• Journal of the Korean Applied Science and Technology
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• v.2 no.1
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• pp.19-23
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• 1985

In order to know the quality changes of the fat and oil foods packed in plastics film by the sunlight, we examined the sunlight transmitting rate by the kind of films and measured the acid value and peroxide value according to it. The results obtained were as follows : 1. The sunlight transmitting rate of various films was explained especial permeability under the wavelength of less than 300nm, but it marked a regular form under that of more than 30nm. 2. The vacuum evaporation film with aluminum on the polyester shuts off most of the sunlight, therefore, it has the best effect that keeps the fats and oils off rancidity. 3. The sunlight transmitting rate of the white color printing film drops about 80% as compared with not printing. 4. The preventive power against the rancidity of fats and oils is PET/Al, PET, PE, nylon and OPP film in that order. The changes of peroxide value and acid value were approximately the same as that of the sunlight transmitting rate.

• Archives of Pharmacal Research
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• v.27 no.8
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• pp.878-883
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• 2004

Tacrolimus (FK506), which is isolated from Streptomyces tsukubaensis, is a new potent immu-nosuppressant. Because of poor solubility in water, the conventional intravenous dosage forms of tacrolimus contain surfactants such as cremophor EL (BASF Wyandotte Co.) or hydroge-nated polyoxy 60 castor oil (HCO-60) which may cause adverse effects. This study relates to a polymer-tacrolimus conjugate, which can be dissolved in water, formed by chemically binding the sparingly soluble drug, tacrolimus, with the water soluble polymer, methoxypoly(ethylene glycol) (mPEG). Water soluble tacrolimus-mPEG conjugates have been synthesized and shown to be function in vitro as prodrugs. These conjugates are in the form of an ester wherein the 24-, 32- or 24,32-positions are esterified. The desired 24-, 32- or 24,32-esterified com-pounds were obtained by initially acylating of tacrolimus with iodoacetic acid at the 24-,32-, or 24,32-positions and then reacting the resulting acylated tacrolimus with a mPEG in the pres-ence of a base such as sodium bicarbonate. These conjugates were converted again into tac-rolimus by the action of enzymes in human liver homogenate, and the half-lives of the conjugates are approximately 10 min in the homogenate, indicating that the esterified tacroli-mus derivatives may be practically applicable as a prod rug for the immunosuppressant.

• Journal of Korea Port Economic Association
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• v.29 no.2
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• pp.63-79
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• 2013

The fundamental endeavor of this study is to investigate the asymmetric relationship between bunker price and Baltic Dry-bulk Index (hereafter BDI). Previous investigations employ linear form based analysis between oil price and BDI but we develop nonlinear and asymmetric cointegration method, which is properly able to capture the decreasing and increasing periods differently. The empirical results show there is no relationships in linear model (e.g. Engle and Granger's methods). On the contrary, our estimate reveals there is significant long-run relationship with asymmetric framework, which implies the necessity of nonlinear and asymmetric consideration to the bunker price analysis.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.35 no.3
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• pp.171-177
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• 2009

This study described formation and dispersion of stable lamellar structure containing ceramide. To characterize of the lamellar structure containing ceramide, we used differential scanning calorimetry, x-ray diffraction, and FT-IR spectra, which enabled us to demonstrate that ceramide with appropriate amounts of lipid, oil and surfactant can assemble to form a stable lamellar-phase. These approaches to use ceramide offers useful means to fabricate a variety of biocompatible emulsion and liposome, which enlarge their applicability in the fields of drug delivery, dermatology and cosmetics.

• Tunnel and Underground Space
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• v.5 no.3
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• pp.251-265
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• 1995

One of the most important matters in stress measurement by hydraulic fracturing technique is the determination of the breakdown pressure, reopening pressure, and shut-in pressure, since these values are the basic input data for the calculation of the in-situ stress. The control of the fracture propagation is also important when the hydraulic fracturing technique is applied to the development of groundwater system, geothermal energy, oil, and natural gas. In this study, a laboratory scale hydraulic fracturing device was built and a series of model tests were conducted with cube blocks of Machon gabbro. A new method called 'flatjack method' was adopted to determine shut-in pressure. The initial stress calculated from the shut-in pressure measured by flatjack method showed much higher accuracy than the stress determined by the conventional method. The dependency of the direction of fracture propagation on the state of the initial stresses was measured by introducin g artificial slots in the borehole made by water jet system. Numerical modeling by BEM was also performed to simulate the fracture propagation process. Both results form numerical and laboratory tests showed good agreement. From this study which provides the extensive results on the determination of shut-in pressure and the control of fracture propagation which are the critical issue in the recent hydraulic fracturing, it is conclued that in-situ stress measurement and the control of fracture propagation could be achived more accurately.

• Ocean Systems Engineering
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• v.8 no.3
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• pp.345-360
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• 2018

Increasing demand for large-sized Floating, Storage and Regasification Units (FSRUs) for oil and gas industries led to the development of novel geometric form of Buoyant Leg Storage and Regasification Platform (BLSRP). Six buoyant legs support the deck and are placed symmetric with respect to wave direction. Circular deck is connected to buoyant legs using hinged joints, which restrain transfer of rotation from the legs to deck and vice-versa. Buoyant legs are connected to seabed using taut-moored system with high initial pretension, enabling rigid body motion in vertical plane. Encountered environmental loads induce dynamic tether tension variations, which in turn affect stability of the platform. Postulated failure cases, created by placing eccentric loads at different locations resulted in dynamic tether tension variation; chaotic nature of tension variation is also observed in few cases. A detailed numerical analysis is carried out for BLSRP using Mathieu equation of stability. Increase in the magnitude of eccentric load and its position influences fatigue life of tethers significantly. Fatigue life decreases with the increase in the amplitude of tension variation in tethers. Very low fatigue life of tethers under Mathieu instability proves the severity of instability.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.20-25
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• 2008

Sulfide stress corrosion cracking (SSCC) of materials exposed to oilfield environment containing hydrogen sulfide ($H_2S$) has been recognized as a materials failure problem. Laboratory data and field experience have demonstrated that extremely low concentration of $H_2S$ may be sufficient to lead to SSC failure of susceptible materials. In some cases, $H_2S$ can act synergistically with chlorides to produce corrosion and cracking failures. SSC is a form of hydrogen embrittlement that occurs in high strength steels and in localized hard zones in weldment of susceptible materials. In the heat-affected zones adjacent to welds, there are often very narrow hard zones combined with regions of high residual stress that may become embrittled to such an extent by dissolved atomic hydrogen. On the base of understanding on sulfide stress cracking and its mechanism, SSC resistance for the several materials, those are ASTM A106 Gr B using in the oil industries, are evaluated.

• Journal of the Korean Applied Science and Technology
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• v.29 no.1
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• pp.63-70
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• 2012

Magnetite in the use of magnetic fluid seal was synthesized by coprecipitation method. Mean particle size of magnetite was measured about 12 nm by using dynamic light scattering(DLS). As a result of XRD test, along with the $NH_4OH$ concentration was increased, the crystallinity of magnetite was increased. The zeta potential of dispersed ferrofluid in water was measured in the range from -49.3 mV to -26.2 mV by DLS. The shape of magnetite particle was sphere form, and the spiking effect of aqueous and oily ferrofulid was confirmed.

• Journal of Microbiology and Biotechnology
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• v.14 no.2
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• pp.411-414
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• 2004

Although conjugated linoleic acid (CLA) exerted potent antitumor activities in several animal models, application of CLA as a bioactive ingredient has been limited due to its hydrophobicity. This study was designed to determine the antitumor activity of arginine-CLA complex (Arg-CLA), a hydrophilic form of CLA. Mouse forestomach cancer was induced by gavage with benzo(a)pyrene (B(a)p) for 4-weeks prior to Arg-CLA (0.2 and 0.5％) feeding. Complete necropsies were performed to determine the number, size and locations of all the forestomach tumors at 20 weeks post-B(a)P administration. All mice in the B(a)P group developed tumors, and tumor incidences were decreased by 31 ％ and 44％ in 0.2％ and 0.5％ Arg-CLA-fed groups, respectively, whereas no decrease was observed when Arg or com oil was given alone. Our results suggest that Arg-CLA suppresses mouse forestomach cancer.

• Journal of the Korean GEO-environmental Society
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• v.10 no.6
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• pp.125-133
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• 2009

Rock fracturing technique through fluid injection into the wellbore has been widely used to extract geothermal heat and to enhance oil and gas production. Single fracture formation is ideal for the production. However, it is very difficult to form single fracture formation. Instead, the formation of segmented fracture is a common phenomenon. Therefore, design parameters are expected to be different from those of single fracture because of mechanical interaction between segmented fractures. In this paper, design parameters such as length, aperture, and net pressure are evaluated by using model of segmented fracture in which numerical technique is incorporated to consider mechanical interaction between segments. Results show that the existence of fracture segmentation affects design parameters in fracturing treatment in rock by fluid injection.