• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.26 no.4
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• pp.43-50
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• 2013

Objectives : This study aims to suggest preliminary standard procedure for face lift and correction of nasolabial folds using thread-embedding (Maeseon) of Korean medicine(KM). Methods : Three KM practitioners of facial correction and rejuvenation who have over hundred case of practice participated in establishment of standard procedure. Standard procedure contains preprocessing, main procedure for correction, and solution of side effects. Results : Standard procedure is comprised of twelve processes with preprocessing and postprocessing. Preprocessing has position, disinfection, and anesthesia. Main process consists of overall structure correction, face lifting, nasolabial folds correction, and mesh making on cheek. Postprocess covers disinfection, edema prevention. Conclusions : To our knowledge, this is the first work to suggest standard procedure of facial rejuvenation using Maeseon. It would contribute to standardized practice in clinical fields and future study of revealing Maeseon's effectiveness.

• Steel and Composite Structures
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• v.28 no.2
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• pp.251-266
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• 2018

Compared to conventional flat web I-beams, the prediction of shear buckling stress of corrugated web steel beams (CWSBs) is not straightforward. But the CWSBs combined advantages of lightweight large spans with low-depth high load-bearing capacities justify dealing with such difficulties. This work investigates experimentally and analytically the shear strength of trapezoidal CWSBs. A set of large scale CWSBs are manufactured and tested to failure in shear. The results are compared with widely accepted CWSBs shear strength prediction models. Confirmed by the experimental results, the linear buckling analyses of trapezoidal corrugated webs demonstrated that the local shear buckling occurs only in the flat plane folds of the web, while the global shear buckling occurs over multiple folds of the web. New analytical prediction model accounting for the interaction between the local and global shear buckling of CWSBs is proposed. Experimental results from the current work and previous studies are compared with the proposed analytical prediction model. The predictions of the proposed model are significantly better than all other studied models. In light of the dispersion of test data, accuracy, consistency, and economical aspects of the prediction models, the authors recommend their proposed model for the design of CWSBs over the rest of the models.

• Journal of Ginseng Research
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• v.22 no.1
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• pp.60-65
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• 1998

The effect of Korean red-ginseng extract on the proliferation and cellular activity of mouse B and T lymphocytes was examined in vitro. Both water and ethanol extract from red-ginseng increased the growth of normal B and T lymphocytes 1.5∼2.5-folds. Saponin and polysaccharide fractions from ginseng extract also stimulated the proliferation of normal lymphocytes much higher than several well-known immunostimulators. B and T lymphoma cell lines responded to the ginseng extract and fractions by growth, too, while non-lymphoid cell lines did not. Immunoglobulin production of unprimed B-lymphocytes was little affected by the ginseng extract and fractions, though the ethanol extract slightly enhanced Ini, production of B-lymphocytes. When cytolytic activity of T lymphocytes against tumor tells was induced in vitro, both of the saponin and polysaccharide fractions and the ginseng ethanol extract increased the cellular activity of cytotoxic T lymphocytes 4-5-folds, while the ginseng water extract did not. Especially, the saponin fraction exhibited 10-times higher stimulatory effect on the cytolytlc activity of cytotoxic T cells than the ethanol extract and the pclysaccharide fraction did. These results suggest that Korean red-ginseng contain potent immunomodulating components to stimulate the proliferation of B and T lymphocytes and the cellular activity of cytotoxic T lymphocytes.

• Journal of Ginseng Research
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• v.20 no.3
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• pp.331-338
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• 1996

This study was conducted to screen the antagonistic plants on northern root-knot nematode (Meloidogyne) and to utilize those in its control. Egg hatching of M. hapla was found to be inhibited by 17 plant methanol extracts, and 11 plant extracts among them were also toxic to M. hapla second stage juvenile. Egg hatching of iW. hapla was also found to be inhibited by squeezed extracts of Cassia tora and Zea mays, and they were also toxic to M. hapla second stage juvenile. Extracts of Achyranthes japonica, Melia axedrach and Acorus graminens were toxic to M. hapla second stage with a juvenile mortality above 70clc at the 10 folds diluted concent ration and A. graminens was toxic to tested juvenile mortality above 50% at the 100 folds diluted concentration. The toxicity was directly propotional to the diluted concentration of the plant extracts and to the exposure period. Punica granatum, Acorns graminens and Melia axedrach were effective in inhibiting root penetration of JW. hapla juveniles, among of them p. granatum is most effective Percent inhibition of penetration by second and third stage juveniles into tomato slants penetrating by it was 72.7 and 82.4%, respectively.

• Journal of Microbiology and Biotechnology
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• v.14 no.3
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• pp.570-575
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• 2004

Three different strains of carotenoid accumulating XantlwphyUomyces dendrorhous mutants, JH1, JH2, and JH3, were isolated by NTG (N-methyl-N'-nitro-N-nitrosoguanidine) mutagenesis, which might potentially be useful for animal feed as well as for studies on the regulation and biosynthesis of astaxanthin. Mutants were selected based on the capability of growth and carotenoid production on the YM agar plate containing chemical inhibitor, $\beta$-ionone. Astaxanthin-overproducing mutant JH1 produced 4.032 mg astaxanthinlg dry cell weight, and this value was about 15-folds higher than that of wild-type. $\beta$-Carotene-overproducing mutant JH2 produced 0.273 mg $\beta$-carotene/g dry cell weight, and this was 4-folds increase from that of wild-type. In contrast, JH3 was a white-colored mutant that was unable to produce carotenoid pigment.

• Journal of Plant Biotechnology
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• v.40 no.2
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• pp.102-110
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• 2013

The novel BrRZFPs genes encoding C3HC4-type RING zinc finger protein were identified from FOX (full length cDNA over-expressing) library of Brassica rapa. Ten full-length cDNAs obtained from the library encode zinc-finger protein containing 346 amino acids, designated BrRZFPs. These genes were classified into four groups by phylogenic analysis showing conserved protein sequences at both termini. The tissue distribution of BrRZFPs transcription was examined by qRT-PCR revealing ubiquitous expression pattern. However, each gene was strongly expressed in the specific tissue. Transcriptional analysis showed that those acquired 10 genes were inducible under abiotic stresses. Likewise, the transcript of BrRZFP3 was strongly induced (~12-folds) by exogenous abscisic acid, whereas the transcripts of BrRZFP1, BrRZFP2 and BrRZFP3 were (> 9-folds) induced by cold. We suggest that these BrRZFPs that function as signal or response to abiotic stress are useful for crop improvement.

• Journal of fish pathology
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• v.22 no.2
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• pp.107-113
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• 2009

Catfish Silurus asotus sampled from a pond farm in Korea, was affected with an epithelial tumor resembling catfish Ameiurus nrbulosus lip and mouth epithelioma. The neoplasm appeared in the form of solitary, multiple, large and fleshy masses upon the skin, fin or barbel. The epithelial tumor proliferation causes papillary folds supported by connective tissue cords. These folds extended above the normal skin surface and into the underlying dermis. In some area, proliferation of mucous cells or club cells were observed. The epithelial cells of the tumor were dispersed with no orderly arrangement. This is the first report on epithelioma of catfish in Korea.

• Korean Journal of Pharmacognosy
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• v.52 no.1
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• pp.41-48
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• 2021

This research was conducted to investigate the antibacterial and anti-inflammatory effects of MeOH Ex. of Salvia miltiorrhiza (MESM) against oral pathogenic bacteria. Minimum inhibitory concentration (MIC), removal effect of biofilm produced by Streptococcus mutans, effect of gene expression of proinflammatory cytokines and effect of production of proinflammatory cytokine of MESM were tested. MESM showed moderated antibacterial activity against oral pathogenic bacteria. About 89±8% of biofilms produced by S. mutans were removed by MESM at a concentration of 1 mg/mL. Gene expression of IL-1β and TNF-α induced by Porphyromonas gingivalis were 8~9 folds reduced by MESM. Gene expression of IL-8 induced by Fusobacterium nucelatum were 12 folds reduced by MESM. Production of IL-1β, TNF-α and IL-8 were significantly suppressed by MESM. Conclusively, MESM showed potent antibacterial and anti-inflammatory effect against oral pathogenic bacteria.

• Journal of Multimedia Information System
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• v.9 no.1
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• pp.21-32
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• 2022

Early-stage diagnosis of Alzheimer's Disease (AD) from Cognitively Normal (CN) patients is crucial because treatment at an early stage of AD can prevent further progress in the AD's severity in the future. Recently, computer-aided diagnosis using magnetic resonance image (MRI) has shown better performance in the classification of AD. However, these methods use a traditional machine learning algorithm that requires supervision and uses a combination of many complicated processes. In recent research, the performance of deep neural networks has outperformed the traditional machine learning algorithms. The ability to learn from the data and extract features on its own makes the neural networks less prone to errors. In this paper, a dense neural network is designed for binary classification of Alzheimer's disease. To create a classifier with better results, we studied result of different activation functions in the prediction. We obtained results from 5-folds validations with combinations of different activation functions and compared with each other, and the one with the best validation score is used to classify the test data. In this experiment, features used to train the model are obtained from the ADNI database after processing them using FreeSurfer software. For 5-folds validation, two groups: AD and CN are classified. The proposed DNN obtained better accuracy than the traditional machine learning algorithms and the compared previous studies for AD vs. CN, AD vs. Mild Cognitive Impairment (MCI), and MCI vs. CN classifications, respectively. This neural network is robust and better.

• Proceedings of the Korea Water Resources Association Conference
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• 2021.06a
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• pp.292-292
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• 2021

최근 데이터 과학의 획기적인 발전으로 딥러닝(Deep Learning) 알고리즘이 개발되어 다양한 분야에 널리 적용되고 있다. 본 연구에서는 인공신경망 중 하나인 LSTM(Long-Short Term Memory) 네트워크를 기반으로 정확한 댐유입량 예측을 수행하는 SWLSTM 모델을 제안하였다. SWLSM은 모델의 정확도를 개선하기 위해 세 가지 주요 아이디어를 채택하였다. (1) 통계적 속성 (PACF) 및 교차 상관 함수(CCF)를 사용하여 적절한 입력 변수와 시퀀스 길이를 결정하였다. (2) 선택된 입력 예측 변수 시계열을 웨이블릿 변환(WT)을 사용하여 하위 시계열로 분해한다. (3) k-folds cross validation 및 random search 기법을 사용하여 LSTM의 하이퍼 매개변수들을 효율적으로 최적화하고 검증한다. 제안된 SWLSTM의 효과는 한강 유역 5개 댐의 시단위/일단위/월단위 유입량을 예측하고 과거 자료와 비교함으로써 검증하였다. 모델의 정확도는 다양한 평가 메트릭(R2, NSE, MAE, PE)이 사용하였으며, SWLSTM은 모든 경우에서 LSTM 모델을 능가하였다. (평가 지표는 약 30 ~ 80 % 더 나은 성능을 보여줌). 본 연구의 결과로부터, 올바른 입력 변수와 시퀀스 길이의 선택이 모델 학습의 효율성을 높이고 노이즈를 줄이는 데 효과적임을 확인하였다. WT는 홍수 첨두와 같은 극단적인 값을 예측하는 데 도움이 된다. k-folds cross validation 및 random search 기법을 사용하면 모델의 하이퍼 매개변수를 효율적으로 설정할 수 있다. 본 연구로부터 댐 유입량을 정확하게 예측한다면 정책 입안자와 운영자가 저수지 운영, 계획 및 관리에 도움이 될 것이다.