Browse > Article
http://dx.doi.org/10.7314/APJCP.2014.15.10.4187

Association of Matrix Metalloproteinase (MMP)-2 and -9 Expression with Extra-gastrointestinal Stromal Tumor Metastasis  

Wang, Chao (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University)
Ma, Hong-Xi (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University)
Jin, Mei-Shan (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University)
Zou, Ya-Bin (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University)
Teng, Yong-Liang (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University)
Tian, Zhuang (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University)
Wang, Hai-Ying (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University)
Wang, Yin-Ping (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University)
Duan, Xiu-Mei (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.10, 2014 , pp. 4187-4192 More about this Journal
Abstract
Matrix metalloproteinase (MMP)-2 and MMP-9 are important proteases involved in invasion and metastasis of various tumors. Extra-gastrointestinal stromal tumors (EGISTs) are rare neoplasms. This study was performed to assess MMP-2 and MMP-9 expression in EGIST tissue samples for association with clinicopathological data from the patients. Twenty-one surgical EGIST tissue specimens were collected for analysis of MMP-2 and MMP-9 expression using immunohistochemistry. MMP-2 and MMP-9 proteins were expressed in all of the epithelial cell types of EGISTs, whereas they were only expressed in 75% of the spindle cell type, although there was no statistically significant difference (p>0.05). Expression of MMP-2 and MMP-9 proteins was associated with tumor size, mitotic rate, tumor necrosis, and distant metastasis (p<0.05). MMP-2 expression was linked with MMP-9 levels (p<0.05). However, there was no correlation between MMP-9 expression and age, sex, primary site, or cell morphology in any of these 21 EGIST patients (p>0.05). Moreover, expression of MMP-2 and MMP-9 proteins increased with the degree of EGIST risk. This study provided evidence of an association of MMP-2 and MMP-9 expression with advanced EGIST behavior.
Keywords
Extra; gastrointestinal stromal tumor (EGIST); MMP-2; MMP-9; tumor invasion and metastasis; biomarker;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Adler G (2004). Has the biology and treatment of pancreatic diseases evolved? Best Pract Res Clin Gastroenterol, 18, 83-90.   DOI   ScienceOn
2 Agaimy A, Wunsch PH (2006). Gastrointestinal stromal tumours: a regular origin in the muscularis propria, but an extremely diverse gross presentation. A review of 200 cases to critically re-evaluate the concept of so-called extra-gastrointestinal stromal tumours. Langenbecks Arch Surg, 391, 322-9.   DOI
3 Backstrom JR, Tokes ZA (1995). The 84-kDa form of human matrix metalloproteinase-9 degrades substance P and gelatin. J Neurochem, 64, 1312-8.
4 Bloomston M, Zervos EE, Rosemurgy AS, 2nd (2002). Matrix metalloproteinases and their role in pancreatic cancer: a review of preclinical studies and clinical trials. Ann Surg Oncol, 9, 668-74.   DOI   ScienceOn
5 Cauwe B, Van den Steen PE, Opdenakker G (2007). The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases. Crit Rev Biochem Mol Biol, 42, 113-85.   DOI   ScienceOn
6 Zeng ZS, Huang Y, Cohen AM, Guillem JG (1996). Prediction of colorectal cancer relapse and survival via tissue RNA levels of matrix metalloproteinase-9. J Clin Oncol, 14, 3133-40.
7 Yamamoto H, Oda Y, Kawaguchi K, et al (2004). c-kit and PDGFRA mutations in extragastrointestinal stromal tumor (gastrointestinal stromal tumor of the soft tissue). Am J Surg Pathol, 28, 479-88.   DOI   ScienceOn
8 Yuan Y, Zhang W, Yan R, et al (2009). Identification of a novel 14-3-3zeta binding site within the cytoplasmic domain of platelet glycoprotein Ibalpha that plays a key role in regulating the von Willebrand factor binding function of glycoprotein Ib-IX. Circ Res, 105, 1177-85.   DOI
9 Yukawa N, Yoshikawa T, Akaike M, et al (2001). Plasma concentration of tissue inhibitor of matrix metalloproteinase 1 in patients with colorectal carcinoma. Br J Surg, 88, 1596-601.   DOI
10 Zhang S, Li L, Lin JY, Lin H (2003). Imbalance between expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in invasiveness and metastasis of human gastric carcinoma. World J Gastroenterol, 9, 899-904.
11 Rodriguez D, Morrison CJ, Overall CM (2010). Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics. Biochim Biophys Acta, 1803, 39-54.   DOI   ScienceOn
12 Liu Z, Li L, Yang Z, et al (2010). Increased expression of MMP9 is correlated with poor prognosis of nasopharyngeal carcinoma. BMC Cancer, 10, 270.   DOI
13 Reith JD, Goldblum JR, Lyles RH, Weiss SW (2000). Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Pathol, 13, 577-85.   DOI   ScienceOn
14 West RB, Corless CL, Chen X, et al (2004). The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol, 165, 107-13.   DOI   ScienceOn
15 Ring P, Johansson K, Hoyhtya M, Rubin K, Lindmark G (1997). Expression of tissue inhibitor of metalloproteinases TIMP-2 in human colorectal cancer--a predictor of tumour stage. Br J Cancer, 76, 805-11.   DOI   ScienceOn
16 Roy R, Yang J, Moses MA (2009). Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer. J Clin Oncol, 27, 5287-97.   DOI   ScienceOn
17 Sier CF, Kubben FJ, Ganesh S, et al (1996). Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma. Br J Cancer, 74, 413-7.   DOI   ScienceOn
18 Yadav L, Puri N, Rastogi V, Satpute P, Ahmad R, Kaur G (2014). Matrix metalloproteinases and cancer - roles in threat and therapy. Asian Pac J Cancer Prev, 15, 1085-91.   과학기술학회마을   DOI   ScienceOn
19 Hatfield KJ, Reikvam H, Bruserud O (2010). The crosstalk between the matrix metalloprotease system and the chemokine network in acute myeloid leukemia. Curr Med Chem, 17, 4448-61.   DOI
20 Dumont N, Bakin AV, Arteaga CL (2003). Autocrine transforming growth factor-beta signaling mediates Smad-independent motility in human cancer cells. J Biol Chem, 278, 3275-85.   DOI
21 Espinosa I, Lee CH, Kim MK, et al (2008). A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors. Am J Surg Pathol, 32, 210-8.   DOI   ScienceOn
22 Klein T, Bischoff R (2011). Physiology and pathophysiology of matrix metalloproteases. Amino Acids, 41, 271-90.   DOI
23 Grigioni WF, D'Errico A, Fortunato C, et al (1994). Prognosis of gastric carcinoma revealed by interactions between tumor cells and basement membrane. Mod Pathol, 7, 220-5.
24 Joensuu H (2008). Risk stratification of patients diagnosed with gastrointestinal stromal tumor. Hum Pathol, 39, 1411-9.   DOI   ScienceOn
25 Kessenbrock K, Plaks V, Werb Z (2010). Matrix metalloproteinases: regulators of the tumor microenvironment. Cell, 141, 52-67.   DOI   ScienceOn
26 Labauge P, Brunereau L, Laberge S, Houtteville JP (2001). Prospective follow-up of 33 asymptomatic patients with familial cerebral cavernous malformations. Neurology, 57, 1825-8.   DOI
27 Langers AM, Verspaget HW, Hawinkels LJ, et al (2012). MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients. Br J Cancer, 106, 1495-8.   DOI   ScienceOn
28 Levy AT, Cioce V, Sobel ME, et al (1991). Increased expression of the Mr 72,000 type IV collagenase in human colonic adenocarcinoma. Cancer Res, 51, 439-44.
29 Wang C, Jin MS, Zou YB, et al (2013). Diagnostic significance of DOG-1 and PKC-theta expression and c-Kit/PDGFRA mutations in gastrointestinal stromal tumours. Scand J Gastroenterol, 48, 1055-65.   DOI