• Journal of Acupuncture Research
• /
• 제36권2호
• /
• pp.113-117
• /
• 2019

Parkinson's disease (PD) is a neurodegenerative disease, where treatment with medication may lead to gastrointestinal (GI) symptoms. The objective of this case study was to investigate the effectiveness of Korean medicine (KM) in treating PD with drug-induced GI dysfunction. A 70-year-old female participant was diagnosed with PD in 2010 and drug-induced gastritis in 2016. Her major symptoms were related to GI, PD, and overall feeling of weakness. She was treated with KM including pharmacopuncture, acupuncture, moxibustion, and herbal medicines, in combination with Western medicines during 46 days of in-patient care. This study showed an improvement in symptoms and scores on the GI symptom scale, Unified Parkinson's disease rating scale, Hoehn and Yahr staging, Berg balance scale, PD quality of life, and stress index at discharge. This case demonstrated that the symptoms of drug-induced GI dysfunctions in PD was improved by treatment with KM.

• 사상체질의학회지
• /
• 제27권2호
• /
• pp.254-269
• /
• 2015

Objectives This study aimed to observe the effect of Taeumjowi-tang on the cisplatin-induced gastrointestinal dysfunctions in rats. Methods Four groups, each of 8 rats per group, were used in this study. Saline and distilled water treated control rats were intact vehicle control group. Delayed gastrointestinal motility was induced by intraperitoneal treatment of cisplatin 2mg/kg, once a week for 5 weeks(Cisplatin control group). Taeumjowi-tang aqueous extracts(TJ) were orally administered in a volume of 5ml/kg, once a day for 14 days from 4th cisplatin treatment(TJ group). Ondansetron 1mg/kg was subcutaneously treated, in a volume of 1ml/kg, as same as TJ(ondansetron group). We measured the body weights, intestinal charcoal transit ratio, fecal parameters, fundus MDA(malondialdehyde), GSH(glutathione) contents and SOD(superoxide dismutase), CAT(catalase) activities, TPH(tryptophanhydroxylase) and MAO(monoamine oxidase) activities, pyloric gastrin and serotonin contents with their immunoreactive cells, colonic serotonin-immunoreactive cells, the histopathology of pylorus, fundus mucosa and colon. Results 1) The body weight gains, the small intestinal charcoal transfer rates, the fecal parameters(numbers, weights and water contents) were increased in TJ, ondansetron group. 2) The inhibit of fundus antioxidant defense systems by cisplatin were decreased in TJ, ondansetron group. 3) The pyloric TPH activities were increased and the pyloric MAO activities were decreased in TJ group. 4) The pyloric gastric contents and the gastrin-immunoreactive cells were increased and the pyloric serotonin contents and the pyloric and colonic serotonin-immunoreactive cells were decreased in TJ group. 5) The pylorus atrophic changes and the gastric surface erosive damage regions by cisplatin were favorably inhibited by treatment of TJ group. Conclusions The results obtained in this study suggest that TJ favorably retarded the cisplatin related GI(gastrointestinal) dysfunctions and constipation through modulations of GI enterochromaffin cells, serotonin and gastrin-producing cells and antioxidative systems.

• 대한한방부인과학회지
• /
• 제33권1호
• /
• pp.19-35
• /
• 2020

Objectives: The purpose of this study was to show effectiveness of Acupuncture treatment on gastrointestinal dysfunctions after Cesarean section by analyzing randomized controlled clinical trials. Methods: We searched randomized controlled clinical trials related with acupuncture treatment on gastrointestinal dysfunctions after Cesarean section through national and overseas database and analyzed them in detail. Results: 6 articles were included according to our selection criteria and 1,084 women were involved. 3 studies used TEAS (Transcutaneous Electrical Acupoint Stimulation), 2 studies used Elastic band and 1 study used Acupressure by hand. Their results were statistically more effective than control groups. The most frequently used acupoints were Neiguan (PC6), Zusanli (ST36) followed by Sanyinjiao (SP6), Hegu (IL4). Conclusions: There was significant difference in the effectiveness of the intervention including Acupuncture treatment. Based on analysis, it could be an effective way for the treatment of gastrointestinal dysfunctions after Cesarean section in clinical practice.

• 사상체질의학회지
• /
• 제25권4호
• /
• pp.343-358
• /
• 2013

Objectives This study aimed to observe the effect of Hyangsayangwi-tang on the cisplatin-induced gastrointestinal dysfunctions in rats. Methods Four groups(each of 8 rats per group) were used in this study. Saline and distilled water treated control rats are Intact vehicle control group. Delayed gatrointestinal mortility was induced by intraperitoneal treatment of cisplatin 2mg/kg, once a week for 5 weeks(Cisplatin control group). Hyangsayangwi-tang aqueous extracts(HY) were orally administered in a volume of 5ml/kg, once a day for 14 days from 4th ciplatin treatmernt(HY group). Ondansetron 1mg/kg was subcutaneously treated, in a volume of 1ml/kg, as same as HY(ondansetron group). We measured the body weights, intestinal charcoal transit ratio, fecal parameters, fundus MDA, GSH contents and SOD, CAT activities, TPH and MAO activities, pyloric gastrin and serotonin contents with their immunoraective cells, colonic serotonin-immunoreactive cells, the histopathology of pylorus, fundus mucosa and colon. Results and Conclusions (1) The body weight gains, the small intestinal charcoal transfer rates, the fecal parameters(numbers, weights and water contents) were increased in HY, ondansetron group. (2) The inhibit of fundus antioxidant defense systems by cisplatin were decreased in HY, ondansetron group. (3) The pyloric TPH activities were increased and the pyloric MAO activities were decreased in HY group. (4) The pyloric gastric contents and the gastrin-immunoreactive cells were increased in HY group. And the pyloric serotonin contents and the pyloric and colonic serotonin-immunoreactive cells were decreased in HY group. (5) The pyloru atrophic changes and the gastric surface erosive damage regions by cisplatin were favorably inhibited by treatment of HY. HY, a representative Soeumin prescription improve GI dysfunctions and constipation retarded by cisplatin through modulations of GI enterochromaffin cells, serotonin and gastrin-producing cells and antioxidative systems. Especially HY showed the highest favorable effects more than those of ondansetron.

• 생명과학회지
• /
• 제29권12호
• /
• pp.1345-1350
• /
• 2019

한약재로 쓰이는 용담(Gentiana scabra)의 열수 추출물(GS-W)을 정상 마우스에 경구 투여할 경우 in vivo 위장관이송률(ITR)이 유의적이고 용량 의존적으로 증가한다는 사실이, 최근 본 연구진에 의해 보고된 바 있다. 이에 본 연구에서는, in vivo 실험적 위장관 운동 기능 저해(GMD) 마우스 모델에서는 GS-W가 ITR에 어떠한 영향을 미치는지 검정하고자 하였다. GS-W는 5 g/kg의 고용량 경구 투여 시에도 정상 마우스에서 급성 독성을 나타내지 않았고, GMD 마우스에서 ITR을 유의적이고 용량 의존적으로 증가시켰으며, 특히 1 g/kg 경구 투여 시의 ITR은 cisapride 투여 시보다 수치 상으로 높았다. 이러한 결과들은, 1990년대까지 임상적으로 널리 처방되었으나 치명적인 부작용으로 인해 2000년 이후 시장에서 철수된 약물인 cisapride를 GS-W가 대체하여, 인간의 다양한 GMD 상황을 예방하거나 그 증상을 완화시킬 수 있는 잠재력이 있음을 시사한다.

• 정신신체의학
• /
• 제6권2호
• /
• pp.210-220
• /
• 1998

The relationships between emotion, stress and gastro-intestinal dysfunction were briefly reviewed. Until now, several kinds of theories on about pathophysiology, such as motility dysfunction, changes of pain perception on the lumen, dysregulations on the central nervous system associated with psychosocial factors were reported. However, none of those factors could'nt give any clues for the causes of the functional bowel disorders. For understanding the meaning of the symptoms and for the treatment approach, clinicians should give attention to the comprehensive point of view, i.e., not only biological but also psychological aspects of the patients with non-organic bowel dysfunctions. Giving warm and kind explanations to the patient about symptom formation and progression and understanding the patient's illness behaviors, and good and strong doctor-patient relationship is essentials for the treatment.

• 한국발생생물학회지:발생과생식
• /
• 제19권4호
• /
• pp.167-180
• /
• 2015

Arsenic is a toxic metalloid that exists ubiquitously in the environment, and affects global health problems due to its carcinogenicity. In most populations, the main source of arsenic exposure is the drinking water. In drinking water, chronic exposure to arsenic is associated with increased risks of various cancers including those of skin, lung, bladder, and liver, as well as numerous other non-cancer diseases including gastrointestinal and cardiovascular diseases, diabetes, and neurologic and cognitive problems. Recent emerging evidences suggest that arsenic exposure affects the reproductive and developmental toxicity. Prenatal exposure to inorganic arsenic causes adverse pregnancy outcomes and children's health problems. Some epidemiological studies have reported that arsenic exposure induces premature delivery, spontaneous abortion, and stillbirth. In animal studies, inorganic arsenic also causes fetal malformation, growth retardation, and fetal death. These toxic effects depend on dose, route and gestation periods of arsenic exposure. In males, inorganic arsenic causes reproductive dysfunctions including reductions of the testis weights, accessory sex organs weights, and epididymal sperm counts. In addition, inorganic arsenic exposure also induces alterations of spermatogenesis, reductions of testosterone and gonadotrophins, and disruptions of steroidogenesis. However, the reproductive and developmental problems following arsenic exposure are poorly understood, and the molecular mechanism of arsenic-induced reproductive toxicity remains unclear. Thus, we further investigated several possible mechanisms underlying arsenic-induced reproductive toxicity.

• 생명과학회지
• /
• 제26권11호
• /
• pp.1253-1258
• /
• 2016

만삼(Codonopsis pilosula)의 뿌리를 말린 한약재인 당삼은 오래 전부터 우리나라와 중국 등지에서 위장관 기능항진에 전통적으로 쓰여 왔다. 본 연구에서는 당삼의 열수 및 에탄올 추출물을 제조하여 실험하였는데, 우선 마우스 단회 투여 경구 독성 시험 결과, 두 추출물 모두 5 g/kg의 고용량 투여 시에도 급성 독성을 나타내지 않았다. 당삼 추출물이 위장관 운동 기능에 미치는 영향을 검정하기 위해, 마우스에서 in vivo 위 배출 속도 및 위장관 이송률을 측정하는 실험을 수행하였다. 두 추출물 모두 마우스의 위 배출 속도에는 유의적인 영향을 주지 못한데 반해, 당삼 열수 추출물은 정상 및 실험적 위장관 운동 저해 마우스에서 모두 위장관 이송률을 유의적으로 증가시켰으며, 용량 의존적 증가 양상을 보였다. 이상과 같이, 본 연구에서는 당삼 열수 추출물이 정상 및 위장관 운동 기능 저해 상황의 마우스에서 모두 위장관 이송률을 증가시켰음을 최초로 보고하였으며, 이는 당삼 열수 추출물이 잠재적으로 인간의 위장관 운동 기능 저해 상황을 개선하는 신약 또는 건강 보조제로 개발될 수 있는 후보 물질임을 시사한다.

• Tuberculosis and Respiratory Diseases
• /
• 제64권1호
• /
• pp.39-43
• /
• 2008

저자 등은 종격동 림프절 비대를 동반한 비소세포폐암환자에서 발생한 지속성 딸꾹질을 경험하였기에 이에 대한 임상적 특성과 치료에 관한 문헌 고찰과 함께 보고하는 바이다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제1권1호
• /
• pp.117-129
• /
• 1990

반복적(反復的) 복통(腹痛)을 주소(主訴)로 1988년(年) 7월(月) 1일(日)부터 1989년(年) 2월(月) 28일(日)까지 서울대(大)병원 소아과(小兒科)를 방문하여 기질적(器質的) 원인(原因)이 배제(排除)된 후 소아정신과(小兒精神科)로 의뢰된 만 6재(才)~11재(才)의 아동(兒童) 35명(名)을 연구(硏究) 대상(對象)으로 하여 이들을 정상(正常) 아동(兒童)과 비교하여 반복적(反復的) 복통(腹痛) 환아(患兒)의 특징과 증상(症狀)의 발현(發現)및 유지(維持)에 영향을 줄 수 있는 가능한 요인(要因)들에 대하여 연구(硏究)하였다. 연구(硏究) 결과(結果) 반복적(反復的) 복통(腹痛) 환아(患兒)의 증상(症狀) 호소는 부모(父母)등 돌보아 주는 사람과의 접촉시간(時間)에 많았으며 가족중에 위장관기(胃腸官器) 질환의 병력이 많았다. 반복적(反復的) 복통(腹通) 환아중(患兒中) 정신과적(精神科的) 진단(診斷)이 가능(可能)하였던 경우는 16명(45.8%)이었는데, 적응 장애(適應 障碍) 4명, 과잉불안장애(過剩不安障碍)4명(名), 분리 불안장애(分離 不安障碍) 1명(名), 우울증(憂鬱症) 2명(名), 틱 장애(障碍) 2名, 주의력(注意力) 결함장애(缺陷障碍) 2명(名), 야요증(夜尿症) 1명(名) 등이었다. 행동조사표(行動調査表)에 의하면 반복적(反復的) 복통(腹通) 환아(息兒)는 대조군 아동에 비하여 주회적(柱會的) 수행(遂行) 능력(能力)과 활동(活動)영역의 점수가 유의하게 낮으며, 내향화(內向化) 척도(尺度)의 값이 유의하게 높았다. 가정(家庭) 환경(環境) 진단검사상(診斷檢査上)의 항목별 비교 결과 반복적(反複的) 복통(腹通) 환아(患兒)는 대조군 아동에 비하여 훈육상(訓育上) 부모(父母)와의 마찰이 심하고, 부모(父母)가 자녀(子女)에게 주는 훈육(訓育)이 보다 합리적(合理的)이지 못하고, 지시(指示)의 정도가 많으며, 감정적으로 냉철하지 못하였다. 반면 자녀의 복지에 대한 배려와 애정 표현(愛淸 表現)은 대조군 부모에 비해 높았다. 전반적으로 반복적(反復的) 복통(腹通) 환아(患兒)는 겁이많고 위축적이며 가족 성원 역시 사회적 적응도가 낮으면서 심리적(心理的)으로 불안(不安)한 경우가 많았으며 모(母)와 밀착된 관계를 지속하고 있었고 이러한 갈등의 신체적(身體的) 표현(表現)인 복통(腹通)은 환아(患兒) 자신 뿐 아니라 보다 신체화 증상을 갖고있는 부모(父母)에 의해 선택되어지고 강화되어 반복적(反復的)으로 지속되는것으로 보였다.