Browse > Article
http://dx.doi.org/10.5352/JLS.2016.26.11.1253

Effects of the Dried Root of Codonopsis pilosula on Gastrointestinal Motor Function in Mice  

Kim, Min Woo (Department of Life Science & Biotechnology, Dong-eui University)
Kim, Hyun Jin (Department of Life Science & Biotechnology, Dong-eui University)
Kim, Moon-Moo (Department of Chemistry, Dong-eui University)
Lee, Eun-Woo (Department of Life Science & Biotechnology, Dong-eui University)
Kwon, Hyun Ju (Department of Life Science & Biotechnology, Dong-eui University)
Kim, Byung Woo (Department of Life Science & Biotechnology, Dong-eui University)
Lee, Hyun-Tai (Department of Life Science & Biotechnology, Dong-eui University)
Publication Information
Journal of Life Science / v.26, no.11, 2016 , pp. 1253-1258 More about this Journal
Abstract
Although major advances have been achieved in our understanding and treatment of diseases in many areas of medicine, relatively few improvements have been made in the area of gastrointestinal (GI) motor function. The dried root of Codonopsis pilosula (Franch.) Nannf. (CP) has been used as a traditional folk medicine for improving poor GI function in East Asia, including China and Korea. In the present study, neither aqueous (CP-W) nor ethanolic (CP-E) extracts of CP showed significant toxicity, even at an oral dose of 5 g/kg to mice. The effects of CP-W and CP-E on GI motor function were investigated by measuring in vivo the gastric emptying rate (GER) and intestinal transit rate (ITR) in mice. In normal mice, the ITR was significantly increased by CP-W in a dose-dependent manner, whereas the GER was not significantly affected by any CP extracts. The ITR was significantly retarded in the mice with experimental GI motility dysfunction (i.e., peritoneal irritation by acetic acid) compared with that in normal mice. However, the retardation was significantly recovered by the pre-treatment of CP-W in a dose-dependent manner. The above results suggest that CP-W might be a potential prokinetic agent preventing or alleviating GI motility dysfunctions in human patients.
Keywords
Codonopsis pilosula; gastric emptying; gastrointestinal motor function; intestinal transit; prokinetic agent;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Wang, Z. T., Du, Q., Xu, G. J., Wang, R. J., Fu, D. Z. and Ng, T. B. 1997. Investigations on the protective action of Condonopsis pilosula (Dangshen) extract on experimentallyinduced gastric ulcer in rats. Gen. Pharmacol. 28, 469-473.   DOI
2 Suchitra, A. D., Dkhar, S. A., Shewade, D. G. and Shashindran, C. H. 2003 Relative efficacy of some prokinetic drugs in morphine-induced gastrointestinal transit delay in mice. World J. Gastroenterol. 9, 779-783.   DOI
3 Sun, Y. X. 2009. Immunological adjuvant effect of a watersoluble polysaccharide, CPP, from the roots of Codonopsis pilosula on the immune responses to ovalbumin in mice. Chem. Biodivers. 6, 890-896.   DOI
4 Xu, C., Liu, Y., Yuan, G. and Guan, M. 2012. The contribution of side chains to antitumor activity of a polysaccharide from Codonopsis pilosula. Int. J. Biol. Macromol. 50, 891-894.   DOI
5 Zeinali, F., Stulberg, J. J. and Delaney, C. P. 2009. Pharmacological management of postoperative ileus. Can. J. Surg. 52, 153-157.
6 Zheng, T. Z., Li, W., Qu, S. Y., Ma, Y. M., Ding, Y. H. and Wei, Y. L. 1998. Effects of Dangshen on isolated gastric muscle strips in rats. World J. Gastroenterol. 4, 354-356.   DOI
7 Chen, H. T., Tsai, Y. L., Chen, Y. S., Jong, G. P., Chen, W. K., Wang, H. L., Tsai, F. J., Tsai, C. H., Lai, T. Y., Tzang, B. S., Huang, C. Y. and Lu, C. Y. 2010. Dangshen (Codonopsis pilosula) activates IGF-I and FGF-2 pathways to induce proliferation and migration effects in RSC96 Schwann cells. Am. J. Chin. Med. 38, 359-372.   DOI
8 He, J. Y., Ma, N., Zhu, S., Komatsu, K., Li, Z. Y. and Fu, W. M. 2015. The genus Codonopsis (Campanulaceae): a review of phytochemistry, bioactivity and quality control. J. Nat. Med. 69, 1-21.   DOI
9 He, K., Li, X., Chen, X., Ye, X., Huang, J., Jin, Y., Li, P., Deng, Y., Jin, Q., Shi, Q. and Shu, H. 2011. Evaluation of antidiabetic potential of selected traditional Chinese medicines in STZ-induced diabetic mice. J. Ethnopharmacol. 137, 1135-1142.   DOI
10 Kang, S. Y., Jung, J. K., Lee, S. K., Lee, S. H. and Park, Y. K. 2013. Effects of the ethanol extract of Codonopsis Pilosulae Radix on ovalbumin-induced allergic responses in mice. Kor. J. Herbology 28, 9-15.
11 Lee, H. T. 2014. Prokinetic activity of ethanolic extracts from dried Citrus unshiu peels in mice. J. Life Sci. 24, 260-265.   DOI
12 Lee, H. T., Seo, E. K., Chung, S. J. and Shim, C. K. 2005. Prokinetic activity of an aqueous extract from dried immature fruit of Poncirus trifoliata (L.) Raf. J. Ethnopharmacol. 102, 131-136.   DOI
13 Ryu, H. Y., Ahn, S. M., Kim, J. S. and Sohn, H. Y. 2010. Evaluation of in-vitro anticoagulation activity of 33 different medicinal herbs. J. Life Sci. 20, 922-928.   DOI
14 Ryu, J. H. and Lee, H. T. 2013. Effects of dried Citrus unshiu peels on gastrointestinal motility in rodents. Arch. Pharm. Res. 36, 641-648.   DOI
15 Sanders, K. M., Ward, S. M. and Koh, S. D. 2014. Interstitial cells: regulators of smooth muscle function. Physiol. Rev. 94, 859-907.   DOI