Browse > Article

Estrogenic Activity of Furanocoumarins Isolated from Angelica dahurica  

Piao, Xiang-Lan (School of Pharmaceutical Sciences, Peking University)
Yoo, Hye-Hyun (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology)
Kim, Hyun-Young (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University)
Kang, Tak-Lim (College of Oriental Medincine, Taejon University)
Hwang, Gwi-Seo (College of Oriental Medicine, Kyungwon University)
Park, Jeong-Hill (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University)
Publication Information
Archives of Pharmacal Research / v.29, no.9, 2006 , pp. 741-745 More about this Journal
Abstract
In our efforts to discover novel phytoestrogens to treat menopausal symptoms, eleven furanocoumarins were isolated from Angelica dahurica and tested for their estrogenic activity on the Ishikawa cell line. Among the compounds tested, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin showed strong abilities to induce alkaline phosphatase (AP) with $EC_{50}$ values of 1.1 and $0.8\;{\mu}g/mL$, respectively, whereas the other nine furanocoumarins were weakly or only slightly active.
Keywords
Angelica dahurica; Umbelliferae; Furanocoumarin; Estrogenic activity;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 4  (Related Records In Web of Science)
Times Cited By SCOPUS : 4
연도 인용수 순위
1 Murkies, A. L., Wilcox, G., and Davis, S. R., Clinical review 92: Phytoestrogens. J. Clin. Endocrinol. Metab., 83, 297-303 (1998)   DOI
2 Nishida M., Kasahara K., Kaneko M., Iwasaki H., and Hayashi K., Establishment of a new human endometrial adenocarcinoma cell line, Ishikawa cells, containing estrogen and progesterone receptors. Nippon Sanka Fujinka Gakkai Zasshi, 37, 1103-1111 (1985)
3 Pisha, E. and Pezzuto, J. M., Cell-based assay for the determination of estrogenic and anti-estrogenic activities. Methods Cell Sci., 19, 37-43 (1997)   DOI   ScienceOn
4 Setchell, K. D. R., Phytoestrogens: The biochemistry, physiology, and implications for human health of soy isoflavones. Am. J. Clin. Nutr., 68, 1333S-1346S (1998)   DOI
5 Stanley, W. L. and Vannier, S. H., Psoralens and substituted coumarins from expressed oil of lime. Phytochemistry, 6, 585-596 (1967)   DOI   ScienceOn
6 Yoo, H. H., Kim, T., Ahn, S., Kim, Y. J., Kim, H. Y., Piao, X. L., and Park, J. H., Evaluation of the estrogenic activity of leguminosae plants. Biol. Pharm. Bull., 28, 538-540 (2005)   DOI   ScienceOn
7 Grodstein, F., Stamfer, M. J., Colditz, G. A., Willett, W. C., Manson, J. E., Joffe, M., Rosner, B., Fuchs, C., Hankinson, S. E., Hunter, D. J., Hennekens, C. H., and Speizer, F. E., Postmenopausal hormone therapy and mortality. New Engl. J. Med., 336, 1769-1775 (1997)   DOI   ScienceOn
8 Setchell, K. D. R. and Cassidy, A., Dietary isoflavones: Biological effects and relevance to human health. J. Nutr., 129, 758S-767S (1999)   DOI
9 Tang, W. and Eisenbrand, G., Chinese Drugs of Plant Origin, Chemistry, Pharmacology, and Use in Traditional and Modern Medicine. Springer, Berlin, (1992)
10 Stampfer, M. J., Willett, W. C., Hunter, D. J., and Manson, J. E., Type of postmenopausal hormone use and risk of breast cancer: 12-year follow-up from the Nurses' Health Study. Cancer Causes Control, 3, 433-439 (1992)   DOI
11 Hsu, H. -Y., Chen, Y. -P., Shen, S. -J., Hsu, C. -C., and Chang, H. -C., Oriental Materia Medica: A Concise Guide. Oriental Healing Arts Institute, (1986)
12 Wickelgren, I., Estrogen: A new weapon against Alzheimer's. Science, 276, 676-677 (1997)   DOI
13 Wang, C. -C., Lai, J. -E., Chen, L. -G., Yen, K. -Y. and Yang, L. - L., Inducible nitric oxide synthase inhibitors of Chinese herbs. Part 2: Naturally occurring furanocoumarins. Bioorg. Med. Chem., 8, 2701-2707 (2000)   DOI   ScienceOn
14 Lee, S., Yoo, H. H., Piao, X. L., Kim, J. S., Kang, S. S., and Shin, K. H., Anti-estrogenic activity of lignans from Acanthopanax chiisanensis root. Arch. Pharm. Res., 28, 186-189 (2005)   과학기술학회마을   DOI
15 Henderson, B. E., Ross, R., and Bernstein, L., Estrogen as a cause of human cancer. The Richard and Hinda Rosenthal Foundation Award Lecture. Cancer Res., 48, 246-253 (1988)
16 Piao, X. L., Baek, S. H., Park, M. K., and Park, J. H., Tyrosinaseinhibitory furanocoumarin from Angelica dahurica. Biol. Pharm. Bull., 27, 1144-1146 (2004)   DOI   ScienceOn
17 Harris, R. B., Laws, A., Reddy, F. M., King, A., and Haskell, W. L., Are women using postmenopausal estrogens? A community survey. Am. J. Public Health, 80, 1266-1268 (1990)   DOI
18 Holinka, C. F., Hata, H., Kuramoto, H., and Gurpide, E., Effects of steroid hormones and antisteroids on alkaline phosphatase activity in human endometrial cancer cells (Ishikawa). Cancer Res., 46, 2771-2774 (1986)
19 Liehr, J. G., Genotoxic effects of estrogens. Mutat. Res., 238, 269-276 (1990)   DOI   ScienceOn
20 Kurzer, M. S. and Xu, X., Dietary phytoestrogens. Annu. Rev. Nutr., 17, 353-381 (1997)   DOI   ScienceOn
21 Perry, L. M., Medicinal Plants of East and Southeast Asia: Attributed Properties and Uses. The MIT Press, Cambridge, (1980)
22 Brosage, P., Hormone therapy: The woman's decision. Contemp. Nurse Pract., 1 (S), 3 (1995)
23 Colditz, G. A., Hankinson, S. E., Hunter, D. J., Willett, W. C., Manson, J. E., Stampfer, M. J., Hennekens, C., Rosner, B., and Speizer, F. E., The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. New Engl. J. Med., 332, 1589-1593 (1995)   DOI   ScienceOn
24 Ishihara, K., Fukutake, M., Asano, T., Mizuhara, Y., Wakui, Y., Yanagisawa, T., Kamei, H., Ohmori, S., and Kitada, M., Simultaneous determination of byak-angelicin and oxypeucedanin hydrate in rat plasma by column-switching highperformance liquid chromatography with ultraviolet detection. J. of Chromatogra.B., 753, 309-314 (2001)   DOI   ScienceOn
25 Saiki, Y., Morinaga, K., Okegawa, O., Sakai, S., Amaya, Y., Ueno, A., and Fukushima, S., On the Coumarins of the Root Agelica dahurica Benth. et Hook. Yakugaku Zasshi, 53, 1313-1317 (1971)
26 Bennett, E. L. and Bonner, J., Isolation of Plant Growth Inhibitors from Thamnosma Montana. Amer. J. Botany, 40, 29-33 (1953)   DOI   ScienceOn
27 Bolton, J. L., Pisha, E., Zhang, F., and Qiu, S., Role of quinoids in estrogen carcinogenesis. Chem. Res. Toxicol., 11, 1113- 1127 (1998)   DOI   ScienceOn
28 Bergendorff, O., Dekermendjian, K., Nielsen, M., Shan, R., Witt, R., Ai, J., and Sterner, O., Furanocoumarins with affinity to brain benzodiazepine receptors in vitro. Phytochemistry, 44, 1121-1124 (1997)   DOI   ScienceOn
29 Dreyer, D. L. and Lee A., Constituents of Cneoridium dumosum (Nutt.) Hook. F. Phytochemistry, 8, 1499-1501 (1969)   DOI   ScienceOn
30 Edenharder, R., Speth, C., Decker, M., Kolodziej, H., Kayser, O., and Platt, K. L., Inhibition of mutagenesis of 2-amino-3- methylimidazo[4,5-f]quinoline (IQ) by coumarins and furanocoumarins, chromanones and furanochromanones. Mutat. Res., 345, 57-71 (1995)   DOI   ScienceOn