• Journal of KIISE:Software and Applications
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• v.29 no.9
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• pp.676-683
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• 2002

The success of XML(eXtensible Markup Language) is primarily based on its flexibility : everybody can define the structure of XML documents that represent information in the form he or she desires. XML is so flexible that XML documents cannot be automatically provided with an underlying semantics. Different tag sets, different names for elements or attributes, or different document structures in general mislead the task of classifying and clustering XML documents precisely. In this paper, we design and implement a system that allows checking the semantic-based similarity between XML tags. First, this system extracts the underlying semantics of tags and then expands the synonym set of tags using an WordNet thesaurus and user-defined word library which supports the abbreviation forms and compound words for XML tags. Seconds, considering the relative importance of XML tags in the XML documents, we extend a conventional vector space model which is the most generally used for document model in Information Retrieval field. Using this method, we have been able to check the similarity between XML tags which are represented different tags.

• Korean Journal of Soil Science and Fertilizer
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• v.44 no.4
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• pp.591-596
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• 2011

The applications of chemical fertilizers and various types of organic materials may cause heavy metal accumulation in soil. In this study, we conducted to investigate the relationship between the different chemical forms of heavy metals such as Cr, Cd, Pb, Cu, Ni, and Zn retained in soil and the metal concentrations in Korean raspberry plant. Forty five soil samples were collected from 2 to 6 years old Korean raspberry cultivation fields (RCFs), Gochang, Korea, to determine total, exchangeable (1.0 M $MgCl_2$-extractable), DTPA-extractable metal contents. The leaves and fruits of raspberry plant were sampled at harvest stage. Total metal contents in soils ranged from $0.87mg\;kg^{-1}$ to $66.82mg\;kg^{-1}$. Exchangeable and DTPA-extractable metals ranged between 0.02 and $0.67mg\;kg^{-1}$ and between $0.05mg\;kg^{-1}$ and $7.07mg\;kg^{-1}$, respectively. The metal concentrations in the plant leaf and fruit determined on a dry-basis were between $1.30mg\;kg^{-1}$ and $38.82mg\;kg^{-1}$ and between $0.05mg\;kg^{-1}$ and $21.51mg\;kg^{-1}$, respectively, but Cd and Pb were not detected in the leaf. The total, exchangeable, and DTPA-extractable contents of the metal ions in soil were directly correlated one another, but the contents of different metals in the different fractions were inversely correlated in general. Most of total and DTPA-extractable metals in the soil were directly correlated with the contents of the same metals in the plant, whereas exchangeable metals in the soil were not statistically correlated with the same metals in plants. Thus, we concluded that the metal contents in the raspberry field soils were much lower thanthe levels of Soil Contamination Warning Standard (SCWS), and the plant metal concentrations were also less than the maximum permissible limits. The total and DTPA-extractable metals in the soil were closely related to the metal concentrations in the plant.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.6
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• pp.1678-1727
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• 2006

This study was perfromed to develop the assessment guideline and endpoints for clinical trial with anticancer herbal medicine. The botanical products used to humans for long time may be applied to phase 3 clinical trial after submitting the evidences for safety and efficacy of them or completion of basic requirement of phase 1 and phase 2 for safety confirmation and dose determination. Syndrome improvement was chiefly evaluated by Zubrod and karnofsky(%) methods. We suggest the general clinical trial assessment with botanical products, by following assessment points, that is, tumor size for 50 points, survival fate for 10 points, major syndromes for 40 points. It is recommendable that the each symptom of Qi deficiency syndrome, blood deficiency syndrome and Qi stagnation syndrome was allocated by assessment points, Similarly, the each symptom was given the assessment points according to the severity of symptom, for example, slight for 3 points, moderate for 2 points and severe for 1 point in hepatocelluar carcinoma and lung cancer. Then, the efficacy of botanical products was evaluated by the difference between pre-treatment and post-treatment. Asking the neoplastic patients of questionnaire on physical, emotional, cognitive, social and role subjects availability, three more syndromes (Fatigue, Pain and Nausea/Vomit), quality of life(QOL) will be evaluated by GLM statistics. In addition, in case of lung cancer, 13 questions will be asked by the EORTC QLQ-C13 forms. As the assessment of endpoints for efficacy to reduce side effects induced by chemotherapy and radiotherapy, the data of image scanning and hemato-urinalysis can be usefully applied on immune response, weight loss, indigestion, hemopoietic damage and injury of liver and kidney, while the changes of syndromes of side effect can be evaluated by differentiation methods of Qi and blood and five viscera. However, it is still necessary to determine the ratio between scientific analytical method and Oriental differentiation method as well as confirm the Oriental assessment endpoints by clinical trial. In addition, we suggest the continuous development of assessment endpoints on other carcinomas except of hepatocelluar carcinoma and lung cancer in future.

• Toxicological Research
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• v.33 no.4
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• pp.265-272
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• 2017

Aryl hydrocarbons such as 3-nitrobenzanthrone (NBA), 4-aminobiphenyl (ABP), acetylaminofluorene (AAF), benzo(a)pyrene (BaP), and 1-nitropyrene (NP) form bulky DNA adducts when absorbed by mammalian cells. These chemicals are metabolically activated to reactive forms in mammalian cells and preferentially get attached covalently to the $N^2$ or C8 positions of guanine or the $N^6$ position of adenine. The proportion of $N^2$ and C8 guanine adducts in DNA differs among chemicals. Although these adducts block DNA replication, cells have a mechanism allowing to continue replication by bypassing these adducts: translesion DNA synthesis (TLS). TLS is performed by translesion DNA polymerases-Pol ${\eta}$, ${\kappa}$, ${\iota}$, and ${\zeta}$ and Rev1-in an error-free or error-prone manner. Regarding the NBA adducts, namely, 2-(2'-deoxyguanosin-$N^2$-yl)-3-aminobenzanthrone (dG-$N^2$-ABA) and N-(2'-deoxyguanosin-8-yl)-3-aminobenzanthrone (dG-C8-ABA), dG-$N^2$-ABA is produced more often than dG-C8-ABA, whereas dG-C8-ABA blocks DNA replication more strongly than dG-$N^2$-ABA. dG-$N^2$-ABA allows for a less error-prone bypass than dG-C8-ABA does. Pol ${\eta}$ and ${\kappa}$ are stronger contributors to TLS over dG-C8-ABA, and Pol ${\kappa}$ bypasses dG-C8-ABA in an error-prone manner. TLS efficiency and error-proneness are affected by the sequences surrounding the adduct, as demonstrated in our previous study on an ABP adduct, N-(2'-deoxyguanosine-8-yl)-4-aminobiphenyl (dG-C8-ABP). Elucidation of the general mechanisms determining efficiency, error-proneness, and the polymerases involved in TLS over various adducts is the next step in the research on TLS. These TLS studies will clarify the mechanisms underlying aryl hydrocarbon mutagenesis and carcinogenesis in more detail.

• Journal of Genetic Medicine
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• v.4 no.1
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• pp.22-37
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• 2007

The autosomal dominant spinocerebellar ataxias (SCAs) are a group of neurodegenerative diseases, clinically and genetically heterogeneous, characterized by degeneration of spinocerebellar pathways with variable involvement of other neural systems. At present, 27 distinct genetic forms of SCAs are known: SCA1-8, SCA10-21, SCA23, SCA25-28, DRPLA (dentatorubral-pallidoluysian atrophy), and 16q-liked ADCA (autosomal dominant cerebellar ataxia). Epidemiological data about the prevalence of SCAs are restricted to a few studies of isolated geographical regions, and most do not reflect the real occurrence of the disease. In general a prevalence of about 0.3-2 cases per 100,000 people is assumed. As SCA are highly heterogeneous, the prevalence of specific subtypes varies between different ethnic and continental populations. Most recent data suggest that SCA3 is the commonest subtype worldwide; SCA1, SCA2, SCA6, SCA7, and SCA8 have a prevalence of over 2%, and the remaining SCAs are thought to be rare (prevalence <1%). In this review, we highlight and discuss the SCA7. The hallmark of SCA7 is the association of hereditary ataxia and visual loss caused by pigmentary macular degeneration. Visual failure is progressive, bilateral and symmetrical, and leads irreversibly to blindness. This association represents a distinct disease entity classified as autosomal dominant cerebellar ataxia (ADCA) type II by Harding. The disease affectsprimarily the cerebellum and the retina by the moderate to severe neuronal loss and gliosis, but also many other central nervous system structures as the disease progresses. SCA7 is caused by expansion of an unstable trinucleotide CAG repeat in the ATXN7 gene encoding a polyglutamine (polyQ) tract in the corresponding protein, ataxin-7. Normal ATXN7 alleles contain 4-35 CAG repeats, whereas pathological alleles contain from 36->450 CAG repeats. Immunoblott analysis demonstrated that ataxin-7 is widely expressed but that expression levels vary among tissues. Instability of expanded repeats is more pronounced in SCA7 than in other SCA subtypes and can cause substantial lowering of age at onset in successive generations termed ‘anticipation’ so that children may become diseased even before their parents develop symptoms. The strong anticipation in SCA7 and the rarity of contractions should have led to its extinction within a few generations. There is no specific drug therapy for this neurodegenerative disorder. Currently, therapy remains purely symptomatic. Cellular models and SCA7 transgenic mice have been generated which constitute valuable resources for studying the disease mechanism. Understanding the pathogenetic mechanisms of neurodegeneration in SCAs should lead to the identification of potential therapeutic targets and ultimately facilitate drug discovery. Here we summarize the clinical, pathological, and genetic aspects of SCA7, and review the current understanding of the pathogenesis of this disorder. Further, we also review the potential therapeutic strategies that are currently being explored in polyglutamine diseases.

• Journal of Internet Computing and Services
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• v.17 no.6
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• pp.53-59
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• 2016

Recently, huge stream data have been generated in real time from various applications such as wireless sensor networks, Internet of Things services, and social network services. For this reason, to develop an efficient method have become one of significant issues in order to discover useful information from such data by processing and analyzing them and employing the information for better decision making. Since stream data are generated continuously and rapidly, there is a need to deal with them through the minimum access. In addition, an appropriate method is required to analyze stream data in resource limited environments where fast processing with low power consumption is necessary. To address this issue, the sliding window model has been proposed and researched. Meanwhile, one of data mining techniques for finding meaningful information from huge data, pattern mining extracts such information in pattern forms. Frequency-based traditional pattern mining can process only binary databases and treats items in the databases with the same importance. As a result, frequent pattern mining has a disadvantage that cannot reflect characteristics of real databases although it has played an essential role in the data mining field. From this aspect, high utility pattern mining has suggested for discovering more meaningful information from non-binary databases with the consideration of the characteristics and relative importance of items. General high utility pattern mining methods for static databases, however, are not suitable for handling stream data. To address this issue, sliding window based high utility pattern mining has been proposed for finding significant information from stream data in resource limited environments by considering their characteristics and processing them efficiently. In this paper, we conduct various experiments with datasets for performance evaluation of sliding window based high utility pattern mining algorithms and analyze experimental results, through which we study their characteristics and direction of improvement.

• Cross-Cultural Studies
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• v.29
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• pp.341-366
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• 2012

'Headline Database of Newspaper Articles' is a database which contains about 141,500 newspaper articles from 1949 to March, 2009. They are collected from two perspectives; 'language' and 'language life' by KOKKEN. There were 3312 newspaper articles (about 2.34%) which included the word ONNA at 'Headline Database of Newspaper Articles'. The number of newspaper articles related to ONNA started to increase in 1975 but they decreased afterwards. They increased rapidly in 1980 and maintained the condition. However, they started to decrease rapidly in 1990 and maintained the decreased condition. They increased rapidly again in 2004 and 2007. The main causes of rapid increase were the commercial message of instant noodles "I am the one who is making. I am the one who is eating." in 1975, newspaper articles related to "Starting of full-scale studies on female language" in 1980, comments of "active women" and "men's crime" related to a murder case of an elementary school student in Sasebo City and mixed attendance books in 2004, a comment of "Women are machines which give birth to babies" in 2007. Those six causes of rapid increase suggested that the perception of gender such as 'Men need to work outside and Women need to do housework and take care of child' which was fixed until then was changing and becoming a stereotype of virtual reality rather than reality. The vocabulary related to ONNA appeared 3411 times among 3312 newspaper articles which included ONNA. Typical forms of the vocabulary related to ONNA were and . They appeared 2390 times and occupied 70% of the whole data. (3411 times) The form of ONNANOKO among the vocabulary related to ONNA appeared 113 times and occupied a high rate. ONNANOKO(113) and other words such as SHOJO(115), JOJI(28), YOJO(9) (152 in total) implied that appearing of young women at newspaper articles were increasing. Also, the vocabulary related to 'female language' such as ONNAKOTOBA(28) ONNANOKOTOBA(10) and a woman's heart such as ONNAGOKORO(35) and ONNANOKIMOCHI(34) appeared frequently. The vocabulary related to JOSEI were divided into <$JOSEI^{**}$> and <$^{**}JOSEI$>. <$JOSEI^{**}$> were mainly related to an occupation. <$^{**}JOSEI$> were mainly used to express women by regional groups such as or combined with modifiers to express women such as . In case with modifiers, WAKAIJOSEI appeared 35 times and showed the highest frequency. It had negative evaluations in many cases. The vocabulary related to JOSI appeared on the form of <$JOSI^{**}$> and mainly associated with 'a girl's school' and 'a female student'.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.41 no.4
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• pp.365-376
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• 2021

In general, domestic streams and rivers are composed of alluvial rivers consisting of sand and gravel beds. These rivers can cause erosion and riverbed changes due to sudden changes in flow rates, such as floods, torrential rains, and heavy rains. In particular, there are various types of erosion, such as contraction erosion caused by changes in river shape, or local erosion occurring around obstacles such as piers, abutments or embankments. In addition, river changes can occur in various forms, such as static or dynamic periods, due to limitations such as flow rate, velocity, and shear stress. This study focused on the erosions of embankments directly related to human casualties among various river structures, and evaluated limit velocities and critical shear stress in order to identify changes in strength of natural materials by identifying the characteristics of natural hoan materials and resistance to erosions. In particular, the limitations of materials according to the type of materials in the river, characteristics of particles, and size of particles were studied using Soil loss, which is a change in the volume of the revetment material, and it is intended to be used as basic data for river design and restoration.

• 한국사회정책
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• v.25 no.2
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• pp.191-217
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• 2018

At the turn of the century, social policy in both developed and developing countries confronts new challenges and risks caused by the multiple crises in finance, food, energy and climate change. Changes in the structures of risks are particularly significant. In addition, the global economic crisis starting in 2008 has provided a new context of the global political economy. Both developed and developing countries have responded to these new challenges and risks differently. What risks do these responses aim to address? How can these responses address these risks? Can these diverse responses offer lessons for lower income economies attempting to address social development challenges alongside economic growth in the globalised and increasingly uncertain 21st century context? This paper aims to provide a critical review of the new trends, phenomena or directions of social policy discourse and practice to respond to the new risks in the context of development. Explaining the nature and forms of new challenges and risks and pointing out the potentials and limitations of social policy discourse, it introduces the key points of the previous research we have to keep in mind in formulating alternative social policy approaches. General principles and core elements of social policy in addressing new challenges and risks in the $21^{st}$ century, which are particularly visible in social policy reforms in emerging economies, are highlighted as a conclusion.

• Journal of Korean Theatre Studies Association
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• no.52
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• pp.5-59
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• 2014

This paper investigates the development and aesthetics of Korean political theatre from its quickening period 1920s to democratization era 1990s. Political theatre before 90s developed an antithesis resistant movement toward Korean modern history that had been scattered with suppressing political circumstances such as colonial era and dictatorial government, the movement has powerful activity and social influences. Just like the 20 century political theatre had been quickened under the influence of Marxism at Russia and Germany in 1920s, Korea's political theatre began in socialism theatre movement form around the same time. Proletarian theatre groups had been founded in Japan and Korea, and developed into practical movement with organized connection. However, the political theatre movement in Japanese colonial era was an empty vessel makes great sound but not much accomplishments. Most performance had been canceled or disapproved by suppression or censorship of the Japanese Empire. The political theatre in liberation era was the left drama inherited from Proletarian theatre of the colonial era. Korean Theatre alliance took lead the theatrical world unfold activities based on theatre popularization theory such as 'culture activists' taking a jump up the line and 'independent theatre' peeping into production spot as well as the important event, Independence Movement Day Memorial tournament theatre. Since 1947, US army military government in Korea strongly oppressed the left performances to stop and theatrical movement was ended due to many left theatrical people defection to North Korea. The political theatre in 1960s to 70s the Park regime, developed in dramatically different ways according to orthodox group and group out of power. The political theatre of institutional system handled judgment on sterile people and had indirect political theatre from that took history material and allegory technique because of censorship. In political theatre out of institution, it started outdoor theatre that has modernized traditional performance style and established deep relationship with labor spot and culture movement organizations. Madangguek(Outdoor theatre) is 'Attentive political theatre', satirizing and offending the political and social inconsistencies such as the dictatorial government's oppression and unbalanced distribution, alienation of general people, and foreign powers' pillage sharply as well as laughing at the Establishment with negative characters. The political theatre in 1980s is divided into two categories; political theatre of institutional system and Madangguek. Institutional Political theatre mainly performed in Korea Theatre Festival and the theatre group 'Yeonwoo-Moudae' led political theatre as private theatre company. Madangguek developed into an outdoor theatrical for indoor theatre capturing postcolonial historical view. Yeonwoo-Moudae theatre company produced representative political plays at 80s such as The chronicles of Han's, Birds fly away too, and so on by combining freewheeling play spirit of Madangguek and epic theatre. Political theatre was all the rage since the age of democratization started in 1987 and political materials has been freed from ban. However, political theatre was slowly declined as real socialism was crumbling and postmodernism is becoming the spirit of the times. After 90s, there are no more plays of ideology and propaganda that aim at politicization of theatre. As the age rapidly entered into the age of deideology, political theatre discourse also changed greatly. The concept 'the political' became influential as a new political possibility that stands up to neoliberalism system in the evasion of politics. Rather than reenact political issues, it experiments new political theatre that involves something political by deconstructing and reassigning audience's political sense with provocative forms, staging others and drawing discussion about it.