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http://dx.doi.org/10.7730/JSCM.2013.25.4.343

Beneficial Effect of Hyangsayangwi-tang on the Cisplatin-Induced Gastrointestinal Dysfunctions in Rats  

Seo, Eun-Hee (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Daegu Haany Univ.)
Kim, Seong-Tae (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Daegu Haany Univ.)
Bae, Na-Young (Dept. of Sasang Constitutional Medicine, Div. of clinical medicine, School of Korean Medicine, Pusan National University)
Choi, Ae-Ryun (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Daegu Haany Univ.)
Publication Information
Journal of Sasang Constitutional Medicine / v.25, no.4, 2013 , pp. 343-358 More about this Journal
Abstract
Objectives This study aimed to observe the effect of Hyangsayangwi-tang on the cisplatin-induced gastrointestinal dysfunctions in rats. Methods Four groups(each of 8 rats per group) were used in this study. Saline and distilled water treated control rats are Intact vehicle control group. Delayed gatrointestinal mortility was induced by intraperitoneal treatment of cisplatin 2mg/kg, once a week for 5 weeks(Cisplatin control group). Hyangsayangwi-tang aqueous extracts(HY) were orally administered in a volume of 5ml/kg, once a day for 14 days from 4th ciplatin treatmernt(HY group). Ondansetron 1mg/kg was subcutaneously treated, in a volume of 1ml/kg, as same as HY(ondansetron group). We measured the body weights, intestinal charcoal transit ratio, fecal parameters, fundus MDA, GSH contents and SOD, CAT activities, TPH and MAO activities, pyloric gastrin and serotonin contents with their immunoraective cells, colonic serotonin-immunoreactive cells, the histopathology of pylorus, fundus mucosa and colon. Results and Conclusions (1) The body weight gains, the small intestinal charcoal transfer rates, the fecal parameters(numbers, weights and water contents) were increased in HY, ondansetron group. (2) The inhibit of fundus antioxidant defense systems by cisplatin were decreased in HY, ondansetron group. (3) The pyloric TPH activities were increased and the pyloric MAO activities were decreased in HY group. (4) The pyloric gastric contents and the gastrin-immunoreactive cells were increased in HY group. And the pyloric serotonin contents and the pyloric and colonic serotonin-immunoreactive cells were decreased in HY group. (5) The pyloru atrophic changes and the gastric surface erosive damage regions by cisplatin were favorably inhibited by treatment of HY. HY, a representative Soeumin prescription improve GI dysfunctions and constipation retarded by cisplatin through modulations of GI enterochromaffin cells, serotonin and gastrin-producing cells and antioxidative systems. Especially HY showed the highest favorable effects more than those of ondansetron.
Keywords
Hyangsayangwi-tang; gastrointestinal dysfunctions; cisplatin; Sasang Constitution;
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Times Cited By KSCI : 7  (Citation Analysis)
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1 Hafermann MJ, Namdar R, Seibold GE, Page RL 2nd. Effect of intravenous ondansetron on QT interval prolongation in patients with cardiovascular disease and additional risk factors for torsades: a prospective, observational study. Drug Healthc Patient Saf. 2011;3:53-8.
2 Kim JC, Lee KM, Byun BH, Lim SC, Jung TY, Seo JC, et al. Inhibitory Effects of Sophora flavescens on the Hepatic & Renal Side Effects of Chemotherapy by Cisplatin. The Korean Journal of Meridian & Acupoint. 2005;22(3):165-74. (Korean)   과학기술학회마을
3 Nam JY, Sung JS, Jun HI, Lee JW, Kwon SK, Kim DI. Increasing Effects of Apoptosis When Co-treated Scutellaria barbata D. Don. with Anti-cancer Drugs. The Journal of Oriental Obstetrice & Gynecology. 2009;22(1):125-39. (Korean)   과학기술학회마을
4 Kim HK, Kang YH, Kwak SY, Jung GH, Bae SM, Park EK, et al. Effects of cell growth inhibition on the combination of cisplatin with green tea extracts. Journal of Gynecologic Oncology. 2005;16(4):347-53. (Korean)   과학기술학회마을
5 Rho YS, Ahn KS, Chang SG, Jung JC, Lee KT. Preventive Effect of Crude Drug Preparation (E-kong-san) on Cisplatin induced Nephrotoxicity. Kor. J. Pharmacogn. 1998;29(3):258-64. (Korean)   과학기술학회마을
6 Cho SI, Kim HW. Beneficial Effect of Nodus Nelumbinis Rhizomatis Extract on Cisplatin-Induced Kidney Toxicity in Rats. Kor. J. Herbology. 2003;18(4):127-34. (Korean)   과학기술학회마을
7 Ahn CB, Kwon HY, Youn HM, Jang KJ, Song CH. Beneficial Effect of Scutellaria Balicalensis Georgi. Extract (SBGE) on Cisplatin - Induced Acute Renal Failure in Rabbits. The Journal of Korean Acupuncture & Moxibustion Society. 2002;19(3):156-67. (Korean)
8 Cho SY, Kim CH, Youn HM, Jang KJ, Ahn CB, Song CH. The Effect of Plantaginis Semen Herbal Acupuncture on Acute Renal Failure in Rat. The Korean Journal of Meridian & Acupoint. 2005;22(4):117-27. (Korean)   과학기술학회마을
9 Lee JM. Donguisusebowon. Seoul:Eulyoo Publishing Co., Ltd. 2002:27-278. (Korean)
10 Institute for Laboratory Animal Research. Guide for the Care and Use of Laboratory Animals. 8th ed. Washington, D.C.:The national academics press. 1985:162-6.
11 Tyers MB. 5-HT3 receptors and the therapeuticpotential of 5-HT3 receptor antagonists. Therapie (Paris). 1991;46(6):431-5.
12 Chirino YI, Pedraza-Chaverri J. Role of oxidative and nitrosative stress in cisplatin induced nephrotoxicity. Exp Toxicol Pathol. 2009;61(3):223-42.   DOI   ScienceOn
13 Chang B, Nishikawa M, Sato E, Utsumi K, Inoue M. L-Carnitine inhibits cisplatin induced injury of the kidney and small intestine. Arch Biochem Biophys. 2002;405(1):55-64.   DOI   ScienceOn
14 SM Ahn, GJ Chae, BC Oh, JD Kim. Anti-Emetic Efficacy of Ondansetron Plus Desamethasone in Cisplatin-Based Combination Chemotherapy. Korean Journal of Obstetrics and Gynecology. 1994;37(5):976-94. (Korean)
15 Malik NM, Liu YL, Cole N, Sanger GJ, Andrews PL. Differential effects of dexamethasone, ondansetron and a tachykinin NK1 receptor antagonist (GR205171) on cisplatin-induced changes in behaviour, food intake, pica and gastric function in rats. Eur J Pharmacol. 2007;555(2-3):164-73.   DOI   ScienceOn
16 Martin C, Roman V, Agay D, Fatome M. Anti-emetic effect of ondansetron and granisetron after exposure to mixed neutron and gamma irradiation. Radiat Res. 1998;149(6):631-6.   DOI
17 Han KS, Park SS. The Study on the Formative Process of Soeumin Pharmacology -Focused on Gabobon and Sinchukbon-. J Sasang Constitut Med. 2006;18(2):15-24. (Korean)   과학기술학회마을
18 Badary OA, Awad AS, Sherief MA, Hamada FM. In vitro and in vivo effects of ferulic acid on gastrointestinal motility: inhibition of cisplatin-induced delay in gastric emptying in rats. World J Gastroenterol. 2006;12(33):5363-7.   DOI
19 Kim YB, Kim JW, Seo DG, Lee CM, Park NH, Song YS, et al. A Randomized Comparison of Tropisetron versus Ondansetron in the Control of Nausea and Vomiting in Gynecologic Cancer Patients Undergone Cisplatin- Based Chemotherapy. Korean Journal of Obstetrics and Gynecology. 1998;41(10):2544-50. (Korean)
20 National federation of department of sasang constitutional medicine, colleges of oriental medicine. Sasang constitutional medicine. 2nd Ed. Seoul:Jipmoondang. 2004:260, 265, 276, 394-5, 442-80. (Korean)
21 Kim KY, Han JH, Hong SY. The Theoretical Analysis on Soeumin-Hyangsayangwi-tang. J Sasang Constitut Med. 1992;4(1):213-9. (Korean)
22 Kim KY. An Experimental Study on Some Effects of Soeumin-Hyangsayangwi-tang. J Sasang Constitut Med. 1989;1(1):153-170. (Korean)
23 Choi BC, Ahn TW. Anti-oxidant Effect of Hyangsayangwi-tang Decoction in Stomach, Spleen and Pancreas Cell of SD Rats. J Sasang Constitut Med. 2008;20(2):72-84. (Korean)   과학기술학회마을
24 Wintola OA, Sunmonu TO, Afolayan AJ. The effect of Aloeferox Mill. in the treatment of loperamide-induced constipationin Wistarrats. BMC Gastroenterol. 2010;10:95.   DOI   ScienceOn
25 Odabasoglu F, Cakir A, Suleyman H, Aslan A, Bayir Y, Halici M, et al. Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats. J Ethnopharmacol. 2006;103(1):59-65.   DOI   ScienceOn
26 Sagar L, Sehgal R, Ojha S. Evaluation of antimotility effect of Lantanacamara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice. BMC Complement Altern Med. 2005;5:18.   DOI   ScienceOn
27 Yang ZH, Yu HJ, Pan A, Du JY, Ruan YC, Ko WH, et al. Cellular mechanisms underlying the laxative effect of flavonol naringenin on rat constipation model. PLoS One. 2008;3(10):e3348.   DOI   ScienceOn
28 Comporti M. Lipid peroxidation and cellular damage in toxic liver injury. Lab Invest. 1985;53(6):599-623.
29 Cheeseman KH, Slater TF. An introduction to free radical biochemistry. Br Med Bull. 1993;49(3):481-93.   DOI
30 Suleyman H, Cadirci E, Albayrak A, Polat B, Halici Z, Koc F, et al. Comparative study on the gastroprotective potential of some antidepressants in indomethacininduced ulcer in rats. Chem Biol Interact. 2009;180(2): 318-24.   DOI   ScienceOn
31 Lee HS, Choi SH, Ku SK. Regional distribution and relative frequency of gastrointestinal endocrine cells in the ddN mice: an immunohistochemical study. Anat Histol Embryol. 2010;39(6):521-8.   DOI   ScienceOn
32 Bradner WT, Schurig JE. Toxicology screening in small animals. Cancer Treat Rev. 1981;8(2):93-102.   DOI   ScienceOn
33 Wang Y, Aggarwal SK, Kopachik W. Role of vitamin d on the inhibition of gastrin production after Cisplatin treatment. Met Based Drugs. 2000;7(3):115-9.   DOI   ScienceOn
34 Lee JC. New Sasang Constitutional Medicine 2. Seoul: Wood and Earth. 2003:79-83, 178-80, 241-9. (Korean)
35 Gershon MD, Tamir H. Release of endogenous 5-hydroxytryptamine from resting and stimulated enteric neurons. Neuroscience. 1981;6(11):2277-86.   DOI   ScienceOn
36 Lee GN, Lee JS. File of Clinical Pathology. Seoul: Medical Culture. 1993:526-7. (Korean)
37 Huh So, Park DH, Cho JY, Joh TH, Son JH. A 6.1 kb 5' upstream region of the mouse tryptophan hydroxylase gene directs expression of E, coli lacZ to major serotonergic brain region and pineal pland in transgenic mice. Brain Res Mol Brain Res. 1994;24(1-4):145-52.   DOI   ScienceOn
38 Andrews PL, Horn CC. Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases. Auton Neurosci. 2006;125(1-2):100-15.   DOI   ScienceOn
39 Kishibayashi N, Ichikawa S, Yokoyama T, Ishii A, Karasawa A. Pharmacological properties of KF18259, a novel 5-HT3-receptor antagonist, inrats:inhibition of the distal colonic function. Jpn J Pharmacol. 1993;63(4):495-502.   DOI
40 Lebwohl D, Canetta R. Clinical development of platinum complexes in cancer therapy: an historical perspective and an update. Eur J Cancer. 1998;34(10):1522-34.   DOI   ScienceOn
41 Martin C, Roman V, Agay D, Fatome M. Anti-emetic effect of ondansetron and granisetron after exposure to mixed neutron and gamma irradiation. Radiat Res. 1998;149(6):631-6.   DOI