1 |
Martin, R., Carvalho-Tavares, J., Hernandez, M., Arnes, M., Ruiz-Gutierrez, V. and Nieto, M. L. (2010) Beneficial actions of oleanolic acid in an experimental model of multiple sclerosis: a potential therapeutic role. Biochem. Pharmacol. 79, 198-208.
DOI
|
2 |
Martin, R., Hernandez, M., Cordova, C. and Nieto, M. L. (2012) Natural triterpenes modulate immune-inflammatory markers of experimental autoimmune encephalomyelitis: therapeutic implications for multiple sclerosis. Br. J. Pharmacol. 166, 1708-1723.
DOI
|
3 |
Minutoli, L., Puzzolo, D., Rinaldi, M., Irrera, N., Marini, H., Arcoraci, V., Bitto, A., Crea, G., Pisani, A., Squadrito, F., Trichilo, V., Bruschetta, D., Micali, A. and Altavilla, D. (2016) ROS-mediated NLRP3 inflammasome activation in brain, heart, kidney, and testis ischemia/reperfusion injury. Oxid. Med. Cell. Longev. 2016, 2183026.
|
4 |
Niu, G., Sun, L., Pei, Y. and Wang, D. (2018) Oleanolic acid inhibits colorectal cancer angiogenesis by blocking the VEGFR2 signaling pathway. Anticancer Agents Med. Chem. 18, 583-590.
DOI
|
5 |
MacManus, J. P. and Buchan, A. M. (2000) Apoptosis after experimental stroke: fact or fashion? J. Neurotrauma 17, 899-914.
DOI
|
6 |
Wang, W., Chen, K., Xia, Y., Mo, W., Wang, F., Dai, W. and Niu, P. (2018b) The hepatoprotection by oleanolic acid preconditioning: focusing on PPARalpha activation. PPAR Res. 2018, 3180396.
DOI
|
7 |
Yenari, M. A., Kauppinen, T. M. and Swanson, R. A. (2010) Microglial activation in stroke: therapeutic targets. Neurotherapeutics 7, 378-391.
DOI
|
8 |
Pu, H., Shi, Y., Zhang, L., Lu, Z., Ye, Q., Leak, R. K., Xu, F., Ma, S., Mu, H., Wei, Z., Xu, N., Xia, Y., Hu, X., Hitchens, T. K., Bennett, M. V. L. and Chen, J. (2019) Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke. Proc. Natl. Acad. Sci. U.S.A. 116, 9115-9124.
DOI
|
9 |
Shah, I. M., Macrae, I. M. and Di Napoli, M. (2009) Neuroinflammation and neuroprotective strategies in acute ischaemic stroke - from bench to bedside. Curr. Mol. Med. 9, 336-354.
DOI
|
10 |
Wang, K., Sun, W., Zhang, L., Guo, W., Xu, J., Liu, S., Zhou, Z. and Zhang, Y. (2018a) Oleanolic acid ameliorates Abeta25-35 injectioninduced memory deficit in Alzheimer's disease model rats by maintaining synaptic plasticity. CNS Neurol. Disord. Drug Targets 17, 389-399.
DOI
|
11 |
Yang, F., Wang, Z., Wei, X., Han, H., Meng, X., Zhang, Y., Shi, W., Li, F., Xin, T., Pang, Q. and Yi, F. (2014) NLRP3 deficiency ameliorates neurovascular damage in experimental ischemic stroke. J. Cereb. Blood Flow Metab. 34, 660-667.
DOI
|
12 |
Ayeleso, T. B., Matumba, M. G. and Mukwevho, E. (2017) Oleanolic acid and its derivatives: biological activities and therapeutic potential in chronic diseases. Molecules 22, 1915.
DOI
|
13 |
Ziberna, L., Samec, D., Mocan, A., Nabavi, S. F., Bishayee, A., Farooqi, A. A., Sureda, A. and Nabavi, S. M. (2017) Oleanolic acid alters multiple cell signaling pathways: implication in cancer prevention and therapy. Int. J. Mol. Sci. 18, 643.
DOI
|
14 |
Kelley, N., Jeltema, D., Duan, Y. and He, Y. (2019) The NLRP3 inflammasome: an overview of mechanisms of activation and regulation. Int. J. Mol. Sci. 20, 3328.
DOI
|
15 |
Lee, C. H., Sapkota, A., Gaire, B. P. and Choi, J. W. (2020) NLRP3 Inflammasome activation is involved in LPA1-mediated brain injury after transient focal cerebral ischemia. Int. J. Mol. Sci. 21, 8595.
DOI
|
16 |
Sapkota, A., Lee, C. H., Park, S. J. and Choi, J. W. (2020) Lysophosphatidic acid receptor 5 plays a pathogenic role in brain damage after focal cerebral ischemia by modulating neuroinflammatory responses. Cells 9, 1446.
DOI
|
17 |
Shi, Y. J., Sun, L. L., Ji, X., Shi, R., Xu, F. and Gu, J. H. (2021) Neuroprotective effects of oleanolic acid against cerebral ischemiareperfusion injury in mice. Exp. Neurol. 343, 113785.
DOI
|
18 |
Sairanen, T., Karjalainen-Lindsberg, M. L., Paetau, A., Ijas, P. and Lindsberg, P. J. (2006) Apoptosis dominant in the periinfarct area of human ischaemic stroke--a possible target of antiapoptotic treatments. Brain 129, 189-199.
DOI
|
19 |
Abulafia, D. P., de Rivero Vaccari, J. P., Lozano, J. D., Lotocki, G., Keane, R. W. and Dietrich, W. D. (2009) Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice. J. Cereb. Blood Flow Metab. 29, 534-544.
DOI
|
20 |
An, Q., Hu, Q., Wang, B., Cui, W., Wu, F. and Ding, Y. (2017) Oleanolic acid alleviates diabetic rat carotid artery injury through the inhibition of NLRP3 inflammasome signaling pathways. Mol. Med. Rep. 16, 8413-8419.
DOI
|
21 |
Caltana, L., Rutolo, D., Nieto, M. L. and Brusco, A. (2014) Further evidence for the neuroprotective role of oleanolic acid in a model of focal brain hypoxia in rats. Neurochem. Int. 79, 79-87.
DOI
|
22 |
Castellano, J. M., Garcia-Rodriguez, S., Espinosa, J. M., Millan-Linares, M. C., Rada, M. and Perona, J. S. (2019) Oleanolic acid exerts a neuroprotective effect against microglial cell activation by modulating cytokine release and antioxidant defense systems. Biomolecules 9, 683.
DOI
|
23 |
Gaire, B. P., Sapkota, A. and Choi, J. W. (2020) BMS-986020, a specific LPA1 antagonist, provides neuroprotection against ischemic stroke in mice. Antioxidants 9, 1097.
DOI
|
24 |
Jayaraj, R. L., Azimullah, S., Beiram, R., Jalal, F. Y. and Rosenberg, G. A. (2019) Neuroinflammation: friend and foe for ischemic stroke. J. Neuroinflammation 16, 142.
DOI
|
25 |
Rong, Z. T., Gong, X. J., Sun, H. B., Li, Y. M. and Ji, H. (2011) Protective effects of oleanolic acid on cerebral ischemic damage in vivo and H(2)O(2)-induced injury in vitro. Pharm. Biol. 49, 78-85.
DOI
|
26 |
Muralikrishna Adibhatla, R. and Hatcher, J. F. (2006) Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia. Free Radic. Biol. Med. 40, 376-387.
DOI
|
27 |
Girard, S., Murray, K. N., Rothwell, N. J., Metz, G. A. and Allan, S. M. (2014) Long-term functional recovery and compensation after cerebral ischemia in rats. Behav. Brain. Res. 270, 18-28.
DOI
|
28 |
Gu, S. (2021) Oleanolic acid improved inflammatory response and apoptosis of PC12 cells induced by OGD/R through downregulating miR-142-5P. Nat. Prod. Commun. 16, 1934578X211018019.
|
29 |
Gudoityte, E., Arandarcikaite, O., Mazeikiene, I., Bendokas, V. and Liobikas, J. (2021) Ursolic and oleanolic acids: plant metabolites with neuroprotective potential. Int. J. Mol. Sci. 22, 4599.
DOI
|
30 |
Ismael, S., Zhao, L., Nasoohi, S. and Ishrat, T. (2018) Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke. Sci. Rep. 8, 5971.
DOI
|
31 |
Kim, M. S., Han, J. Y., Kim, S. H., Jeon, D., Kim, H. Y., Lee, S. W., Rho, M. C. and Lee, K. (2018) Oleanolic acid acetate attenuates polyhexamethylene guanidine phosphate-induced pulmonary inflammation and fibrosis in mice. Respir. Physiol. Neurobiol. 252-253, 1-9.
DOI
|
32 |
Lapchak, P. A. (2010) A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy? Expert. Opin. Pharmacother. 11, 1753-1763.
DOI
|
33 |
Lenart, N., Brough, D. and Denes, A. (2016) Inflammasomes link vascular disease with neuroinflammation and brain disorders. J. Cereb. Blood Flow. Metab. 36, 1668-1685.
DOI
|
34 |
Liu, J. (2005) Oleanolic acid and ursolic acid: research perspectives. J. Ethnopharmacol. 100, 92-94.
DOI
|
35 |
He, Y., Hara, H. and Nunez, G. (2016) Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem. Sci. 41, 1012-1021.
DOI
|
36 |
Castellano, J. M., Guinda, A., Delgado, T., Rada, M. and Cayuela, J. A. (2013) Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes. Diabetes 62, 1791-1799.
DOI
|
37 |
Martin, R., Cordova, C., San Roman, J. A., Gutierrez, B., Cachofeiro, V. and Nieto, M. L. (2014) Oleanolic acid modulates the immune-inflammatory response in mice with experimental autoimmune myocarditis and protects from cardiac injury. Therapeutic implications for the human disease. J. Mol. Cell. Cardiol. 72, 250-262.
DOI
|
38 |
Schmidt-Pogoda, A., Bonberg, N., Koecke, M. H. M., Strecker, J. K., Wellmann, J., Bruckmann, N. M., Beuker, C., Schabitz, W. R., Meuth, S. G., Wiendl, H., Minnerup, H. and Minnerup, J. (2020) Why most acute stroke studies are positive in animals but not in patients: a systematic comparison of preclinical, early phase, and phase 3 clinical trials of neuroprotective agents. Ann. Neurol. 87, 40-51.
DOI
|
39 |
Wang, J. L., Ren, C. H., Feng, J., Ou, C. H. and Liu, L. (2020) Oleanolic acid inhibits mouse spinal cord injury through suppressing inflammation and apoptosis via the blockage of p38 and JNK MAPKs. Biomed. Pharmacother. 123, 109752.
DOI
|
40 |
Xu, K., Chu, F., Li, G., Xu, X., Wang, P., Song, J., Zhou, S. and Lei, H. (2014) Oleanolic acid synthetic oligoglycosides: a review on recent progress in biological activities. Pharmazie 69, 483-495.
|
41 |
Xu, Q., Zhao, B., Ye, Y., Li, Y., Zhang, Y., Xiong, X. and Gu, L. (2021) Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke. J. Neuroinflammation 18, 123.
DOI
|
42 |
Jin, R., Yang, G. and Li, G. (2010) Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J. Leukoc. Biol. 87, 779-789.
DOI
|
43 |
Msibi, Z. N. P. and Mabandla, M. V. (2019) Oleanolic acid mitigates 6-hydroxydopamine neurotoxicity by attenuating intracellular ROS in PC12 cells and striatal microglial activation in rat brains. Front. Physiol. 10, 1059.
DOI
|
44 |
O'Collins, V. E., Macleod, M. R., Donnan, G. A., Horky, L. L., van der Worp, B. H. and Howells, D. W. (2006) 1,026 experimental treatments in acute stroke. Ann. Neurol. 59, 467-477.
DOI
|
45 |
Xu, S., Lu, J., Shao, A., Zhang, J. H. and Zhang, J. (2020) Glial cells: role of the immune response in ischemic stroke. Front. Immunol. 11, 294.
DOI
|
46 |
Ye, X., Shen, T., Hu, J., Zhang, L., Zhang, Y., Bao, L., Cui, C., Jin, G., Zan, K., Zhang, Z., Yang, X., Shi, H., Zu, J., Yu, M., Song, C., Wang, Y., Qi, S. and Cui, G. (2017) Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse. Exp. Neurol. 292, 46-55.
DOI
|
47 |
Gladstone, D. J., Black, S. E. and Hakim, A. M. (2002) Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions. Stroke 33, 2123-2136.
DOI
|