• Proceedings of the Acoustical Society of Korea Conference
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• spring
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• pp.15-18
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• 2002

Prosodic features of speech are known to play an important role in the transmission of linguistic information in human conversation. Their roles in the transmission of para- and non- linguistic information are even much more. In spite of their importance in human conversation, from engineering viewpoint, research focuses are mainly placed on segmental features, and not so much on prosodic features. With the aim of promoting research works on prosody, a research project 'Prosody and Speech Processing' is now going on. A rough sketch of the project is first given in the paper. Then, the paper introduces several prosody-related research works, which are going on in our laboratory. They include, corpus-based fundamental frequency contour generation, speech rate control for dialogue-like speech synthesis, analysis of prosodic features of emotional speech, reply speech generation in spoken dialogue systems, and language modeling with prosodic boundaries.

• Genomics & Informatics
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• v.2 no.1
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• pp.19-29
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• 2004

Gene expression profiles may offer more information than morphology and provide an alternative to morphology- based tumor classification systems. Informative gene selection is finding gene subsets that are able to discriminate between tumor types, and may have clear biological interpretation. Gene selection is a fundamental issue in gene expression based tumor classification. In this report, techniques for selecting informative genes are illustrated and supervised shaving introduced as a gene selection method in the place of a clustering algorithm. The supervised shaving method showed good performance in gene selection and classification, even though it is a clustering algorithm. Almost selected genes are related to leukemia disease. The expression profiles of 3051 genes were analyzed in 27 acute lymphoblastic leukemia and 11 myeloid leukemia samples. Through these examples, the supervised shaving method has been shown to produce biologically significant genes of more than $94\%$ accuracy of classification. In this report, SVM has also been shown to be a practicable method for gene expression-based classification.

• Journal of applied mathematics & informatics
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• v.39 no.5_6
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• pp.769-783
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• 2021

Demirci ((1999) Vague groups. J. Math. Anal. Appl. 230, 142-156) introduced the concept of vague groups as one of uncertain reasoning structures where indistinguishable operators separate points. In this paper, we consider vague groups in which an indistinguishable operator does not need to separate points because it seems more appropriate to handle ambiguous situations. For our purposes we generalize or redefine some notions such as: vague closed subset, vague subgroup, vague kernel and vague injectiveness. Consequently we generalize most of the known results and obtain some new additional fundamental properties of vague groups, some of which are similar to ones of ordinary groups.

• Genomics & Informatics
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• v.16 no.4
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• pp.24.1-24.4
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• 2018

Taxonomic identification is fundamental to all microbiology studies. Particularly in metagenomics, which identifies the composition of microorganisms using thousands of sequences, its importance is even greater. Identification is inevitably affected by the choice of database. This study was conducted to evaluate the accuracy of three widely used 16S databases-Greengenes, Silva, and EzBioCloud-and to suggest basic guidelines for selecting reference databases. Using public mock community data, each database was used to assign taxonomy and to test its accuracy. We show that EzBioCloud performs well compared with other existing databases.

• Journal of applied mathematics & informatics
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• v.41 no.5
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• pp.973-988
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• 2023

In real-life scenarios, we may have to deal with real numbers or numbers in intervals or a combination of both to solve multi-criteria decision-making (MCDM) problems. Also, we may come across a situation where we must combine this interval and actual number membership values into a single real number. The most significant factor in combining these membership values into a single value is by using aggregation operators or scoring algorithms. To overcome such a situation, we suggest the cubic hypersoft set (CHSS) concept as a workaround. Ultimately, this makes it simple for the decision-maker to obtain information without misconceptions. The primary aim of this study is to establish some operational laws for the cubic hypersoft set, present the fundamental properties of aggregation operators and propose an algorithm by using the technique of order of preference by similarity to the ideal solution (TOPSIS) technique based on correlation coefficients to analyze the stress-coping skills of workers.

• Journal of applied mathematics & informatics
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• v.41 no.6
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• pp.1393-1407
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• 2023

In this study, we propose a dynamic SEIQRV mathematical model and examine it to comprehend the dynamics of COVID-19 pandemic transmission in the Coimbatore district of Tamil Nadu. Positiveness and boundedness, which are the fundamental principles of this model, have been examined and found to be reliable. The reproduction number was calculated in order to predict whether the disease would spread further. Existing arrangements of infection-free, steady states are asymptotically stable both locally and globally when R₀ < 1. The consistent state arrangements that are present in diseases are also locally steady when R₀ < 1 and globally steady when R₀ > 1. Finally, the numerical data confirms our theoretical study.

• Journal of Computing Science and Engineering
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• v.7 no.2
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• pp.99-111
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• 2013

Approximating a divergence between two probability distributions from their samples is a fundamental challenge in statistics, information theory, and machine learning. A divergence approximator can be used for various purposes, such as two-sample homogeneity testing, change-point detection, and class-balance estimation. Furthermore, an approximator of a divergence between the joint distribution and the product of marginals can be used for independence testing, which has a wide range of applications, including feature selection and extraction, clustering, object matching, independent component analysis, and causal direction estimation. In this paper, we review recent advances in divergence approximation. Our emphasis is that directly approximating the divergence without estimating probability distributions is more sensible than a naive two-step approach of first estimating probability distributions and then approximating the divergence. Furthermore, despite the overwhelming popularity of the Kullback-Leibler divergence as a divergence measure, we argue that alternatives such as the Pearson divergence, the relative Pearson divergence, and the $L^2$-distance are more useful in practice because of their computationally efficient approximability, high numerical stability, and superior robustness against outliers.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.14 no.1
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• pp.15-35
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• 2010

Objectives : The purpose of this study is to find out the correlation between the Vocal indicators and the 'Buzhongyiqi-Tang questionnaire' and the 'Chalder fatigue scale.' Methods : This study examined the mean value of each factor in the 'Buzhongyiqi-Tang Questionnaire,' 'Chalder fatigue scale' and the different voice indicators conducted on 81 healthy adult participants in relation to the results of the /a/ /e/ /i/ /o/ /u/ pronunciation test. Results : There was significant correlation between the pronunciation of /a/ /e/ /i/ /o/ /u/ vowels' F0 indexes and 'the Deficiency symptoms of Buzhongyiqi-Tang'. The results of the regression analysis showed the following significant findings for each pronouncing vowels: /i/ as a factor for 'the Deficiency symptoms of Buzhongyiqi-Tang'.; /a/ for 'the Consumptive fever of Buzhongyiqi-Tang'.; /i/ for 'the Vocal inflammation of Buzhongyiqi-Tang.; and /e/ as a factor of 'the Chadler physical fatigue'. Conclusions : The study showed a negative correlation between the Fundamental Frequency and the mean value of the questionnaire, which could be understood as higher the fatigue level, increased level of vocal vibration and higher pitch tone compared to the less fatigued group. We expect future studies to conduct research on methods to diagnose other illnesses using the vocal indicators based on the correlation between the vocal index and illnesses prescribed under traditional oriental medicine.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.9
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• pp.273-285
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• 2021

This study estimates the financial value of return on investment (ROI) of research funds. Four simulation estimations are employed to measure ROI finance value that considers the outputs, outcomes, impacts and total ROI from the allocation input received. Research outputs, outcomes, and impacts can be quantitatively measured based on improvements to existing systems. In terms of input, the Malaysian government has allocated MYR301,350,000 for fundamental research in the 2021 budget compared with 2019, up 9.5 percent from 2019. It brings up the question: To what extent does the input of research funds allocated by the government yield a good return in outputs, outcomes, and impacts to the academic community, society, and country? The result of total ROI shows around MYR7 return is generated by researchers for each Malaysian ringgit channeled by the funder. More specifically, for a research project, it is more difficult to produce impacts and outcomes compared to research outputs. The positive return is evidence that all the allocated funds are beneficial to the stakeholders. The government can apply this approach in calculating ROI for evaluation and fund allocation to universities. Furthermore, the positive financial value of research output, outcome, and impact automatically contribute to a positive innovation environment in Malaysia.

• Genomics & Informatics
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• v.10 no.4
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• pp.244-248
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• 2012

Oxidative stress, which results in an excessive product of reactive oxygen species (ROS), is one of the fundamental mechanisms of the development of hypertension. In the vascular system, ROS have physical and pathophysiological roles in vascular remodeling and endothelial dysfunction. In this study, ROS-hypertension-related genes were collected by the biological literature-mining tools, such as SciMiner and gene2pubmed, in order to identify the genes that would cause hypertension through ROS. Further, single nucleotide polymorphisms (SNPs) located within these gene regions were examined statistically for their association with hypertension in 6,419 Korean individuals, and pathway enrichment analysis using the associated genes was performed. The 2,945 SNPs of 237 ROS-hypertension genes were analyzed, and 68 genes were significantly associated with hypertension (p < 0.05). The most significant SNP was rs2889611 within MAPK8 (p = $2.70{\times}10^{-5}$; odds ratio, 0.82; confidence interval, 0.75 to 0.90). This study demonstrates that a text mining approach combined with association analysis may be useful to identify the candidate genes that cause hypertension through ROS or oxidative stress.