• The Korean Journal of Physiology and Pharmacology
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• 제8권2호
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• pp.77-81
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• 2004

The loss of neurons and synaptic contacts following cerebral ischemia may lead to a synaptic plastic modification, which may contribute to the functional recovery after a brain lesion. Using synapsin I and GAP-43 as markers, we investigated the neuronal cell death and the synaptic plastic modification in the rat hippocampus of a middle cerebral artery occlusion (MCAO) model. Cresyl violet staining revealed that neuronal cell damage occurred after 2 h of MCAO, which progressed during reperfusion for 2 weeks. The immunoreactivity of synapsin I and GAP-43 was increased in the stratum lucidum in the CA3 subfield as well as in the inner and outer molecular layers of dentate gyrus in the hippocampus at reperfusion for 2 weeks. The immunoreactivity of phosphosynapsin was increased in the stratum lucidum in the CA3 subfield during reperfusion for 1 week. Our data suggest that the increase in the synapsin I and GAP-43 immunoreactivity probably mediates either the functional adaptation of the neurons through reactive synaptogenesis from the pre-existing presynaptic nerve terminals or the structural remodeling of their axonal connections in the areas with ischemic loss of target cells. Furthermore, phosphosynapsin may play some role in the synaptic plastic adaptations before or during reactive synaptogenesis after the MCAO.

• 구강회복응용과학지
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• 제30권2호
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• pp.159-169
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• 2014

다발성 안면골절 시 연조직 및 경조직의 소실로 인해 적절한 과두-디스크의 기능을 회복할 위치를 찾는데 어려움이 있다. 다발성 안면골절 및 양측 과두골절과 부족한 수직고경 및 안면비대칭을 가진 환자가 내원하였다. 교합안정장치를 이용하여 골절된 과두를 정복하고 과두-디스크 복합체에 새로운 기능적 위치를 선정하였다. 추적조사를 통해 과두의 위치가 편안감과 안정성이 적절하다고 판단한 뒤 임플란트와 고정성 보철물을 이용한 완전구강회복을 시행하였다. 환자는 심미성과 기능에 만족하였으며 안정적 교합상태를 보였지만 추가적인 교합변화의 가능성을 배제할 수 없기 때문에 야간안정장치 및 정기적인 관리가 필요할 것으로 사료된다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제44권6호
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• pp.275-281
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• 2018

Objectives: Isolated mandibular fractures contribute to approximately 45% of maxillofacial traumas. Improper management of mandibular fractures can cause myriad potential complications and can lead to serious functional and aesthetic sequelae. The objective of the study is to design a stepwise approach for managing isolated mandibular fractures using open reduction and internal fixation (ORIF) with regional anesthesia on outpatient basis. Materials and Methods: Patients with isolated mandibular fractures presenting to the department of maxillofacial surgery were selected for ORIF under regional anesthesia based on occlusion, age, socioeconomic status, general condition, habits, and allied medical ailments. Standard preoperative, intraoperative, and postoperative protocols were followed. All patients were followed up for a minimum of 4 weeks up to a maximum of 1 year. Results: Of 23 patients who received regional anesthesia, all but one had good postoperative functional occlusion. One patient was hypersensitive and had difficulty tolerating the procedure. Two patients developed an extraoral draining sinus, one of whom was managed with local curettage, while the other required hardware removal. One patient, who was a chronic alcoholic, returned 1 week after treatment with deranged fracture segments after he fell while intoxicated. Conclusion: With proper case selection following a stepwise protocol, the majority of mandibular fractures requiring ORIF can be managed with regional anesthesia and yield minimal to no complications.

• 대한구순구개열학회지
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• 제13권2호
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• pp.63-76
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• 2010

After introduction of Delaire's basic philosophy, to consider the normal and pathologic anatomy, the role of some structures, such as nasal septum, musculature, and tongue, and some functions, such as dental occlusion or nasal respiration, which play important roles in maxillary and particularly premaxillary growth, on the Korean Journal of cleft lip and palate in 2009, Delaire's primary functional cheilorhinoplasty (FCR) in the unilateral and bilateral cleft lip patients was summarized and introduced according to already published literatures and lectures. This paper will be the second publishment of Delaire philosophy with Korean language.

• Biomolecules & Therapeutics
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• 제30권1호
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• pp.55-63
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• 2022

Oleanolic acid (OA), a natural pentacyclic triterpenoid, has been reported to exert protective effects against several neurological diseases through its anti-oxidative and anti-inflammatory activities. The goal of the present study was to evaluate the therapeutic potential of OA against acute and chronic brain injuries after ischemic stroke using a mouse model of transient middle cerebral artery occlusion (tMCAO, MCAO/reperfusion). OA administration immediately after reperfusion significantly attenuated acute brain injuries including brain infarction, functional neurological deficits, and neuronal apoptosis. Moreover, delayed administration of OA (at 3 h after reperfusion) attenuated brain infarction and improved functional neurological deficits during the acute phase. Such neuroprotective effects were associated with attenuation of microglial activation and lipid peroxidation in the injured brain after the tMCAO challenge. OA also attenuated NLRP3 inflammasome activation in activated microglia during the acute phase. In addition, daily administration of OA for 7 days starting from either immediately after reperfusion or 1 day after reperfusion significantly improved functional neurological deficits and attenuated brain tissue loss up to 21 days after the tMCAO challenge; these findings supported therapeutic effects of OA against ischemic stroke-induced chronic brain injury. Together, these findings showed that OA exerted neuroprotective effects against both acute and chronic brain injuries after tMCAO challenge, suggesting that OA is a potential therapeutic agent to treat ischemic stroke.

• Journal of Korean Neurosurgical Society
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• 제46권5호
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• pp.488-491
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• 2009

A 31-year-old man presented with right hemiparesis, and magnetic resonance imaging revealed a small infarct at left basal ganglia. Digital subtraction angiography showed left cervical internal carotid artery (ICA) occlusion and severe stenosis of the ipsilateral external carotid artery (ECA) with collateral cerebral circulation fed by ECAs. Based on the results of a functional evaluation of cerebral blood flow, we performed preventive ECA angioplasty and stenting for advanced ECA stenosis to ensure sufficient blood flow to the superficial temporal artery. Eight weeks later, superficial temporal artery to middle cerebral artery (STA-MCA) anastomosis was performed. His postoperative course was uneventful and no additional transient ischemic attacks have occurred. To our knowledge, this is the first report of preventive angioplasty and stenting for advanced narrowing of an ECA before STA-MCA anastomosis for ipsilateral ICA occlusion.

• 대한치과보철학회지
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• 제55권4호
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• pp.451-457
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• 2017

벨마비는 원인이 명확하지 않은 급성 말초성 안면 신경마비로 주로 편측으로 나타난다. 일부에서는 완전히 회복되지 못하여 안면 근육의 불완전 마비, 구축 등의 후유증으로 인해 하악의 편측 변위 또는 편측 저작 습관 및 부조화가 나타나며, 따라서 만약 무치악 환자에서 총의치로 수복한다면 더욱 세심한 주의가 필요하다. 본 증례에서는 벨마비의 후유증과 불안정한 하악 운동으로 인해 술자에 의한 중심위 채득이 어려운 무치악 환자에서 고딕아치 묘기법으로 재현성 있는 중심위를 채득하고, 중심위와 환자의 습관적인 하악 기능 운동 범위 간의 자유도 부여를 위해 설측 교합을 이용하여 총의치를 제작함으로써 기능 및 심미적으로 양호한 결과를 얻었기에 보고하는 바이다.

• 구강회복응용과학지
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• 제19권4호
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• pp.317-323
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• 2003

When making crown and bridges on anterior regions, many practitioners consider the esthetics the most. For this reason functional aspect are not considered as much as the esthetics. If the occlusion on the anterior region are not formed correctly, movement of the temporomandibular joint can be disturbed and excessive stress can be occur that pathologic condition can be under lied. On this case presentation will show the importance of the anterior guidance and suggest the appropriate protocol of using customized anterior guide table. A 45years old male had to remake both of the upper central and lateral PFM because of the porcelain fracture. The new PFM crowns were made conventional methods without considering the anterior guidance. After the temporary setting, the patient complained of discomfort and short looking upper anteriors. To solve these problems we had to restore the palatal contour and length of the new crowns by making customized anterior guide table using temporary crowns that contains patient's old anterior guidance. This procedure which is copying the pt's comfortable anterior guidance to the final prosthesis made them to be esthetic and patients to feel comfortable.

• 대한치과보철학회지
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• 제50권4호
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• pp.311-317
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• 2012

총의치 장착시, 환자는 생리적으로 안정된 범위 내에서 자연스럽게 기능하기를 원하며 이를 위해서는, 안모의 회복(심미적 효과), 생물학적으로 안정된 인공치 배열과 외형, 의치 동요가 없는 교합접촉이 반드시 필요하다. 이에 본 증례보고에서는 총의치를 제작하기에 불리한 조건을 가진 환자를 대상으로 인상면, 연마면, 교합면에 있어서의 의치의 안정을 증대시키기 위해, 기능적 변연 형성을 통한 인상채득, 중립대 확인, 생리적 중심위 재확립, 안정된 교합을 형성시켜 주었으며, 임상적으로 기능과 심미적인 측면에 있어서 만족할 만한 결과를 얻었기에 이를 보고하고자 한다.

• 구강회복응용과학지
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• 제32권3호
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• pp.202-208
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• 2016

점진적인 마모는 정상적인 과정이지만 교합면의 마모가 병적으로 과도하게 진행되어 교합평면이 붕괴된 경우 교합, 저작근, 치수병변 등의 문제가 나타날 수 있다. 본 증례에서는 광범위한 마모를 보이는 환자에서 수직고경을 증가하여 임시 수복물을 제작한 후 약 12주간 환자의 적응 여부와 심미성을 평가하였다. 임시 수복물을 바탕으로 CAD/CAM 단일구조 지르코니아를 이용해 전악 고정성 보철물로 수복 하였으며, 기능적인 면과 심미적인 면에서 만족스러운 결과를 얻었기에 이를 보고하는 바이다.