• 대한산업공학회지
• /
• 제39권6호
• /
• pp.473-479
• /
• 2013

This paper introduces user intervention to control simulation states during the execution of a simulation for military engagements. In an engagement simulation, it covers both a discrete event system and a continuous state system. Thus a system for the engagement simulation can have numerous simulation states, because there are lots of factors to decide states of an engagement that are derived during an execution of the simulation (e. g. detection probability, moving speed, moving path, and so on). It means both a result and progression of simulations are important outputs. Configuration of an engagement simulation scenario and expectation of simulation states, though, is hindered by the number of generate-able states. In order to solve the obstacle, the engagement simulation system should be controllable by user intervention during a simulation execution. This paper is to define objects of user intervention, and to design control processes of defined objects.

• 한국신뢰성학회:학술대회논문집
• /
• 한국신뢰성학회 2005년도 학술발표대회 논문집
• /
• pp.265-269
• /
• 2005

Cox's proportional hazards model (PHM) has been widely applied in the analysis of lifetime data, and it can be characterized by the baseline hazard function and covariates influencing systems' lifetime, where the covariates describe operating environments (e.g. temperature, pressure, humidity). In this article, we consider the constant baseline hazard function and a discrete random variable of a covariate. The estimation procedure is developed in a parametric framework when there are not only complete data but also incomplete one. The Expectation-Maximization (EM) algorithm is employed to handle the incomplete data problem. Simulation results are presented to illustrate the accuracy and some properties of the estimation results.

• 대한방사선기술학회지:방사선기술과학
• /
• 제32권1호
• /
• pp.45-52
• /
• 2009

유방 촬영술(Digital mammography)은 유방암의 조기 진단에서 매우 중요한 진단 방법으로서 비촉지성 유방암의 조기 발견율을 높여 유방암에 따른 여성의 사망률을 감소시키고 있다. 그 중에서도 유방 병변의 미세석회화(Microcalcification)는 조기 유방암의 진단에 있어서 중요한 병변으로 보고 되고 있으며, 선별 검사로 임상적 유용성이 확립된 상태이다. 유방 촬영술에서 미세석회화 소견은 영상의학과 전문의가 판독하여 조직 검사에서 양성 및 악성 병변에 대하여 각각 군집의 개수, 군집 당 석회화 수, 미세석회화 크기와 범위, 미세석회화 형태, 동반 종괴의 유무 등을 분석하여 최종적으로 진단을 확정한다. 그러므로 군집화된 미세석회화의 정보는 유방암 예측에 있어 임상적인 실질 정보를 가지고 있으며, 의사에게 진단을 위한 검사의 기본적인 가이드라인을 제시한다. 따라서 본 연구에서는 유방 촬영술의 디지털 영상에 나타난 미세석회화의 정량적인 계산을 위해서 DoG filter, Adaptive thresholding, Expectation Maximization의 3단계를 제안한다. 제안한 알고리듬을 실험을 통하여 군집화 및 각 클러스터 내의 미세석회화의 분포 개수, 길이를 측정하였으며, 임상의 사에게 디지털 유방영상의 분석을 통하여 초기 유방암 진단의 지표를 제시할 것으로 사료된다. 그리고 이는 객관적인 유방암 컴퓨터자동검출(CAD)에 사용될 수 있는 병변의 정보로서 가능성을 보였다.

• 공학교육연구
• /
• 제10권3호
• /
• pp.21-37
• /
• 2007

정보화 사회에서 여성의 사회 참여와 인적 개발은 국가 경쟁력 강화의 필수 요건이 되었다. 최근 공학계열에서도 꾸준히 여성 인력이 늘어나고 있으며, 여성들의 특성인 섬세함과 정확성은 공학인으로 성공할 수 있는 중요한 요인으로 인식되기도 한다. 하지만, 공학교육에서 여성을 위한 제도나 환경적 배려가 없는 실정이며, 여성인적자원 개발을 위한 체계적 연구들은 많이 부족한 실정이다. 본 연구에서는 학습자 인식 분석을 바탕으로 여성공학교육의 방향을 탐색해 보고자 하였다. 이를 위하여 여성 공학교육에 대한 인적자원개발적 맥락 관점과 교수학습 방법적 관점에서 문헌조사를 실시하였으며, 공학교육에 대한 학습자 인식 분석과 전문가 협의 등을 통한 여학생 공학교육의 현황과 앞으로 나아갈 방향에 대한 권고사항들을 제안하였다. 399명(남: 206명, 여: 193명)의 P 대학 학습자 인식을 분석한 결과에 따르면 (a)교과이론 이해도, (b)만족도, (c)동기, (d)학습 능력, (e)부모 기대, (f)수업 즐거움, (g)교과 성적 기대에서 성별에 따른 유의미한 차이가 나타났다. 이를 바탕으로 권고사항을 인지적 영역, 정의적 영역, 동기적 영역, 교수학습 전략 및 환경 제도 개선 영역의 관점에서 도출하였다. 본 연구 결과는 여성 인적자원개발을 위한 단초를 제공하는 역할을 할 것이라 기대한다.

• Journal of Pharmaceutical Investigation
• /
• 제29권2호
• /
• pp.111-115
• /
• 1999

We have studied the transdermal flux of prostaglandin $E_1$ $(PGE_1)$ from a hydrogel patch through hairless mouse skin, to test the possibility of developing a transdermal delivery system. Karaya gum patch containing $PGE_1$ was prepared by casting method. $PGE_1$ was stable in the patch for 10 weeks. The effect of current application, enhancer (propylene glycol monolaurate : PGML), adhesive and patch thickness on the flux was studied using side-by-side diffusion cell. Passive flux of $PGE_1$ was negligible. Cathodal delivery increased the flux about 20 fold. As the concentrations of PGML increased, flux increased. When 5% PGML was used as the enhancer, maximum flux by cathodal iontophoresis was $55\;{\mu}g/cm^2\;hr$. It increased about 2 folds to $100\;{\mu}g/cm^2\;hr$, when the amount of PGML used was 9%. Large increase in flux and the decrease in time to reach maximum flux were observed when the skin was pretreated with neat PGML (maximum flux obtained was about $200\;{\mu}g/cm^2\;hr$). Use of adhesive decreased the flux significantly. To the contrary of our expectation, increase in current density decreased the flux. These flux data together with the stability data indicate that, though the onset of sufficient delivery occur after 1-2 hours of application, therapeutic amount of $PGE_1$ can be delivered through skin using iontophoresis and penetration enhancer.

• Clinical and Experimental Reproductive Medicine
• /
• 제42권2호
• /
• pp.58-61
• /
• 2015

Objective: The XIST gene is considered to be an attractive candidate gene for skewed X-chromosome inactivation and a possible cause of primary ovarian insufficiency (POI). The purpose of this study was to investigate whether the XIST gene promoter mutation is associated with idiopathic POI in a sample of the Korean population. Methods: Subjects consisted of 102 idiopathic POI patients and 113 healthy controls with normal menstrual cycles. Patients with the following known causes of POI were excluded in advance: cytogenetic abnormalities, prior chemo- or radiotherapy, or prior bilateral oophorectomy. Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. Results: The mean age of onset of ovarian insufficiency was $28.7{\pm}8.5years$ and the mean values of serum luteinizing and follicle-stimulating hormones and estradiol in the POI group were $31.4{\pm}18.2mIU/mL$, $74.5{\pm}41.1mIU/mL$, and $30.5{\pm}36.7pg/mL$, respectively. We found no cytosine to guanine (C43G) variation in the XIST gene in both POI patients and controls. Conclusion: The C43G mutation in the promoter region of the XIST gene was not present in the Korean patients with idiopathic POI in our study, in contrast to our expectation, suggesting that the role of XIST in the pathogenesis of POI is not yet clear.

• 수산경영론집
• /
• 제49권4호
• /
• pp.37-52
• /
• 2018

Busan is a representative of ocean cities in South Korea, which attracts many Chinese tourists. As a number of Chinese tourists increase, Chinese tourists' evaluations of sightseeing resources in Busan appear extremely important. However, there are few researches on Chinese tourists' evaluations of sightseeing in Busan. The purpose of this paper is to analyze Chinese tourists' evaluations of Busan tourism. Chinese tourists who travel to Busan are chosen as research objects and several aspects including marine, fisheries and general tourism are investigated to evaluate the tourists' overall satisfaction of the tourism in Busan. IPA analysis, factor analysis multiple regression analysis are used for the research. The results are as follows. Chinese tourists' evaluations of the importance and performance level of variables on Busan tourism were significantly different (total 19 of 25 variables) and the performance was lower than importance. This means the outputs of the various Busan tourism elements do not live up to their expectations. The findings show that Chinese visitors have high satisfaction on infrastructures of fisheries tourism (e.g. cleanness of aquatic product tourism facilities and sanitary state on fishery products), but low satisfaction in terms of the contents (e.g. unique cooking method experience of seafood and traditional seafood cooking consumption). The factors of fisheries tourism (e.g. product services of fisheries tourism and the attractiveness of seafood in Busan) never affect their satisfaction and intention to revisit and recommend the city.

• Child Health Nursing Research
• /
• 제13권3호
• /
• pp.318-328
• /
• 2007

Purpose: Because it is important to prevent adolescents from becoming involved in smoking, this study was done to explore important factors influencing cigarette use and the increase in smoking frequency. Method: For this study the Korea Youth Panel Survey (KYPS) was analyzed. Because the KYPS is longitudinal, a fixed effect regression method was used to control for the effects of time-independent factors. More specifically, a logistic regression was used to explore factors affecting cigarette use, and a Poisson regression was used to explore smoking frequency. Result: As the adolescents got older, the number of male adolescents who tried smoking increased, while the number of female adolescents who tried smoking decreased. Also, the frequency of cigarette use among male and female smokers increased over time. Significant factors affecting cigarette use were friends who smoked, delinquent behavior, and loneliness at schools. Important factors affecting the increase in smoking frequency were grade (e.g., the 2nd- and 3rd-year of middle school), friends who smoked, delinquent behavior, monthly pocket money, expectation for the highest level of education, and attack tendency. Conclusions: To solve the problems linked to adolescent smoking, it is critical to develop intervention programs that target specific homogeneous subgroups of smokers, and that take into consideration gender difference in smoking and factors affecting levels of smoking behavior.

• 한국농공학회논문집
• /
• 제49권2호
• /
• pp.61-74
• /
• 2007

A mathematical modeling program called Hydrological Simulation Program-FORTRAN (HSPF) developed by the United States Environmental Protection Agency (EPA) was applied to Hwaseong watershed. It was run under BASINS (Better Assessment Science for Integrating Point and Nonpoint Sources) program, and the model was validated using monitoring data of $2002{\sim}2005$. The model efficiency of runoff ranged from good to fair in comparison between simulated and observed data, while it was from very good to poor in the water quality parameters. But its reliability and performance were within the expectation considering complexity of the watershed and pollutant sources. The nonpoint source (NPS) loading for T-N and T-P during the monsoon rainy season (June to September) was about 80% of total NPS loading, and runoff volume was also in a similar range. However, NPS loading for BOD ($55{\sim}60%$) didn't depend on rainfall because BOD was mostly discharged from point source (more than 70%). And water quality was not necessarily high during the rainy season, and showed a decreasing trend with increasing water flow. BASINS/HSPF was applied to the Hwaseong watershed successfully without difficulty, and it was found that the model could be used conveniently to assess watershed characteristics and to estimate pollutant loading including point and nonpoint sources in watershed scale.

• 대한화장품학회:학술대회논문집
• /
• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
• /
• pp.291-312
• /
• 2003

Reactive oxygen species are capable of damaging biomolecules such as lipids, proteins, and DNA, which can not only lead to various diseases, but also oxidative damage resulting aging. In our previous study, Cercis chinensis (Leguminosae) showed a potent antioxidant activity. Nineteen compounds were isolated through antioxidant activity-guided fractionation. The C. chinensis extract and some of the constituents exhibited a potent antioxidant activity on the free radicals and lipid peroxidation and a notable protective effect on the t-BuOOH induced oxidative damage. In vivo test of skin damage induced by UVB irradiation, the extract of C. chinensis and a constituent, piceatannol, exhibited a significant protective effect. The life-span of the HEK-N/F cells were extended by 1.21-2.12 fold as a result of the continuous administration of 3 $\mu\textrm{g}$/ml of the C. chinensis extract and the active constituents compared to that of the control. These observations were attributed to the inhibitory effect of the C. chinensis extract and its constituents on the age-dependent shortening of the telomere. Thus, C. chinensis was demonstrated to protect the skin cells against oxidative stress and inhibit thereby the cellular aging, followed by expectation as anti-aging cosmetic ingredient.