• Journal of the Korean Society of Food Science and Nutrition
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• v.28 no.5
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• pp.1180-1186
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• 1999

A wide ranges of chemicals released into the environment have potential to interfere with physiological and development process by disrupting endocrine pathways. Endocrine system embraces a multitude of mechanisms of action, including effect on growth, behavior, reproduction and immune function. These environmental endocrine disruptors are present in environment and pose potential health consequences to human and wildlife. The best known form in endocrine distruptors involves substances which mimic or block the action of natural hormone in the body. Endocrine disruptor have been variously defined as exogenous agents that interfere with the synthesis, secretion, transport, metabolism, binding action or elimination of the natural hormones in the body which are responsible for the maintenance of homeostasis, reproduction developmental and/or behavior. Many compounds polluted into the environment by human activity are capable of disrupting the endocrine system of animals, including fish, wildlife, and humans. Among these chemicals are pesticides, industrial chemicals, and other anthropogenic products. It has been alleged that several adverse effects on human health are linked with exposure to chemicals which are claimed to be endocrine disrupters, that is, increased incidence of testicular, prostate and female breast cancer, time dependent reductions in sperm quality and quantity, increased incidence of cryptorchidism (undescended testicles) and hypospadias(malformation of the penis), altered physical and mental de velopment in children. This observation is currently the only example of chemically mediated endocrine disruption which has resulted in a clear effect at the population level.

• Journal of computational fluids engineering
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• v.1 no.1
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• pp.81-87
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• 1996

The aerodynamic charateristics of high speed train can be improved by well-designing of its fore-body shape. In this paper, as a way of the design a fore-body shape which has optimal aerodynamic charasteristics, 9 models of fore-body shapes are proposed and the change of aerodynamic charateristics is studied through calculations of flow field around high speed train for each fore-body shape. The flow field around high speed trains are calculated using Thin-Layer Navier-Stokes equation and Chimera grid technique. The application of Chimera grid technique to these flow calculations over high speed train which has ground plane under the train makes grid generation easily. As a computaional algorithm, Pulliam and Chaussee's Diagonal algorithm, the modified form of the Beam and Warming's AF scheme which operates on block-tridiagonal matrices, is selected to reduce computaional time. Introducing hole points flag concept to this Diagonal algorithm. a algorithm for Chimera grid is generated. The variational trends of aerodynamic characteristics are studied from the results of flow calculations around high speed trains for 9 fore-body shapes.

• 한국전산유체공학회:학술대회논문집
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• 2003.10a
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• pp.294-298
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• 2003

The complex, unsteady, self-sustained pressure oscillations induced by supersonic flow past a rectangular cavity is investigated using numerical simulations. The present numerical study is performed using a parallel, multiblock solver for the two-dimensional, compressible Navier­Stokes equations. Open cavities with length-to-depth (L / D) ratio in the range 0.5 - 3.3 are considered. This paper sheds light on the cavity physics, cavity oscillatory mechanism, and the organisation of vortical structures inside the cavity. The vortex shedding phenomenon, the shear layer impingement event at the aft wall and the movement of the acoustic/compression wave within the cavity are well predicted. The vortical structures· and the source of the acoustic disturbances are found to be located near the aft wall of the cavity. With the increase in the cavity length, strong recompression of the flow near the aft wall leading to a sudden jump in the cavity form drag is observed. The estimated cavity tones are in good agreement with the available semi­empirical relation. Multiple peaks are noticed in deep and long cavities. For the present free­stream Mach number 1.71, it is observed that around L/D=2.0, the cavity oscillatory mechanism changes from the transverse to longitudinal oscillatory mode. The effects of this transition on various fluid dynamics and acoustic properties are also discussed.

• Bulletin of the Korean Chemical Society
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• v.35 no.12
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• pp.3542-3546
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• 2014

Relationship between molecular freedom of amyloidogenic protein and its self-assembly into amyloid fibrils has been evaluated with ${\alpha}$-synuclein, an intrinsically unfolded protein related to Parkinson's disease, by restricting its structural plasticity through an end-to-end disulfide bond formation between two newly introduced cysteine residues on the N- and C-termini. Although the resulting circular form of ${\alpha}$-synuclein exhibited an impaired fibrillation propensity, the restriction did not completely block the protein's interactive core since co-incubation with wild-type ${\alpha}$-synuclein dramatically facilitated the fibrillation by producing distinctive forms of amyloid fibrils. The suppressed fibrillation propensity was instantly restored as the structural restriction was unleashed with ${\beta}$-mercaptoethanol. Conformational flexibility of the accreting amyloidogenic protein to pre-existing seeds has been demonstrated to be critical for fibrillar extension process by exerting structural adjustment to a complementary structure for the assembly.

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.1081-1099
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• 2010

The TVM 430 system manufactured by Ansaldo STS in France is currently used in ground signalling system for Kyungbu HSR. It transmits the speed information to the on-board signalling system in the form of continuous signal via the track, and the rolling stock in Kyungbu HSR runs with 300km/h max. operating speed by using the corresponding information. Looking from the recent international trends in HSR, reducing the travelling time and increasing of the line capacity is promoting via the improvement of train speed. In case of TGV Est, they are realizing the normal operation with 320km/h max. operating speed by using TVM SEI signalling system, which is similar to TVM 430. Furthermore, in case Honam HSL, which is under construction, is looking over faster speed than the limited one of Kyungbu HSR(i.e. over 300km/h). In this paper, it is assumed that the existing TVM 430 ground signalling system is used and train speed is improved, therefore the number of block section to be increased depending on the increase of train speed and the standard speed to be used in this case is drawn via the simulation of the train model and described the method accordingly.

• Journal of Internet Computing and Services
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• v.14 no.6
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• pp.41-47
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• 2013

GP-GPUs are general purposed GPUs for numerical computation based on multiple threads which are originally for graphic processing. GP-GPUs provide cache memory in a form of shared memory which user programs can access directly, unlikely typical cache memory. In this research, we implemented the parallel block LU decomposition program to utilize cache memory in GP-GPUs. The parallel blocked LU decomposition program designed with Nvidia CUDA C run 7~8 times faster than nun-blocked LU decomposition program in the same GP-GPU computation environment.

• The Plant Pathology Journal
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• v.29 no.4
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• pp.454-459
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• 2013

The Potexvirus Alternanthera mosaic virus (AltMV) has multifunctional triple gene block (TGB) proteins, among which our studies have focused on the properties of the TGB1 protein. The TGB1 of AltMV has functions including RNA binding, RNA silencing suppression, and cell-to-cell movement, and is known to form homologous interactions. The helicase domains of AltMV TGB1 were separately mutated to identify which regions are involved in homologous TGB1 interactions. The yeast two hybrid system and Bimolecular Fluorescence Complementation (BiFC) in planta were utilized to examine homologous interactions of the mutants. Helicase motif I of AltMV TGB1 was found to be critical to maintain homologous interactions. Mutations in the remaining helicase motifs did not inhibit TGB1 homologous interactions. In the absence of homologous interaction of TGB1, subcellular localization of helicase domain I mutants showed distinctively different patterns from that of WT TGB1. These results provide important information to study viral movement and replication of AltMV.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2004.11a
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• pp.43-48
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• 2004

The purpose of this study is to analyze the typological characteristics of super high-rise housings in Hong Kong. The results are as follows; 1) The Plan types of the residential building in Hong Kong are mostly tower types and they show lots of curves on the external resident blocks so each resident families can face maximum open air. 2)Household arrangements or resident families form are shown as symmetrical and systematic type of structures that centers around the core. 3)The core types are mostly central core types and a portion of central core is planned to place void and alight garden for improving the lighting and ventilating problems. 4)If we review our room arrangements, they are arranged from entrance kitchen, livingroom bedroom to bathroom to the end. Livingrooms and dinning rooms are normally formed together. 5)If external resident blocks are facing the open air, one of the surface is on view axis, kitchen or bathroom are symmetrically located on the other side which faces the units for the purpose of ventilating.

• Geomechanics and Engineering
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• v.15 no.1
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• pp.621-630
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• 2018

In the note a comprehensive and optimal passive-active mode for describing the limit failure of circular shallow tunnel with settlement is put forward to predict the catastrophic stability during the geotechnical construction. Since the surrounding soil mass around tunnel roof is not homogeneous, with tools of variation calculus, several different curve functions which depict several failure shapes in different soil layers are obtained using virtual work formulae. By making reference to the simple-form of Power-law failure criteria based on numerous experiments, a numerical procedure with consideration of combination of upper bound theorem and stochastic medium theory is applied to the optimal analysis of shallow-buried tunnel failure. With help of functional catastrophe theory, this work presented a more accurate and optimal failure profile compared with previous work. Lastly the note discusses different effects of parameters in new yield rule and soil mechanical coefficients on failure mechanisms. The scope of failure block becomes smaller with increase of the parameter A and the range of failure soil mass tends to decrease with decrease of unit weight of the soil and tunnel radius, which verifies the geomechanics and practical case in engineering.

• Journal of Korea Multimedia Society
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• v.15 no.7
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• pp.891-902
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• 2012

Reversible data hiding scheme is a form of steganography in which the secret embedding data can be retrieved from a stego image for the purpose of identification, copyright protection and making a covert channel. The reversible data hiding should satisfy that not only are the distortions due to artifacts against the cover image invisible but also it has large embedding capacity as far as possible. In this paper, we propose a robust reversible data hiding scheme by exploiting the differences between a center pixel and its neighboring pixels in each sub-block of the image to embed secret data into extra space. Moreover, our scheme enhances the embedding capacity and can recover the embedded data from the stego image without causing any perceptible distortions to the cover image. Simulation results show that our proposed scheme has lower visible distortions in the stego image and provides robustness to geometrical image manipulations, such as rotation and cropping operations.