• The Korean Journal of Legal Medicine
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• v.40 no.2
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• pp.61-64
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• 2016

Ehlers-Danlos syndrome type IV (EDS IV) is a hereditary disorder of the connective tissue, characterized by easy bruising, thin skin with visible veins, and spontaneous rupture of the large arteries, uterus, or bowel. EDS IV is caused by mutations of the gene for type III procollagen (COL3A1), resulting in insufficient collagen production or a defect in the structure of collagen. EDS IV can have fatal complications such as the rupture of great vessels or organs, which can cause hemorrhaging and sudden unexpected death. Here, we report a case of a 43-year-old female who collapsed after a struggle with a neighbor. In this patient, the bifurcation of the bilateral common iliac artery ruptured, with no evidence of trauma, inflammation, or atherosclerosis. Genetic analysis of COL3A1 showed the presence of a c.2771G>A (p.Gly924Arg) mutation, which may be associated with EDS IV. The forensic pathologist should consider the possibility that the spontaneous visceral or arterial rupture was caused by EDS IV. Genetic analysis is not currently a routine procedure during autopsy. However, in this case, we suggest that the patient possibly had an underlying EDS IV condition, and we recommended family members of the deceased to seek genetic analysis and counseling.

• Journal of the Society of Disaster Information
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• v.13 no.2
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• pp.267-275
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• 2017

This research is about the development of e-forensic tool that extract & analyze different forms of digital evidence that individuals come across in a disaster scene. The tool utilizes digital forensic techniques which makes the tool efficient in any disaster analysis situation. In order for the forensic evidence to be selected as legal evidence, the evidence needs to be proven that it is in its original state with no forgery involved. This is where the e-forensic tool comes in, as its ability to collect digital evidence during investigation has proven; that the tool can keep the evidence in its original state and increase the integrity by generating hash TAG and adding the forensic evidence to a password encoded file.

• Analytical Science and Technology
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• v.37 no.3
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• pp.189-199
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• 2024

In forensic genetics, when it is not possible to confirm an individual's identity through STR profile analysis, additional information about the individual can be obtained using DNA-based phenotypic traits estimation. Recently, various researches have been conducted on methods to determine externally visible characteristics (EVC) such as eyes, hair, and skin color. However, relying solely on such phenotypic traits information has limitations for application in East Asian regions, including Korea. In this study, in order to utilize EVC related to an individual's appearance as investigative information, SNPs related to eye shape, hair thickness, skin color, as well as baldness, body type, high myopia, facial shape, acne, and behavioral habits were explored. A total of 50 SNPs were selected, and a targeted amplicon NGS panel capable of amplifying them all at once was developed. Experimental results confirmed the allelic types and frequencies of the 50 SNPs in 14 samples. We plan to use this panel to investigate the correlation between genotype and phenotype using various samples, and to develop methods for interpreting the results.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.4977-4982
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• 2014

Background: Cytochrome P450 2E1 (CYP2E1) might be involved in the development of bladder cancer. However, previous studies of any association between CYP2E1 RsaI/PstI polymorphism and bladder cancer risk have yielded conflicting results. In this study, we performed a more precise estimation of the relationship by a meta-analysis based on the currently available evidence from the literature. Method: To assess the effect of CYP2E1 RsaI/PstI polymorphism on bladder cancer susceptibility, a meta-analysis of 6 available studies with 1,510 cases and 1,560 controls were performed through Feb 2014. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to estimate the strength of association for CYP2E1 RsaI/PstI polymorphism under different genetic models. Results: When available studies were pooled into the meta-analysis, we found that the C1C2 and C2C2 genotypes of CYP2E1 RsaI/PstI polymorphism significantly decreased bladder cancer risk under different genetic models (heterozygote: OR=0.766, 95%CI=0.613-0.957, $P_{OR}$=0.019; homozygote: OR=0.51, 95%CI=0.303-0.858, $P_{OR}$=0.011; dominant: OR=0.733, 95%CI=0.593-0.905, $P_{OR}$=0.004; recessive: OR=0.565, 95%CI=0.337-0.947, $P_{OR}$=0.030). Subgroup analysis indicated that C2C2 genotype was significantly associated with decreased bladder cancer risk under the homozygote genetic model in Caucasians. There was no evidence of heterogeneity or publication bias. Conclusions: The current meta-analysis suggested that the CYP2E1 RsaI/PstI polymorphism might be associated with bladder cancer susceptibility, especially in Caucasians. Further studies are needed to validate the above conclusion.

• Journal of Korea Multimedia Society
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• v.24 no.12
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• pp.1641-1652
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• 2021

To analyze the crime scene, the role of digital evidence such as CCTV and black box is very important. Such digital evidence is often damaged due to device defects or intentional deletion. In this case, the deleted video can be restored by well-known techniques like the frame-based recovery method. Especially, the data such as the video can be generally fragmented and saved in the case of the memory used almost fully. If the fragmented video were recovered in units of images, the sequence of the recovered images may not be continuous. In this paper, we proposed a new video restoration method to match the sequence of recovered images. First, the images are recovered through a frame-based recovery technique. Then, after analyzing the time information marked on the images, the time information was extracted and recognized via optical character recognition (OCR). Finally, the recovered images are rearranged based on the time information obtained by OCR. For performance evaluation, we evaluate the recovery rate of our proposed video restoration method. As a result, it was shown that the recovery rate for the fragmented video was recovered from a minimum of about 47% to a maximum of 98%.

• Journal of Welding and Joining
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• v.34 no.5
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• pp.47-53
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• 2016

The aim of this study is to consider effect of weld elastic modulus on simulations of stress concentration and fatigue life for pressure vessel. The investigations include analysis with ADINA and WINLIFE softwares for whole body model about using condition of the boiler vessel. Values of weld elastic modulus were divided by 5 steps in butt weld area of the boiler vessel body. The stress concentration of the butt weld more was increased in case of higher elastic modulus of weld area because of higher difference of material properties between matrix and weld. It was concluded that the fatigue lives were decreased along increasing stress concentration due to high elastic modulus of weld. The matrix microstructure was estimated as pearlitic structure of ${\alpha}$ ferrite and pearlite. And the microstructures of welds along 5 steps of elastic modulus were estimated as bainitic fine pearlite and martensite as increasing elastic modulus.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2012.05a
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• pp.463-466
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• 2012

Smartphones along with the development of crime evidence has been using smartphones. Phone's internal storage medium can be used as evidence in the case of images, video, phone, GPS information, there are Internet access and other data records. Therefore, these data to collect evidence of a systematic procedure for collecting and analyzing evidence is needed. In this paper, the target mobile phone forensics forensic evidence collection, evidence analysis, and reporting results to the procedures and how to draw. Through this paper, phone forensics and will serve as a basis for the investigation.

• Genomics & Informatics
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• v.11 no.4
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• pp.277-281
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• 2013

RNA analysis has become a reliable method of body fluid identification for forensic use. Previously, we developed a combination of four multiplex quantitative PCR (qRT-PCR) probes to discriminate four different body fluids (blood, semen, saliva, and vaginal secretion). While those makers successfully identified most body fluid samples, there were some cases of false positive and negative identification. To improve the accuracy of the identification further, we tried to use multiple markers per body fluid and adopted the NanoString nCounter system instead of a multiplex qRT-PCR system. After measuring tens of RNA markers, we evaluated the accuracy of each marker for body fluid identification. For body fluids, such as blood and semen, each body fluid-specific marker was accurate enough for perfect identification. However, for saliva and vaginal secretion, no single marker was perfect. Thus, we designed a logistic regression model with multiple markers for saliva and vaginal secretion and achieved almost perfect identification. In conclusion, the NanoString nCounter is an efficient platform for measuring multiple RNA markers per body fluid and will be useful for forensic RNA analysis.

• Transactions on Electrical and Electronic Materials
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• v.18 no.4
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• pp.221-224
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• 2017

This paper dealt with the extraction of series arc signals based on wavelet transform in order to improve the accuracy of arc detection in indoor wiring systems. Three types of arc sources including a cord-cord, a terminal-cord, and an outlet-plug were fabricated to simulate typical arc defects. An arc generator fabricated according to UL 1699 was used to generate arcs. The optimal mother wavelet was selected as bior1.5 by calculating the correlation coefficients between the detected single current pulse and the wavelet. The detected arc current signals were then decomposed into eight levels using the discrete wavelet transform that implements the multi-resolution analysis method. By analyzing the decomposed components, the detail components D6, D7, and D8 were associated with arc signals, which were used for signal reconstruction. From the result, it was verified that the proposed method can be used for the extraction of the series arc signal from the AC mains, which is expected to be applied to further analysis of arc signals in indoor wiring systems.

• Toxicological Research
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• v.28 no.3
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• pp.195-199
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• 2012

The records of 255 cyanide poisoning deaths obtained from National Forensic Service (NFS) headquarters, located in Seoul of Korea, from 2005 to 2010 were retrospectively reviewed. The mean age was $41.88{\pm}13.09$ and range was 6~80 years (unknown in seven cases). The number of deaths of males and females were 200 and 53, respectively (unknown in two cases). The largest number of cases occurred in people aged 40-49 years (81 cases, 31.8%), followed by the age groups 30~39 years (51 cases, 20%), 50~59 years (44 cases, 17.2%) and 20~29 years (43 cases, 16.9%). The total number of deaths among other age groups (below 10, 10~19, 60~69, 70~79, over 80 years and unknown) were 36, representing only 14.1%. Of all cyanide poisoning deaths, 97.3% were due to suicide, and 14.5% of the total number who died received medical treatment. The most frequent site for ingestion was the person's own residence (120 cases, 47.1%) and the route of administration was mainly oral (252, 98.8%). From the total of 255 cyanide poisoning cases, white powders were submitted for analysis in 92 cases. Potassium cyanide and sodium cyanide occupied 51 and 41 cases, respectively. This study showed that poisoning deaths due to cyanide are one of the continuously reported public health problems in Korea. Enforcement of regulations and safety education to prevent cyanide poisoning should be carried out by the government.