• Plant Resources
• /
• 제3권2호
• /
• pp.123-130
• /
• 2000

The medicinal constituents contained in Korean and Chinese Angelicae dahuricae Radix were compared by confirming their qualities. From the extracts of Angelicae dahuricae Radix, oxypeucedanin, imperatorin, and alloisoimperatorin etc. furanocoumarin derivatives were identified by GC/MS analysis. Through GC/FID analysis, the furanocoumarin derivatives content of Baizi cultivated in Korea was more than that cultivated in China, except for one cultivated at Ankuk province, and so confirmed to possess, on the whole, good quality medicinal constituents by content, as compared with the ones cultivated in China.

• 생약학회지
• /
• 제21권1호
• /
• pp.74-82
• /
• 1990

The effects of naturally occurring furanocoumarins on cytochrome P-450 have been investigated in rat liver microsomes. Incubation of microsomes with an NADPH-generating system and four furanocoumarins such as imperatorin, isoimperatorin, phellopterin and byakangelicin at $37^{\circ}$ in vitro resulted in a significant destruction of cytochrome P-450. A single treatment(50 mg/kg, i.p.) of rats with each furanocoumarin caused a rapid loss of cytochrome P-450 accompanied by the loss of heme from the microsomes but not by the loss of cytochrome $b_5$. It is suggested that cytochrome P-450 is specifically destroyed by furanocoumarins in a metabolic process involving destruction of its heme group and as a consequence, hepatic enzyme activities are depressed markedly.

• Archives of Pharmacal Research
• /
• 제23권5호
• /
• pp.467-470
• /
• 2000

Five furanocoumarins including a new one were isolated from the root of Angelica dahurica by repeated silica gel column chromatography. Their chemical structures were determined to be isoimperatorin (1), oxypeucedanin hydrate-3"-butyl ether (2), imperatorin (3), knidilin (4), and oxypeucedanin hydrate (5). This represents the first study in which the compound 2 has been isolated and identified, The long-range coupling ($^{5}J$) in the $^1H$-NMR spectrum observed in the linear furanocoumarin skeleton was also investigated in detail.

• 생약학회지
• /
• 제23권4호
• /
• pp.218-220
• /
• 1992

From the benzene soluble parts of Dystaenia takeshimana Kitagawa which is indigenous to Korea, three furanocoumarins have been isolated and identified as psoralen, xanthotoxin and dimethylsuberosin.

• 생약학회지
• /
• 제23권4호
• /
• pp.221-224
• /
• 1992

From the roots of Angelica dahurica Bentham et Hooker(Umbelliferae), three coumarin glycosides have been isolated and identified as skimmin, $8-O-{\beta}-D-glucopyranosyl$ xanthotoxol and $tert.-O-{\beta}-D-glucopyranosyl-heralenol$. $8-O-{\beta}-D-Glucopyranosyl-xanthotoxol$ was isolated for the first time from plant source.

• Archives of Pharmacal Research
• /
• 제15권1호
• /
• pp.73-77
• /
• 1992

From the roots of Angelica dahurica Bentham et Hooker (Umbelliferae), five coumarin glucosides together with adenosine have been isolated and identified as nodakenin, 3'-hydroxymarmesinin, tert-O-$\beta$-D-glucopyranosyl-byakangelicin, sec-O-$\beta$-D-glucopyranosyl-byakangelicin and scopolin. This is the first report of the occurrence of these compounds in this plant.

• Bulletin of the Korean Chemical Society
• /
• 제24권11호
• /
• pp.1699-1701
• /
• 2003

• 대한약학회:학술대회논문집
• /
• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
• /
• pp.247.1-247.1
• /
• 2002

A number of patients suffering from atrial fibrillation are increasing and many cardiologists are trying to develop the ideal antiarrhythmic drugs for atrial fibrillation. Previously, we found out that CW-2202, a furanocoumarin derivative inhibited the hKvl.5 current expressing predominantly in human atrium without affecting the HERG current expressing mainly in ventricle. (omitted)

• 생약학회지
• /
• 제31권1호
• /
• pp.77-81
• /
• 2000

The MeOH extract of Notopterygium incisum showed a strong cytotoxicity against B16 murine melanoma cell line. From this extract three furanocoumarins including bergamottin, isoimperatorin, notopterol and one polyacetylenic compound (falcarindiol) together with one phenylpropanoid (caffeic acid methyl ester) and one triterpenoid (pregnenolone) were isolated. The isolated compounds were evaluated for cytotoxic activity against four kinds of cancer cell lines, e.g. P388 (murine lymphocytic leukemia), B16 (murine melanoma), A549 (human lung carcinoma) and SK-OV-3 (human ovarian cancer). Among the isolates, falcarindiol and caffeic acid methyl ester expressed a significant antiproliferative activity against all tested cell lines.

• Archives of Pharmacal Research
• /
• 제29권9호
• /
• pp.741-745
• /
• 2006

In our efforts to discover novel phytoestrogens to treat menopausal symptoms, eleven furanocoumarins were isolated from Angelica dahurica and tested for their estrogenic activity on the Ishikawa cell line. Among the compounds tested, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin showed strong abilities to induce alkaline phosphatase (AP) with $EC_{50}$ values of 1.1 and $0.8\;{\mu}g/mL$, respectively, whereas the other nine furanocoumarins were weakly or only slightly active.