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http://dx.doi.org/10.22889/KJP.2021.52.1.41

Antibacterial Activity and Anti-inflammatory Effect of Methanol Extracts of Saliva miltiorrhiza Against Oral Pathogenic Bacteria  

Lee, JungHyeok (College of Pharmacy, Sahmyook University)
Yim, Dongsool (College of Pharmacy, Sahmyook University)
Choi, SungSook (College of Pharmacy, Sahmyook University)
Publication Information
Korean Journal of Pharmacognosy / v.52, no.1, 2021 , pp. 41-48 More about this Journal
Abstract
This research was conducted to investigate the antibacterial and anti-inflammatory effects of MeOH Ex. of Salvia miltiorrhiza (MESM) against oral pathogenic bacteria. Minimum inhibitory concentration (MIC), removal effect of biofilm produced by Streptococcus mutans, effect of gene expression of proinflammatory cytokines and effect of production of proinflammatory cytokine of MESM were tested. MESM showed moderated antibacterial activity against oral pathogenic bacteria. About 89±8% of biofilms produced by S. mutans were removed by MESM at a concentration of 1 mg/mL. Gene expression of IL-1β and TNF-α induced by Porphyromonas gingivalis were 8~9 folds reduced by MESM. Gene expression of IL-8 induced by Fusobacterium nucelatum were 12 folds reduced by MESM. Production of IL-1β, TNF-α and IL-8 were significantly suppressed by MESM. Conclusively, MESM showed potent antibacterial and anti-inflammatory effect against oral pathogenic bacteria.
Keywords
Anti-inflammatory effects; MeOH Ex. of Salvia miltiorrhiza; Oral pathogenic bacteria; IL-$1{\beta}$ TNF-${\alpha}$;
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