• Journal of the Korean Society of Safety
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• v.35 no.6
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• pp.32-45
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• 2020

The problem of determining the discharge rates of gases from pressurized vessels through pressure relief devices was dealt with comprehensively. First, starting from basic fluid flow equations, detailed modeling procedures were presented for isentropic nozzle flows and frictional flows in a pipe, respectively. Meanwhile, physical explanations were given to choking phenomena in terms of the acoustic velocity, elucidating the widespread use of Mach numbers in gas flow models. Frictional flows in a pipe were classified into adiabatic, isothermal, and general flows according to the heat transfer situation around the pipe, but the adiabatic flow model was recommended suitable for gas discharge through pressure relief devices. Next, for the isentropic nozzle flow followed by adiabatic frictional flow in the pipe, two equations were established for two unknowns that consist of the Mach numbers at the inlet and outlet of the pipe, respectively. The relationship among the ratio of downstream reservoir pressure to upstream pressure, mass flux, and total frictional loss coefficient was shown in various forms of MATLAB 2-D plot, 3-D surface plot and contour plot. Then, the profiles of gas properties and velocity in the pipe section were traced. A method to quantify the relationship among the pressure head, velocity head, and total friction loss was presented, and was used in inferring that the rapid increase in gas velocity in the region approaching the choked flow at the pipe outlet is attributed to the conversion of internal energy to kinetic energy. Finally, the Levenspiel chart reproduced in this work was compared with the Lapple chart used in API 521 Standatd.

• Journal of Ginseng Research
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• v.47 no.3
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• pp.440-447
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• 2023

Background: The human hair follicle undergoes cyclic phases-anagen, catagen, and telogen-throughout its lifetime. This cyclic transition has been studied as a target for treating hair loss. Recently, correlation between the inhibition of autophagy and acceleration of the catagen phase in human hair follicles was investigated. However, the role of autophagy in human dermal papilla cells (hDPCs), which is involved in the development and growth of hair follicles, is not known. We hypothesized that acceleration of hair catagen phase upon inhibition of autophagy is due to the downregulation of Wnt/β-catenin signaling in hDPCs, and that components of Panax ginseng extract can increase the autophagic flux in hDPCs. Methods: We generated an autophagy-inhibited condition using 3-methyladenine (3-MA), a specific autophagy inhibitor, and investigated the regulation of Wnt/β-catenin signaling using the luciferase reporter assay, qRT-PCR, and western blot analysis. In addition, cells were cotreated with ginsenoside Re and 3-MA and their roles in inhibiting autophagosome formation were investigated. Results: We found that the unstimulated anagen phase dermal papilla region expressed the autophagy marker, LC3. Transcription of Wnt-related genes and nuclear translocation of β-catenin were reduced after treatment of hDPCs with 3-MA. In addition, treatment with the combination of ginsenoside Re and 3-MA changed the Wnt activity and hair cycle by restoring autophagy. Conclusions: Our results suggest that autophagy inhibition in hDPCs accelerates the catagen phase by downregulating Wnt/β-catenin signaling. Furthermore, ginsenoside Re, which increased autophagy in hDPCs, could be useful for reducing hair loss caused by abnormal inhibition of autophagy.

• Nuclear Engineering and Technology
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• v.56 no.3
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• pp.1066-1080
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• 2024

SMART100 has a containment pressure and radioactivity suppression system (CPRSS) for passive containment cooling system (PCCS). This prevents overheating and over-pressurization of a containment through direct contact condensation in an in-containment refueling water storage tank (IRWST) and wall condensation in a CPRSS heat exchanger (CHX) in an emergency cool-down tank (ECT). The Korea Atomic Energy Research Institute (KAERI) constructed scaled-down test facilities, SISTA1 and SISTA2, for the thermal-hydraulic validation of the SMART100 CPRSS. Three separate effect tests were performed using SISTA1 to confirm the heat removal characteristics of SMART100 CPRSS. When the low mass flux steam with or without non-condensable gas is released into an IRWST, the conditions for mitigation of the chugging phenomenon were identified, and the physical variables were quantified by the 3D reconstruction method. The local behavior of the non-condensable gas was measured after condensation inside heat exchanger using a traverse system. Stratification of non-condensable gas occurred in large tank of the natural circulation loop. SISTA2 was used to simulate a small break loss-of-coolant accident (SBLCOA) transient. Since the test apparatus was a metal tank, compensations of initial heat transfer to the material and effect of heat loss during long-term operation were important for simulating cooling performance of SMART100 CPRSS. The pressure of SMART100 CPRSS was maintained below the design limit for 3 days even under sufficiently conservative conditions of an SBLOCA transient.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2004.05a
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• pp.365-369
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• 2004

Recently, Inconel 625 is used widely in offshore processing piping in order to extend the maintenance tenn and improve the quality of anti-corrosion. According to the resistance to attack in various corrosive media at temperatures from $200^{\circ}C$ to aver $1090^{\circ}C$, in combination with good low- and high-temperature mechanical strength. In general, High quality weldments for this material are readily produced by commonly used processes. in recent years, the flux cored arc welding(FCAW) process is becoming more popular due to higher deposition rate and a better weld quality as compared to the shielded metal arc welding (SMAW) process, at the same time, exhibiting equally good weld metal toughness similar to the SAW process. In this study, the weldability and weldment characteristics(mechanical properties and corrosive environment) of Inconel 625 are considered in FCAW weld associated with the several weld shielding gases($80\%Ar\;+\;20\%\;CO_2,\;50\%Ar\;+\;50\%\;CO_2,\;100\%\;CO_2$) in viewpoint of welding productivity.

• Journal of Advanced Marine Engineering and Technology
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• v.33 no.2
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• pp.244-251
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• 2009

Porous media have especially large surface area per volume, which contain complex fluid passage. If porous media can be applied to cool a CPU or an electronic device with large heat dissipation, it could result in heat transfer enhancement due to the enlargement of the heat transfer area and the flow disturbance. This study is aimed to identify the heat transfer and pressure drop characteristics of high-porosity metal foams in a horizontal channel. Experiment is performed with the various heat flux, velocity and pore density conditions. Permeabilities, which is deduced from Non-Darcy flow model, become lower with increasing pore density. Nusselt number also decreases with higher pore density. High pore density with same porosity case shows higher pressure loss due to the increase of surface area per unit volume. The fiction factor decreases rapidly with increase of Reynolds number in Darcy flow region. However, it converges to a constant value of the Ergun coefficient in Non-Darcy flow region.

• The Bulletin of The Korean Astronomical Society
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• v.38 no.2
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• pp.95.1-95.1
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• 2013

The RBSPICE (Radiation Belt Storm Probes Ion Composition Experiment) is one of five instrument suites onboard the twin Van Allan Probes (or Radiation Belt Storm Probes; RBSP), launched August 30, 2012 by NASA. One of science targets of RBSPICE instrument is to determine "how changes in that ring current affect the creation, acceleration, and loss of radiation belt particles?". For that purpose, it measures ions and electrons simultaneously. Ion's energy range is from ~20 keV to ~1 MeV and electron's energy channel is from ~35 keV to 1 MeV in order to provide supplementary information about the radiation belts. In this paper, we investigate a reliability of the electron flux measured from the RBSPICE by comparing with ECT (The Energetic Particle, Composition and Thermal Plasma Suite) data. We found there is a critical proton contamination problem in the electron channels of ~ 1MeV of RBSPICE observations during one moderate storm event of Sym H ~ -76 nT on March 1, 2013.

• Proceedings of the KSME Conference
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• 2004.11a
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• pp.96-101
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• 2004

Conventionally, SMAW process was applied to join pipes of RCL, which caused lot of loss in time and cost due to excessive heat input and defects in joining section. Recently, narrow-gap welding(NGW) process was introduced to overcome the disadvantages of SMAW. However, the application of NGW to nuclear power plant is not yet common because safety of NGW process is not proven. In present paper, the welded coupons are made of carbon steel. They are manufactured under different processes; general welding(GW), post-weld heat treatment(PWHT) after GW, repair welding after GW and PWHT with repair welding after GW in carbon steel. Performed are various mechanical tests investigation of microstructure, hardness test, tensile test at room and high temperature, bending test, impact test and J-R test. It is verified that the mechanical properties of carbon steel are greatly changed after repair welding process due to applied heat flux, and that the effect of PWHT is beneficial.

• Molecules and Cells
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• v.43 no.5
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• pp.431-437
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• 2020

The hypothalamus is a crucial organ for the maintenance of appropriate body fat storage. Neurons in the hypothalamic arcuate nucleus (ARH) detect energy shortage or surplus via the circulating concentrations of metabolic hormones and nutrients, and then coordinate energy intake and expenditure to maintain energy homeostasis. Malfunction or loss of hypothalamic ARH neurons results in obesity. Accumulated evidence suggests that hypothalamic inflammation is a key pathological mechanism that links chronic overconsumption of a high-fat diet (HFD) with the development of obesity and related metabolic complications. Interestingly, overnutrition-induced hypothalamic inflammation occurs specifically in the ARH, where microglia initiate an inflammatory response by releasing proinflammatory cytokines and chemokines in response to excessive fatty acid flux. Upon more prolonged HFD consumption, astrocytes and perivascular macrophages become involved and sustain hypothalamic inflammation. ARH neurons are victims of hypothalamic inflammation, but they may actively participate in hypothalamic inflammation by sending quiescence or stress signals to surrounding glia. In this mini-review, we describe the current state of knowledge regarding the contributions of neurons and glia, and their interactions, to HFD-induced hypothalamic inflammation.

• Transactions of the Korean Society of Mechanical Engineers
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• v.11 no.1
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• pp.105-109
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• 1987

Artificial roughness as a means of improving heat transfer gains more interest, especially for application to various heat exchanger. This study present experimental information for single-phase free and force convection heat transfer in a circular tube containing a internal spiral ribs. To examine the effect of inclined angle of tube, it was varied from 0 deg to 90 deg (0.deg., 22.5.deg., 45.deg., 90.deg.) with horizontal. Length of tube is 1.6m, and width, height and helix angle of rib are 4.2mm, 1.5mm, and 60 deg respectively. Water was used as a working fluid and test piece was heated with a constant heat flux by electric heater. Experiments have been performed with the range of modified Grashof number from 2 * 10$^{6}$ to 15 * 10$^{6}$ for free convection and with the range of Reynolds number from 3,000 to 40,000 for forced convection. Since the increase in heat transfer coefficients influence directly to the friction coefficient of the tube, the changes of the friction factors are also presented for several different cases considered in this investigation.

• Proceedings of the KIEE Conference
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• 2007.11b
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• pp.12-14
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• 2007

A voltage transformer (VT) is used to transform a high voltage into a low voltage as an input for a metering device or a protection relay. VTs use an iron core which maximizes the flux linkage. The primary current of the VT has non-fundamental components caused by the hysteresis characteristics of the iron core. It causes a voltage drop in the winding impedances resulting in the error of the VT. This paper describes a compensation algorithm for the VT. The proposed algorithm can compensate the secondary voltage of VT by calculating the primary current from the exciting current of the hysteresis loop in the voltage transformer. In this paper, the exciting branch was divided into a non-linear core loss resistor and a non-linear magnetizing inductor. The performance of the proposed algorithm was validated under various conditions using EMTP generated data. Test results show that the proposed compensation algorithm can improve the accuracy of the VT significantly.