• Title/Summary/Keyword: first degree family

Search Result 317, Processing Time 0.032 seconds

Clinical Charicteristics of Primary Lung Cancer Patients in a Tertiary Hospital (3차 의료기관에서 진단된 원발성 폐암의 임상적 특성)

  • Ryu, Jeong-Seon;Lee, Hun-Jae;Leem, Jong-Han;Kim, Lucia;Lee, Kyung-Hee;Cho, Jae-Hwa;Yoon, Young-Han;Kwak, Seung-Min;Lee, Hong-Lyeol;Kim, Kwang-Ho;Loh, John-Kyu;Jung, Soo-Kyung
    • Tuberculosis and Respiratory Diseases
    • /
    • v.60 no.3
    • /
    • pp.321-329
    • /
    • 2006
  • Background : To evaluate the clinical characteristics of lung cancer patients in Korea, where there is a higher number of smokers than in Western countries. Methods : A retrospective study was performed on 1655 lung cancer patients, who were diagnosed at a university hospital between September 1996 and August 2005. Age, gender, cell types and clinical stage were analysed. Of 941 patients, who responded to a questionnaire at the time of diagnosis, the smoking habits, occupational history, family history of lung cancer in the first-degree relatives, coexisting diseases (diabetes mellitus and cardiovascular disease), body weight loss, ECOG performance status and presenting symptoms, were examined prospectively. In addition, coexisting diseases including chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and active pulmonary tuberculosis were evaluated. Results : Of the 1655 patients, the male to females ratio was 3.6. Squamous cell carcinoma was the most common cancer whereas adenocarcinoma was more common in lifetime nonsmokers or women. 19.9% of the patients were non smokers and 80.1% ever smokers. Since 2000, there was an increase in the incidence of adenocarcinoma with a corresponding decrease in the incidence of squamous cell carcinoma. 6.2% of patients were asymptomatic. A coincident diagnosis of chronic obstructive pulmonary disease, cardiovascular disease, diabetes mellitus, active pulmonary tuberculosis, and idiopathic pulmonary fibrosis was made in: 44.1%, 22.2%, 10.7%, 3.9%, and 1.6% of patients, respectively. A positive family history of lung cancer in the first-degree relatives was identified in 4.4% of patients. An occupational history relevant to lung cancer was identified in 12.2% of patients. Conclusion : There is a high proportion of cigarette smokers in Korean lung cancer patients. The most common cell type was squamous cell carcinoma. However, a more detailed, prospective study of the clinical characteristics will be needed to better characterize lung cancer in Korea.

Cloning and Expression of the Cathepsin F-like Cysteine Protease Gene in Escherichia coli and Its Characterization

  • Joo, Han-Seung;Koo, Kwang-Bon;Park, Kyun-In;Bae, Song-Hwan;Yun, Jong-Won;Chang, Chung-Soon;Choi, Jang-Won
    • Journal of Microbiology
    • /
    • v.45 no.2
    • /
    • pp.158-167
    • /
    • 2007
  • In this study, we have cloned a novel cDNA encoding for a papain-family cysteine protease from the Uni-ZAP XR cDNA library of the polychaete, Periserrula leucophryna. This gene was expressed in Escherichia coli using the T7 promoter system, and the protease was characterized after partial purification. First, the partial DNA fragment (498 bp) was amplified from the total RNA via RT-PCR using degenerated primers derived from the conserved region of cysteine protease. The full-length cDNA of cysteine protease (PLCP) was prepared via the screening of the Uni-ZAP XR cDNA library using the $^{32}P-labeled$ partial DNA fragment. As a result, the PLCP gene was determined to consist of a 2591 bp nucleotide sequence (CDS: 173-1024 bp) which encodes for a 283-amino acid polypeptide, which is itself composed of an 59-residue signal sequence, a 6-residue propeptide, a 218-residue mature protein, and a long 3'-noncoding region encompassing 1564 bp. The predicted molecular weights of the preproprotein and the mature protein were calculated as 31.8 kDa and 25 kDa, respectively. The results of sequence analysis and alignment revealed a significant degree of sequence similarity with other eukaryotic cysteine proteases, including the conserved catalytic triad of the $Cys^{90},\;His^{226},\;and\;Asn^{250}$ residues which characterize the C1 family of papain-like cysteine protease. The nucleotide and amino acid sequences of the novel gene were deposited into the GenBank database under the accession numbers, AY390282 and AAR27011, respectively. The results of Northern blot analysis revealed the 2.5 kb size of the transcript and ubiquitous expression throughout the entirety of the body, head, gut, and skin, which suggested that the PLCP may be grouped within the cathepsin F-like proteases. The region encoding for the mature form of the protease was then subcloned into the pT7-7 expression vector following PCR amplification using the designed primers, including the initiation and termination codons. The recombinant cysteine proteases were generated in a range of 6.3 % to 12.5 % of the total cell proteins in the E. coli BL21(DE3) strain for 8 transformants. The results of SDS-PAGE and Western blot analysis indicated that a cysteine protease of approximately 25 kDa (mature form) was generated. The optimal pH and temperature of the enzyme were determined to be approximately 9.5 and $35^{\circ}C$, respectively, thereby indicating that the cysteine protease is a member of the alkaline protease group. The evaluation of substrate specificity indicated that the purified protease was more active towards Arg-X or Lys-X and did not efficiently cleave the substrates with non-polar amino acids at the P1 site. The PLCP evidenced fibrinolytic activity on the plasminogen-free fibrin plate test.

Family Income Inequality and Medical Care Expenditure In Korea (한국 의료보장제도 의료비 부담과 가족소득 불평등의 관계)

  • Lee, Yong-Jae
    • The Journal of the Korea Contents Association
    • /
    • v.16 no.8
    • /
    • pp.366-375
    • /
    • 2016
  • This study evaluates the degree of the inequality of medical care expenditure and private health insurance benefits and the relation with household income inequality in korea health care system. This study used the 2014 korea Health Panel survey, and study method is Gini coefficient. The main results are as follow. First, average household income in 1st income quartile is 6,290,000won and 10st income quartile is 101,930,000won. And Gini coefficient of Korea household income is 0.3756. In other words, family income inequality is quite serious. Second, the Gini coefficient of the public institution supported medical care expenditure, such as health insurance and public assistance, is 0.0761, and the Gini coefficient of the expenditure of transportation fee and medical materials etc that don't supported is 0878. The inequality in medical care expenditure in public health care system and without public support aren't serious all. Third, Gini coefficient in excluding household medical care expenditure from household income slightly increased. That is, the medical care expenditure of our country household is the factor of aggravating the inequality of household income. Fourth, Gini coefficient of private health insurance benefits is 0.0927. Therefore, the ineqality in private insurance benefits is low. In addition, the Gini coefficient of the sum of private insurance benefits and household income is 0.3672. it decrease from Gini coefficient(0.3756) of household's. Private health insurance perform the functions somewhat weaken household income inequality. However, it is very little improvement.

호스피스 케어가 말기암환자 가족들의 죽음에 대한 인식 변화에 미치는 영향

  • Gye Gwang-Won;Kim Jae-Song;Won Ju-Hui;Lee Seong-Ok;Lee Chae-Yeong;Jo Seong-Hun;Park Yun-Mi;Yun Yeong-Mi;Lee Myeong-Suk;Ju Seon-Mi
    • Korean Journal of Hospice Care
    • /
    • v.5 no.2
    • /
    • pp.75-85
    • /
    • 2005
  • The objective of this research is to provide the basic material for effective hospice care by analyzing the recognition of families who have terminally ill patients over death. To do so, this research is designed to investigate the general tendency toward death and changes after hospice care. To analyse the initial status of the recognition about the death, questionnaires were provided to the families of the terminally ill patients who were taken hospice care from June 1st, 2005 to September 10th, 2005 at Saemmul Hospice. The same questionnaires were distributed to research some changes of the recognition of the death after 3 weeks. As the Data Analysis Methodology, SPSS v.10.0 statistics program were utilized. The summary of this research is as follows. First, by gender, it is analyzed that women have more fear than men in terms of incompetence sense after death. By religion, Christians have less fear than other religious people in terms of fear toward after death and general sense of death. Second, those who experienced deaths of close family members, relatives, friends for the past 3 years have more fear toward the moment of death than those who did not experience it. Third, statistically valid difference was found in terms of fear toward the moment of death, fear toward incompetence, fear toward after death, and fear toward death before and after the hospice care was taken. Based on the result of this research, terminally ill patients' families facing death have shown significant differences on fear and incompetence before and after hospice care was offered. It is necessary that the hospice care should be settled more professionally by expanding the opportunities of hospice care and institutionalizing the system. In addition, hospice activities which are focused on providing hope after death and facing death with dignity and peace should be expanded increasingly as the family members who experienced deaths showed higher degree of fear and powerlessness and Christians have less fear toward death with the help of biblical influence. It is also required that hospice care specialized in recognizing the importance of terminal cancer patients and their families at the same time.

  • PDF

Polarimetry of solar system small bodies using the Seoul National University 61cm telescope and TRIPOL

  • Jin, Sunho;Ishiguro, Masateru;Kwon, Yuna Grace;Geem, Jooyeon;Bach, Yoonsoo P.;Seo, Jinguk;Sasago, Hiroshi;Sato, Shuji
    • The Bulletin of The Korean Astronomical Society
    • /
    • v.44 no.1
    • /
    • pp.64.2-64.2
    • /
    • 2019
  • It is known that lights scattered by comets and asteroids are partially polarized. From polarimetric observations of those objects, we can investigate physical properties, such as albedos, sizes of cometary dust particles and regolith of asteroids. Since the polarization degrees of those objects highly depend on their phase angles (Sun-object-observer's angles), long-term monitoring observations are required. Moreover, comets show unforeseeable activations (i.e., outbursts) which need follow-up observations to understand the mechanism. In order to realize such monitoring and transient observations, we installed the Triple-Range Imager and POLarimeter (TRIPOL) on the 61cm telescope of Seoul National University (Hereafter, SNU) Gwanak campus. With this combination, we can obtain g', r', i' bands photopolarimetric images simultaneously with $8.0^{\prime}{\times}8.0^{\prime}$ field of view and pixel resolution of 0.94" pixel-1. Here, we make a presentation regarding the photometric and polarimetric performances of TRIPOL on the SNU 61cm telescope. In addition, we introduce initial polarimetric results of asteroid and comets with the instruments. First, we determine the limiting magnitudes (defined as magnitudes for S/N=5) of $15.17{\pm}0.06$ (g'-band), $15.68{\pm}0.01$ (r'-band), $16.24{\pm}0.03$ (I'-band), respectively, with total 240-seconds exposure (four 60-seconds exposure images, each was taken at different rotation angle for the half-wave plate). Second, we found that the instrumental polarization is negligibly small, ($-0.32{\pm}0.04%$ in the g', $-0.36{\pm}0.05%$ in the r' and $-0.21{\pm}0.04%$ in the i'-bands), while the polarization efficiencies are large enough to maximize the performance (i.e., $97.52{\pm}0.03%$ in the g', $98.83{\pm}0.02%$ in the r' and $99.15{\pm}0.02%$ in the i'-bands). With the instruments, we made observations of three Jupiter-family comets, 21P/Giacobini-Zinner, 38P/Stephan-Oterma, and 46P/Wirtanen and plan to observe one near-Earth asteroid, (433) Eros, on a trial basis. Especially for comets, we discriminate signals from dust and gas to eliminate gas contamination, which are known to change observed degree of linear polarization, using multi-band images. We confirm that the phase angle dependency of these comets are consistent with previous observations, probably because polarimetric property of Jupiter-family comets are broadly homogeneous unlike asteroids. We will also describe future observation plans using TRIPOL and SNU 61cm telescope.

  • PDF

Mediating Effect of Interest in Elderly Job Project and Resilience on the Relationship between MZ and X Generation's Social Support and Retirement Readiness (MZ·X세대의 사회적지지와 노후준비도 관계에서 노인일자리사업 관심도와 회복탄력성의 매개효과)

  • Kim, Geon-hui;Hong, Sang-Ook
    • Industry Promotion Research
    • /
    • v.7 no.4
    • /
    • pp.63-74
    • /
    • 2022
  • The purpose of this study is to examine the mediating effect of interest in the elderly job project and resilience in the relationship between social support and retirement readiness of the MZ·X generation. This survey conducted reliability and frequency analysis, t/f-verification, descriptive statistical analysis, and analysis of reliability and frequency using SPSS 27.0 and AMOS 27.0 programs on the collected data of 359 MZ and X generations of G, Y, and A cities in D and G provinces. Analysis was performed using correlation analysis and structural relationship statistics. As a result of the study, first, it was found that there was a significant correlation between the level of interest in the employment project for the elderly, social support, resilience and readiness for old age. Second, in the relationship between social support and retirement readiness, the degree of interest and resilience of the elderly job project were partially mediated. Therefore, in order to increase the MZ and X generations' interest in and resilience in the job projects for the elderly, the provision of emotional, evaluative, informational, and material support systems as a social support system and the elderly in government agencies such as the Ministry of Health and Welfare, the Ministry of Employment and Labor, and the Ministry of Gender Equality and Family A realistic policy of job business policy is needed.

Correlation among Adolescent Smoking, Stress, and Self-esteem (중학교 1학년 학생들의 흡연과 자아존중감, 스트레스와의 관계연구)

  • Park, In-Hyae;Ryu, Hyun-Sook
    • Journal of the Korean Society of School Health
    • /
    • v.13 no.2
    • /
    • pp.271-282
    • /
    • 2000
  • Primary school is regarded as an important period when many health-related behaviors and life-styles begin to be formed. Acquiring them through school heath education has a strong influence on the health promotion of not only the family but also the community. The goal of this study is to provide baseline data to develop a suitable smoking prevention program for the first graders of middle school. In order to provide this baseline data, the relationships between knowledge and attitudes of the adolescent regarding smoking, and the degree of their stress and self-esteem of the adolescent were explored To achieve this goal a self-administered questionnaire was distributed to the students in two middle schools in Kwang-ju City by school nurses, 400 questionnaires were collected and analyzed using SAS-Fe. The findings were as follows; 1. The subjects of this study were 225 male and 179 female, their average age of than was 12.7. Two students were smoking currently and 49 students had smoked. They started smoking at the mean age of 10.0. 2. Students who were not smoking showed more positive attitudes regarding anti- smoking(F=34.07, p=0.0001), perceived less stress(F=8.32, p=0.0003), and had higher self-esteem(F=15.35, p=0.0001). 3. Those who had the intention to smoke in the future showed more negative attitudes regarding anti-smoking(F=38.97, p=0.0001), perceived more stress(F=4.87, p=0.002) and had lower self-esteem(F=5.55, p=0.0042) 4. Those who had a better self-perception of school performance showed more positive attitudes regarding smoking(F=8.28, p=0.0003), perceived less stress(F=3.48, p=0.0316), and had higher self-esteem(F=22.36, p=0.0001). Those who frequently communicate with their parent showed more positive attitudes regarding anti-smoking(F=4.27, p=0.0082), and had high self-esteem(F=13.28, p=0.0001). 5. There were positive correlations between the attitudes regarding smoking and the self esteem of the adolescent(r=0.36498, p=0.0001), and a negative correlation between the self esteem and the perceived stress of the adolescent(r=-0.34763, p=0.0001). From the above results, we notice adolescent's smoking were related not only with knowledge regarding smoking but also with the intention to smoke in the future, attitudes regarding smoking, and the degree of their stress and self-esteem. So the smoking prevention program to reduce adolescent smoking should include the strategies to increase self-esteem and to address the perceived stress and the dangers of smoking.

  • PDF

Settlement and Adaptation Status of Urban to Rural Migrants and Policy Implications : the Case of Gyeongbuk Province (귀농·귀촌인(가구)의 정착 및 적응 실태와 정책적 함의 - 경상북도를 사례로 -)

  • Lee, Chul Woo
    • Journal of the Korean association of regional geographers
    • /
    • v.21 no.2
    • /
    • pp.207-225
    • /
    • 2015
  • This study attempts to explore settlement and adaptation status involved in differing urban-to-rural migration types in Gyeongbuk Province and suggests policy implications based on this analysis. The attributes of urban-to-rural migrants in Gyeongbuk Province differ spatio-temporally, and their status of settlement and adaptation is also different depending on urban-to-rural migration types. "U-turn" migrants who are mostly first-generation rural-to-urban migrants with experience in farming and rural community life engage primarily in crop agriculture. "J-turns" and "I-turns," who have no experience in farming or rural community life, migrated for idyllic rural life. The household income of these types is relatively low compared to U-turn type. U-turns' degree of adaptation is relatively lower than the other types, and U-turn migrants mainly rely on family and community assets in order to solve problems. J-turns' and I-turns' degree of satisfaction is relatively high. However they typically have substantial difficulties in adapting due to lack of pre-migration preparation. Policy implications are : 'switching away from general and inclusive policies of support,' 'transition to policies embedded in the attributes of regions and migration types,' 'improvement of policy governance,' 'enhancement of support for pre-migration preparation and customized support based on the needs of migrants,' and 'comprehensive improvements of settlement environment to better integrate migrants with current residents.'.

  • PDF

A STUDY FOR THE CURRICULUM DEVELOPMENT OF SOCIAL WORK IN KOREA (한국 사회사업교과과정 개발을 위한 연구)

  • Nam, Sae-Jin
    • Korean Journal of Social Welfare
    • /
    • v.1
    • /
    • pp.51-71
    • /
    • 1979
  • During last five years several workshops and seminars among social work educators, in and out country, has taken place. In those gatherings there has been, criticism on American model on which curriculum of social work in Korea has mainly based, and many proposals which most developing countries should consider and adopt for developing their own curriculums. The proposals could be summarized as follows; 1. Specification of developmental functions of social work should be made so that the curriculum could involve. It also must come from own societal needs and own national development task. 2. Social work should participate and make contribution to plan and solve the main social problems in own countries. 3. Clarification of educational objective in undergraduate level should be made and one of them must be related to the first professional degree. 4. There should be the courses which provide the content of macro level participation. How much of the proposals are reflected in the current curriculum of Korea? What are the problems Korean social work education has been faced in connection with reflecting the proposals? What kinds of task we should or could perform in order to adopt the proposals? These are the questions which deserved to be studied. The followings are the answers to the questions; 1. The new courses such as social welfare policy and planning, Social Development, Population Dynamics and Family Planning, Social problems, Special Issues in Social Welfare, etc, are placed in the curriculum. 2. Though the new courses are added the courses of case work, group work, and community organization are strongly remained it means that integrative method is not quite adopted and that conflicts are taking place between new and old fashion. 3. Fieldwork placement policy has been changes from concurrent to block and from social work method oriented to social problem oriented. 4. There are lack of integration among the all courses, of consistency between pre and post courses and connection among the related courses. 5. Establishment of image of social worker with B, A. degree should be urgently taken place. It can't be done by social work field alone but by cooperation with all the forces related to the social work practice. 6. B. A. graduate should have a common base of knowledge and competence. It could be come from the clear and specified objectives of undergraduate level education. And agreement among the member schools on the objectives can call on the fundamental similarities in each curriculums. Different programs from one school to another can be tolerated as long as there are fundamental similarities among the schools. Basic concepts and framework of social work should be kept clearly. It is a slow and long process to make social work recognized as a profession in the developing countries. Korea can't be and exception. Failure of having social work be indegenous can't be the reason to refuse an change the basic concepts of social work. One of he most important task which social work education in Korea must achieve in the near future is to establish the minimum requirement courses in the curriculum. Social work field, on the other hand, must find the positions for the social works in the various settings and institute. Clear role and image of social worker can be obtained by doing that.

  • PDF

Analysis of Department of Home Economics Education Curriculum of College of Education through Keyword Network Analysis (키워드 네트워크 분석을 통한 사범대학 가정교육과 교육과정 분석)

  • Park, Jisoon;Ju, Sueun
    • Journal of Korean Home Economics Education Association
    • /
    • v.35 no.1
    • /
    • pp.105-124
    • /
    • 2023
  • The purpose of this study was to identify the characteristics of the contents included in the curriculum and 382 syllabi of the department of home economics education of College of Education in Korea and analyze the correlation by detailed area through the keyword network method. In order to analyze the home economics education curriculum and 382 syllabuses of a total of 11 universities, the frequency of keyword occurrence was analyzed using the KrKwic program, also the degree of connection between keywords and various centrality scales were calculated and visualized. The results of this study were as follows. First, as a result of analyzing the entire syllabi, keywords representing various fields such as family, secondary school, clothing, food, consumer, and design appeared evenly, and keywords related to teaching methods such as 'method', 'practice', 'change', and 'principle' were appeared. Those keywords showed high degree of connection and centrality. Second, in the detailed sectoral analysis, core keywords for each area appeared, and each subject were found to reflect the core keywords of the academic base. This study contributes to the conversion of curriculum of the department of home economics education to future-oriented and convergent curriculum.