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사회관계망에서 중요 노드 식별을 위한 지역정보 기반 매개 중심도 (Local Information-based Betweenness Centrality to Identify Important Nodes in Social Networks)

  • 손진곤;김용환;한연희
    • 정보처리학회논문지:컴퓨터 및 통신 시스템
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    • 제2권5호
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    • pp.209-216
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    • 2013
  • 전통적인 사회관계망 분석에 있어서 각 노드의 매개 중심도는 메시지 전달 측면에서의 각 노드들의 상대적인 중요도를 파악하는 척도로 오랫동안 사용되어 왔다. 하지만, 매개 중심도를 산출하기 위한 계산 복잡도가 높기 때문에 노드의 수와 간선의 수가 매우 많은 대규모 사회관계망에서는 각 노드의 매개 중심도를 산출하기가 어렵다. 본 논문에서는 각 노드들마다 자신의 지역정보, 즉 이웃노드들이 지닌 각각의 이웃노드 정보를 활용하여 구성가능한 확장 자아 네트워크(Expanded Ego Network)를 새롭게 정의하고 이러한 네트워크를 기반으로 확장 자아 매개 중심도(Expanded Ego Betweenness Centrality)를 정의한다. 일반적인 사회관계망의 특성인 척도 없는 네트워크(Scale-free Network)를 생성할 수 있는 Barab$\acute{a}$si-Albert 네트워크 모델을 사용한 실험을 통하여 제안한 확장 자아 매개 중심도의 각 노드별 순위는 기존의 전통적인 방식으로 산출한 매개 중심도의 각 노드별 순위와 거의 일치함을 보인다.

Effect of Comprehensive Breast Care on Breast Cancer Outcomes: A Community Hospital Based Study from Mumbai, India

  • Gadgil, Anita;Roy, Nobhojit;Sankaranarayanan, Rengaswamy;Muwonge, Richard;Sauvaget, Catherine
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권4호
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    • pp.1105-1109
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    • 2012
  • Breast cancer is the second most common cancer in women in India and the disease burden is increasing annually. The lack of awareness initiatives, structured screening, and affordable treatment facilities continue to result in poor survival. We present a breast cancer survival scenario, in urban population in India, where standardised care is distributed equitably and free of charge through an employees' healthcare scheme. We studied 99 patients who were treated at our hospital during the period 2005 to 2010 and our follow-up rates were 95.95%. Patients received evidence-based standardised care in line with the tertiary cancer centre in Mumbai. One-, three- and five-year survival rates were calculated using Kaplan-Meier method. Socio-demographic, reproductive and tumor factors, relevant to survival, were analysed. Mortality hazard ratios (HR) were calculated using Cox proportional hazard method. Survival in this series was compared to that in registries across India and discrepancies were discussed. Patients mean age was 56 years, mean tumor size was 3.2 cms, 85% of the tumors belonged to T1 and T2 stages, and 45% of the patients belonged to the composite stages I and IIA. Overall 5-year survival was 74.9%. Patients who presented with large-sized tumors (HR 3.06; 95% CI 0.4-9.0), higher composite stage (HR 1.91; 0.55-6.58) and undergone mastectomy (HR 2.94; 0.63-13.62) had a higher risk of mortality than women who had higher levels of education (HR 0.25; 0.05-1.16), although none of these results reached the significant statistical level. We observed 25% better survival compared to other Indian populations. Our results are comparable to those from the European Union and North America, owing to early presentation, equitable access to standardised free healthcare and complete follow-up ensured under the scheme. This emphasises that equitable and affordable delivery of standardised healthcare can translate into early presentation and better survival in India.

노인복지시설의 급식관리 및 영양 건강 증진에 관한 연구 - 급식과 건강관리 - (Management of Food Service and Health Care in Long-Term Care in Korea - Food Service and Health Care -)

  • 김화영;양은주;원혜숙
    • 한국식생활문화학회지
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    • 제12권3호
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    • pp.331-339
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    • 1997
  • With increases in senior citizens and changes in family structure, the need for long-term care system for elderly is increasing, however, the capacity and environment of Korean facilities are very limited. Health and nutritional status of long-term care residents are worse than free-living elderly. In this study, general food service management and health care practices in long-term care systems were investigated. Questionnaire were sent to the directors of all 162 long-term care facilities in Korea and 81 returned the complete answers. The results showed 1) There are slow but steady increase in long-term care systems in Korea, however, the capacity is far from adequate. Less than 10,000 elderly were resided in the facilities. Most of the systems were free-nursing homes and supported by the goverment. Staffing structure revealed that most of the facilities had a director, a secretary, nurses, but only 21% of the systerm hired a dietitian. It showed the shortage of nurses, physical therapists, and dietitians. Therefore, food purchasing, menu planning, food delivery, and the other food service management processes are handled by non-professionals, such as director, secretary, or cooks. Modified fool frequency questionnaire were used to get the frequencies of each food items used in menu and a menu-analysis was made on the one-day menu provided by the facilities. The results showed relatively satisfactory in nutrients content and food frequencies., however, this was about what was used in menu, not what was eaten by the residents. Therefore this results did not tell that the food intake status of individuals. In most facilities general health checkup was done on a regular basis, and had residents with various chronic degenerative diseases, such as hypertension, neuralgia, stroke, arthritis, diabetes. But the items checked on health checkup included weight, height, blood and urine tests, X-ray test, which suggested that the checkup lists should be revised to accomodate the health problem of the aged today.

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미백성분이 포함된 나노입자의 제조와 응용 (Preparation and Application of Wnitening Ingredient Entrapped in Solid Lipid Nanoparticle [SLN])

  • 한성철;김연주;이기영;김동운
    • KSBB Journal
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    • 제19권3호
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    • pp.178-186
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    • 2004
  • 복합한방 재료인 옥용산에 대해 UV 흡수능, tyrosinase 저해활성 그리고 free radical 소거활성을 측정함으로서 미백활성을 검정하고 비교 시험군으로서 비타민C와 함께 Eudragit 이 코팅된 coconut oil을 이용한 SLN을 제조할 수 있었다. 실험 결과, 옥용산은 UV 영역에서 흡수능을 가지며 tyrosinase 저해 활성과 free radical 소거활성을 가진 것으로 확인되었다. 제조된 E-SLN을 TEM을 이용하여 관찰한 결과 크기 50∼300 nm인 구형의 양호한 입자를 형성하고 있음을 확인하였다. 또한 그 크기분포와 캡슐화 효율 분석을 통해 EUD의 농도가 2.0% (w/v), w/o 비율은 1 : 9, emulsion과 pour solution의 비율은 1 : 10, 그리고 실온에서 제조한 E-SLN의 캡슐화 효율이 가장 높고 크기의 분포가 가장 양호한 것을 알 수 있었다. E-SLN을 이용하여 in vitro 방출시험을 실시한 결과 E-SLN은 pH와 온도 의존적으로 약물을 방출하는 경향을 나타냈다. 결과적으로 제조된 E-SLN은 pH와 온도 의존적으로 약물을 전달할 필요가 있는 계에 대한 약물전달 시스템으로 적합할 것으로 보인다. 폐쇄 첩포시험과 자외선 조사에 의한 인공색소침착과 시료도포에 의한 미백효능 판정에 의한 임상시험 결과 옥용산과 비타민C, 그리고 이를 포함하는 E-SLN은 대조군의 경우와 비교하여 미백효과를 가지는 것으로 확인되었으며 이는 기능성화장품에의 응용 가능성을 높여주었다.

Role of salvage radiotherapy for regional lymph node recurrence after radical surgery in advanced gastric cancer

  • Kim, Byoung Hyuck;Eom, Keun-Yong;Kim, Jae-Sung;Kim, Hyung-Ho;Park, Do Joong
    • Radiation Oncology Journal
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    • 제31권3호
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    • pp.147-154
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    • 2013
  • Purpose: To evaluate the role of salvage radiotherapy (RT) for the treatment of regional lymph node recurrence (RLNR) after radical surgery in advanced gastric cancer. Materials and Methods: We retrospectively analyzed medical records of 26 patients who underwent salvage treatment after diagnosis of RLNR between 2006 and 2011. Patients with peritoneal seeding or distant metastasis were excluded. Eighteen patients received RT with or without chemotherapy and the other 8 did chemotherapy only without RT. A three-dimensional conformal RT was performed with median dose of 56 Gy (range, 44 to 60 Gy). Sixteen patients had fluoropyrimidine-based chemotherapy, 5 did taxane-based chemotherapy, and irinotecan was applied in 4. Results: With a median follow-up of 20 months (range, 5 to 57 months), median overall survival (OS) and progression-free survival (PFS) after diagnosis of RLNR were 29 months and 12 months in the entire patients, respectively. Radiotherapy (p = 0.007) and disease-free interval (p = 0.033) were statistically significant factors for OS in multivariate analysis. Median OS was 36 months in patients who received RT and 16 months in those who did not. Furthermore, delivery of RT (p < 0.001), complete remission after salvage treatment (p = 0.040) and performance status (p = 0.023) were associated with a significantly better PFS. Gastrointestinal toxicities from RT were mild in most patients. Conclusion: Salvage RT combined with systemic chemotherapy may be an effective treatment managing RLNR from advanced gastric cancer.

Effect of Drug Loading on the Physicochemical Properties and Stability of Cationic Lipid-based Plasmid DNA Complexes

  • Jeong, Ui-Hyeon;Jung, Ji-Hye;Davaa, Enkhzaya;Park, Se-Jin;Myung, Chang-Seon;Park, Jeong-Sook
    • Journal of Pharmaceutical Investigation
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    • 제39권5호
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    • pp.339-343
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    • 2009
  • Recently, co-delivery of drug and gene has been attempted for higher therapeutic effects of anticancer agents. In this study, cationic liposomes were prepared using 1,2-dioleoyl-3-trimethylammoniopropane (DOTAP) as a cationic lipid to investigate the effect of drug loading on the physicochemical characteristics of cationic liposomes/DNA complexes. The complex formation between cationic liposomes and negatively charged plasmid DNA was confirmed and the protection from DNase was observed. Particle size of complexes was reduced not by drug loading, but by the increased ratio of cationic lipid to plasmid DNA. Meanwhile, zeta potential of complex was increased by the addition of cationic liposomes to complexes and the effect of drug loading on the zeta potential was not much higher than on particle size. Gel retardation of complexes was indicated when the complexation weight ratios of cationic lipid to plasmid DNA were higher than 24:1 for drug free complexes and 20:1 for drug loaded ones, respectively. Agarose gel retardation showed the similar complexation between plasmid DNA and drug free liposomes or drug loaded liposomes. Both complexes protected plasmid DNA from DNase independent of complexation temperature. From the results, drug loading may affect not the complex formation of cationic liposomes and plasmid DNA, but the particle size of complex.

소복축어탕(少腹逐瘀湯)이 흰쥐의 적출 자궁에 미치는 영향 (A Study on the Effects of Sobokchukeo-Tang on the Isolated Uterine Muscle of Rats)

  • 진천식;양승정
    • 대한한방부인과학회지
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    • 제18권4호
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    • pp.72-84
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    • 2005
  • Purpose : This study was carried out to investigate the relaxational response to the water extract of Sobokchukeo-Tang(SCT) in isolated uterine muscle in rats. Methods : Segments of uterine muscle obtained from female rats immediately after delivery were mounted in organ baths superfused on a polygraph. The effects of SCT on the tension of potassium induced contracture were studied in rat uterine smooth muscles. All experiments were performed in Krebs-Henseit solution which was aerated with 100% oxygen and kept at $37^{\circ}C$. Results : KCI did not produce contraction in calcium-free solution, but $CaCl_2$ induced concentration-dependent contraction after depolarizing with KCI. SCT inhibited the tonic contraction of uterine muscle as dose dependent manner. And when SCT was pretreated in calcium-free medium, it showed more powerful relaxational effect. The effect of 10mg/ml concentration of SCT was equal to that of 9nM and 70nM of nifedipine and verapamil and the relaxational effect of SCT on rat uterine muscle can be assumed to be concerned with the action of cyclic AMP. But the action mechanism of relaxation on the rat uterine muscles were concerned with the calcium channel. Conclusion : From this study we could suggest that the relaxtional effect of SCT on uterine muscle be available to preventing and curing dysmenorrhea.

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아두이노 기반 WiT(WiFi Trashcan)의 설계 및 구현 (Design and Implementation of a WiFi Trashcan based on Arduino)

  • 유종열;김현일;이장호;양동민
    • 한국정보통신학회논문지
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    • 제20권11호
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    • pp.2143-2148
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    • 2016
  • 최근 IT기술의 발전에 힘입어 사람이 생활하는 환경에 IT기술들이 스며들고, 환경적 요소와 융합하는 아이디어와 기술들이 나날이 발전하고 있다. 이러한 기술들은 사람들의 생활환경에 도움을 주는 역할을 하고 있으며, 앞으로의 초연결사회의 필수 구성 요소이다. 본 논문에서는 IT기술을 환경적 요소와 융합하여 활용하는 동시에 더욱 쾌적한 환경을 만들 수 있는 WiT(WiFi Trashcan)를 제안한다. WiT는 쓰레기통에 쓰레기를 넣으면 WiFi를 무료로 제공해주는 쓰레기통이다. WiFi와 Trash-can을 합성한 WiT(WiFi Trashcan)는 사람이 쓰레기를 넣었을 때, 투입 여부 및 부피를 감지하여 쓰레기를 버린 사용자에게 WiFi를 무료로 제공해주는 시스템이다. 쓰레기를 감지하기 위해 초음파 센서를 사용하고, 쓰레기의 무게를 측정하기 위해 무게 센서를 사용한다. 그리고 파이썬 프로그래밍을 통해 측정된 센서 값을 라즈베리파이에 전송하여, WiFi 제공시간을 결정한다. WiT는 아두이노와 라즈베리파이를 활용하여 설계 및 구현되었다.

OFDM-TDMA 메쉬 네트워크를 위한 다중경로 QoS 라우팅 프로토콜 (A Multi-path QoS Routing Protocol for the OFDM-TDMA Mesh Networks)

  • 최정욱;이혁준
    • 한국ITS학회 논문지
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    • 제14권1호
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    • pp.57-67
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    • 2015
  • 무선 메쉬 네트워크에서 다중경로 라우팅 프로토콜은 QoS 충족 또는 링크 단절에 대한 강건성 확보를 위한 해결책으로 자주 사용되어 왔으며, 무선 전술통신 및 재난구조 통신에서는 QoS와 강건성을 동시에 충족시키는 방법에 대한 필요성이 강조되고 있다. 본 논문에서 제안하는 라우팅 프로토콜은 OFDM-TDMA collision-free MAC을 기반으로 on-demand 방식으로 대역폭 및 지연시간 제한을 포함하는 사용자의 세션별 QoS 요구사항을 충족시켜 줄 수 있는 다중경로들을 탐색 및 관리하고, 전송실패가 발생할 경우 경로 재탐색 이전에 대체경로를 선택하여 데이터를 재전송하도록 함으로써 지연 및 수용능력 간 트레이드오프를 완화하는 동시에 강건성을 증가시킨다. 본 논문에서는 시뮬레이션을 통해 제안하는 프로토콜의 성능을 분석하여 제안하는 프로토콜이 QoS 보장 측면과 데이터의 전송성공률 측면에서 우수을 보인다.

포르말린으로 유도된 통증 유발 쥐에서 무침주입기를 이용한 봉독약침의 진통효과 (Comparative Study of Therapeutic Effect of Needle-free Bee Venom Aqua-acupuncture (BVA) into Zusanli (ST36) in the Rat Formalin Test)

  • 정인재;함대현;정우병;한지희;채윤병;임형수;이혜정;강성길;김장현
    • 동의생리병리학회지
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    • 제20권2호
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    • pp.365-371
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    • 2006
  • Bee Venom aqua-acupuncture (BVA) simultaneously exerts pharmacological effects of biologically active compounds, existed in the whole bee venom, and medicinal effect of the stimulation of acupuncture points. BVA has been considered as a promising therapeutic method for treating various chronic diseases, mainly accompanying severe pain and inflammation. As a painless injection device, jet injectors have been commercially marketed for various clinical applications including insulin injection and vaccination. Among them, a pressure-driven jet injector system could be used for intradermal delivery of a variety of drugs. The aim of this study was to investigate the analgesic effects of the BVA using a needle-free injector (Biojector $2000^{\circledR}$, Bioject Inc., OR, USA), compared to the conventional BV aqua-acupuncture using a typical syringe. Adult Sprague-Dawley rats were injected with bee venom $(0.08mg/kg,\;50{\mu}l)$ using Biojector $2000^{\circledR}$ (BVA-B) or a syringe (BVA-5) into the Zusanli (ST36) acupoint, 30 minutes before plantar injection of 2% formalin. It was found that BVA-B-, or BVA-5-treated rats, compared to controls, exhibited significantly less licking behavior during the late phase in the rat formalin test, when compared to controls. During early phase, however, those effects were not significant but substantial. The analgesic effect of BVA-B was also compatible with that of the conventional BVA-5. In the immunohistochemical studies, BVA-B significantly suppressed the expression of formalin-evoked c-fos, a biomarker of neuronal activity, in the lumbar dorsal horn of the spinal cord. These results indicated that BVA-B waseffective in the modulation of pain in the rat formalin test, compared to BVA-5. Taken together, the needle-free jet injector system could be substituted for the conventional aqua- acupuncture with the advantage of little pain.