• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6263-6267
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• 2012

Background: Glutathione-S-transferase (GST) is an important phase II xenobiotic compound metabolizing enzyme family, involved in tolerance to a particular drug or susceptibility to a diseasec. This study focused the GSTM1 and T1 null allele frequency in the Gujarat population with a comparison across other Inter- and Intra-Indian ethnic groups to predict variation in the possible susceptible status. Methods: DNA was isolated by a salting out method and GSTM1 and T1 homozygous null genotypes were detected by multiplex polymerase chain reaction in 504 unrelated individuals. The genotype distribution of null alleles was compared with Indian and non Indian ethnics reported earlier in the literature using Fisher's test. Results: The frequencies of the homozygous null genotypes of GSTM1 and GSTT1 were 20% (95%CI 16.7-23.9) and 35.5% (95%CI 31.4-39.9) respectively. GSTM1 null frequency did not deviate from most other Indian ethnic groups but differed from the majority of those of non Indian ethnicity studied. The frequency of homozygous null type of GSTT1 was significantly higher and deviated from all Indian groups and a few of non Indian ethnicity. Conclusions: Gujarat ethnicity, possibly the most susceptible for GSTT1 dependent drug disposition and diseases regarding effects of pollution. Further, the results have implications for GSTT1 dependent drugs used for treatment, a serious problem which needs to be solved by physicians and clinical researchers.

• Steel and Composite Structures
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• 제22권4호
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• pp.889-913
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• 2016

Vibration analysis of embedded functionally graded (FG)-carbon nanotubes (CNT)-reinforced piezoelectric cylindrical shell subjected to uniform and non-uniform temperature distributions are presented. The structure is subjected to an applied voltage in thickness direction which operates in control of vibration behavior of system. The CNT reinforcement is either uniformly distributed or functionally graded (FG) along the thickness direction indicated with FGV, FGO and FGX. Effective properties of nano-composite structure are estimated through Mixture low. The surrounding elastic foundation is simulated with spring and shear constants. The material properties of shell and elastic medium constants are assumed temperature-dependent. The motion equations are derived using Hamilton's principle applying first order shear deformation theory (FSDT). Based on differential cubature (DC) method, the frequency of nano-composite structure is obtained for different boundary conditions. A detailed parametric study is conducted to elucidate the influences of external applied voltage, elastic medium type, temperature distribution type, boundary conditions, volume percent and distribution type of CNT are shown on the frequency of system. In addition, the mode shapes of shell for the first and second modes are presented for different boundary conditions. Numerical results indicate that applying negative voltage yields to higher frequency. In addition, FGX distribution of CNT is better than other considered cases.

• 센서학회지
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• 제10권2호
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• pp.142-147
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• 2001

인터디지털 표면음파 변환기의 교차장 모델에 기초한 전송선 등가회로를 사용하여 SPICE에 의한 SAW 필터의 효율적인 시뮬레이션 기법을 제안하였다. 표면음파의 전파를 전송선으로 모델하므로 인터디지털 변환기의 등가회로에서는 주파수 의존 회로소자가 필요하지 않게 된다. 그래서 주파수 의존 회로소자에 대한 등가회로를 근사적으로 구하지 않아도 되고, 필터의 등가회로에 작은 수의회로소자를 사용하므로 시뮬레이션 시간도 많이 단축된다. 삽입손실, 입력 어드미턴스, 통과대역 리플, 그리고 고조파 주파수 응답과 같은 SAW 필터 특성에 대한 시뮬레이션을 통하여 제안된 기법의 유용성을 보였다.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제50권5호
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• pp.243-248
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• 2001

In this paper, we present theoretical and experimental study on the viscous damping of the on-substrate torsional micromirrors, oscillating near the silicon substrates. In this theoretical study, we develop theoretical models and test structures for the viscous damping of the on-substrate torsional micromirrors. From a finite element analysis, we estimate the theoretical damping coefficients of the torsional micromirrors. From a finite element analysis, we estimate the theoretical damping coefficients of the torsional micromirrors, fabricated by the surface-micromaching process. From the electrostatic test of the fabricated devices, frequency-dependent rotationalvelocity of the micromirrors has been measured at the atmospheric pressure using devices, frequency-dependent rotational velocity of the micromirrors has been measured at the atmospheric pressure using the Mach-Zehnder interferometer system. Experimental damping coefficients have been extracted from the least square fit of the measured rotational velocity within the filter bandwidth of 150 kHz. We have compared the theoretical values and the experimental results on the dynamic performance of the micromirrors. The theoretical analysis overstimates the resonant frequency in the amount of 15%, while underestimating the viscous damping in the factors of 10%.

• Nuclear Engineering and Technology
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• 제53권5호
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• pp.1391-1402
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• 2021

The aim of this work is to prepare a neutron noise calculator based on the second order of average current nodal expansion method (ACNEM). Generally, nodal methods have the ability to fulfill the neutronic analysis with adequate precision using coarse meshes as large as a fuel assembly size. But, for the zeroth order of ACNEM, the accuracy of neutronic simulations may not be sufficient when coarse meshes are employed in the reactor core modeling. In this work, the capability of second order ACNEM is extended for solving the neutron diffusion equation in the frequency domain using coarse meshes. For this purpose, two problems are modeled and checked including a slab reactor and 2D BIBLIS PWR. For validating of results, a semi-analytical solution is utilized for 1D test case, and for 2D problem, the results of both forward and adjoint neutron noise calculations are exploited. Numerical results indicate that by increasing the order of method, the errors of frequency dependent coarse mesh solutions are considerably decreased in comparison to the reference. Accordingly, the accuracy of second order ACNEM can be acceptable for the neutron noise calculations by using coarse meshes in the nuclear reactor core.

• 한국재료학회지
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• 제21권7호
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• pp.403-409
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• 2011

Micro speakers are used to reproduce sound in small electric and information and communications devices, such as cellular phones, PMPs, and MP3 players. The acoustical properties and sound quality, which are changed due to the decreased size of the speaker, are often adjusted varying the type and thickness of the diaphragm. The most widely used diaphragm material is thin polymer. It was previously reported by the author of this paper that the resonance frequency of a micro speaker is changed by the type and thickness of a polymer diaphragm. In this paper, the frequency response near the resonance frequency of a micro speaker was studied as functions of the type and thickness of the polymer diaphragm. While $R_{max}$ and $R_{DC}$ were affected by the type and thickness, an analysis of the electrical impedance curve revealed that $R_o(= R_{max}/R_{DC})$ and ${\Delta}f$ were not changed. Thus, $Q_{TS}$ which was function of $R_o$, ${\Delta}f$, and the resonance frequency, is only related to the resonance frequency. The increase of the resonance frequency led to a proportional rise of $Q_{TS}$. The change of the frequency response near the resonance frequency was not dependent on the type or thickness of the polymer diaphragm, but was affected by the resonance frequency.

• Restorative Dentistry and Endodontics
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• 제21권1호
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• pp.150-160
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• 1996

The present study was to evaluate the accuracy of the frequency dependent type apex locator, Root-ZX. The subjects included 505 root canals of 238 teeth treated by the Department of Conservative Dentistry, and 22 human premolars which were schduled to be extracted for the orthodontic reasons. The results were as follows ; 1. The working lengths determined by Root-ZX were compared with radiographic readings. Of the total 505 root canals, 66 % showed coincidence within ${\pm}0.5mm$ and the average readings of Root-ZX were $0.13mm{\pm}1.05$ longer than those of radiographic readings. 2. The length difference between the file tip determined by Root-ZX and the apical constriction in extracted teeth were measured. Of the total 24 root canals, 70.8 % showed coincidence within ${\pm}0.5mm$ and the average readings of Root-ZX were $0.12mm{\pm}0.50$beyond the apical constriction. 3. The vitality of the teeth did not show any statistical difference(p>0.05) in the accuracy of the Root-ZX readings. The presence of the periapical lesions, however, significantly lowered the percentage of ${\pm}0.5mm$ accuracy in Root-ZX measurements.(p<0.05). In the presence of periapical lesions, the percentage within ${\pm}0.5mm$ was significantly lower.

• 대한전자공학회논문지SD
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• 제41권6호
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• pp.91-98
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• 2004

본 논문은 일반적인 SPICE 시뮬레이터에서 사용 가능한 PCB 평판 해석 모형을 제안한다. 제안된 모형은 주파수에 따라 증가하는 두 가지 손실, 즉, 표피 손실과 유전 손실의 영향을 반영한다. 평판은 메시(mesh) 구조로 조각을 낸 후, 각각의 단위모형은 전송선 소자와 손실 모형을 이용하여 모형화된다. 손실 모형은 DC 손실을 위해서 하나의 저항이 요구되고, 표피 손실을 위해 직렬 RL ladder 회로, 유전 손실을 위해서 직렬 RC ladder 회로가 요구된다. 제안된 모형의 검증을 위해 주파수 가변저항을 사용한 SPICE ac 해석결과를 통해 비교하고, 전형적인 데스크탑 PC용 FR4 4층 PCB 적층 구조를 만들어 VNA 측정치와도 비교할 것이다. 이 모형은 RLGC 수동 소자들로만 구성되므로 주파수 영역 및 시간 영역에서도 다양한 선형/비선형 소자들과 결합하여 과도 해석이 가능하다.

• 전자공학회논문지
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• 제51권12호
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• pp.197-203
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• 2014

뇌격전류가 정보통신설비의 접지시스템에 유입되었을 때 발생하는 과도전위상승에 대한 해석은 접지시스템을 효과적으로 설계하기 위해서 요구되는 사항 중에 하나이다. 접지시스템의 성능은 보통 접지시스템의 전기적 특성을 나타내는 접지임피던스와 과도전위상승으로 평가된다. 뇌격전류의 입사점에 따른 접지임피던스를 계산하는 방법을 제안하였다. 뇌격전류가 수평접지전극의 중앙에 입사되는 경우 델타갭소스 모델을 이용하여 접지임피던스를 계산하였다. 디바이 모델(Debye Model)을 이용하여 주파수의존적인 토양 파라미터를 적용할 수 있는 프로그램을 제안하였다. 그 이유는 접지시스템의 성능을 분석하는 상용프로그램은 주파수 의존적인 토양 파라미터 특성을 적용할 수 없기 때문이다. 동일한 조건에서의 시뮬레이션 결과의 신뢰성을 확인하기 위해서 실험을 수행하였다. 마지막으로, 토양 파라미터의 주파수의존성을 반영한 접지임피던스를 이용하여 뇌격전류파형에 따른 수평접지전극의 과도전위상승을 분석하였다.

• 대한한의학방제학회지
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• 제32권1호
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• pp.29-37
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• 2024

Objectives : The purpose of this study was to examine the effects of insurance herbal medicines on colonic interstitial Cells of Cajal (ICC) in mice. Methods : Among the insurance herbal medicines, we chose Gamisoyo-san (GSS), Banhasasim-tang (BHSST) and Bojungikki-tang (BGIKT). We made the ICC culture in large intestine in mice and used the electrophysiological method to record pacemaker potentials. Also we used MTT assay to check cell viability and examined the ICC protein expression by western blot. Results : 1. GSS (1-10 mg/ml) induced the pacemaker potential depolarization and decreased frequency with concentration-dependent manners in colonic ICC. EC50 is 2.99 mg/ml. BHSST (1-10 mg/ml) induced the pacemaker potential depolarization and decreased frequency with concentration-dependent manners in colonic ICC. EC50 is 2.76 mg/ml. BGIKT (1-10 mg/ml) induced the pacemaker potential depolarization and decreased frequency with concentration-dependent manners in colonic ICC. EC50 is 4.49 mg/ml. 2. GSS, BHSST and BGIKT had no effects on cell viability in colonic ICC. 3. GSS and BGIKT increased the Anoctamin-1 (ANO1) protein expression and BHSST increased the transient receptor potential melastatin-subfamily member 7 (TRPM7) protein expression in colonic ICC. Conclusions : These results suggest that GSS, BHSST, and BGIKT have shown the potential to regulate gastrointestinal (GI) motility by regulating colonic ICC and may show the potential to treat colon-derived GI diseases such as irritable bowel syndrome (IBS).