• Radiation Oncology Journal
• /
• 제36권3호
• /
• pp.172-181
• /
• 2018

Successful anticancer strategies require a differential response between tumor and normal tissue (i.e., a therapeutic ratio). In fact, improving the effectiveness of a cancer therapeutic is of no clinical value in the absence of a significant increase in the differential response between tumor and normal tissue. Although radiation dose escalation with the use of intensity modulated radiation therapy has permitted the maximum tolerable dose for most locally advanced cancers, improvements in tumor control without damaging normal adjacent tissues are needed. As a means of increasing the therapeutic ratio, several new approaches are under development. Drugs targeting signal transduction pathways in cancer progression and more recently, immunotherapeutics targeting specific immune cell subsets have entered the clinic with promising early results. Radiobiological research is underway to address pressing questions as to the dose per fraction, irradiated tumor volume and time sequence of the drug administration. To exploit these exciting novel strategies, a better understanding is needed of the cellular and molecular pathways responsible for both cancer and normal tissue and organ response, including the role of radiation-induced accelerated senescence. This review will highlight the current understanding of promising biologically targeted therapies to enhance the radiation therapeutic ratio.

• 한국재료학회지
• /
• 제11권7호
• /
• pp.590-598
• /
• 2001

본 연구에서는 특별하게 고안된 In-situ VHP 제조 공정을 이용하여 상온에서 $500^{\circ}C$까지의 진공 열간 압축과 canning 작업 없이 $520^{\circ}C$에서 연속 압출옳 하여 Sicp/pure Al과 SiCp/2024Al MMCs를 제조하였다. 복합재료의 인장강도와 미세구조에 영향을 주는 SiC 입자크기, 체적률, 압출비에 대해서 조사하였다. 압출비 10:1의 경우에는 SiCp/pure Al과 SiCp/2024Al 복합재료 둘 다 건전한 외형과 SiCp의 일정한 분산을 가지면서 SiCp의 균열이 없는 좋은 미세 구조를 가지고 있었다. 그러나 압출비 16:1의 경우에는 체적률이 증가할수록 파괴된 SiC 입자의 수가 증가하였으며 2024Al 기지내의 복합재료와 순수한 Al 기지재 복합재료를 서로 비교하였다. 동일한 체적률과 압출비의 경우에는 SiCp의 크기가 작은 복합재료가 SiCp가 큰 복합재료보다 인장강도가 더 높았다.

• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 2005년도 춘계학술대회 논문집
• /
• pp.1812-1818
• /
• 2005

Even though SMA actuators have high power to volume ratio, there exist disadvantages such as hysteresis and saturation. So the model identification for SMA actuators is very difficult. For the qualitative model identification, we described the behavior of SMA actuators using a so-called diagonal model, which can readily expect the turning point of an incomplete phase transformation. For the quantitative model identification, we developed the general dynamics of SMA actuators using the modified Liang's model. Using this dynamics we can describe the hysteresis and the saturation very well. It is also very important to notice that the modified Liang's model maintains a continuous martensite fraction at the change of the phase transformation but the original model cannot.

• 생약학회지
• /
• 제42권1호
• /
• pp.61-67
• /
• 2011

In this study, we evaluated the bioactivities of methanol extract and its solvent fractions of Sonchus asper (L.) Hill. The EtOAc fraction of S. asper exhibited more strong antioxidant activity than other extracts as evidenced by the strongest 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity with a $EC_{50}$ value at $33.55\;{\mu}g/mL$ and reducing power, the total polyphenol (180.71 mg GAE/g) and flavonoid contents (145.86 mg QE/g) of S. asper extract were higher than other extracts. The EtOAc fraction of the S. asper also showed 47.38% mushroom tyrosinase inhibition activity, 56.22% ${\alpha}$-glucosidase inhibition and 46.58% ${\alpha}$-amylase inhibition ratio at 1 mg/mL. Both methylene chloride and EtOAc fractions of methanol extract of S. asper effectively reduced of the 86.34% and 62.03% angiotensin I converting enzyme (ACE) activity at 2 mg/mL, respectively. These findings suggest that the EtOAc fraction of the S. asper could be a potential antioxidant in food additive, medicinal, and industry product.

• 대한기계학회논문집B
• /
• 제23권3호
• /
• pp.419-430
• /
• 1999

Measurements of local blowing ratio and ammonia-diazo flow visualizations have been conducted for a shower-head film cooling on a first-stage turbine stator. In this study, six rows of normal holes are drilled symmetrically on the semicircular leading edge of a simulated blunt body. The measurements show that for an average blowing ratio based on freestream velocity, M, of 0.5, local average mass flow rate through the first two rows of the holes is less than those through the second and third two rows of the holes, and the fraction of mass flow rate through the first two rows to total mass flow rate has a tendency to increase with the increment of M. The flow visualizations reveal that the injection through the first two row results in inferior film coverage even In the case of M = 0.5, meanwhile the row of holes situated at farther downstream location provides higher film-cooling performances for all tested M. This is because film-cooling effectiveness depends on local mainflow velocity at the hole location as well as the mass flow rate through each row.

• 소성∙가공
• /
• 제20권5호
• /
• pp.339-343
• /
• 2011

This paper presents methods for analyzing the extent of cylindrical-shaped void closure. In addition, a quantitative relationship between change in void fraction and height reduction ratio of a compressed specimen is proposed. The height reduction ratio, number of deformation steps and billet rotation were chosen as key process parameters influencing the void closing behavior, namely, the changes in void shape and size during hot open die forging of a large ingot. The extent of void closure was analyzed from microscopic observations and estimated from tensile test results. The tensile strengths of specimens with closed voids and those without were compared for various reduction ratios in height. The results confirmed that void closure occurs at reduction ratios greater than 30 %. The void closing behavior could be expressed as a hyperbolic tangent function of reduction ratio in height, number of paths, and billet rotation. The knowledge presented in this paper could be helpful for optimizing deformation paths in open die forging processes.

• Journal of information and communication convergence engineering
• /
• 제7권2호
• /
• pp.148-151
• /
• 2009

We consider the problem of optimizing the performance of a system with resources shared by non-cooperative users. The worst-cast ratio between the cost of a Nash equilibrium and the optimal cost, called Price of Anarchy, is investigated. It measures the performance degradation due to the users' selfish behavior. As the objective function of the optimization problem, we are concerned in a load balancing measure, which is different from that used in the previous works. Also we consider the Stackelberg scheduling which can assign a fraction of the users to resources while the remaining users are free to act in a selfish manner.

• 대한기계학회논문집B
• /
• 제29권3호
• /
• pp.376-383
• /
• 2005

In the paper we investigate characteristics of a transitional behavior from a premixed flame to a triple flame in a lifted flame according to the change of equivalence ratio. In previous study, we showed that the stabilized laminar lifted flame regime is categorized by regimes of premixed flame, triple flame and critical flame. A gas-chromatograph is used to measure concentration field, a smoke-wire system is used to measure streak line, and a PIV system is used to measure velocity field in lifted flame. In the visualization experiment of smoke wire, the flow divergence and redirection reappeared in premixed flame as well as triple flame. Thus we cannot express the flame front of lifted flame has a behavior of triple flame with only flow divergence and redirection. In PIV measurement, flow velocity for those three flames has minimum value at the tip of flame front. To differentiate triple flame and premixed flame, $\Phi$ value of partially premixed fraction is employed. The partially premixed fraction $\Phi$ was constant in premixed flame. In critical flame small gradient appears over the whole regime. In triple flame, typical diffusion flame shape is obtained as parabolic distribution type due to diffusion flame trailing.

• 동의생리병리학회지
• /
• 제17권3호
• /
• pp.629-632
• /
• 2003

Scutellaria barbata has been used as a traditional Chinese Herb for treating liver, lung and rectal tumors. In the present study, cytotoxic effect of Scutellaria barbata MC fradtion was investigated and it was found to inhibit proliferation of human leukemic U937 cells with an IC50 of approximately 10 μg/ml in a dose-dependent manner. We also demonstrated that Scutellaria barbata MC fraction caused apoptosis in U937 cells. In the flow cytometric assay, the MC fraction-treated U937 cells showed an increase in hypo-diplold Sub G1 DNA contents. DNA fragmentation was observed by TUNEL assay. An increase of Bax:Bcl-2 ratio, activation of caspase-9, caspase-3, and cleavage of poly (ADP-ribose) polymerase (PARP) were demonstrated by western blot analysis. Taken together, these results exerted that the MC fraction suppressed human leukemic U937 cell proliferation by inducing apoptosis via the mitochondrial pathway.

• 한국자동차공학회논문집
• /
• 제11권3호
• /
• pp.48-57
• /
• 2003

A cylindrical constant volume combustion chamber was used to investigate the flow characteristics at spark plug and the combustion characteristics of homogeneous charge methane-air mixture under various initial pressure, excess air ratio and ignition times in quiescent mixture. The flow characteristics such as mean velocity and turbulence intensity was analyzed by hot wire anemometer. Combustion pressure development measured by piezoelectric pressure transducer and flame propagation acquired by ICCD camera were used to investigate the effect of initial pressure, excess air ratio and ignition times on pressure, combustion duration, flame speed and burning velocity. Mean velocity and turbulence intensity had the maximum value at 200 or 300ms and then decreased to near 0 value gradually after 3 seconds. Combustion duration, flame speed and burning velocity were observed to be promoted with excess air ratio of 1.1, lower initial pressure and ignition time of 300ms.