• 동의생리병리학회지
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• 제23권3호
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• pp.704-709
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• 2009

The emergence of methicillin-resistant of Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) has led to an urgent need for the discovery and development of new antibacterial agents. As part of an ongoing investigation into the antibacterial properties of the natural products, (2S)-7,4'-dihydroxy-5-methoxy-8-(${\gamma}$, ${\gamma}$-dimethylally)-f1avanone (2S-DMDF), isolated from the roots of Sophora flavescens, was found to be antibacterial active MRSA and VRE. Sophora flavescens has been used as antibacterial, antiviral, antiprotozoal, anti-inflammatory. Therefore, this study investigated the antibacterial activity of 2S-DMDF against all the bacterial strains tested. In this result, at the end point of an optically clear well, the minimum inhibitory concentrations (MICs) ranged from 0.97 to 15.6 mg/ml for 2S-DMDF, from 125 to 256 mg/ml for ampicillin, and from 64 to 512 mg/ml for gentamicin with MRSA, also, 7.8 to 15.6 mg/ml for 2S-DMDF, from 125 to 256 mg/ml for ampicillin, and from 512 to 1024< mg/ml for vacomicin with VRE. These findings indicated that the application of the tested 2S-DMDF alone might prove useful in the control and treatment of MRSA and VRE infections.

• 한국산림과학회지
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• 제90권3호
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• pp.266-276
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• 2001

물들메나무(F. chiisanensis Nakai)의 분류학적 실체를 규명하기 위해 국내에 자생하는 4종(種)(쇠물푸레나무, 물푸레나무, 물들메나무, 들메나무)과 근연종으로 판단되는 중국, 일본의 F. platypofa Oliv.의 형태 및 flavonoids분석을 실시하였다. 물들메나무는 화서가 전년지(前年技)에 달리며 꽃잎이 없고 꽃받침이 존재하며, 나아(裸芽)(naked bud)를 가져 화서가 당년지(들에나무제외)에 달리거나 인아(鱗芽)(scaled bud)를 가지는 다른 3종(種)과 뚜렷이 구분되었다. 한편, flavonoids성분에서는 다른 3종(種)에서 flavonols와 C-glycosylflavone, flavanone 성분이 존재한 반면(물푸레나무형) 물들메나무에서는 3종류의 flavonoids 이외의 flavones성분이 확인(물들메나무형)되어 뚜렷한 종의 특성을 보였다. 따라서 물들메나무는 전북 내장산, 덕유산, 충청북도 민주지산, 전라남도 지리산, 백운산 등 전라남북도에 국한하여 분포하는 우리나라 특산종으로서 기존의 들메나무와 물푸레나무의 자연 교잡종이라는 주장보다는 독립종으로 처리하는 것이 타당하다. 특히, 형태적 특정에 의해 물들메나무는 들메나무아속(亞屬)(subgen. Fraxinus) 물들메나무절(節)(sect. Melioides)에 속하지만 중국과 일본의 물들메나무절(節)의 F. platypoda Oliv.는 인아(scaled bud)를 가지며 사과의 날개가 꽃받침까지 내려오며 화학적으로는 물푸레나무형이 확인되어 물들메나무와는 근연관계가 없고 오히려 북미대륙에 분포하는 동일 절(section)의 4종이 물들메나무에 더 가까운 것으로 생각된다.

• Bulletin of the Korean Chemical Society
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• 제27권3호
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• pp.426-428
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• 2006

• Journal of Applied Biological Chemistry
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• 제53권1호
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• pp.60-64
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• 2010

None of genes from Lespedeza bicolor involved in isoflavonoid biosynthesis have been biochemically characterized. An isoflavone synthase from Lespedeza bicolor was cloned. To verify its catalytic activity, a fusion protein of LbIFS with P450 reductase from rice was made. Using this construct, production of isoflavone from flavanone was confirmed.

• 약학회지
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• 제37권3호
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• pp.262-269
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• 1993

Poncirin which is one of the flavanone rhamnoglucosides showed anti-inflammatory activity as the major component of fruit of Poncirus trifoliata. Poncirin did not show antiinflammatory effect when it was intraperitoneally administered, but it was very effective when orally administered. Poncirin was not metabolized by blood and liver enzymes but by intestinal bacteria of human and rats. Among the human intestinal bacteria, Streptococcus Y-25 converted poncirin to ponciretin through the poncirenin and Staphylococcus Y-88 converted to ponciretin directly.

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 춘계총회 및 학술대회
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• pp.174.3-175
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• 2000

• Bulletin of the Korean Chemical Society
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• 제35권10호
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• pp.3092-3094
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• 2014

• 대한약학회:학술대회논문집
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• 대한약학회 2001년도 Proceedings of International Convention of the Pharmaceutical Society of Korea
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• pp.148.1-148.1
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• 2001

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.376.1-376.1
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• 2002

Phytochemical examination of Barks of Ulmus macrocarpa isolated two flavanone, three flavanonol, three flavan 3-ol and one procyanidin compounds. We also determinated the antioxidative activity of these compounds by measuring the radical scavenging effect on 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radicals. Three flavan 3-ol (catechin, epicatechin and catechin-7-O-$\beta$-O-xylopyranoside) and procyanidin B1 showed significant antioxidative activity. (omitted)

• Archives of Pharmacal Research
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• 제16권1호
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• pp.18-24
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• 1993

In this inverstigation, the various flavonoid aglycones were evaluated for their inhibitory activities against croton-oil or arachidonic acid induced mouse ear edema by oral or topical administration. The compounds tested were thirteen derivatives of flavan-3-ol(catechin and epicatechin), flavanone (flavanone and naringenin), flavone (flavone, chrysin and apigenin), flavonol(favonol, galangin, quercetin and morin) and isoflavone (biochanin A and 2-carbethoxy-5,7-dihydroxy-4'-methoxyisoflavone), along with hydrocortisone, indomethacin, 4-bormophenacyl bromide, nordihydroguaiaretic acid and phenidone as positive controls. A(isoflavone) were found to show broad inhibitoty activities (14-52%) against croton-oil or arachidonic acid induced ear edema by oral or topical application at the dose of 2 mg/mouse, although they showed less activity than hydrocortisone (26-88%) or indomethacin (36-80%). Flavonoid agtlycones tested showed higher activity when aplied topically than by the oral administration. It was also found that they inhibited arachidonic acid induced edema more profoundly than croton-oil induced edema by topical application. In arachidonic acid induced edema when applied topically, flavone derivatives such as flavone, chrysin and apigenin were revealed to be the good inhibitory agents in addition to flavonols and isoflavones. When quercetin and biochanin. A were selected for evaluating in carrageenan induced rat pleurisy and biochanin both flavonoids showed antiinflammatory activity at the dose of 70 mg/kg by the oral adminis-tration. All of these results revealed that flavonoid aglycones, especially 5,7-dihydroxy-flavonols having hydroxyl group(s) in B-ring and biochanin A (isoflavone) possessed in vivo antiinflammatory activity.