• Computers and Concrete
• /
• v.25 no.3
• /
• pp.205-214
• /
• 2020

Cytoskeleton components in living cell bear large compressive force and are responsible in maintaining the cell shape. Actually these filaments are surrounded by viscoelastic media within the cell. This surrounding, viscoelastic media affects the buckling behavior of these filaments when external force is applied on these filaments by exerting continuous pressure in opposite directions to the incipient buckling of the filaments. In this article a mechanical model is applied to account the effects of this media on the buckling behavior of intermediate filaments network of cytoskeleton. The model immeasurably associates; filament's bending rigidity, adjacent system elasticity, and cytosol viscosity with buckling wavelength, buckling growth rate and buckling amplitude of the filaments.

• Polymer(Korea)
• /
• v.35 no.3
• /
• pp.232-237
• /
• 2011

The relaxation spectra of polyacrylonitrile-poly(vinyl chloride) copolymer filament fibers were obtained by applying the experimental stress relaxation curves to the theoretical equation of relaxation spectrum. The theoretical equation of relaxation spectrum was derived from the Ree-Eyring and Maxwell model. The experimental of stress relaxation was carried out using a tensile tester with a solvent chamber. The determination of relaxation spectra was performed by computer calculation. From the relaxation spectra, the fine structures, viscoelastic properties and hole volumes of solid polymers were studied. It was observed that the relaxation spectra of these samples were directly related to the distribution of molecular weights and self diffusions of flow segments.

• Molecules and Cells
• /
• v.42 no.10
• /
• pp.729-738
• /
• 2019

Autophagy is an important process for protein recycling. Oligomerization of p62/SQSTM1 is an essential step in this process and is achieved in two steps. Phox and Bem1p (PB1) domains can oligomerize through both basic and acidic surfaces in each molecule. The ZZ-type zinc finger (ZZ) domain binds to target proteins and promotes higher-oligomerization of p62. This mechanism is an important step in routing target proteins to the autophagosome. Here, we determined the crystal structure of the PB1 homo-dimer and modeled the p62 PB1 oligomers. These oligomer models were represented by a cylindrical helix and were compared with the previously determined electron microscopic map of a PB1 oligomer. To accurately compare, we mathematically calculated the lead length and radius of the helical oligomers. Our PB1 oligomer model fits the electron microscopy map and is both bendable and stretchable as a flexible helical filament.

• Journal of Conservation Science
• /
• v.35 no.1
• /
• pp.71-80
• /
• 2019

This study examined the applicability of digital technologies based on three-dimensional(3D) scanning, modeling, and printing to the restoration of damaged artifacts. First, 3D close-range scanning was utilized to make a high-resolution polygon mesh model of a roof-end tile with a missing part, and a 3D virtual restoration of the missing part was conducted using a haptic interface. Furthermore, the virtual restoration model was printed out with a 3D printer using the material extrusion method and a PLA filament. Then, the additive structure of the printed output with a scanning electron microscope was observed and its shape accuracy was analyzed through 3D deviation analysis. It was discovered that the 3D printing output of the missing part has high dimensional accuracy and layer thickness, thus fitting extremely well with the fracture surface of the original roof-end tile. The convergence of digital virtual restoration based on 3D scanning and 3D printing technology has helped in minimizing contact with the artifact and broadening the choice of restoration materials significantly. In the future, if the efficiency of the virtual restoration modeling process is improved and the material stability of the printed output for the purpose of restoration is sufficiently verified, the usability of 3D digital technologies in cultural heritage restoration will increase.

• Journal of the Korean Society of Industry Convergence
• /
• v.26 no.5
• /
• pp.937-943
• /
• 2023

In this study, the mast cover of submarine was reverse engineered and structural analysis was performed. In order to print with the 3D printer, the modeling was reduced to 1/5 size by applying geometric similarity. From the structural analysis results, it was found that the maximum value of equivalent stress generated in the mast cover was 180.9 MPa. This stress value occurs on the inner surface in the major axis. As a result of applying the load condition at a diving depth of 600 m, the mast cover is in a completely elastic state. The 1/5 size model printed on FDM 3D printer with PLA filament was the same as the reverse engineered modeling and it was printed in a perfect shape with no apparent defects. The 1/5 size model printed on PBF 3D printer with SUS316L powder was perfectly manufactured with no apparent defects.

• Composites Research
• /
• v.15 no.6
• /
• pp.38-43
• /
• 2002

Rapid Prototyping(RP) technologies provide the ability to fabricate initial prototypes from various model materials. Stratasys' Fused Deposition Modeling(FDM) is a typical RP process that can fabricate prototypes out of plastic materials, and the parts made from FDM were often used as load-carrying elements. Because FDM deposits materials in about 300$\mu$m thin filament with designated orientation, parts made from FDM show anisotropic material properties. In this paper an analytic model was proposed to predict the tensile strength of FDM parts. Applying the Classical Lamination Theory, which was developed for laminated composite materials, a computer code was implemented. Tsai-Wu failure criterion was added to the code to predict the failure of the FDM parts. The tensile strengths predicted by the analytic model were compared with experimental data. The data and prediction agreed reasonably well to prove the validity of the model. In addition, a web-based advisory service(FDMAS) was developed to provide strength prediction and design rules for FDM parts.

• Journal of Acupuncture Research
• /
• v.21 no.3
• /
• pp.145-167
• /
• 2004

Objective : Neuropathic pain can be caused by a partial peripheral nerve injury. This kind of pain is usually accompanied by spontaneous burning pain, allodynia and hyperalgesia. It is not clear that scolopendrid aqua-acupuncture can control neuropathic pain effectively. The purpose of this study is to examine if scolopendrid aqua-acupuncture may be effective to the neuropathic pain (mechanical allodynia, cold allodynia) in a rat model of neuropathic pain. Methods : To produce the model of neuropathic pain, under isoflurane 2.5% anesthesia, tibial nerve and sural nerve was resected. After the neuropathic surgery, the author examined if the animals exhibited the behavioral signs of allodynia. The allodynia was assessed by stimulating the medial malleolus with von Frey filament and acetone. Three weeks after the neuropathic surgery, scolopendrid aqua-acupuncture was injected at Hwando(GB30) one time a day for one week. After that the author examined the withdrawl response of neuropathic rats' legs by von Frey filament and acetone stimulation. And also the author examined c-fos in the midbrain central gray of neuropathic rats and the change of WBC count in the blood of neuropathic rats. Results & Conclusion : 1. The scolopendrid aqua-acupuncture injected at Hwando(GB30) decreased the withdrawl response of mechanical allodynia in SHA-1, SHA-2 and SAH-3 group as compared with control group. 2. The scolopendrid aqua-acupuncture injected at Hwando(GB30) decreased the withdrawl response of chemical allodynia(cold allodynia) in SHA-1, SHA-2 and SAH-3 group as compared with control group. 3. The scolopendrid aqua-acupuncture injected at Hwando(GB30) showed the significant difference between sham group and control group(p=0.01), sham and SHA-3 group(p=0.026), control group and SHA-1 group(p=0.01), control group and SHA-2 group(p=0.024) in the c-fos expression. 4. The scolopendrid aqua-acupuncture injected at Hwando(GB30) showed the significant difference between sham group and SHA-3 group(p=0.010), control group and SHA-3 group(p=0.006) in the WBC count.

• The Korean Journal of Pain
• /
• v.20 no.2
• /
• pp.100-105
• /
• 2007

Background: Ginseng has been used to manage various types of pain in folk medicine. This study characterized the effect of treatment with intrathecal ginsenosides, the active components of ginseng in a postoperative pain model. Methods: Male Sprague-Dawley rats were implanted with lumbar intrathecal catheters. An incision was made in the plantar surface of the hindpaw. Withdrawal thresholds following the application of a von Frey filament to the wound site were measured. To determine the role of the opioid or GABA receptors following treatment with the ginsenosides, naloxone, bicuculline (a $GABA_A$ receptor antagonist), and saclofen (a $GABA_B$ receptor antagonist) were administered intrathecally 10 min before the delivery of the ginsenosides and the changes of the withdrawal thresholds after application of the von Frey filament were Observed. Results: Treatment with the intrathecal ginsenosides increased the withdrawal threshold in a dose dependent manner. Pre-treatment with intrathecal naloxone reversed the antinociceptive effect of the ginsenosides. However, pre-treatment with intrathecal bicuculline and saclofen failed to have an effect on the activity of the ginsenosides. Conclusions: These results suggest that ginsenosides are effective to alleviate the postoperative pain evoked by paw incision. The opioid receptor, but not GABA receptors, may be involved in the antinociceptive action of the ginsenosides at the spinal level.

• The Korean Journal of Pain
• /
• v.20 no.2
• /
• pp.92-99
• /
• 2007

Background: A correlation between a T-type voltage activated calcium channel (VACC) and pain mechanism has not yet been established. The purpose of this study is to find out the effect of ethosuximide and mibefradil, representative selective T-type VACC blockers on postoperative pain using an incisional pain model of rats. Methods: After performing a plantar incision, rats were stabilized on plastic mesh for 2 hours. Then, the rats were injected with ethosuximide or mibefradil, intraperitoneally and intrathecally. The level of withdrawal threshold to the von Frey filament near the incision site was determined and the dose response curves were obtained. Results: After an intraperitoneal ethosuximide or mibefradil injection, the dose-response curve showed a dose-dependent increase of the threshold in a withdrawal reaction. After an intrathecal injection of ethosuximide, the threshold of a withdrawal reaction to mechanical stimulation increased and the increase was dose-dependent. After an intrathecal injection of mibefradil, no change occurred in either the threshold of a withdrawal reaction to mechanical stimulation or a dose-response curve. Conclusions: The T-type VACC blockers in a rat model of postoperative pain showed the antihyperalgesic effect. This effect might be due to blockade of T-type VACC, which was distributed in the peripheral nociceptors or at the supraspinal level. Further studies of the effect of T-type VACC on a pain transmission mechanism at the spinal cord level would be needed.

• The Journal of the Acoustical Society of Korea
• /
• v.21 no.2
• /
• pp.134-141
• /
• 2002

In this paper, a free wake analysis based on the curved vortex element and CVC wake model is used to predict the aerodynamic performance and noise for HAWT. Also for prediction of RPM, a maximum value through a quadratic regression was suggested. And for a noise prediction, the broadband noise prediction method based on experimental equation was used. The curved vortex element uses a BCVE and an SIVE instead of a straight vertex element. In the CVC wake model, the vortex strengths are assumed to be constant along a span and a vortex filament. The free wake structure made by the curved vortex element and CVC was substituted for a vortex lattice, so it has an advantage for the less calculation time and a depiction of accurate wake structure. For the verification of this program, calculated results are compared with Mr. Kim's experiment model and Zond Z-40FS for performance and with WTS-4 and USWP models for noise. Good agreements are obtained between the predicted and the measured data for the performance and far-field noise spectra.