• Title/Summary/Keyword: functional compound

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HPLC Validation of Valerian Ethanol Extract as a Functional Food (건강기능식품 원료로서 길초근 주정 추출물의 지표성분 분석법 검증)

  • Jo, Kyungae;Han, Sung Hee;Bae, Song-Hwan;Shin, Jung Cheul;Suh, Hyung Joo
    • The Korean Journal of Food And Nutrition
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    • v.31 no.1
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    • pp.104-108
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    • 2018
  • The purpose of this study was to establish valerenic acid as a marker compound for the standardization of ethanol extract of Valerinan officinalis (valerian) root as a functional health food. We established valerenic acid as a marker compound using HPLC. HPLC was used to quantify the marker compound in the valerian extract after validation of methods with linearity, accuracy, and precision. The specificity for retention time was met by comparative analysis of the valerian extract and standard compound using HPLC. The method showed high linearity of the calibration curve with a coefficient of correlation ($R^2$) of 0.9999. The limit of quantification (LOQ) was $10{\mu}g/mL$. The accuracy of measurement was 99.88~00.68% and the relative standard deviation (RSD) value was 0.59%. In addition, our analytical method yielded a 29% mean content of valerenic acid in the valerian ethanol extract. These results indicate that the established HPLC method facilitated the determination of marker compounds in the valerian extract for the standardization of health functional foods.

Synthesis and Biological Evaluation of Heterocyclic Ring-substituted Chalcone Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B

  • Chen, Zhen-Hua;Sun, Liang-Peng;Zhang, Wei;Shen, Qiang;Gao, Li-Xin;Li, Jia;Piao, Hu-Ri
    • Bulletin of the Korean Chemical Society
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    • v.33 no.5
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    • pp.1505-1508
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    • 2012
  • Protein tyrosine phosphatase 1B (PTP1B) is a key factor in negative regulation of the insulin pathway, and is a promising target for the treatment of type-II diabetes, obesity and cancer. Herein, compound ($\mathbf{4}$) was first observed to have moderate inhibitory activity against PTP1B with an $IC_{50}$ value of $13.72{\pm}1.53{\mu}M$. To obtain more potent PTP1B inhibitors, we synthesized a series of chalcone derivatives using compound ($\mathbf{4}$) as the lead compound. Compound $\mathbf{4l}$ ($IC_{50}=3.12{\pm}0.18{\mu}M$) was 4.4-fold more potent than the lead compound $\mathbf{4}$ ($IC_{50}=13.72{\pm}1.53{\mu}M$), and more potent than the positive control, ursolic acid ($IC_{50}=3.40{\pm}0.21{\mu}M$). These results may help to provide suitable drug-like lead compounds for the design of inhibitors of PTP1B as well as other PTPs.

Studies on the Physical Properties of Twisted Yam Woven Fabrics by High Functional Covering Machine and Compound Twister (고성능 커버링기 및 복합연사기를 이용한 연사직물의 물성분석 연구)

  • Jun, Byung Ik;Song, Min Kyu;Choi, Jae Woo
    • Fashion & Textile Research Journal
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    • v.2 no.3
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    • pp.227-233
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    • 2000
  • The purpose of this study was to develop the High Functional Covering machine and the Compound Twister to produce the high value added textile goods and to meet the consumer's needs. For the study, 8 yarns and 12 fabrics were made with two developed machines and the tensile characteristics of the samples were tested and analysed. The result indicated that the sample fabrics kept their elongation regardless of buffering process. Elongation of the sample yarns was higher than those of yarns made with a traditional covering method. Elastic recovery of the sample fabrics was more effected by the recovery rate than by the number of extension and the characteristics of the sample yarns and fabrics were comparable to the yarns and fabrics made with a traditional covering method in terms of the position of Spandex yarns in their yarn structure and buffering effect.

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Antimicrobial Characterictics of Antimicrobial Agent (Antibiotics) and Reduction Effect on Mal-ordour. (항균제의 항균특성 및 악취제거 효과)

  • Shin, Choon-Hwan;Kim, Jong-Hyun;Han, Sun-Hong
    • Journal of Environmental Science International
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    • v.3 no.2
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    • pp.157-164
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    • 1994
  • Various antimicrobial agents are widely used for the purpose of antimicrobial process. We investigated antimicrobial activity and reduction efficiency of mal-ordour by the diphenyl ether compound (2,4,4'- trichloro -2'- hydroxy diphenyl ether) against Sraphylocom aureus(S.aureus and Proton vulgaris(p.vulgaris causing the mal-ordour, Especially, the diphenyl ether compound is not restricted to the regulation of water-contamination. In this research, we found that the optimum concentration of diphenyl ether compound was 1.5w% for both strains and antimicrobial expressions were c0.38t= 2.56 for S.aureus, c0.38t=2.67 for P.vulgaris. We found also that -OH group played the role of antimicrobial functional group. Lastly, reduction effect of mal-ordour was more than 90% for both strain at the optimum conditions. Key Words : antimicrobial agents, antimicrobial activity, reduction effect of mal-ordour, antimicrobial expression, antimicrobial functional group.

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Isolation of Ginsenoside Rh1 and Compound K from Fermented Ginseng and Efficacy Assessment on Systemic Anaphylactic Shock

  • Kim, Mi-Soon;Kwon, Bin;Park, Myeong-Soo;Ji, Geun-Eog
    • Food Science and Biotechnology
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    • v.17 no.4
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    • pp.805-808
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    • 2008
  • Ginsenosides are responsible for the pharmacological and biological activities of ginseng. In this study, ginsenoside Rh1 and compound K were isolated and purified from fermented ginseng substrate and their anti-allergic effects were assessed in compound 48/80-induced anaphylactic shock model. The fermented ginseng substrate was extracted by methanol and ginsenoside Rh1 and compound K were efficiently purified by preparative high performance liquid chromatography (prep HPLC). Their quality and quantity were analyzed by liquid chromatography-mass spectrometer (LC-MS) and HPLC. Ginsenoside Rh1 showed better anti-allergic effects than compound K in compound 48/80-induced anaphylactic shock model. This study suggested that fermented ginseng extracts with enriched Rh1 may be utilized as a potential biomaterial of functional food for the alleviation of allergic symptoms.

Spin Exchange Coupling in Dimethoxo-Bridged Dichromium(III) Complexes: A Density Functional Theory Study

  • Kang, Dae-Bok
    • Bulletin of the Korean Chemical Society
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    • v.29 no.5
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    • pp.963-968
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    • 2008
  • For the [$Cr_2(H_2tmp)_2Cl_4$] compound, simplified models with two bridging methoxo ligands have been studied. The influence of the bridging Cr-O-Cr bond angles on the exchange coupling between metal atoms in the model compound has been analyzed by means of density functional calculations with the broken-symmetry approach. Coupling constant calculated for the full structure is in good agreement with the experimentally reported value, confirming the validity of the computational strategy used in this work to predict the exchange coupling in a family of related dinuclear Cr(III) compounds. The calculations indicate a good correlation between the calculated coupling constant and the sum of the squared energy gap of three pairs of metal $t_{2g}$ OMSOs with a limited variation of the Cr-O-Cr angle. The spin density distribution and the mechanism of magnetic coupling interactions are discussed.

Preparation of Functional Food in Combination of Tartary Buckwheat and Bean Flour Mixes by Hot Melt Extrusion Process

  • Azad, Obyedul Kalam;Kang, Wie Soo;Park, Cheol Ho
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 2018.04a
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    • pp.71-71
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    • 2018
  • The aim of this study was to prepare a new functional food with enriched bioactive compound by the combination of Tartary buckwheat and bean flour mixes. Two types of bean such as: black bean and white bean with the ratio of 5, 10, 15 % were used to develope a food formulation. The solid formulation of functional food was prepared by the hot melt extrusion process (HME) at the temperature of 60, 90, $120^{\circ}C$. Total phenolic content (TPC), total flavonoid (TF) and DPPH were analysed of the prepared food by the use of spectrophotometer. Results demonstrated that TPC (254 mg/g), TF (18.22 mg/g) and DPPH (88%) were significanlty increased in the receipe of 10% black bean and 90% Tartary buckwheat mixes among the formulation at $90^{\circ}C$. As therefore, it is concluded that the optimum ratio of bean and Tartary buckwheat flour mixes should be considerd for the preparation of high quality functional food.

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Effect of Functionalized BR Content on the Wear Particulate Matters and Physical Properties in TBR Tire Tread Compounds

  • Junhwan Jeong;Sanghoon Song;Jin Uk Ha;Daedong Park;Jaeyun Kim;Yeongmin Jung;Donghyuk Kim;Kiwon Hwang;Sungwook Chung;Wonho Kim
    • Elastomers and Composites
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    • v.59 no.2
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    • pp.64-72
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    • 2024
  • As air pollution continues to increase owing to increasing traffic centered in urban areas, the tire industry is researching methods to reduce particulate matter. In this study, functionalized lithium butadiene rubber (F-LiBR) was applied to a natural rubber (NR)/butadiene rubber (BR) blend compound often used in truck bus radial (TBR) tire treads. The effect of the functional group that can react with carbon black (CB) in BR was investigated in terms of the dispersion of CB and the compound performance, including the generation of particulate matter. Compounds that were substituted with F-LiBR exhibited enhanced interaction with CB, resulting in excellent filler dispersion. Although F-LiBR exhibited lower crosslinking density and inferior abrasion resistance due to its high vinyl content, the compound with 30 phr of F-LiBR was advantageous in terms of its rolling resistance due to the excellent filler dispersion, which was also effective in reducing the amount of generated particulate matter (up to 56% reduction for PM2.5, and 67% reduction for PM10). The results confirmed the benefits of the introduction of functional groups into TBR tire tread compounds, which can aid in improving the fuel efficiency and reducing particulate matter generation.

Isolation and Identification of a Sterol and Three Glucosides from the Peel of Pear (Pyrus pyrifolia Nakai cv. Chuhwangbae) (추황배(Pyrus pyrifolia Nakai cv. Chuhwangbae) 과피로부터 1종의 Sterol과 3종의 배당체 화합물의 단리 · 동정)

  • Lee, Yu Geon;Cho, Jeong-Yong;Lee, Hyun Joo;Lee, Yong Hyun;Lee, Sang-Hyun;Han, Tae-Ho;Kim, Wol-Soo;Park, Keun-Hyung;Moon, Jae-Hak
    • Korean Journal of Food Science and Technology
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    • v.45 no.5
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    • pp.557-564
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    • 2013
  • We isolated and identified antioxidants from acidic and neutral ethyl acetate fractions of the peel of pear (Pyrus pyrifolia N. cv. Chuhwangbae). We isolated 4 compounds from the methanol extract, by using 3 different types of column chromatography (Sephadex LH-20, silica gel, and octadecylsilane) and preparative HPLC. We identified the isolated compounds as (S)-(+)-2-cis-abscisic acid O-${\beta}$-D-glucopyranosyl ester (compound 1), 1-[4-O-${\beta}$-D-glucopyranosyl]phenyl ethanone (picroside, compound 2), ${\beta}$-sitosterol (compound 3), and ${\beta}$-sitosteryl 3-O-${\beta}$-D-glucopyranoside (compound 4) by nuclear magnetic resonance analysis. We are the first to report the identification of compounds 1, 2, and 4 from pear.