• Journal of Oral Medicine and Pain
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• v.37 no.1
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• pp.27-33
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• 2012

Oral lichen planus(OLP) is a chronic inflammatory disease with cell-mediated immune responses, but the exact cause is unknown. The treatment aim of OLP is not complete cure but to alleviate symptoms. In this study, two kinds of corticosteroid gargling solutions used for comparing the effects. From 2002 to 2010, 180 patients diagnosed with oral lichen planus and received topical steroid therapy in the Pusan National University Dental Hospital. Each of two types of solution contained dexamethasone (dexamethasone disodium phosphate) and prednisolone ($solondo^{(R)}$). A period of relief of symptoms and recurrence was recorded. The group using solution containing dexamethasone(dexa gargle) was prescribed to 33 patients(25 female, 8 male) and another group containing prednisolone (solon gargle) included 147 patients (114 female, 33 male). The effect of dexa gargle seemed faster than the solon gargle. There was no significant difference for recurrent rate between the groups using dexa and solon gargle.

• Journal of the korean academy of Pediatric Dentistry
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• v.43 no.3
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• pp.306-312
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• 2016

Gargle solution has typically been used for the prevention of oral infectious disease such as dental caries and periodontitis. However, the use of most gargle solutions is controversial in application for children because some gargle solutions have harmful side effects. Electrolyzed water is generated by passed an electric current and has antimicrobial activity. The purpose of this study was to investigate and compare the efficacy of electrolyzed water in various conditions for eliminating cariogenic bacteria. Electrolyzed water was generated by a platinum electrode in the presence of sodium chloride at various concentrations. Streptococcus mutans and Streptococcus sobrinus were cultivated into a brain heart infusion broth. After harvesting planktonic bacteria, the pellets were treated with the electrolyzed water and commercial gargle solutions and plated on a mitis-salivarius agar plate. Also, the anti-biofilm activity of the electrolyzed water and commercial gargle solutions was investigated after biofilm formation of S. mutans and S. sobrinus. The bacteria in the biofilm were plated onto a mitis-salivarius agar plate. The plates were incubated, and the colony forming unit was measured. The electrolyzed water containing sodium chloride showed significant antibacterial activity against S. mutans and S. sobrinus as well as some gargle solutions. Furthermore, the electrolyzed water had more disruptive effect on the biofilm of S. mutans and S. sobrinus and killed more bacteria in the biofilm than commercial gargle solutions. The results demonstrate that electrolyzed water may be a useful gargle solution for prevention of dental caries.

• The Journal of the Korea Contents Association
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• v.13 no.4
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• pp.312-319
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• 2013

The purpose of this study was to evaluate the efficacy of gargle and toothpaste containing low concentration with sodium fluoride on the remineralization through the surface microhardness and mineral content in enamel. After 4 weeks-application, the enamel surface was measured using microhardness tester and the calcium (Ca) and phosphorous (P) concentration of mineral content by electron probe microanalyzer (EPMA) analysis. By combining fluoridated gargle with toothpaste, a remineralized enamel resulted in significantly significant differences among the four groups (p<0.05). The Ca change treated with 0.23% fluoridated toothpaste and 0.02% fluoridated gargle with 0.23% toothpaste demonstrated the highest among the other groups. In conclusion. the fluoridated gargle with toothpaste by low concentration showed a significantly greatest synergistic effect on remineralization of the enamel than the other groups.

• The Journal of Korean Medicine
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• v.31 no.4
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• pp.115-128
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• 2010

Objectives: The aim of this study was to investigate deodorizing effectsof medicinal herbs (Mume Fructus, Eriobotryae Folium, Acanthopanacis Cortex, Angelicae Dahuricae Radix) for development of a gargle solution. Methods: 1. The antimicrobial effects of medicinal herbs were evaluated with the minimal bactericidal concentration (MBC) and the change of the number of viable cells in the herb extracts(1%) for 48 hrs against P. gingivalis 2561 and Pr. intermedia ATCC 25611. 2. Deodorizing activity of each herb and Garglin $Mint^{(R)}$gainst methyl mercaptan were analyzed by gas chromatography (GC). 3. We used the malodor modeling of the salivary sediment system with a Halimeter. 4. In the preliminary clinical study, the baseline concentration of VSC in the oral cavity of each subject was measured by Halimeter. Subjects would gargle for 30 seconds with cysteine. After 4 minutes subjects would gargle for 30 seconds with Garglin and herb extracts (2%). Subsequently, concentration of VSC were measured at 0, 4, 8, 12 and 20 minutes. Results: 1. MBC of Mume Fructusfor P. gingivalis 2561 was determined to be <1% and MBCs of Eriobotryae Folium for P. gingivalis 2561 and Pr. intermedia ATCC 25611 were determined to be <2% and <1%, respectively. Mume Fructus (1%) completely suppressed the P. gingivalis cell viability from 5 hrs and Eriobotryae Folium (1%) completely suppressed the Pr. intermedia cell viability from 48 hrs. 2. In GC analysis, deodorizing activities were 91.54% with Mume Fructus, 87.97% with Eriobotryae Folium, 100% with Acanthopanacis Cortex, 72.36% with Angelicae Dahuricae Radix and 40.54% with Garglin $Mint^{(R)}$. 3. In malodor modeling of the salivary sediment system, each of the medicinal herbs had significantly inhibitory effect on malodor formation (p<0.05). 4. In the preliminary clinical study, the concentration of VSC of the herb groups was significantly lower than of the control group, but not in Garglin $Mint^{(R)}$. Conclusions: Mume Fructus, Eriobotryae Folium, Acanthopanacis Cortex and Angelicae Dahuricae Radixhave deodorizing activities and potential as an effective mouthwash against oral malodor.

• Biomedical Science Letters
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• v.30 no.1
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• pp.17-23
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• 2024

In this study, the changes in occlusal strength and oral environment before and after the use of natural gargles containing cinnamon were confirmed. This study involved 42 adults aged 19 or older living in Busan from November 25 to December 2, 2023. Twenty-one people were randomly selected for each of the regular and natural gargles. In this study, the group using natural gargles confirmed an increase in saliva buffering power, a decrease in O'Leary index, and an increase in occlusal strength. Through this, it was confirmed that natural gargles containing cinnamon are helpful in improving the oral environment and occlusal strength.

• The Journal of the Convergence on Culture Technology
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• v.8 no.1
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• pp.591-596
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• 2022

Various COVID-19 quarantine guidelines and measures are being taken by country at the WHO, but the number of confirmed cases has not decreased significantly. In order to prevent the inflow and outflow of COVID-19 through individual droplets, it is mandatory to wear a mask anytime, anywhere. However, as virus bacteria entering the mask amplify, it pollutes the mask and causes a disgusting smell. In this paper, a new method of preventing the spread of COVID-19 was proposed by sterilizing the mask with a dental gait spray introduced into the mask that has been used for a long time. Dental gargle water is usually produced by electrolysis of tap water, and the unstable ion water (HOCl) dissolved in water penetrates the cell barrier of various viruses and fails to act in its nucleus, causing water to self-purify. As a result of the experiment, when the mask used for a long time was washed with gargle water spray, the washed mask was dried after 10 minutes, and the smell of virus droplets or saliva almost disappeared. In particular, as a result of MOS testing the fit of the subjects who participated in the mask cleaning, it was excellent at 4.4 on average. Therefore, the mask was disposable, but if the spray was washed in the proposed method more than twice a day, the mask could be used in a comfortable state for more than a week.

• Journal of Periodontal and Implant Science
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• v.29 no.2
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• pp.325-333
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• 1999

The antibacterial efficacy of a mouthrinse(Denta Gargle) containing CPC(cetylpyridinium chloride), NaF and UDCA(ursodeoxycholic acid), on major periodontopathogens, was in vitro examined and compared with that of Listerine by a broth dilution method. The bacteria tested were Actinobacillus actinomycetemcomitans, Bacteroides forsythus, Fusobacterium nucleatum subsp. vincentii, Prevotella intermedia, Porphyromonas gingivalis and Treponema denticola. The growth of all the bacteria were completely inhibited by a 1-min exposure to the both mouthrinses. When diluted at 1:5 or more, all bacteria analyzed but P. intermedia were not inhibited by Listerine. In contrast, Denta Gargle showed highly increased maximum inhibitory dilutions(MID) against all periodontopathogens included in this study, with MIDs ranging from 5-fold(F. nucleatum) to 160-fold dilutions(P. intermedia). The MIDs against A. actinomycetemcomitans, B. forsythus, P. gingivalis and T. denticola. were 1:40, 1:80, 1:80 and 1:80, respectively.

• Biomedical Science Letters
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• v.29 no.2
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• pp.75-80
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• 2023

In this study, natural mouthwash was developed based on natural substances based on cinnamon and ginger, which are familiar to the public, to check the effectiveness of mouthwash and changes in microbial distribution. This study was conducted on 24 people who fully explained the purpose and method of the study and agreed to participate among those who visited D University from October 2021 to December 2021. The subject's oral cavity was examined and placed in three groups to have similar conditions, and after using mouthwash for a week, a survey, saliva test, breath measurement test, and PCR test were performed. As a result of the experiment, the amount of saliva after using natural mouthwash increased compared to the control group (P<0.05). In the comparison of bacteria, it was confirmed that Pg and Fn bacteria decreased after using natural mouthwash (Pg t=4.852, P=.002, Fn t=2.888, P=.023). Following this study, it is expected that research on the development and efficacy of natural mouthwash will be conducted through various clinical applications, which will be useful in real life and dental care institutions.

• Journal of dental hygiene science
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• v.2 no.1
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• pp.11-14
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• 2002

The purpose of this study was to investigate that the effect of Citrex and CPC on the growth of oral microorganism such as Streptococcus mutans KCTC 3065, Candida albicans KCTC 7122, and Staphylococcus aureus KCTC 1916 which were cariogenic, candidiasis(bleeding gum, dry mouth and tongue, thrush) and angular cheilitis inducing bacteria, respectively. The efficacy of complex of Citrex and CPC was determined in assays measuring Halo Test. The gargle containing Citrex(0.02%) and CPC(0.02%) demonstrated broad-spectrum anti-microbial properties, with activity against both Gram-positive and Gram-negative and a yeast(Candida albicans).

• Journal of dental hygiene science
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• v.7 no.3
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• pp.129-133
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• 2007

This study was carried out to see the effect of dental auxiliary product groups being used in case of not being able to brush teeth. This study was executed for 70 students in the Dept. of Dental Hygiene of S Health College, and it was divided into the group which used brushing teeth, the one which used only dental auxiliary products, the one which did onion juice gargle, etc, and measured the effect on the reduction of oral malodor. The experimental results of the study were as below. 1) After onion juice gargle, in the experimental group A which brushed teeth, it showed lasting decrease of oral malodor until 20min since the experiment, and after 30min, the degree of oral malodor started to increase again. 2) After onion juice gargle, the result of the experimental group B which took only supplementary products such as garglin, chewing gum, intaking green tea with roasted rice & brushing a tongue and so on, was as follows. First, in case of experimental group BG which used garglin, until 30 min has passed since the experiment, it showed the lasting reduction of oral malodor as the same trend with the experimental group BG. Second, in chewing gum (experimental group BC), intaking green tea with roasted rice (experimental group BT), and brushing a tongue (experimental group BO), continuous reduction of oral malodor was shown until 10minutes has passed since the experiment, but, after 20minutes, we could see the degree of oral malodor started to increase again. 3) After onion juice gargle, in the experimental group C which only the degree of oral malodor was measured with the passage of time, neither brushing teeth nor using auxiliary goods, until 30min since the experiment, it showed the similar trend of the reduction of oral malodor with other experimental groups, but, it showed high degree of oral malodor, as compared with other experimental groups A and B.