• 대한골관절종양학회지
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• 제13권2호
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• pp.142-145
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• 2007

위장관이외의 장소에서 위장관 간질 종양(Gastrointestinal stromal tumor, GIST)이 발생하는 경우는 매우 드물기 때문에 일차적 병소가 아닌 전이 병소로 진단되는 경향이 있다. 이에 본 저자들은 25세 남자에서 좌측 둔부 중둔근, 소둔근에서 발생한 위장관 간질 종양이 복부의 일차 병소없이 인접한 장골 및 천골을 침범한 1례를 경험하였다. 이에 위장관외 간질종양(Extragastrointestinal stromal tumor, EGIST)이라는 진단명과 함께 보고하고자 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권10호
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• pp.4187-4192
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• 2014

Matrix metalloproteinase (MMP)-2 and MMP-9 are important proteases involved in invasion and metastasis of various tumors. Extra-gastrointestinal stromal tumors (EGISTs) are rare neoplasms. This study was performed to assess MMP-2 and MMP-9 expression in EGIST tissue samples for association with clinicopathological data from the patients. Twenty-one surgical EGIST tissue specimens were collected for analysis of MMP-2 and MMP-9 expression using immunohistochemistry. MMP-2 and MMP-9 proteins were expressed in all of the epithelial cell types of EGISTs, whereas they were only expressed in 75% of the spindle cell type, although there was no statistically significant difference (p>0.05). Expression of MMP-2 and MMP-9 proteins was associated with tumor size, mitotic rate, tumor necrosis, and distant metastasis (p<0.05). MMP-2 expression was linked with MMP-9 levels (p<0.05). However, there was no correlation between MMP-9 expression and age, sex, primary site, or cell morphology in any of these 21 EGIST patients (p>0.05). Moreover, expression of MMP-2 and MMP-9 proteins increased with the degree of EGIST risk. This study provided evidence of an association of MMP-2 and MMP-9 expression with advanced EGIST behavior.

• Journal of Chest Surgery
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• 제50권4호
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• pp.308-311
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• 2017

A 71-year-old man was referred for an anterior chest wall mass. Chest computed tomography (CT) and positron emission tomography-CT suggested a malignant tumor. Surgical biopsy through a vertical subxiphoid incision revealed an extra-gastrointestinal stromal tumor (EGIST). En bloc resection of the tumor, including partial resection of the sternum, costal cartilage, pericardium, diaphragm, and peritoneum, was performed. Pathologic evaluation revealed a negative resection margin and confirmed the tumor as an EGIST. On postoperative day 17, the patient was discharged without any complications. At the 2-week follow-up, the patient was doing well and was asymptomatic.