• 약학회지
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• 제34권3호
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• pp.161-165
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• 1990

An automated, simple, and reliable method was developed for determining in vitro drug release rate from transdermal delivery dosage forms. The patch is held in position in the heating block by sandwiching it between the middle plate and the bottom plate of diffusion cell. The dissolution profile of the commercially available transdermal scopolamine patch was determined over a 72-h period, and the results were compared with those obtained with other methods; paddle-over-disk method, reciprocating method, and diffusion cell method. It was demonstrated that the flow-through method is equivalent in terms of release rate profile and accumulated released drug amount over the lifetime of the dosage form tested. Also this method is simple, reliable and reproducible. Therefore, this technique can be used in a quality control for assuring product uniformity.

• 대한수의학회지
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• 제39권6호
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• pp.1112-1118
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• 1999

Galectin-3 plays an important role in cell development, differentiation and cancer metastasis, including cell-cell/extracellular matrix (ECM) interactions and is supposed to have an effect of apoptosis on T-cells in thymic clonal selection. In this study, to know the effect of galectin-3 on thymocyte development, we used recombinant human galectin-3 (rHgal-3) from Escherichia coli, JM105, which was inserted with human gal-3 gene-transformed plasmid vector (prGal-3) to express human galectin-3. Expressed rHgal-3 was confirmed by western blot using the culture supernant of hybridoma (M3/38) producing monoclonal antibody to human galectin-3. Sepharose gel affinity chromatography was used to purify the expressed rHgal-3. Thymocytes and hepatocytes from 6-week-old male BALB/c mice were incubated with rHgal-3 and showed marked increase of apoptotic population on analysis using flow cytometry with 7-AAD in a dosedependent manner. However, rHgal-3 failed to induce apoptosis on hepatocytes. Interestingly, this apoptotic effect was not inhibited by lactose, a specific lectin domain inhibitor. From these results, we concluded that extrinsic -3 induces apoptosis on mouse thymocytes, and galectin-3 may have an apoptotic effect on T-cells in thymic clonal selection.

• Journal of Electrochemical Science and Technology
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• 제2권1호
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• pp.20-25
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• 2011

This work focuses on the behavior of the overpotential increase due to a utilization rise in a molten carbonate fuel cell. The behavior is generally explained by Nernst loss, which is a kind of voltage loss due to the thermodynamic potential gradients in a polarization state due to the concentration distribution of reactant species through the gas flow direction. The evaluation of Nernst loss is carried out with a traditional experimental method of constant gas utilization (CU). On the other hand, overpotential due to the gas-phase mass-transport resistance at the anode and cathode shows dependence on the utilization, which can be measured using the inert gas step addition (ISA) method. Since the Nernst loss is assumed to be due to the thermodynamic reasons, the voltage loss can be calculated by the Nernst equation, referred to as a simple calculation (SC) in this work. The three values of voltage loss due to CU, ISA, and SC are compared, showing that these values rise with increases in the utilization within acceptable deviations. When we consider that the anode and cathode reactions are significantly affected by the gas-phase mass transfer, the behavior strongly implies that the voltage loss is attributable not to thermodynamic reasons, namely Nernst loss, but to the kinetic reason of mass-transfer resistance in the gas phase.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2008년도 제31회 추계학술대회논문집
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• pp.411-415
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• 2008

이 논문은 고도모사 시험설비의 전체 사양을 결정에 관계되는 엔진 입구에서의 고도비행 경험을 위한 모의대기 요구 조건, 모의 비행중 쇼요되는 연료 소모량 및 공급 방법, 시험모드별 냉각부하 예측, 효과적인 압력 회복률을 위한 배기 이젝터의 최적형상 결정에 관한 고려사항을 기술하였다. 이를 위하여 엔진의 연료소모량을 고려한 엔진 배기가스의 온도 및 배출량 등의 계산을 수행되었다.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2008년도 제31회 추계학술대회논문집
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• pp.31-35
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• 2008

본 시험장치는 가스터빈 관련 교육기관, 연구소 등에 가스터빈 엔진의 작동 원리와 구조에 대한 기초지식을 제공하고 가스터빈 엔진의 이론적 열역학 계산을 실제 성능시험을 통하여 비교해 볼 수 있도록 개발되었다. 추력 30lbf급 마이크로 터보제트 엔진을 대상으로 하여 NI DAQ(데이터 수집)장치와 LabVIEW 프로그램으로 각 구성품의 온도, 압력과 추력, 연료유량, 공기유량 등의 실시간 데이터를 모니터링 및 획득할 수 있도록 시험장치를 구성하였다.

• BioChip Journal
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• 제12권4호
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• pp.257-267
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• 2018

Inertial microfluidics has attracted significant attention in recent years due to its superior benefits of high throughput, precise control, simplicity, and low cost. Many inertial microfluidic applications have been demonstrated for physiological sample processing, clinical diagnostics, and environmental monitoring and cleanup. In this review, we discuss the fundamental mechanisms and principles of inertial migration and Dean flow, which are the basis of inertial microfluidics, and provide basic scaling laws for designing the inertial microfluidic devices. This will allow end-users with diverse backgrounds to more easily take advantage of the inertial microfluidic technologies in a wide range of applications. A variety of recent applications are also classified according to the structure of the microchannel: straight channels and curved channels. Finally, several future perspectives of employing fluid inertia in microfluidic-based cell sorting are discussed. Inertial microfluidics is still expected to be promising in the near future with more novel designs using various shapes of cross section, sheath flows with different viscosities, or technologies that target micron and submicron bioparticles.

• 한국임상수의학회지
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• 제40권4호
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• pp.298-302
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• 2023

A 7-year-old neutered male, domestic shorthair cat presented anorexia and lethargy. The complete blood cell count revealed severe non-regenerative anemia, lymphocytic leukocytosis, neutropenia, and thrombocytopenia. On the peripheral blood smear examination, medium to large lymphoblastic cells with moderate amounts of basophilic cytoplasm were observed in up to 70% of peripheral leukocytes. Feline leukemia and immunodeficiency viruses were not detected using a commercial diagnostic kit. While splenomegaly and blunt margins of the caudoventral liver were observed in abdominal radiography, changes in the intra-abdominal lymph nodes were not remarkable. Ultimately, flow cytometric immunophenotyping from the peripheral blood revealed a negative for B-cell markers (CD21-/CD79a-) and T-cell markers (CD3-/CD4-/CD5-/CD8-). Based on the hematological examination and the immunophenotyping assay, the cat was diagnosed with non-B, non-T acute lymphoblastic leukemia. Here, we report a rare case of non-B, non-T acute lymphoblastic leukemia to raise awareness and provide information on clinical symptoms and laboratory test and immunophenotyping analysis results.

• 한국자동차공학회논문집
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• 제17권2호
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• pp.150-158
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• 2009

A centrifugal turbo blower is one of the part to generate electric power of fuel cell electric vehicle(FCEV). In order to generate the electric power of FCEV, the centrifugal turbo blower operates at very high speed above 30,000rpm in order to increase the pressure of the air, which supplied to a stack of FCEV, using rotation of its impeller blades. Vibration which originated from the blower is generated by unbalance of mechanical components, rotation of bearings and rotating asymmetry that rotate at high speed. The vibration is transmitted to receiving structure through vibration isolators and it can causes serious problems in the noise, vibration and harshness(NVH) performance. Thus, the study about reducing this kind of vibration is an important task. Quantifying the effectiveness of vibration isolation can be effectively accomplished by using vibrational power flow because relative contributions of each isolator to the total vibration transmission can be easily represented. In this paper, vibrational power flow is applied to the centrifugal turbo blower mounted on FCEV in order to analyze the most dominant vibration transmitting path. As a result, the main contributor among four isolators is a mount #3 of the blower. Also, a 30 percent lowering of the mount #3 stiffness shows 34 percent decrement of vibrational power flow by the simulation.

• Nuclear Engineering and Technology
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• 제16권2호
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• pp.47-57
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• 1984

2상유동을 해석하기 위한 3차원 코드인 THERMIT-6S의 미분 방정식을 세우기 위해, 수학적으로 정확하게 유도된 시간과 공간에 대해 평균한 보존 방정식을 단순화했다. 미분 방정식을 불연속화(discretization)하여 THERMIT-6S의 차분방정식을 얻는다. First-order spatial scheme, donor cell method, 그리고, staggered mesh layout을 써서 공간에 대한 불연속화를 한다. 그리고 시간에 대한 불연속화는 first-order semi-implicit scheme으로써, sonic terms와 국부적인 전달 현상에 관계되는 항들은 implicit하게 그리고 대류 전달 항들은 explicit하게 취급한다. 이렇게 얻어진 방정식들은Newton-Raphson 방법으로 선형화된다. 축소된 압력 방정식을 만들기 위해 모든 변수들이 mesh cells사이에서 단지 압력 변수를 통해서만 결부되도록, 선형화된 방정식들을 처리한다. OPERA-15 실험을 수치해석적으로 모의실험하여 본 결과, THERMIT-6S가 flow coastdown, 역류, 유체진동(flow oscillation) 등을 포함하고, sodium boiling 후의 원자로내의 변화를 예측하는데 매우 유효하다는 것이 밝혀졌다.

• 에너지공학
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• 제11권1호
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• pp.26-33
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• 2002

본 연구에서는 butterfly valve주위의 비압축성 및 압축성유동 특성을 수치해석을 통하여 조사하였다. 밸브는 문제를 단순화시키기 위하여 평판 디스크로 간주하였으며, 다양한 디스크 각도 및 압력비 변화에 대한 계산을 수행하였다. 각도가 증가함에 따라 디스크 상류면의 정체점은 디스크의 중심으로 이동하는 것을 볼 수 있었고, 입구공기의 유입 속도는 감소함을 볼 수 있었다. 최고 유속은 디스크와 벽면사이에 형성되는 vena contracta 효과에 의해 생기는 목의 하류에서 형성됨을 볼 수 있었다. 압력비를 감소함에 따라 압축성 효과는 증대되며 유동이 초음속화 되면서 생성되는 강한 wall jet에 의해 shock cell structure가 형성되는 것을 볼 수 있었다. 입구유량은 디스크 각도와 압력비의 증가에 따라서 감소하며, 압력손실계수는 디스크 각도의 증가 및 압력비의 감소에 따라 증가하였다.