contain from 36->450 CAG repeats. Immunoblott analysis demonstrated that ataxin-7 is widely expressed but that expression levels vary among tissues. Instability of expanded repeats is more pronounced in SCA7 than in other SCA subtypes and can cause substantial lowering of age at onset in successive generations termed ‘anticipation’ so that children may become diseased even before their parents develop symptoms. The strong anticipation in SCA7 and the rarity of contractions should have led to its extinction within a few generations. There is no specific drug therapy for this neurodegenerative disorder. Currently, therapy remains purely symptomatic. Cellular models and SCA7 transgenic mice have been generated which constitute valuable resources for studying the disease mechanism. Understanding the pathogenetic mechanisms of neurodegeneration in SCAs should lead to the identification of potential therapeutic targets and ultimately facilitate drug discovery. Here we summarize the clinical, pathological, and genetic aspects of SCA7, and review the current understanding of the pathogenesis of this disorder. Further, we also review the potential therapeutic strategies that are currently being explored in polyglutamine diseases.

• 인터넷정보학회논문지
• /
• 제17권6호
• /
• pp.53-59
• /
• 2016

최근 무선 센서 네트워크, 사물 인터넷, 소셜 네트워크 서비스와 같은 다양한 응용 분야에서 대용량 스트림 데이터가 실시간으로 생성되고 있으며, 효율적인 기법을 통해 처리 및 분석하여 유용한 정보를 찾아내고, 이를 의사 결정을 위해 사용할 수 있도록 하는 것은 중요한 이슈 중에 하나이다. 스트림 데이터는 끊임없이 빠른 속도로 생성되므로 최소한의 접근을 통해 처리해야 하며, 신속한 저전력 처리를 필요로 하는 자원이 제한된 환경에서 분석될 수 있도록 적합한 기법이 요구된다. 이러한 문제를 해결하기 위해, 슬라이딩 윈도우 개념이 제안되어 연구되고 있다. 한편, 대용량 데이터로부터 의미 있는 정보를 찾아내기 위한 데이터 마이닝 기법 중에 하나인 패턴 마이닝은 중요 정보를 패턴 형태로 추출한다. 전통적인 빈발 패턴 마이닝은 이진 데이터베이스를 대상으로 하고 모든 아이템을 동일한 중요도로 고려함으로써 데이터 마이닝 분야에서 중요한 역할을 수행해 왔지만, 실제 데이터 특성을 반영하지 못하는 단점을 지닌다. 하이 유틸리티 패턴 마이닝은 비 이진 데이터베이스로부터 상대적인 아이템 중요도를 반영하여 더욱 의미 있는 정보를 찾아내기 위해 제안되었다. 정적 데이터를 대상으로 하는 하이 유틸리티 패턴 마이닝 기법은 그러나 스트림 데이터 처리에 적합하지 못하다. 제한된 환경에서 스트림 데이터의 특성을 반영하고 효율적으로 처리하여 중요한 정보를 찾아내기 위해 슬라이딩 윈도우 기반의 접근법이 제안되었다. 본 논문은 슬라이딩 윈도우 기반 하이 유틸리티 패턴 마이닝 기법들의 성능을 평가하고 분석하여 해당 기법들의 특성 및 발전 방향을 고찰한다.

• 비교문화연구
• /
• 제29권
• /
• pp.341-366
• /
• 2012

'Headline Database of Newspaper Articles' is a database which contains about 141,500 newspaper articles from 1949 to March, 2009. They are collected from two perspectives; 'language' and 'language life' by KOKKEN. There were 3312 newspaper articles (about 2.34%) which included the word ONNA at 'Headline Database of Newspaper Articles'. The number of newspaper articles related to ONNA started to increase in 1975 but they decreased afterwards. They increased rapidly in 1980 and maintained the condition. However, they started to decrease rapidly in 1990 and maintained the decreased condition. They increased rapidly again in 2004 and 2007. The main causes of rapid increase were the commercial message of instant noodles "I am the one who is making. I am the one who is eating." in 1975, newspaper articles related to "Starting of full-scale studies on female language" in 1980, comments of "active women" and "men's crime" related to a murder case of an elementary school student in Sasebo City and mixed attendance books in 2004, a comment of "Women are machines which give birth to babies" in 2007. Those six causes of rapid increase suggested that the perception of gender such as 'Men need to work outside and Women need to do housework and take care of child' which was fixed until then was changing and becoming a stereotype of virtual reality rather than reality. The vocabulary related to ONNA appeared 3411 times among 3312 newspaper articles which included ONNA. Typical forms of the vocabulary related to ONNA were and . They appeared 2390 times and occupied 70% of the whole data. (3411 times) The form of ONNANOKO among the vocabulary related to ONNA appeared 113 times and occupied a high rate. ONNANOKO(113) and other words such as SHOJO(115), JOJI(28), YOJO(9) (152 in total) implied that appearing of young women at newspaper articles were increasing. Also, the vocabulary related to 'female language' such as ONNAKOTOBA(28) ONNANOKOTOBA(10) and a woman's heart such as ONNAGOKORO(35) and ONNANOKIMOCHI(34) appeared frequently. The vocabulary related to JOSEI were divided into <$JOSEI^{**}$> and <$^{**}JOSEI$>. <$JOSEI^{**}$> were mainly related to an occupation. <$^{**}JOSEI$> were mainly used to express women by regional groups such as or combined with modifiers to express women such as . In case with modifiers, WAKAIJOSEI appeared 35 times and showed the highest frequency. It had negative evaluations in many cases. The vocabulary related to JOSI appeared on the form of <$JOSI^{**}$> and mainly associated with 'a girl's school' and 'a female student'.

• 대한토목학회논문집
• /
• 제41권4호
• /
• pp.365-376
• /
• 2021

일반적인 국내 하천은 모래, 자갈하상으로 이루어진 충적하천으로 구성되어 있다. 이러한 하천들은 홍수나 집중호우, 폭우등의 급격한 유량변화로인해 침식 및 세굴등의 하상변화를 초래할 수 있다. 특히 세굴현상은 하천형상의 변화로 인해 발생하는 수축세굴이나 교각, 교대, 제방 등 흐름의 장애물 주위에서 발생하는 국부세굴등 다양한 형태의 세굴이 있다. 또한 유량이나 유속, 소류력등의 한계력에 의해 정적세굴이나 동적세굴등의 다양한 형태로 하천의 변화가 발생할 수 있다. 본 연구에서는 다양한 하천구조물 중 인명피해와 직결되는 제방에 발생하는 세굴에 초점을 두었으며, 자연형 호안재료의 특성과 세굴에 대한 방어능력등의 특성을 파악하고 자연재료의 강도를 증진시켜 강도증진의 변화를 파악하기 위해, 증진된 강도를 한계 유속과 한계소류력을 산정하여 제방 재료의 강도평가에 관한 연구를 진행하였다. 하상의 재료의 종류, 입자의 특성, 입자의 크기에 따라 재료가 가지는 한계를 호안 재료의 부피 변화인 토양 유실율을 이용하여 연구를 진행하였으며, 재료의 안전성에 대한 평가를 통해 하천설계 및 피해복구 시 활용할 수 있는 기초자료로 활용하고자 한다.

• 한국사회정책
• /
• 제25권2호
• /
• pp.191-217
• /
• 2018

세기말 개발도상국과 선진국의 사회정책은 금융, 식량, 에너지, 기후분야 등의 복합적인 위기로 인해 새로운 도전에 직면하면서, 대응해야할 위기 구조의 변화가 명확해졌다. 2008년부터 시작된 전세계적금융, 경제 위기로 인해 세계정치경제 구조의 새로운 조건이 만들어지기도 했다. 이에 많은 발전도상국과 선진국들은 새로운 위기와 도전에 응하기 위해 사회정책의 개혁을 다양한 방식으로 추구하기 시작했다. 이들 개혁들은 어떤 특정한 위기와 도전에 대응하였는가? 이러한 다양한 개혁방안들은 사회정책 개혁을 추구하는 국가들, 특히 세계화와 불확실성 시대인 21세기에 경제성장과 사회개발을 동시에 추구해야하는 개발도상국에 어떤 교훈을 주는가? 본 논문은 새로운 도전과 위기에 대응하기 위한 사회정책 개혁 담론과 정책에서 발견되는 새로운 동향을 비판적으로 평가하는 것을 그 목적으로 한다. 이를 위해 본 논문은 첫째, 사회정책이 대응해야 할 새로운 위기와 도전의 본질과 다양한 형태를 분석한다. 둘째, 개혁담론과 정책의 한계점을 논의한 후, 신흥부국의 사회정책 개혁이 주는 긍정적인 측면과 그 정책적 시사점을 밝힌다. 이를 토대로 새로운 위기와 도전에 대응할 수 있는 사회정책의 근간이 되는 원칙과 핵심요소를 제시한다.

• 한국연극학
• /
• 제52호
• /
• pp.5-59
• /
• 2014

This paper investigates the development and aesthetics of Korean political theatre from its quickening period 1920s to democratization era 1990s. Political theatre before 90s developed an antithesis resistant movement toward Korean modern history that had been scattered with suppressing political circumstances such as colonial era and dictatorial government, the movement has powerful activity and social influences. Just like the 20 century political theatre had been quickened under the influence of Marxism at Russia and Germany in 1920s, Korea's political theatre began in socialism theatre movement form around the same time. Proletarian theatre groups had been founded in Japan and Korea, and developed into practical movement with organized connection. However, the political theatre movement in Japanese colonial era was an empty vessel makes great sound but not much accomplishments. Most performance had been canceled or disapproved by suppression or censorship of the Japanese Empire. The political theatre in liberation era was the left drama inherited from Proletarian theatre of the colonial era. Korean Theatre alliance took lead the theatrical world unfold activities based on theatre popularization theory such as 'culture activists' taking a jump up the line and 'independent theatre' peeping into production spot as well as the important event, Independence Movement Day Memorial tournament theatre. Since 1947, US army military government in Korea strongly oppressed the left performances to stop and theatrical movement was ended due to many left theatrical people defection to North Korea. The political theatre in 1960s to 70s the Park regime, developed in dramatically different ways according to orthodox group and group out of power. The political theatre of institutional system handled judgment on sterile people and had indirect political theatre from that took history material and allegory technique because of censorship. In political theatre out of institution, it started outdoor theatre that has modernized traditional performance style and established deep relationship with labor spot and culture movement organizations. Madangguek(Outdoor theatre) is 'Attentive political theatre', satirizing and offending the political and social inconsistencies such as the dictatorial government's oppression and unbalanced distribution, alienation of general people, and foreign powers' pillage sharply as well as laughing at the Establishment with negative characters. The political theatre in 1980s is divided into two categories; political theatre of institutional system and Madangguek. Institutional Political theatre mainly performed in Korea Theatre Festival and the theatre group 'Yeonwoo-Moudae' led political theatre as private theatre company. Madangguek developed into an outdoor theatrical for indoor theatre capturing postcolonial historical view. Yeonwoo-Moudae theatre company produced representative political plays at 80s such as The chronicles of Han's, Birds fly away too, and so on by combining freewheeling play spirit of Madangguek and epic theatre. Political theatre was all the rage since the age of democratization started in 1987 and political materials has been freed from ban. However, political theatre was slowly declined as real socialism was crumbling and postmodernism is becoming the spirit of the times. After 90s, there are no more plays of ideology and propaganda that aim at politicization of theatre. As the age rapidly entered into the age of deideology, political theatre discourse also changed greatly. The concept 'the political' became influential as a new political possibility that stands up to neoliberalism system in the evasion of politics. Rather than reenact political issues, it experiments new political theatre that involves something political by deconstructing and reassigning audience's political sense with provocative forms, staging others and drawing discussion about it.