• Genomics & Informatics
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• 제16권4호
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• pp.23.1-23.5
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• 2018

Virus taxonomy was initially determined by clinical experiments based on phenotype. However, with the development of sequence analysis methods, genotype-based classification was also applied. With the development of genome sequence analysis technology, there is an increasing demand for virus taxonomy to be extended from in vivo and in vitro to in silico. In this study, we verified the consistency of the current International Committee on Taxonomy of Viruses taxonomy using an in silico approach, aiming to identify the specific sequence for each virus. We applied this approach to norovirus in Caliciviridae, which causes 90% of gastroenteritis cases worldwide. First, based on the dogma "protein structure determines its function," we hypothesized that the specific sequence can be identified by the specific structure. Firstly, we extracted the coding region (CDS). Secondly, the CDS protein sequences of each genus were annotated by the conserved domain database (CDD) search. Finally, the conserved domains of each genus in Caliciviridae are classified by RPS-BLAST with CDD. The analysis result is that Caliciviridae has sequences including RNA helicase in common. In case of Norovirus, Calicivirus coat protein C terminal and viral polyprotein N-terminal appears as a specific domain in Caliciviridae. It does not include in the other genera in Caliciviridae. If this method is utilized to detect specific conserved domains, it can be used as classification keywords based on protein functional structure. After determining the specific protein domains, the specific protein domain sequences would be converted to gene sequences. This sequences would be re-used one of viral bio-marks.

• 대한두개안면성형외과학회지
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• 제24권4호
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• pp.145-158
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• 2023

Vascular anomalies encompass a variety of malformations and tumors that can result in severe morbidity and mortality in both adults and children. Advances have been made in the classification and diagnosis of these anomalies, with the International Society for the Study of Vascular Anomalies establishing a widely recognized classification system. In recent years, notable progress has been made in genetic testing and imaging techniques, enhancing our ability to diagnose these conditions. The increasing sophistication of genetic testing has facilitated the identification of specific genetic mutations that help treatment decisions. Furthermore, imaging techniques such as magnetic resonance imaging and computed tomography have greatly improved our capacity to visualize and detect vascular abnormalities, enabling more accurate diagnoses. When considering reconstructive surgery for facial vascular anomalies, it is important to consider both functional and cosmetic results of the procedure. Therefore, a comprehensive multidisciplinary approach involving specialists from dermatology, radiology, and genetics is often required to ensure effective management of these conditions. Overall, the treatment approach for facial vascular anomalies depends on the type, size, location, and severity of the anomaly. A thorough evaluation by a team of specialists can determine the most appropriate and effective treatment plan.

• 대순사상논총
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• 제21권
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• pp.1-28
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• 2013

The intention of this article is to check for the believers in Daesoonjinrihoe how to perceive the gods who they believe in. For that intention, I explained how the perception of gods in Daesoonjinrihoe is different from the perception of gods in other religions. To make a long story short, because of its polytheism the idea of god in Daesoonjinrihoe is different from monotheism such as Christianity, Islam. In addition, in spite of its polytheism it is different from other polytheism such as the religion in ancient India, especially rig-vedicreligion. In this article it is said that the believers in Daesoonjinrihoe have understood the distinction between Shin(神) and Shinmyung(神明). Nowadays Shin that has been used in Korea, China, Japan, is the word that was translated from English god. Therefore we need to reappraise the meaning of the word Shin. Anyway Shin that is being used in general means Shinmyung in Daesoonjinrihoe. Instead when they say the name of functional gods and the name to which the meaning of its origin affixed, the word Shin is used. Meanwhile, it has the advantage of classifying the ideas of god, but we can't explain all of them through the use of those classifications. I checked some classifications in this article and tried to apply the idea of gods in Daesoonjinrihoe. As a result, each classification has some critical points. There fore in this article I explained the distinguishing ideas of god in Daesoonjinrihoe from that in other religions, instead of the explaining fitted those classifications.

• 인터넷정보학회논문지
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• 제18권1호
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• pp.77-88
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• 2017

최근 지식과 정보가 가치를 생산하는 지식기반사회로 접어들면서 지식재산권의 대표적인 형태인 특허에 대한 중요성이 매우 높아지고 있으며 출원되는 특허의 양도 매년 증가하고 있다. 방대한 양의 특허정보를 효과적으로 이용하기 위해서 특허문서를 그 발명의 기술적 주제에 따라 적절하게 분류하는 것이 필요하며 이를 위해 IPC(International Patent Classification)가 주로 사용되고 있다. 현재 주로 사람의 손으로 이뤄지는 특허문서의 IPC 분류과정의 효율성을 높이기 위하여 다양한 데이터마이닝과 기계학습 알고리즘을 기반으로 IPC 자동분류에 관한 연구들이 수행되어 왔다. 하지만 기존의 IPC 자동분류에 관한 연구의 대부분은 특허문서의 구조적 특징과 같은 특허문서 고유의 데이터 특성에 대한 고려보다는 다양한 기계학습 알고리즘을 특허문서로 적용하는 것에 초점을 맞춰왔다. 이에 본 논문에서는 IPC 자동분류를 위해 특허문서의 특징과 구조적 필드의 역할을 기반으로 특허문서 분류에 영향을 끼치는 두 가지 필드, 기술분야 및 배경기술 필드의 활용을 제안한다. 그리고 특허문서가 동시에 다수의 IPC 분류코드를 가지는 점을 반영하여 다중 레이블 분류(multi-label classification) 모델을 구축한다. 또한 IPC 다중 레이블 분류의 실제 현장에서의 적용 가능성 확인을 위해 630개의 범주를 가지는 IPC 서브클래스 레벨까지 분류 가능한 수법을 제안한다. 이를 위해 국내에서 등록된 564,793건의 특허문서를 대상으로 특허문서의 구조적 필드의 영향을 확인하기 위한 IPC 다중 레이블 분류 실험을 수행하였고, 그 결과 제목, 요약, 청구항, 기술분야 및 배경기술 필드를 활용한 실험에서 87.2%의 싱글매치 정확도를 얻었다. 이를 통해 기술분야 및 배경기술 두 필드가 IPC 서브클래스 레벨까지의 다중 레이블 분류의 정확도를 향상시키는데 중요한 역할을 하고 있음을 확인하였다.

• 디지털융복합연구
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• 제10권6호
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• pp.303-310
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• 2012

본 연구는 의료수요자(환자)들을 대상으로 의료기관별 역할 인지, 낯선 질환 발병 시 이용 의료기관, 질병의 경 중증 인식 등에 관한 분석을 통하여 효율적인 의료전달체계를 위한 요인들을 파악하였다. 서울 소재 일반인 400명을 대상으로 2011년 4월 25일부터 5월 18일까지 14일간 자기기입방식(self-administration)을 통한 설문조사를 실시하였다. 성별, 연령, 교육수준 별로 차이가 있는지 분석했고, 분석방법은 빈도분석, 카이제곱검정, t-test를 실시하였다. 의료기관별 역활 인지 및 낯선 질병 발병 시 방문하는 의료기관에 관한 분석결과는 둘 다 성별에 따라 유의한 차이가 없는 것으로 나타났지만, 연령과 교육정도에 대한 검증결과는 유의한 차이를 보였다. 질병의 경 중증에 대한 인식을 분석한 결과는 경증은 성별과 연령에서 유의한 차이가 있었고, 중증은 연령과 교육정도에서 매우 유의한 차이가 있는 것으로 나타났다. 지속가능하고 효과적인 의료체계의 확보를 위해 1차 의료기관의 활성화 및 의료기관별 기능과 경 중증 질병 분류 기준에 대한 맞춤형 교육과 홍보가 필요하다.

• 대한족부족관절학회지
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• 제12권1호
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• pp.93-99
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• 2008

Purpose: To evaluate the result of the early exercise and rehabilitation after limited posterior operative treatment of the calcaneal fractures. Materials and Methods: Between May 2005 and December 2007, 43 cases with intraarticular calcaneal fractures were treated by open reduction with K-wires and Steinmann pins. Mean age and mean follow-up period were 42.5 years old and 15 months. All patients were treated with the same postoperative protocol, the early exercise of subtalar joint without short leg splint and cast was began after postoperative 1 day, non-weight bearing crutch ambulation did after 2 weeks, partial-weight bearing crutch ambulation did after 6 weeks, without crutch ambulation did after 10 weeks. The fractures was classified by Essex-Lopresti and Sanders classification using radiographs and the functional outcomes were evaluated by circle draw exercise, AOFAS score. Results: By Essex-Lopresti classification, the tongue type was 6 cases (14%), the joint depression type was 15 cases (35%), the combined type was 22 cases (51%). By Sanders classification, type II were 10 cases (23%), type III were 15 cases (58%), and type IV were 8 cases (19%). By AOFAS functional evaluation, the mean preoperative scores were 70.3 and 70.5 respectively, mean postoperative scores were 83.7 and 86.9 respectively. There were satisfactory results in 40 cases but 3 cases were unsatisfactory including on case of lateral impingement and 2 cases of traumatic arthritis of subtalar joint. Conclusion: We obtained satisfactory result of the early exercise of subtalar joint without short leg splint and cast and rehabilitation after limited posterior operative treatment of the calcaneal fractures.

• Journal of Gastric Cancer
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• 제15권1호
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• pp.46-52
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• 2015

Purpose: The aim of this study was to compare the short-term surgical and long-term functional outcomes of Billroth I, Billroth II, and Roux-en-Y reconstruction after laparoscopic distal gastrectomy. Materials and Methods: We retrospectively collected data from 697 patients who underwent laparoscopic distal gastrectomy for operable gastric cancer between January 2009 and December 2012. The patients were classified into three groups according to the reconstruction methods: Billroth I, Billroth II, and Roux-en-Y. The parameters evaluated included patient and tumor characteristics, operative details, and postoperative complications classified according to the Clavien-Dindo classification. Endoscopic findings of the remnant stomach were evaluated according to the residue, gastritis, bile (RGB) classification and the Los Angeles classification 1 year postoperatively. Results: Billroth I, Billroth II, and Roux-en-Y were performed in 165 (23.7%), 371 (53.2%), and 161 patients (23.1%), respectively. Operation time was significantly shorter ($173.4{\pm}44.7$ minute, P<0.001) as was time to first flatus ($2.8{\pm}0.8$ days, P=0.009), time to first soft diet was significantly faster ($4.3{\pm}1.0$ days, P<0.001), and postoperative hospital stay was significantly shorter ($7.7{\pm}4.0$ days, P=0.004) in Billroth I in comparison to the other methods. Postoperative complications higher than Clavien-Dindo grade III occurred in 61 patients (8.8%) with no statistically significant differences between groups (P=0.797). Endoscopic findings confirmed that gastric residue, gastritis, bile reflux, and reflux esophagitis were significantly lower in Roux-en-Y (P<0.001) patients. Conclusions: Roux-en-Y reconstruction after laparoscopic distal gastrectomy for middle-third gastric cancer is beneficial in terms of long-term functional outcome, whereas Billroth I reconstruction for distal-third gastric cancer has a superior short-term surgical outcome and postoperative weight change.

• 한국항만경제학회지
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• 제35권2호
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• pp.77-92
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• 2019

2000년대 초반 이래로 중국의 경제성장축이 연안 중심에서 중서부 내륙으로 이전되어가면서 내륙항의 건설이 촉진되었다. 내륙항은 내륙에서 연해 항만의 기능을 부여함으로써 수출입 물류와 통관을 효율화하는 데 있다. 본 연구는 중국 내륙항의 기능적/지리적 유형화와 지역별 내륙항의 SWOT-PEST분석을 통해 경쟁력과 잠재력을 파악하는 데 목적이 있다. 연구결과 내륙항의 기능적 분류는 항만지원형, 산업지원형, 유통지원형, 통관지원형으로 유형화될 수 있으며, 동부지역에는 항만지원형이 중서부지역에는 산업과 유통지원형 그리고 북서부지역에는 주변국가와의 무역을 촉진하기 위한 통관지원형의 내륙항이 다수를 차지하는 것으로 나타났다. 동부지역의 내륙항이 높은 경쟁력을 보유하고 있지만 중서부 지역의 내륙항들이 잠재력 면에서 높은 것으로 나타났다. 특히 '일대일로' 정책은 중서부 지역 및 접경지역의 내륙항의 발전을 촉진시키는 중요한 요인으로 작용할 것으로 예상된다.

• 대한족부족관절학회지
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• 제11권1호
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• pp.72-78
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• 2007

Purpose: This study is to analysis the outcome of patient with surgically treated Maisonneuve fracture and find out the factors that might influence the outcome. Material and methods: 20 patients who had surgical treatment due to Maisonneuve fracture between February, 2001 to March, 2005 were studied. The patients were followed for at least 1 year and average follow up period was 25 months. The average age was 41 years, 16 were male and 4 were female. Mechanism of injury according to Rouge-Hansen classification was supination-external rotation. In all cases, percutaneous screw fixation was applied proximal to tibiofibular syndesmosis. The screws were removed after 8 weeks under local anesthesis. Clinical, functional and radiographic results were evaluated. Results: 17 cases (85%) showed satisfying clinical and radiographic results. The mean functional score according to Ankle Scoring System was 91 (83 to 95). Complication occurred in 1 case with underlying systemic disease and 2 cases with initial ankle joint dislocation. Conclusion: Surgical treatment of Maisonneuve fracture showed relatively satisfying result. However, initial injury state and accompanying disease seem to have great effect on the result.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.78-82
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• 2005

Three of the genus Pseudomonas (P. aeruginosa, P. putida, P. syringae) show highly different phenotypic characteristics among them. Two of the three members are pathogenic and the other is non-pathogenic. Comparative analyses of the complete genomes can elucidate the genomic similarities and differences among them. We analyzed the three genomes and the genes of them to reveal the degree of conservation of chromosomes and similarity of the genes. The 2-dimensional dot plot between the pathogenic P. aeruginosa and non-pathogenic P. putida shared higher portion of the nucleotide sequences than other two combinations. Comparison of the nucleotide compositions by calculating the genome-scale plot of G+C contents and GC skew showed the variation of location. Comparison of the metabolic capabilities using the functional classification of KEGG orthology revealed that the differences in the number of genes for the specific functional categories resulted in the phenotypic differences. Finally combination of the analyses using the protein homologs supported the evolutionary distance of the P. putida obtained from other genome-scale comparisons.