• 대한한의학원전학회지
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• 제23권2호
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• pp.157-189
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• 2010

Many chapters of the Hwangjenaegyeong[HN] explain the process of transmission and transmutation of disease. The transmission and transmutation process in the HN can be categorized into one between the viscera and bowels, and another of the external pathogenic gi itself. The process between the viscera and bowels indicates the transport of the pathologic burden between each viscera and bowel. This again is categorized into three types. Interpromoting, intercontrolling and that by Saeng-yang(生陽), Sa-eum(死陰). Next, the transport of the pathogenic gi can be categorized into one moving inwards from the exterior according to personal traits, and that according to the three Eum and three Yang. Although there are numerous types of transmission and transmutation, there are two main criteria in understanding the process. First, whether the process is in accordance with the physiological or natural flow of the body. Interpromoting and three Eum three Yang processes are such examples. To follow the physiological flow of the body means to correspond to either the Heaven and Earth or the original physiology of the human body. Therefore, the disease progresses according to a certain date or season. This indicates a partial malfunction in the circulation of the vital energy, which is relatively easy to recover. In contrast, there are processes that go against the physiological flow, for example, intercontrolling transmission and transmutation. This process focuses on the movement of the pathogenic gi rather than the vital gi. The disease progresses regardless of the flow of the vital energy, and sequential functional damage occurs accordingly. Consequently, as the transmission and transmutation continue, formerly passed organs are left damaged, and the whole process is headed towards death. The second criteria for understanding the process is whether it is cyclic or not. To have a cyclic pattern means that the occurrence of a disease and the time of death is not fixed. Transmission and transmutation processes that have a cyclic pattern mostly follow the physiological flow of the body. As a result, they rarely end in deaths, and the process is centered on vital energy. On the other hand, those with acyclic patterns have a fixed occurrence and death point in the course of the disease. They are mostly unnatural processes, found in fatal acute diseases or consumption diseases.

• Journal of Yeungnam Medical Science
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• 제6권1호
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• pp.31-41
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• 1989

1988년 가을 대구, 경북 및 그 인접지역에서 발생한 쯔쯔가무시병 26례를 경험하여 다음과 같은 결과를 얻었다. 1) 발병시기는, 9월말에서 11월말 까지였으며, 11월에 집중적으로 발생하였다. 2) 연령 분포는 18세에서 69세 까지였고, 50대에서 가장 발병률이 높았다. 주증상은 고열과 오한(88%), 근육통(65%), 두통(54%), 오심, 구토(31%) 순이었고 이학적 소견으로는 피부발진이 26례중 18례로 (69%) 가장 많았다. 가피는 26례중 18례에서 (69%) 관찰되었고, 여자에서 다소 빈도가 더 높았고, 50세이상이 14례로 85%를 차지하였다. 3) 검사소견상 백혈구 증가 4례(15%), 혈소판 감소 2례(8%)였고, SGOT 14례(54%), SGPT 15례(58%), LDH가 7례(27%)에서 증가하였다. 4) 치료는 tetracycline 또는 chloramphenicol을 투여하였고, 투약후 해열기간은 tetracycline 사용시 2.1일, chloramphenicol 사용시 2.5일로 큰 차이는 없었다. 합병증은 뇌막염이 2례, 쇽이 1례 관찰되었으나 항생제 및 강압제 투여후 회복되었고, 사망한예는 없었다. 이상의 결과와 같이 대구, 경북지역에서도 쯔쯔가무시병이 발병할 수 있으며, 지금까지의 국내 타보고자와 유사한 양상을 나타내었다.

• Annals of Geriatric Medicine and Research
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• 제22권4호
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• pp.176-183
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• 2018

Background: Although the frequency and intensity of headaches decrease in older adults, headaches in this population are still an important neurological disorder. The purpose of this study was to investigate the associations of headache characteristics in older adults with the development of cardiovascular disease and cognitive dysfunction. Methods: We prospectively enrolled 125 older (${\geq}65$ years old) patients with headache who were making their first visit to outpatient clinics and who had no prior history of cognitive dysfunction from 11 hospitals in Korea between August 2014 and February 2015. We investigated the occurrence of newly developed/or recurrent headache, cardiovascular disease, cognitive dysfunction, and poor functional outcomes. Results: The mean age of all included patients was 72.6 years, 68.8% were women, and 43 (34.4%) had newly developed/or recurrent headache during follow-up. During a median follow-up of 31 months (interquartile range, 28-34 months), 21 participants (16.8%) experienced cardiovascular disease, and 26 (20.8%) developed cognitive dysfunction. Upon multivariate analysis and after adjusting for sex, age, and other factors, presence of newly developed/or recurrent headache was found to be associated with cardiovascular disease (hazard ratio [HR], 4.03; 95% confidence interval [CI], 1.28-12.61; p=0.017) and frequency of headache for the recent 3 months was related with cognitive dysfunction (HR, 1.05; 95% CI, 1.00-1.09; p=0.017) and poor functional outcomes (HR, 1.06; 95% CI, 1.01-1.11; p=0.011). Conclusion: Our study demonstrated that there is an increased risk of cardiovascular disease, cognitive dysfunction, and poor functional outcomes in older patients with frequent, newly developed, or recurrent headache.

• 한국수정란이식학회지
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• 제26권1호
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• pp.37-43
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• 2011

A total 5,946 cows from 24 dairy farms were carried out for the improvement of reproductive performance. Dairy cows in post-parturition 30 day were performed periodic reproductive examination to check for recovery of post-parturition ovary and uterus and for the early diagnosis of reproductive disease. The results obtained from this studies were as follow. The result of 1,126 cows with ovario-uterine disease were 579 slient heat and error of estrus detection (51.4%), 296 ovarian disease (26.3%), 248 uterine disease (22%), mummification and freematin were each 1 head (0.1%), respectively. Hormonal therapeutic effects were follicular cyst 81.5%, luteal cyst 90.7%, endometritis 86.9%, mucometra 90.1%, pyometra 60.9%, respectively. In cows, even if the 1st treatment fails, 2nd, 3rd treatment were performed. Therapeutic effect of 2nd, 3rd were reduced, but the number of cured cows were gradually increased. The cured cows after hormonal treatment were performed service repeatedly and the cumulative conception rate were increased. The cows treated with hormones at first service, the conception rate were follicular cyst 26%, luteal cyst 64.1%, endometritis 38.7%, mucometra 40%, pyometra 20.5%, respectively. The cumulative conception rates were increased by repeated service follicular cyst 57.3%, luteal cyst 84.6%, endometritis 67%, mucometra 75%, pyometra 64.1%, respectively.

• Journal of Veterinary Science
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• 제23권5호
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• pp.73.1-73.8
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• 2022

Background: Lumpy skin disease (LSD), a disease transmitted by direct and indirect contact with infected cattle, is caused by the Lumpy skin disease virus (LSDV). The disease affects cattle herds in Africa, Europe, and Asia. The clinical signs of LSD range from mild to the appearance of nodules and lesions in the skin leading to severe symptoms that are sometimes fatal with significant livestock economic losses. Objectives: This study aimed to characterize LSDV strains in the blood of infected cattle in Thailand based on the GPCR gene and determine the phylogenetic relationship of LSDV Thailand isolates with published sequences available in the database. Methods: In total, the blood samples of 120 cattle were collected from different farms in four provinces in the northeastern part of Thailand, and the occurrence of LSDV was examined by PCR based on the P32 antigen gene. The genetic diversity of LSDV based on the GPCR gene was analyzed. Results: Polymerase chain reaction assays based on the P32 antigen gene showed that 4.17% (5/120) were positive for LSDV. All positive blood samples were amplified successfully for the GPCR gene. Phylogenetic analysis showed that LSDV Thailand isolates clustered together with LSDVs from China and Russia. Conclusions: The LSD outbreak in Thailand was confirmed, and a phylogenetic tree was constructed to infer the branching pattern of the GPCR gene from the presence of LSDV in Thailand. This is the first report on the molecular characterization of LSDV in cattle in Thailand.

• 식물병연구
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• 제10권4호
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• pp.268-271
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• 2004

작약검은뿌리썩음병은 연작을 할 경우 현저히 발생이 증가하였으며, 태백작약 품종에 비해 의성작약 품종에서 좀 더 심한 발병을 보였다. 종구로 사용하는 뇌두를 약제에 침지시 병원균은 검출되지 않았으나 물에만 침지한 경우 병원균이 검출되었다. 연작지의 토양개량시 검은뿌리썩음병의 방제는 효과가 없었으나 다조메입제로 토양을 훈증소독할 경우 토양훈증처리구에서 주근중과 근장이 단순연작구와 비교하여 50% 정도 증가하였으며 검은뿌리썩음병의 발병율은 무처리구의 경우 40.6% 정도 발병되었으나 토양훈증처리구는 4.7% 정도로 발병되어 아주 높은 방제효과를 보였으며 종구소독과 훈증처리를 병행시 발병율은 더욱 낮아졌다.

• The Plant Pathology Journal
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• 제22권1호
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• pp.16-20
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• 2006

Four leguminous crops grown in greenhouses and fields in Korea were surveyed from 2000 through 2002. Sclerotinia rot most severely occurred up to $60\%$ in Phaseolus vulgaris grown in greenhouses but occurred as low as $0-0.5\%$ in that grown in fields. Incidence of the disease in Pisum sativum grown in greenhouses ranged $1-5\%$, and that in Vicia Java and Vigna sinensis grown in fields was $0.8\%$ and $2\%$, respectively. Symptoms of Sclerotinia rot commonly developed on stems and pods of the crops. A total of 59 isolates of Sclerotinia species were obtained from diseased stems and pods of the crops. All of the isolates were identified as Sclerotinia sclerotiorum based on their morphological characteristics. Eight isolates of the fungus were tested for their pathogenicity to four host crops by artificial inoculation. All of the isolates induced rot symptoms on stems of the host crops tested, which were similar to those observed in the fields. The pathogenicity tests revealed that there was no significant difference in the susceptibility to the isolates among the leguminous crops tested This is the first formal report that S. sclerotiorum causes the Sclerotinia' rot of the four leguminous crops in Korea.

• 식물병연구
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• 제26권1호
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• pp.19-28
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• 2020

대추나무 빗자루병은 1950년대에 남한지역에 대발생하여 대추 재배지를 황폐화시킨 고위험 식물병이다. 최근 전국적으로 대추 재배면적이 크게 증가하고 있어 빗자루병 대발생 위험성을 사전에 파악하기 위한 기초자료를 얻고자 2017년과 2019년에 걸쳐 보은 지역의 대추 과원에서 병조사를 하였다. 또한, 빗자루병 조기 진단에 활용할 수 있는 다양한 병징을 찾아내고, 성보싸이클린수화제(OTC, 옥시테트라사이클린칼슘알킬트리메틸암모늄 수화제, 유효성분 17%)의 수간주사 방제효과 증진을 위한 연구를 수행하였다. 그 결과 현재까지 충북 보은 지역의 대추나무 빗자루병 발병률(이병주율)은 매우 낮았으나, 발생 지역과 발생 농가를 중심으로 점차 의미 있게 증가하고 있었다. OTC 방제시험 결과 처리 시기는 대추나무 생육 초기가 가장 효과적이었다. 그러나 발병이 심한 나무에서는 수간주사 후 당해 연도에도 같은 나무의 다른 건전한 가지에서 병징이 발현되었다. 6월에 1차 수간주사를 한 처리에서 2차 수간주사는 5개월 후보다 한 달 후에 하였을 때 방제효과가 더 좋았다. 이러한 결과는 조기 병징을 활용한 진단과 이를 근거로 한 조기 방제가 빗자루병 피해를 사전에 차단하고 병 방제효과를 높이는 데 매우 효과적일 수 있음을 시사한다.

• The Journal of Korean Physical Therapy
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• 제2권1호
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• pp.21-33
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• 1990

The purpose of this study is to investigated the occurrence properties of the cerebrovascular accidents. Clinical observations were done 252 cases, were carried from June, 1989 to May, 1990 at 4 general hospital in Taegu, Korea. The following results have been obtained ; 1. Among the 252 cases of cerebrovascular accidents, males was noted in $51.6\%$ and females in $48.4\%$. The ratio between males and females was 1.1 : 1 in whole groups of cerebrovascular accidents, and in aging distribution, it was showed variety distribution in age groups, fifties, sixties and forties were in order of frequency, particulary, more than half was shelved from 50 to 69. 2. Among the 252 cases of cerebrovascular accidents, cerebral hemorrhage was rioted in $64.3\%$, cerebral infarction in $25.8\%$, cerebral thrombosis in $6.3\%$, subarachnoid hemorrhage in $2.4\%$ and cerebral embolism in $1.2\%$. 3. In distribution of academic career, high school level was noted in $37.7\%$, elementary school level in $30.5\%$, middle school level in $17.1\%$, elementary school level in $30.5\%$, middle school level in $17.1\%$ arid college level in $14.7\%$. 4. In distribution of occupation, office worker was noted in $21.8\%$, housewife in $20.2\%$, the others in $19.1\%$, physical laborer in $18.3\%$ and inoccupation in $18.3\%$. 5. In seasonal distribution, spring was noted in $34.9\%$, winter in $32.5\%$, autumn in $20.3\%$ and summer in $12.3\%$. 6. Among the preceding diseases at the onset of cerebrovascular accidents, hypertension was noted in $51.6\%$, no preceding disease in $20.2\%$, other disease in $10.3\%$ and diabetes mellitus in $9.5\%$ and cardiovalvular disease in $6.0\%$. 7. In systolic blood pressure on admission, 160-199mmHg was noted in $32.2\%$, 200-239mmHg in $23.4\%$, 140-159mmHg in $19.4\%$, below 140mmHg in $16.3\%$, and above 240mmHg in $8.7\%$, While, in diastolic blood pressure, above 130mmHg noted in $24.6\%$, below 90 mmHg in $17.1\%$, 120-129mmHg in $13.1\%$ and was 90-99mmHg in $11.1\%$. 8. In major predisposing factors of patients, emotional stress was noted in $20.2\%$, physical action in $17.9\%$, rest in $16.9\%$, while sleeping in $10.7\%$, drinking in $9.9\%$ and defecation in $7.9\%$. 9. In distribution of affected side, left was noted in $48.4\%$, right in 42.1 and both $9.5\%$. 10. In rates of recurrent cases, first attach was noted in $79.0\%$, 1st recurrence in $17.0\%$, 2nd recurrence in $3.6\%$ and 3rd recurrence in $0.4\%$.

• The Plant Pathology Journal
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• 제17권5호
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• pp.300-304
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• 2001

Apple is the most economically important fruit in Korea. The suspected viroid disease of dapple apple was found in apple fruits cultivated in Kyungpook province. Symptoms begin in mid-July as small circular spots, which stand out against the background color on the young fruit. Dappling of the fruit becomes more intense and easier to detect as the fruit approaches maturity; the affected spots remain yellowish as the fruit matures. no leaf or bark syndromes have been associated with this disease. The infected fruits are downgraded considerably during quality grading. The low molecular weight RNA containing viroid RNA molecules were extracted from the peels of the apples with dapple symptoms. The RNA molecules were extracted from the apples using Qiagen column chromatography. The purified RNAs were used for the synthesis of cDNA with RT-PCR. The PCR products were then ligated into a pGEM-T Easy vector, cloned and sequenced. The sequence of the viroid RNA molecule shows 331 nucleotides with one base difference ("G" insertion between the position of 133 and 134) compared with that of the Apple scar skin viroid (ASSVd) reported by Hashimoto and Koganezawa in Japan. This is the first report on the occurrence of the ASSVd in apple trees cultivated in Korea, as well as the identification of a new Korean strain of the ASSVd.the ASSVd.