• KSCE Journal of Civil and Environmental Engineering Research
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• v.40 no.3
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• pp.303-314
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• 2020

The hydrological characteristics of watersheds and hydraulic systems of urban and river floods are highly nonlinear and contain uncertain variables. Therefore, the predicted time series of rainfall-runoff data in flood analysis is not suitable for existing neural networks. To overcome the challenge of prediction, a NARX (Nonlinear Autoregressive Exogenous Model), which is a kind of recurrent dynamic neural network that maximizes the learning ability of a neural network, was applied to forecast a flood in real-time. At the same time, NARX has the characteristics of a time-delay neural network. In this study, a hydrological model was constructed for the Taehwa river basin, and the NARX time-delay parameter was adjusted 10 to 120 minutes. As a result, we found that precise prediction is possible as the time-delay parameter was increased by confirming that the NSE increased from 0.530 to 0.988 and the RMSE decreased from 379.9 ㎥/s to 16.1 ㎥/s. The machine learning technique with NARX will contribute to the accurate prediction of flow rate with an unexpected extreme flood condition.

• Journal of Pharmacopuncture
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• v.16 no.3
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• pp.11-22
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• 2013

Objectives: The present investigation aimed at examining if post-cancer treatment with a potentized homeopathic drug, Condurango 30C, which is generally used to treat oesophageal cancer, could also show an ameliorating effect through apoptosis induction on lung cancer induced by benzo[a]pyrene (BaP) in white rats (Rattus norvegicus). Methods: Lung cancer was induced after four months by chronic feeding of BaP to rats through gavage at a dose of 50 mg/kg body weight for one month. After four months, the lung-cancer-bearing rats were treated with Condurango 30C for the next one ($5^{th}$), two ($5^{th}-6^{th}$) and three ($5^{th}-7^{th}$) months, respectively, and were sacrificed at the corresponding time-points. The ameliorating effect, if any, after Condurango 30C treatment for the various periods was evaluated by using protocols such as histology, scanning electron microscopy (SEM), annexinV-FITC/PI assay, flow cytometry of the apoptosis marker, DNA fragmentation, reverse transcriptase-polymerase chain reaction (RT-PCR), immunohistochemistry, and western blot analyses of lung tissue samples. Results: Striking recovery of lung tissue to a near normal status was noticed after post-cancerous drug treatment, as evidenced by SEM and histology, especially after one and two months of drug treatment. Data from the annexinV-FITC/PI and DNA fragmentation assays revealed that Condurango 30C could induce apoptosis in cancer cells after post-cancer treatment. A critical analysis of signalling cascade, evidenced through a RT-PCR study, demonstrated up-regulation and down-regulation of different pro- and anti-apoptotic genes, respectively, related to a caspase-3-mediated apoptotic pathway, which was especially discernible after one-month and two-month drug treatments. Correspondingly, Western blot and immunohistochemistry studies confirmed the ameliorative potential of Condurango 30C by its ability to down-regulate the elevated epidermal growth factor receptor (EGFR) expression, a hallmark of lung cancer. Conclusion: The overall result validated a positive effect of Condurango 30C in ameliorating lung cancer through caspase-3-mediated apoptosis induction and EGFR down-regulation.

• The Journal of the Korea Contents Association
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• v.12 no.4
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• pp.401-406
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• 2012

Shanghai Stock Exchange is the largest stock exchange of emerging markets that there were listed firms 905, listed securities 1,537, listed stocks 949, total number of listed stocks 2 trillion 2000 billion shares. There is more development that is expected to occur in the future. The purpose of this study is to find determinants of capital structure to listed manufacturing firms in Shanghai Stock Exchange using multiple regression. Conclusions of this study are summarized as follows. First, firm size is positively related to debt ratio significantly at 1% significance level.. Second, the profitability is negatively related to debt ratio significantly at 1% significance level. Third, the growth ability is positively related to debt ratio significantly at 1% significance level. fourth, cash flow, the largest shares ownership, negotiable shares ratio are negatively related to debt ratio but they are not significant statistically. The result of this study provides information for investors and can be utilized to improvement of financial structure.

• The Journal of the Korea Contents Association
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• v.16 no.2
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• pp.287-294
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• 2016

The whole design process drawing outputs from design planning is based on designers' intuitive ideas and differences in technical ability. However, every design professional agrees to the fact that such design process is filled with individuals' implicit acts or inherent intuition rather than following directions in a certain defined frame. If the design process based on such intuition and experience can start from the rational and scientific process, it would be possible to move more systematic design process to the next step. This study aims to examine what system of thinking are used by designers to conduct the design information process, by using the protocol analysis which is the representative qualitative study method of cognitive science, on designers' cognitive behaviors like the contents of the design sketch process which is the initial step of the kitchenware development process, in order to understand professionals' and non-professionals' design application direction. Thus, the scope of this paper would be limited to "the initial protocol analysis on kitchenware" and "encoding of the analysis on thinking" in the qualitative study that can be the most basic to understand the design cognitive science. As a procedure to solve this study question, it aimed to seek for the product development flow and the educational effect by considering the preceding researches and also re-interpreting cognitive thinking in systematic methods.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.4 no.1
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• pp.177-197
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• 1998

This experimental study was carried out to evaluate the effect of Yipahnsan on angiogenic inhibition mechanism. This study investigates the effects of Yipahnsan on angiogenic inhibition mechanism evaluate cell adhesive inhibition effect, DNA fragmantaion analysis, nuclear condensation assay, FACScan analysis, angiogenic lumen formation assay, immunocytochemistry analysis, RT-PCR for mRNA expression, western blot analysis, confocal analysis for $Ca^{2+}influx$. The results were summarized as follows : 1. The cell adhesive inhibition ability was strongly increased from $5{\mu}g/ml$ on ECV304 cell line and ECVPAR cell line. 2. YY water extract caused $G_0/G_1$ arrest peak to existed on the ECV304 cell line. 3. YY water extract caused inhibition of proliferation and inducement of apoptosis on the collagen coated plate in ECV304 cell line. 4. YY water extract inhibited the lumen formation on the matrigel coated plate in ECV304 cell line. 5. YY water extract inhibited the expressions of LFA-1 and ELAM-1 on ECV304 cell line and ECVPAR cell line. 6. YY water extract inhibited the expressions of MMP-9 and uPA on ECV304 cell line and ECVPAR cell line. 7. YY water extract inhibited the expression of integrin ${\alpha}_v{\beta}_3$ on ECV304 cell line and ECVPAR cell line. 8. YY water extract decreased the change of $Ca^{2+}$ in intracellular on ECV304 cell line and ECVPAR cell line. According to the results, Yipahnsan showed to be a key antagonist of integrin ${\alpha}_v{\beta}_3$, and to be induction of apoptosis by p53 through flow cytometry. This report also demonstrated that expressions of MMP-9 and uPA were blocked under the angiogenesis model. Thus, we suggested that Yipahnsan blocks angiogenesis by inducing apoptosis in ECV304 and ECVPAR cell lines, and another oriental herbal medicine that treats qi-stagnation and blood-stasis type also has angiogenic inhibition effects.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.4 no.1
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• pp.17-36
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• 1998

This experimental study was carried out to evaluate the effects of Hwallakhyoreungdan on angiogenic inhibition mechanism. In order to investigate the effects of Hwallakhyoreungdan on angiogenic inhibition mechanism, MTT assay, cell adhesive inhibition effect, DNA fragmantaion analysis, Nuclear condensation assay, FACScan analysis, Angiogenic lumen formation assay, Immunocytochemistry analysis, RT-PCR for mRNA expression, Western blot analysis and Confocal analysis for $Ca^{2+}$ change were performed. The results were summarized as follows: 1. The cell adhesive inhibition ability was strong from $5{\mu}g/ml$. 2. The $G_0/G_1$ arrest peak was existed on ECV304 cell-line. 3. The cells on Collagen plate were inhibition of proliferation and inducement of apoptosis by HR water extract. 4. Angiogenic lumen formation was inhibited by HR water extract. 5. LFA-1 and ELAM-1's expression were inhibited by HR water extract. They are commenly participation on inflammation and tumor regeneration. 6. The expression of MMP-9 and uPA were inhibited by HR water extract. 7. The expression of integrin ${\alpha}_v{\beta}_3$ was inhibited by HR water extract. 8. The expression of intracellular molecule were successively inhibited by HR water extract therefore the proliferation of ECV304 cell line was stopped and apoptosis was induced. 9. The change of $Ca^{2+}$ was decreased by HR water extract it cause confusion of signal transduction pathway therefore it was take part in apoptosis. According to the results, Hwallakhyoreungdan showed to be a key antaonist of integrin ${\alpha}_v{\beta}_3$, and to be induction of apoptosis by p53 through flow cytometry. This report also demonstrated that expressions of MMP-9 and uPA was blocked under the angiogenesis model. Thus, we suggests that Hwallakhyoreungdan blocks angiogenesis by inducing apoptosis of ECV304 and ECVPAR cell lines and another oriental herbal medicine that treats blood-stasis type also has angiogenic inhibition effects.

• The Journal of the Korea Contents Association
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• v.18 no.3
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• pp.256-264
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• 2018

The purpose of this study was to investigate the relationship between oral health behaviors and the results of the oral dysentery test for dental hygienists and students at Gyeonggi - do and Chungcheongnam - do. Self - filling questionnaires and oral diseases. The following conclusions were obtained. The most common toothbrushing frequency was three times a day (60.2%), and the most dominant frequency of eating between meals was once or less(49.7%). The most common snack that they had was stickiness-free sweetened food(66.5%), and the type of beverage that they had the most was sweetened beverages(49.7%). The average stimulated saliva flow rate was 9.41ml, and they got a mean of 9.52 in the buffering capacity of saliva. The average glucose clearance time was a mean of 12.02. When they took a streptococcus mutans colony count test, 80.1 percent belonged to the low-risk group(<$10^5$), and 82.6 percent belonged to the low-risk group(<$10^5$) when a lactobacillus test was conducted. There was a positive correlation between the irritant saliva fraction and the non-irritating saliva and saliva buffering ability. In the fluoride application experience, the glucose retention time was 10.66 minutes and the fluoride application experience was 13.33 minutes. (P = .008). The importance of oral health, which is directly linked to general health, should be emphasized in order to improve the quality of life as well as the life expectancy. For oral health, which is directly linked to systemic health, it is necessary to provide opportunities for oral health education that can be easily accessed by the public, and to continuously develop and provide oral health care programs for a lifetime.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.9B
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• pp.751-759
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• 2008

Carrier Ethernet backbone network integrates distributed layer-2 based metro networks. In this networks, Multiple Spanning Tree Protocol (MSTP) has been uscd as a main routing protocol that allows multiple spanning trees in a network. A better routing protocol called IEEE802.1aq - Shortest Path Bridging (SPB) is recently proposed, that generates the shortest spanning tree per a destination node. As SPB provides a routing path per a destination node, there is no way to adapt network traffic at normal condition. If we are free from the principle of "a spanning tree per a destination node", we can achieve adaptive routing. Based on this philosophy, we propose a new spanning tree based protocol - Edge Node Divided Spanning Tree (ENDIST). ENDIST divides an edge node into sub-nodes as many as connecting links from the node and each sub-node generates a single shortest path tree based on SPB. Depending on network or nodal status, ENDIST chooses a better routing path by flow-basis. This added traffic engineering ability contributes to enhanced throughput and reduced delay in backbone networks. The simulation informs us that ENDIST's throughput under heavy load performs about 3.4-5.8 and 1.5-2.0 times compared with STP's and SPB's one respectively. Also, we verified that ENDIST's throughput corresponds to the theoretical upper bound at half of cases we investigated. This means that the proposed ENDIST is a dramatically enhanced and the close-to-perfect spanning tree based routing schemes.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1299-1308
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• 2016

Our previous studies clearly demonstrated that a combination of WP 631 and Epo B has higher activity against ovarian cancer cells than either of these compounds used separately. In order to fully understand the exact mechanism of action in combination, we assessed effects on the cell cycle of SKOV-3 cells. We evaluated three control points essential for WP 631 and Epo B action to determine which cell cycle-regulating proteins (CDK1/cyclin B complex, EpCAM or HMGB1) mediate activity. The effects of the drug on the cell cycle were measured based on the nuclear DNA content using flow cytometry. Expression of cell cycle-regulating genes was analyzed using real-time PCR. It was discovered that WP 631, at the tested concentration, did not affect the SKOV-3 cell cycle. Epo B caused significant G2/M arrest, whereas the drug combination induced stronger apoptosis and lower mitotic arrest than Epo B alone. This is very important information from the point of view of the fight against cancer, as, while mitotic arrest in Epo B-treated cells could be overcame after DNA damage repair, apoptosis which occurs after mitotic slippage in combination-treated cells is irreversible. It clearly explains the higher activity of the drug combination in comparison to Epo B alone. Epo B acts via the CDK1/cyclin B complex and has the ability to inhibit CDK1, which may be a promising strategy for ovarian cancer treatment in the future. The drug combination diminishes EpCAM and HMGB1 expression to a greater degree than either WP 631 and Epo B alone. Owing to the fact that the high expression of these two proteins is a poor prognostic factor for ovarian cancer, a decrease in their expression, observed in our studies, may result in improved efficacy of cancer therapy. The presented findings show that the combination of WP 631 and Epo B is a better therapeutic option than either of these drugs alone.

• Geophysics and Geophysical Exploration
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• v.7 no.2
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• pp.109-116
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• 2004

Petroleum reservoir characterization is a process for quantitatively describing various reservoir properties in spatial variability using all the available field data. Porosity and permeability are the two fundamental reservoir properties which relate to the amount of fluid contained in a reservoir and its ability to flow. These properties have a significant impact on petroleum fields operations and reservoir management. In un-cored intervals and well of heterogeneous formation, porosity and permeability estimation from conventional well logs has a difficult and complex problem to solve by conventional statistical methods. This paper suggests an intelligent technique using fuzzy logic and neural network to determine reservoir properties from well logs. Fuzzy curve analysis based on fuzzy logics is used for selecting the best related well logs with core porosity and permeability data. Neural network is used as a nonlinear regression method to develop transformation between the selected well logs and core analysis data. The intelligent technique is demonstrated with an application to the well data in offshore Korea. The results show that this technique can make more accurate and reliable properties estimation compared with previously used methods. The intelligent technique can be utilized a powerful tool for reservoir characterization from well logs in oil and natural gas development projects.