• The Journal of Internal Korean Medicine
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• v.13 no.2
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• pp.141-155
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• 1992

This study has been carried out to investigate the cause symptom and treatment of Poong-On(風溫) by referring to 29 leteratures. The results were obtained as follows; 1. The factors causing Poong-On(風溫) is wind and heat. 2. The symptom of Poong-On(風溫) is as follows. fever, chilling, cough, sweating sign, chest discomfort, thirst, Doo Chang Wan Bi(頭脹脘痺), Yang Maeg Boo Hwal(陽脈浮滑), Eum Maeg Yoo Yak(陰脈濡弱), Seol Tae Baek Bak(舌苔白薄). 3. The treatment-method of Poong-On(風溫) is as follows. Sin Ryang Hae Pyo(辛凉解表), San Poong Han Ii Rae Pyo(散風寒以解表), Seol Yeol Hwa Eum(泄熱和陰), So Sul Ii Hae Pyo(疏泄以解表). 4. The treatment-herbs of Poong-On(風溫) is as follows, Eun Gyo San(銀翹散), Ma Haeng Gam Sug Tang(麻杏甘石湯), Jo Wee Sung Gi Tang(調胃承氣湯), An Goong Woo Hwang Hwan(安宮牛黃丸), Seo Gag Ji Hwang Tang(犀角地黃湯), Baek Ho Tang(白虎湯), Sa Sam Maeg Moon Dong Tang(沙蔘麥門冬湯), Ga Gam Bok Maeg Tang(加減伏脈湯), Saeng Maeg San(生脈散).

• Journal of Microbiology and Biotechnology
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• v.15 no.6
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• pp.1229-1239
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• 2005

Human immunodeficiency virus-like particles (HIVVLPs) with native conformations similar to that of the wild-type virion could be valid candidates for vaccine development. To this end, we used a Semliki Forest Virus (SFV) expression system to produce HIV- VLPs containing high quantities of native envelope proteins. Here, we described a single SFV replicon containing the HIV gagpol and env genes under the control of separate subgenomic promoters. Mature VLPs incorporating the Gag and Env proteins were detected in the supernatant of replicon-expressing cells by Western blot analysis. The HIV-VLPs showed the expected molecular density (1.14-1.18 g/ml) on a $20-60\%$ sucrose gradient; the particles were 100-120 nm in diameter and Env proteins were observed on their surfaces by immunogold electron microscopy. RT-PCR analysis of VLP-associated RNAs in mature HIV-VLPs revealed two SF V-derived RNA species (full-length and subgenomic). Immunization studies in Balb/c mice showed that these HIV-VLPs were capable of inducing both HIV-specific antibodies and cell-mediated immune responses. Taken together, our results indicate that the SFV replicon system is useful for the production of HIV-VLPs, which may be valuable candidates for an HIV vaccine.

• Journal of Microbiology and Biotechnology
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• v.15 no.6
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• pp.1258-1266
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• 2005

The present study was carried out in order to assess the protective effects of calycosin-7-O-$\beta$-D-glucopyranoside, isolated from Astragali radix (AR), on hyaluronidase (HAase) and the recombinant human interleukin-$1\beta$ (IL-$1\beta$)-induced matrix degradation in human articular cartilage and chondrocytes. We isolated the active component from the n-butanol soluble fraction of AR (ARBu) as the HAase inhibitor and structurally identified as calycosin-7-O-$\beta$-D-glucopyranoside by LC-MS, IR, ${1}^H$ NMR, and ${13}^C$ NMR analyses. The $IC_{50}$ of this component on HAase was found to be 3.7 mg/ml by in vitro agarose plate assay. The protective effect of ARBu on the matrix gene expression of immortalized chondrocyte cell line C28/I2 treated with HAase was investigated using a reverse transcription polymerase chain reaction (RT-PCR), and its effect on HAase and IL-$1\beta$-induced matrix degradation in human articular cartilage was determined by a staining method and calculating the amount of degraded glycosaminoglycan (GAG) from the cultured media. Pretreatment with calycosin-7-O-$\beta$-D-glucopyranoside effectively protected human chondrocytes and articular cartilage from matrix degradation. Therefore, calycosin-7-O-$\beta$-D-glucopyranoside from AR appears to be a potential natural ant-inflammatory or antii-osteoarthritis agent and can be effectively used to protect from proteoglycan (PG) degradation.

• Journal of Microbiology and Biotechnology
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• v.10 no.5
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• pp.663-669
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• 2000

The fur (ferric uptake regulation) expression vector pMON2064 was modified to produce a Fur-fusion expression vector. A kinker site, factor Xa cleavage site, and several restriction endonuclease sites were introduced to facilitate easy cloning and isolating of the fusion protein. The resulting fusion expression vector, pMONSTER, was then used to make fusion expression vector, pMONSTER, was then used to make fusion proteins with $\beta$-galactosidase and the protease of the human immunodeficiency virus type 1 (HIV-1 PR). Strain SW4020 harboring the Fur $\beta$-galactosidase fusion vector produced blue colonies on a 5-bromo-4-chloro-3-indolyl-$\beta$-D-galactoside plate and the resulting 133 kDa fusion protein reacted with an anti-Fur antibody. The strain harboring the Fur-HIV-1 PR fusion vector produced a 29 kDa fusion protein, which also reacted with an anti-Fur antibody. The Fur-HIV-1 PR fusion protein was purified by a single column application that was designed to isolate the Fur protein. The purified Fur-HIV-1 PR fusion protein digested with factor Xa cleaved a recombinant Gag protein to release smaller fragments, including a p24 capsid protein. The Fur-HIV-1 PR fusion protein itself did not exhibit any proteolytic activity.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.17 no.4
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• pp.123-128
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• 2017

This paper relates with the Hybrid-SMMA adaptive equalization algorithm that is possible to improve the equalization performance based on adaptive modulus and adaptive stepsize which is propotional to the output power of equalizer in the current SMMA (Sliced Multi Modulus Algorithm). The fixed statistic modulus of transmitted signal is used in current SMMA algorithm in order to generate the error signal for updating the tap coefficient of equalizer. The proposed Hybrid-SMMA based on the adaptive modulus which is propotion to the equalizer output signal power and adaptive stepsize which is fuction of the nonlinearties of error signal. The computer simulation was performed in order to confirm the improved equalization performance of proposed algorithm. As a result of computer simulation, the proposed Hybrid-SMMA has fairly good in every performance than the current SMMA.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.13 no.4
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• pp.209-215
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• 1993

A stability analysis program(CSLOP) which can obtain the factor of safety and the critical failure surface at the same time is developed from this study. In order to improve existing slice methods, the general slice method of Gussmann is applied to compute the factor of safety, and the constrained simplex algorithm proposed by Box is applied to systematically locate the critical failure surface in slopes. The proposed method is applied to two examples of circular and noncircular slope stability and the results are compared to previously published solutions. Constrained simplex method is recommended to improve slope stability programs which provide for an automatic search of the critical failure mechanisms.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.14 no.1
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• pp.30-36
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• 2005

This study is to investigate a damage estimation of single edge notched tensile specimens as a function of acoustic emission(AE) according to the uni-directionally oriented carbon fiber/epoxy composites, CFRP In fiber reinforced composite materials, AE signals due to several types of failure mechanisms are typically observed. These are due to fiber breakage, fiber pull-out matrix cracking, delamination, and splitting or fiber bundle breaking. And these are usually discriminated on the basis of amplitude distribution, event counts, and energy related parameters. In this case, AE signals were analyzed and classified 3 regions by AE event counts, energy and amplitude for corresponding applied load. Bath-tub curve shows 3 distinct periods during the lifetime of a single-edge-notch(SEN) specimen. The characterization of AE generated from CFRP during SEN tensile test is becoming an useful tool f3r the prediction of damage failure or/and failure mode analysis.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.15 no.4
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• pp.98-104
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• 2006

In this paper, for the purpose of investigation the acoustic emission(AE) behaviors during resistance spot welding process and tension test of spec steels. As the results present the resistance spot welding method that can get suitable welding qualities or structural integrity estimating method. The resistance spot welding process consists of several stages: set-down of the electrodes; squeeze; current flow; forging; hold time; and lift-off. Various types of AE signals are produced during each of these stages. For tensile-shear test and cross tensile test in resistance spot welded specimens, fracture pa 야 ems are produced: tear fracture; shear fracture; and plug fracture. Tensile-shear specimens strength appeared higher than cross tensile specimens one. In case of tensile-shear specimen happened tear fracture that crack happens in most lower plate. Also, in case of cross tensile specimens, upper plate and lower plate are detached perfect fracture was exposed increases a little as acting force is lower than ordinary welding condition. Therefore, the structure which is combined by resistance spot welding confirmed that welding design must attain so that shear stress may can interact mainly.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.15 no.2
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• pp.99-104
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• 2015

This paper proposes the RMMA (Region based Multiple Modulus Algorithm) algorithm that is possible to improving the performance of MMA adaptive equalization algorithm in order to the reduction of intersymbol interference occurs at the communication channel. In RMMA algorithm, the output constellation of equalizer are divided by 4 different regions in order to get the error signal for adapting the channel characteristic, and the small error signal is obtained by mapping each region to 4-QAM signal. The conversion effect of constant modulus from nonconstant modulus signal was obtained. In this paper, the adaptive equalization performance of proposed RMMA were evaluated comared to the present MMA. As a result of computer simulation, the convergence speed and residual quantity were improved in residual isi and MD. Especially the superiorities of robustness was confirm in SER performance compared to present MMA.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.11 no.6
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• pp.31-39
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• 2011

For rapid formed the ad hoc wireless backbone network in disaster scene, It is necessary for real-time deployment scheme of wireless ad hoc relay devices by first responders without pre-planning. However, in order to realize this scheme, redundant deployment should be minimized, as well as optimal location of relay devices should be selected to expand communication coverage. Therefore, in this paper, we propose a new deployment scheme of relay devices to optimize communication coverage and then through simulations showed that improved performance of algorithm.