• 대한수의학회지
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• 제57권1호
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• pp.55-57
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• 2017

A 5-year-old, 2.7 kg, spayed female Scottish Fold cat presented with hematemesis after administration of oral zaltoprofen, a non-steroidal anti-inflammatory drug, by the owner. Diagnostic imaging and blood analyses indicated development of acute kidney injury (AKI) resulting from zaltoprofen ingestion. To correct dehydration and anemic conditions, the cat received intravenous fluid therapy with whole blood transfusion and peroral N-acetylcysteine. Clinical signs resolved, but persistent azotemia was unresolved indicating that AKI could progress to chronic kidney disease. This case suggests that although zaltoprofen may have low adverse effects on humans, administration of zaltoprofen in cats can have serious adverse effects.

• 한국동물위생학회지
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• 제44권2호
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• pp.113-117
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• 2021

Cocklebur poisoning in livestock can cause sudden death, with clinical signs include depression, inappetite, blindness, reluctance to move, hypersensitivity, ataxia and coma. The cause of cocklebur poisoning is ingestion of cocklebur sprout or seed, which contains carboxyatractyloside. In December 2020, a 47 month-old Hanwoo suddenly developed ataxia, and died after several hours. Hay mixed cocklebur seeds was fed to Hanwoo for 4 days before the symptoms. At autopsy, petechia and ecchymosis were seen on serous membrane of rumen and intestines. Peritoneal cavities contained a yellowish fluid and, hypoglycemia (Glu <20 mg/dL) was measured in blood test result. Microscopic lesions were karyolysis of centriloular hepatocyte and hemorrhage. Based on autopsy, blood and histopathological test, we diagnosed this case as cocklebur poisoning in Hanwoo.

• Applied Microscopy
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• 제35권2호
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• pp.81-87
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• 2005

주류의 섭취가 산업화학물질의 생체 내 독성유발에 어떠한 영향을 미치는지를 검초하기 위해 흰쥐를 이용하여 15% 에탄올을 6주간 섭취시킨 후, cyclohexane (CH)을 2일 간격으로 4회 복강 투여하고 24시간 후 다음과 같은 결과를 얻었다. 체중 당 폐 무게와 폐 세척액 내 단백질 함량은 에탄올 전처치군이 대조군과 비교하여 증가되었고, 폐 조직 중 glucose-6-phosphatase의 활성은 감소되었다. 형태학적 변화에서도 CH만 투여한 군과 비교하여 에탄올 6주 섭취 후 CH를 투여한 군에서 부분적인 무기폐현상과 색전현상이 심화되어 나타났다. 따라서 CH 투여 시 에탄올을 전처치함으로써 간 조직 중 CH 효소의 활성이 증가되어, 과잉의 대사부산물들이 폐에 분포됨으로 인해 폐 조직의 손상이 심화되는 것으로 나타났다.

• Clinical and Experimental Pediatrics
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• 제54권10호
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• pp.414-421
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• 2011

Purpose: Recently, an increase in the number of patients sensitized to rice allergen with or without clinical symptoms has been reported. This study was designed to determine the major allergens in rice and their clinical significance. Methods: Twenty-four children (15 boys and 9 girls; mean age, 16.3 months) with allergic disease, who were sensitized to rice antigen (by UniCAP) in the Pediatric Allergy Respiratory Center at Soonchunhyang University Hospital, were enrolled in this study. The allergenicity of various types of rice (raw, cooked, and heat-treated, simulated gastric fluid [SGF], and simulated intestinal fluid [SIF]) was investigated using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoglobulin E (IgE) immunoblots. The patients' medical records, including laboratory data and allergy symptoms after ingestion of rice were reviewed. Results: Patients were sensitized to an average of 13.5 food antigens and their mean total IgE was 6,888.7 kU/L. In SDS-PAGE, more than 16 protein bands were observed in the raw rice, whereas only 14-16 kDa and 31-35 kDa protein bands were observed in cooked rice. The common SDS-PAGE protein bands observed in SGF-, SIF-, and heat-treated rice were 9, 14, and 31 kDa. In a heated-rice IgE immunoblot, protein bands of 9, 14, and 31-33 kDa were found in 27.8%, 38.9%, and 38.9% of all sera, respectively, and in 50%, 50%, and 75%, of ser a from the 4 symptomatic patients, respectively. Conclusion: The 9-, 14-, and 31-kDa protein bands appeared to be the major allergens responsible for rice allergy symptoms.

• Tuberculosis and Respiratory Diseases
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• 제49권5호
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• pp.639-643
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• 2000

A 33-year-old woman was presented with dyspnea and chest discomfort after indigesting approximately 500ml of oil paint brush washing fluid. Hypoxic symptoms and radiographic infiltrates rapidly progressed. The patient was intubated and received mechanical ventilation. Bronchoalveolar lavage and transbronchial lung biopsies were performed. The CT scan of the lung showed bilateral extensive pneumonitis with necrosis and the lung tissue pathologic findings showed diffuse alveolar damage with extensive necrosis and numerous lipid-laden macrophages. After intensive medical care with mechanical ventilation, her symptoms and radiological findings improved.

• 대한임상독성학회지
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• 제7권1호
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• pp.38-40
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• 2009

Formalin is a water-soluble, colorless, pungent, irritating and highly reactive gas. A 40% solution of formaldehyde in water, also known as formalin, is used as a disinfectant, antiseptic, deodorant, tissue fixative and embalming fluid. Ingestion can lead to immediate deleterious effects on almost all systems of the body including gastrointestinal tract, central nervous system, cardiovsacular system and hepato-renal system, causing gastrointestinal hemorrhage, cardiovsacular collapse, unconsciousness or convulsions, severe metabolic acidosis and acute respiratory distress syndrome. We treated a 39-year-old woman who ingested 300 ml formalin in a suicidal attempt. Despite hemodialysis, death occurred after 23 h.

• 한국임상수의학회지
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• 제32권4호
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• pp.385-388
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• 2015

Three cases of hepatic encephalopathy were diagnosed in scimitar-horned oryxs housed at a zoo. Administration of amino acid and ornithine-aspartate fluid therapy via an intravenous injection decreased serum levels of ammonia and liver enzymes in cases 1 and 2. Further, additional oral ingestion of non-absorbable disaccharide lactulose to eliminate intestinal nitrogenous products enabled recovery of two oryxs. However, in case 3, the serum levels of ammonia and liver enzymes increased even after treatment, and the oryx died. Necropsy revealed cecum and colon compaction due to stiff dried feces, and this condition could have an adverse effect on increased blood ammonia levels that may have caused mortality. Overconsumption of pellets may have been the primary cause of hepatic encephalopathy. Thus, a fiber rich diet with decreased amount of pellets is needed to prevent hepatic encephalopathy, since the normal diet of scimitar-horned oryxs is rich in fiber.

• Advances in aircraft and spacecraft science
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• 제5권3호
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• pp.349-362
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• 2018

A non-linear numerical simulation technique for predicting the unsteady performances of an airbreathing engine is developed. The study focuses on the simulation of integrated propulsion systems, where a closer coupling is needed between the airframe and the engine dynamics. In fact, the solution of the fully unsteady flow governing equations, rather than a lumped volume gas dynamics discretization, is essential for modeling the coupling between aero-servoelastic modes and engine dynamics in highly integrated propulsion systems. This consideration holds for any propulsion system when a full separation between the fluid dynamic time-scale and engine transient cannot be appreciated, as in the case of flow instabilities (e.g., rotating stall, surge, inlet unstart), or in case of sudden external perturbations (e.g., gas ingestion). Simulations of the coupling between external and internal flow are performed. The flow around the nacelle and inside the engine ducts (i.e., air intakes, nozzles) is solved by CFD computations, whereas the flow evolution through compressor and turbine bladings is simulated by actuator disks. Shaft work balance and rotor dynamics are deduced from the estimated torque on each turbine/compressor blade row.

• Tuberculosis and Respiratory Diseases
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• 제65권3호
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• pp.239-242
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• 2008

외인성 지방성 폐렴은 자세한 병력 청취 없이는 의심하기 힘든 비교적 드문 질환이다. 저자들은 비특이적인 임상 증상과 방사선 소견을 보인 환자에서 스쿠알렌을 섭취한 과거력에 주목하였으며 외인성 지방성 폐렴을 의심 하에 기관지폐세척술 및 폐 생검을 통하여 확진하였다.

• Nutritional Sciences
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• 제9권2호
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• pp.124-130
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• 2006

To examine the effects of alcohol consumption on body fluid restoration and fat mobilization following exercise induced dehydration, nine healthy collegiate men ($24{\pm}2yrs,\;177{\pm}5cm,\;72{\pm}8kg,\;10.5{\pm}2.3%$ body fat) underwent three experiments. In each experiment, subjects ran on a treadmill to reduce individual body mass to $2.2{\pm}0.1%$ and consumed one of three beverages containing 0, 4, or 8% alcohol over 60 min followed by 4 hr of resting recovery. They consumed approximately 150% of weight loss $(2053{\pm}204,\;2091{\pm}149,\;and\;1943{\pm}295mL)$ and content of alcohol was $9.9{\pm}1.0(0%),\;71.9{\pm}5.1(4%)$, and $132.2{\pm}20.1g$ (8% trial). Body weight, urine volume and samples, blood samples, and thirst sensation were measured five times; at baseline, immediately after exercise, and 0, 1st, and 4th hr of recovery. Blood alcohol concentration after ingestion was $0.0{\pm}0.0(0%),\;0.1{\pm}0.02(4%)$, and $0.2{\pm}0.03%$ (8% trial). No differences in blood sodium and potassium concentrations, and urine specific gravity were noticed over time periods and trials. Thirst sensation tended to be elevated in all trials immediately after exercises and urine output was elevated during the recovery. The magnitude of changes in these variables was proportional to the alcohol concentrations, but not statistically significant. While serum osmolality was not different among trials and time periods in 0 and 4% trials, it was higher during recovery than the baseline in the 8% trial (P<0.01). Triglycerides did not change throughout the time period and among trials. Free fatty acids were elevated after exercise in all trials and 4th hr of recovery in 0% (P<0.05). Subjects' net body fluid balance at 4th hr of recovery was negatively maintained and proportional to alcohol concentrations. Only 8% trials showed a significant reduction at 1st and 4th hr of recovery compared to 0 hr. The results suggested that diuretic effect of alcohol after moderate level of dehydration appeared dose dependent, but beverage containing alcohol up to 4% did not induce impaired rehydration than alcohol free drinks. Alcohol effects on fat mobilization during recovery appeared to be minimal and the mechanism is unclear.