• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.24
• /
• pp.10577-10583
• /
• 2015

Background: Triple-negative breast cancer (TNBC), characterized by the lack of expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2, is typically associated with a poor prognosis. The majority of TNBCs show the expression of basal markers on gene expression profiling and most authors accept TNBC as basal-like (BL) breast cancer. However, a smaller fraction lacks a BL phenotype despite being TNBC. The literature is silent on non-basal-like (NBL) type of TNBC. The present study was aimed at defining behavioral differences between BL and NBL phenotypes. Objectives: i) Identify the TNBCs and categorize them into BL and NBL breast cancer. ii) Examine the behavioral differences between two subtypes. iii) Observe the pattern of treatment failure among TNBCs. Materials and Methods: All TNBC cases during January 2009-December 2010 were retrieved. The subjects fitting the inclusion criteria of study were differentiated into BL and NBL phenotypes using surrogate immunohistochemistry with three basal markers $34{\beta}E12$, c-Kit and EGFR as per the algorithm defined by Nielsen et al. The detailed data of subjects were collated from clinical records. The comparison of clinicopathological features between two subgroups was done using statistical analyses. The pattern of treatment failure along with its association with prognostic factors was assessed. Results: TNBC constituted 18% of breast cancer cases considered in the study. The BL and NBL subtypes accounted for 81% and 19% respectively of the TNBC group. No statistically significant association was seen between prognostic parameters and two phenotypes. Among patients with treatment failure, 19% were with BL and 15% were with NBL phenotype. The mean disease free survival (DFS) in groups BL and NBL was 30.0 and 37.9 months respectively, while mean overall survival (OS) was 31.93 and 38.5 months respectively. Treatment failure was significantly associated with stage (p=.023) among prognostic factors. Conclusions: Disease stage at presentation is an important prognostic factor influencing the treatment failure and survival among TNBCs. Increasing tumor size is related to lymph node positivity. BL tumors have a more aggressive clinical course than that of NBL as shown by shorter DFS and OS, despite having no statistically significant difference between prognostic parameters. New therapeutic alternatives should be explored for patients with this subtype of breast cancer.

• The KIPS Transactions:PartB
• /
• v.14B no.4
• /
• pp.287-294
• /
• 2007

Many classification algorithms for real world data suffer from a data class imbalance problem. To solve this problem, various methods have been proposed such as altering the training balance and designing better sampling strategies. The previous methods are not satisfy in the distribution of the input data and the constraint. In this paper, we propose a focused sampling method which is more superior than previous methods. To solve the problem, we must select some useful data set from all training sets. To get useful data set, the proposed method devide the region according to scores which are computed based on the distribution of SOM over the input data. The scores are sorted in ascending order. They represent the distribution or the input data, which may in turn represent the characteristics or the whole data. A new training dataset is obtained by eliminating unuseful data which are located in the region between an upper bound and a lower bound. The proposed method gives a better or at least similar performance compare to classification accuracy of previous approaches. Besides, it also gives several benefits : ratio reduction of class imbalance; size reduction of training sets; prevention of over-fitting. The proposed method has been tested with kNN classifier. An experimental result in ecoli data set shows that this method achieves the precision up to 2.27 times than the other methods.

• Archives of Reconstructive Microsurgery
• /
• v.3 no.1
• /
• pp.45-53
• /
• 1994

Suture microvascular anastomosis is time-consuming and tedious and demands long and continuous training. Techinique of anastomosis of microvessel was presented interrupted suture and continuous suture. Recently the unilink instrument system is created as a fast and simple method to achieve high patency rates without long and continuous training in the anastomosis of small vessels. The author experimentally studied the femoral artery of 20 mice(0.5-1.0mm, av. 0.7mm), the femoral vein of 20 mice(0.8-1.6mm, av. 1.2mm) after anastomosis with interrupted suture in 20 cases and continuous sutre in 20 cases. For the unilink apparatus we used the carotid arteries of 15 cases in 14 rabbits(1.0-1.6mm, av. 1.3mm) and facial veins of 12 cases in 14 rabbits(0.9mm-2.2mm, av. 1.5mm). A total of 27 arterial and venous anastomoses were performed. We examined the postoperative patency at immediate, 2 weeks, and 8 weeks. The results were as followings, 1. In the arterial anastomosis the rate of patency was 90%(18/20) in interrupted suture, 90%(18/20) in continuous suture and 93%(13/15) in unilink apparatus. In the venous anastomosis the rate of patency was 90%(18/20) in interrupted suture, 80%(16/20) in continuous suture and 100%(9/9) in unilink apparatus. 2. The mean time for completion of the arterial anastomosis were 12.2 minutes in interrupted suture group, 10.3 minutes in continouous suture group and 8.5 minutes in unillnk apparatus group. The mean time for completion of the venous anastomosis were 13.6 minutes in interrupted suture group, 11.0 minutes in continuous suture group and 6.2 minutes in unilink apparatus group. 3. At the histological examination of suture group, hyperplastic reaction of middle layer and subintimal hyperplasia were observed. In unilink apparatus group, the endothelium layer was continued and the thickness of vessel wall was decreased due to moderate atrophy of the media and mild degree of nonspecific chronic inflammation were seen around the unilink apparatus. 4. No significants was noticied in foreign body reaction among the interrupted, continuous and unilink apparatus group. 5. A case of the arterial anastomosis was released with acting out at 15 minutes after operation. 6. The important factors in the technical problems were accurate apposition of the cut vessel edges in suture group and the proper selection of the ring size and optimal fitting between two rings in unilink apparatus group. Even though the outer diamater of vessel in suture group was different from that in unilink apparatus group the unilink method provides a very safe, fast, and simple way to perform microvascular anastomoses especially in anastomosis of vein. But howerver suture was needed in vessels below 1 mm outer diamater. In that situation continuous suture was benefit than the interrupted suture in operation time.

• Journal of Fashion Business
• /
• v.3 no.3
• /
• pp.27-37
• /
• 1999

The purpose of this study is to provide for the basic data useful to the effective production and marketing of the brassiere befitting adult women's body shapes and preferences, and thereby, help them improve their apparel life. For this purpose, 563 Korean adult women aged between 20-59 were sampled to survey their practices of purchasing the brassieres and positively identify the factors affecting the practices and thereupon, determine the correlations among them by age group. Data is processed by a computer(SAS) and analyzed by using frequency, percentage, $\chi^2$-test, ANOVA, Duncan-test. The main results of this study are as follows; 1. The adult women tend to use such mass media as TV, magazines, catalogues and DM to decide for themselves which brassiere befits them most, and to check the brand-name(78.8%) or the sizes(93.4%), but more than 90% of them purchase their brassieres without trying on them. 2. The places of purchasing on which adult women rely most for their brassiere are department stores(32.6%), agencies(26.1%) and discount or pension shops(25.4%), while more than 90% of the sample women often visit bargain sale shops. The average number of brassieres possessed by our adult women is 5.7, and an adult women buys 2.6 brassiere costing 10-30 thousand wons a year on average and consumes a brassiere for the period from 6 months to 2 years. 3. It had been disclosed that the brand favored most by adult women is Venus(56.2%), followed by Vivien (17.6%), Wacoal(6.8%), Amie(2.5%) and Body Guard(2.3%). The most influential factors for the popularity of brands are fitting condition(40.3%) and design(23.8%), which suggests that consumers appreciate functionality and aesthetics. The most important reference affecting our women's choice of brassiere is size(64.4%), followed by design and functionality. The brassiere style favored most by adult women is a wire-type 3/4 cup brassiere made of thin material with sewing lines, while the most favorite color is white. In all, it has been found through this study that adult women's practices of buying their brassieres differ by age group, which may well suggest that brassiere production need to take such age-wise practices into consideration in setting up their brassiere production and marketing strategies.

• Korean Chemical Engineering Research
• /
• v.53 no.2
• /
• pp.150-155
• /
• 2015

Recently, LNG receiving terminals have been widely constructed and expanded for an increase in LNG demand. Selection of the storage tank for send-out and estimation of send-out flow rate have significant influence to process operation and economics. In this study, a send-out flow rate of each storage tank is optimized in order to minimize the total BOG generation rate. Considering a size and characteristic of each storage tanks, BOG flow rates are estimated using a dynamic simulation with varying liquid levels in the tanks. The regression model is developed fitting BOG flow rates and tank liquid levels, which are boil off rate model to predict BOG flow rates with particular level data. The objective function and constraints including required total send-out flow rate and level limit in the tanks are formulated to optimize a send-out flow rate of each tank. This method for optimization of send-out operation is applied to the Incheon LNG receiving terminal considering two scenarios for various liquid levels and maximum and minimum required send-out flow rates. For maximum required send-out flow rate, this method achieves BOG reduction of 9% comparing with assumed conventional operation.

• Clean Technology
• /
• v.19 no.4
• /
• pp.430-436
• /
• 2013

In this study, experiments on the static adsorption of benzene were carried out using activated carbon made from Pinus koraiensis which is normally discarded waste timber in South Korea. The experiment were performed at 303.15 K, 318.15 K and 333.15 K under the pressure up to 7.999 kPa. Isothermal adsorption curves were obtained using Langmuir isotherm, Freundlich isotherm and Toth isotherm for comparison. Based on the fitting, the adsorption quantity of Benzene (q), the isothermal adsorption curves obtained from Langmuir isotherm and Toth isotherm showed the higher accuracy. Although there was little difference in accuracy between result from Langmuir isotherm and that from Toth isotherm, the adsorption quantity of Benzene (q) was expressed in terms of Langmuir isotherm because less parameters were required for Langmuir isotherm than for Toth isotherm. Moreover SEM images of the activated carbon from Pinus koraiensis and the commercial activated carbon were taken to observe the pore size development. The results showed that the perforation development of activated carbon from Pinus koraiensis (waste timber) was better than that of commercial activated carbon (DARCO A.C., SPG-100 A.C.). Adsorption quantity of benzene on activated carbon from Pinus koraiensis was confirmed to be higher than that on commercial activated carbon. Therefore, we may conclude that it is feasible to commercialize the process to manufacturing activated carbon from waste timber.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• v.34 no.6
• /
• pp.398-403
• /
• 2012

Purpose: Mandible resection and discontinuity defect created lead to aesthetic and functional problems. The iliac crest bone graft exhibits relative ease for bone harvesting, possibility of two team approach, ability to close the wound primarily, large amount of corticocancellous bone and relatively few complications. Whereas the use of free vascularized flaps has donor site morbidity and worse-fitting bone contour, the use of nonvascularized iliac bone graft has advantages in the operation time and patients' recovery time. So, nonvascularized iliac bone graft could be an attractive option. Methods: Twenty-one patients (M:F=1:1.1) underwent iliac crest bone harvesting for reconstruction of mandibular discontinuity defect (mean length : $61.6{\pm}17.8$ mm), from May 2005 to October 2011 at the Department of Oral and Maxillofacial Surgery in Kyungpook National University. The average age was $44.1{\pm}16.4$ years and the mean follow up periods was $28.2{\pm}22.7$ months. Bone resorption rate, according to age, sex, primary lesion, location and distance of defect, type of fixation plate, time of graft and pre-operative radiation therapy, were measured in each patient. Results: The mean bone resorption rate was $16.1{\pm}9.0%$. Bone resorption rate was significantly increased in mandibular defect that is over 6 cm in size (P=0.015, P<0.05) and the cases treated pre-operative radiation therapy (P=0.017, P<0.05). All was successfully fixed and maintained for the long-term follow-up. There were a few donor site complications and almost all patients were shown favorable outcome without severe bone resorption in this study. Conclusion: The nonvascularized iliac bone graft seems to be a reasonably reliable treatment option for reconstruction of mandibular discontinuity defects.

• Progress in Medical Physics
• /
• v.23 no.4
• /
• pp.234-238
• /
• 2012

A tumor on the eyelid is often treated using a high-energy electron beam, with a metallic eye shield inserted between the eyelid and the eyeball to preserve the patient's sight. Pretreatment quality assurance of the inner eyelid dose on the metallic shield requires a very small dosimetry tool. For enhanced accuracy, a flexible device fitting the curved interface between the eyelid and the shield is also required. The radiochromic film is the best candidate for this device. To measure the doses along the curved interface and small area, a 3-mm-wide strip of EBT2 film was inserted between the phantom eyelid and the shield. After irradiation with 6 MeV electron beams, the film was evaluated for the dose profile. An acrylic eye shield of the same size as the real eye shield was machined, and CT images free from metal artifacts were obtained. Monte Carlo simulation was performed on the CT images, taking into account eye shield material, such as tungsten, aluminum, and steel. The film-based interface dose distribution agreed with the MC calculation within 2.1%. In the small (millimeter scale) and curved region, radiochromic film dosimetry promises a satisfactory result with easy handling.

• Journal of Korean Home Economics Education Association
• /
• v.21 no.1
• /
• pp.141-155
• /
• 2009

Purchasing used school uniforms is to reduce environmental pollution and expenses, and to enhance a feeling of wearing satisfaction for school uniforms by improving size fitting. In order to improve reutilization of used school uniforms, uniform purchasing behavior, awareness of the reutilizing markets of used school uniforms, and the running conditions of reutilizing markets of used school uniforms were analyzed through the survey. The subjects are 741 students of middle and high schools in Seoul and Kyeonggi Province in this study. The results are as follows. First, the better-fitted uniforms students wear, the higher satisfaction they feel. Therefore, it is desirable for students to wear the uniforms which are well fitted for each student. Second, the higher aware of environment students are and the more environmental preservation behavior they do, the higher awareness of wearing used school uniforms they are. In order to enhance students' awareness of reutilizing markets of used school uniforms, it is important to educate students about the environment systematically and to promote recycling events. Third, the reasons for not purchasing used school uniforms are difficulty in access to the repurchasing market and the sanitary problem. Therefore, it is suggested that environmental education which boosts students' awareness of environment and reutilization events should be held to make reutilizing markets of used school uniforms vigorous. Moreover, it is necessary to make reutilizing markets easy to access and improve cleaning and repairing system.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.27 no.3_4
• /
• pp.407-417
• /
• 2003

The purpose of this study is to develop designs and patterns of a functional brassiere. For this purpose, women who have protruding and drooping breasts with 75B for their brassiere size were sampled. The fitting test for the fitness and function of test brassiere and control brassiere were carried out twice and compared the results from the both in terms of front, rear and side looks. The results of this study can be summarized as follows; 1. The results from measuring the level of sag and spread, and volume and protrusion of breasts shows that there are some distinctive differences in the measurements before and after wearing the test brassiere and the test brassiere is proved to be very effective in correcting breasts' shapes. 2. Front look: Since the two front cutting lines of the test brassiere served to have the curved main part pressing against the breasts, it could support breasts to more than satisfactory level. In addition, upperline panel and side panels of the test brassiere were found to have the upperline of the upper cup pressed against the breasts and at the same time it pressed and gathered the flab around upper part of the breasts and armpits that helped to rearrange the shape of the breasts. It is also proved that the two-pieced test brassier was found to be more functional in supporting the lower cup of the breasts. 3. Rear look: The test brassier was made up of two wide U-shaped wings with 2.5cm tape on its lower sides. Each wing has 4 lines and 3 hems (5.5cm). For this reason, the test brassiere was tighter and better fitted on its back. 4. Side look and entire look: The wings of the test brassiere might look wider than that of the control brassier which has conventional straight-shaped wings, but it was analyzed that the test brassiere held the upper and lower sides of the wings more effectively to be more pressed against the breast. Therefore, the test brassiere scored higher in terms of adjusting to body movements, while the control brassiere looked better in overall terms. 5. The functional brassier fur protruding and drooping breasts developed from the experiments of this study is a full side stretch brassiere which covers the entire breasts satisfactorily. The pattern drafting methods are suggested in to .