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Acute kidney injury caused by administration of zaltoprofen in a cat

  • Baek, Woon-Bum (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University) ;
  • Kim, Hak-Hyun (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University) ;
  • Kang, Byeong-Teck (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University) ;
  • Kang, Ji-Houn (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University) ;
  • Yang, Mhan-Pyo (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University)
  • Received : 2016.08.10
  • Accepted : 2017.01.09
  • Published : 2017.03.31

Abstract

A 5-year-old, 2.7 kg, spayed female Scottish Fold cat presented with hematemesis after administration of oral zaltoprofen, a non-steroidal anti-inflammatory drug, by the owner. Diagnostic imaging and blood analyses indicated development of acute kidney injury (AKI) resulting from zaltoprofen ingestion. To correct dehydration and anemic conditions, the cat received intravenous fluid therapy with whole blood transfusion and peroral N-acetylcysteine. Clinical signs resolved, but persistent azotemia was unresolved indicating that AKI could progress to chronic kidney disease. This case suggests that although zaltoprofen may have low adverse effects on humans, administration of zaltoprofen in cats can have serious adverse effects.

Keywords

References

  1. Beale BS. Use of nutraceuticals and chondroprotectants in osteoarthritic dogs and cats. Vet Clin North Am Small Anim Pract 2004, 34, 271-289. https://doi.org/10.1016/j.cvsm.2003.09.008
  2. Court MH, Greenblatt DJ. Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms. Pharmacogenetics 2000, 10, 355-369. https://doi.org/10.1097/00008571-200006000-00009
  3. Gaunt SD, Baker DC, Green RA. Clinicopathologic evaluation N-acetylcysteine therapy in acetaminophen toxicosis in the cat. Am J Vet Res 1981, 42, 1982-1984.
  4. Hietanen E, Vainio H. Interspecies variations in small intestinal and hepatic drug hydroxylation and glucuronidation. Acta Pharmacol Toxicol (Copenh) 1973, 33, 57-64.
  5. Innes JF, Clayton J, Lascelles BDX. Review of the safety and efficacy of long-term NSAID use in the treatment of canine osteoarthritis. Vet Rec 2010, 166, 226-230. https://doi.org/10.1136/vr.c97
  6. Ito A, Mori Y. Effect of a novel anti-inflammatory drug, 2-(10,11-dihydro-10-oxo-dibenzo[b,f]-thiepin-2-yl)propionic acid (CN-100), on the proteoglycan biosynthesis in articular chondrocytes and prostaglandin E2 production in synovial fibroblasts. Res Commun Chem Pathol Pharmacol 1990, 70, 131-142.
  7. King JN, Hotz R, Reagan EL, Roth DR, Seewald W, Lees P. Safety of oral robenacoxib in the cat. J Vet Pharmacol Ther 2012, 35, 290-300. https://doi.org/10.1111/j.1365-2885.2011.01320.x
  8. Lascelles BD, Court MH, Hardie EM, Robertson SA. Nonsteroidal anti-inflammatory drugs in cats: a review. Vet Anaesth Analg 2007, 34, 228-250. https://doi.org/10.1111/j.1467-2995.2006.00322.x
  9. Luna SP, Basilio AC, Steagall PVM, Machado LP, Moutinho FQ, Takahira RK, Brandao CVS. Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs. Am J Vet Res 2007, 68, 258-264. https://doi.org/10.2460/ajvr.68.3.258
  10. Pezzilli R, Morselli-Labate AM, Corinaldesi R. NSAIDs and acute pancreatitis: a systematic review. Pharmaceuticals (Basel) 2010, 3, 558-571. https://doi.org/10.3390/ph3030558
  11. Richardson JA. Management of acetaminophen and ibuprofen toxicoses in dogs and cats. J Vet Emerg Crit Care 2000, 10, 285-291. https://doi.org/10.1111/j.1476-4431.2000.tb00013.x
  12. Simpson KW. Pancreatitis and triaditis in cats: causes and treatment. J Small Anim Pract 2015, 56, 40-49 https://doi.org/10.1111/jsap.12313
  13. Sparkes AH, Heiene R, Lascelles BD, Malik R, Sampietro LR, Robertson S, Scherk M, Taylor P; ISFM and AAFP. ISFM and AAFP consensus guidelines: long-term use of NSAIDs in cats. J Feline Med Surg 2010, 12, 521-538. https://doi.org/10.1016/j.jfms.2010.05.004
  14. Tsurumi K, Kyuki K, Niwa M, Mibu H, Fujimura H. Pharmacological investigations of the new antiinflammatory agent 2-(10,11-dihydro-10-oxodibenzo[b,f] thiepin-2-yl)propionic acid. 2nd communication: inhibitory effects on acute inflammation and prostaglandin-related reactions. Arzneimittelforschung 1986, 36, 1801-1805.
  15. Weir MR. Renal effects of nonselective NSAIDs and coxibs. Cleve Clin J Med 2002, 69 (Suppl), SI53-58.