• The Korean Journal of Nuclear Medicine
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• v.24 no.1
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• pp.29-36
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• 1990

Most of the diagnostic methods currently used for the detection of neoplastic masses provide indirect evidence. To obtain greater specificity in the interpretation of neoplasias by in vivo methods, the immunological approach appears to be most promising. Two problems that interfered with progress in this field were the lack of tumor specific antigen and the lack of well-defined and reproducible antibodies. To improve the sensitivity and specificity of radioimmunoscintigraphy as a technique for tumor localization, the use of monoclonal antibodies, fragments of antibodies and single photon emission computerized tomography (SPECT) are reasonable. The obvious advantages of monoclonal antibodies are their homogeneity, their specificity for the immunizing antigen and the reaction with a single determinant-thus no large immunecomplexes with antigen are formed. Monoclonal antibody technique has recently provided an opportunity to reevaluate the role of nuclear medicine for the diagnosis of malignant diseases by using the immunological approach. Out first results by means of radioimmunoscintigraphy of CEA and CA 19-9 producing tumors using a cocktail of fragments F $(ab')_2$, of mocolonal antibodies to CA 19-9 and CEA labeled with $^{131}I$ (IMACIS-1) are reported. The aims of this investigation was to evaluate the role of immunoscintigraphy in patients with colorectal and other cancers for diagnosis of local recurrences and metastasis. This report contains results of the first 8 colorectal and pancreas cancer patients with the elevation of the level of serum CEA and/or CA 19-9. IMACIS-1 was injected intravenously during 30 minutes in 100 ml saline solution after skin test. Planar scintigrams were recorded 3, 5 and 7 days after the injection of the IMACIS-1. Anterior, lateral and posterior views of the liver as well as anterior and posterior views of the pelvis were obtained in each patients as an $^{131}I-antibody$ image. We were able to localize exactly the malignant process with the double-nuclide double-compound $^{99m}Tc\;^{131}I$ (Tc+l) scintigrams. In Tc & I double-nuclide scintigraphy, computer subtraction display provided more clear localization of the tumor. We compared the results of radioimmunoscintigraphy with CT, ultrasonograms, conventional scintigrams. The results were as follows: 1) The sensitivity and specificity of radioimmunoscintigraphy using the fragments $F(ab')_2$ of the cocktails of CEA and CA 19-9 monoclonal antibodies were 80% and 100% respectively. 2) Tumor detection rate was not proportionated to the level of serum tumor markets. 3) Second tracer technique was essential for tumor localization as an anatomic landmark using double-nuclide scintigraphy. 4) A slow infusion of the antibodies was necessary to prevent the formation of large immune complexes. 5) Tumor/non-tumor radioactivity was most elevated at 7 days delayed imaging. 6) Using planar scintigraphic technique of $^{131}I$ labeled monoclonal antibodies are possible for imaging most of the tumors.

• Journal of Family Relations
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• v.22 no.4
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• pp.181-204
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• 2018

Objectives: The aim of this study is to integrate the results of the previous studies from 1900 to 2016 according to the types of dependent variables individually and statistically to obtain the results of the overall level of the marital education program I need to figure it out. In other words, the general and valid study on the overall effectiveness of the marriage education program will lead to more concluded conclusions and draw up an integrated and holistic conclusion about the effectiveness of the marriage education program. Method: The purpose of this study was to investigate the effect of married couples' education program on married couples' education program. The results of this study are as follows. First, Comprehensive Meta-Analysis. In other words, funnel plot, forest plot, and trim & fill were used to analyze all the variables related to the education of the couple, and homogeneity test After choosing an analytical model for the analysis, we calculated the 'standardized mean difference' effect size (d) that can compare different individual studies through the analytical model. The results of this study are as follows. Results: The purpose of this study was to investigate the overall effect size of domestic couples education programs after 1990, and to investigate the effect sizes of dependent variable types and program - related variables. First, the total effect size of the domestic marriage education program was close to the level of the large effect size and had a substantial and preventive effect. Self-esteem, communication, marital adjustment, emotion, and self control have a substantial and prophylactically significant change depending on the type of subordinate variables related to the marital education program But there was no change in origin family and life satisfaction. Third, as a result of the categorization of the dependent variable categorization of the Korean couple education program, it was found that the marital relations of the participant in the individual inner and the marital relations The effect was significant enough to change. Fourth, Korean couple education program was most effective when mixed age couples were participated in various family life cycle. Conclusions: Based on the results of this study, it is necessary to study more deeply about marital education program effect of marriage education for various special groups such as married couples who are in a crisis of divorce, . It also means that the results of the research for the last 30 years from 1900 to 2016 were comprehensively and systematically summarized through meta - analysis. The results of this study provide information on how to provide the most effective couples education programs for practitioners in the field. The result of this study will be the data of judgment about how to organize the marital education program for people of any ages and characteristics in the future.

• Journal of the Korea Convergence Society
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• v.12 no.1
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• pp.211-218
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• 2021

This study is composed of a convergence research design plan as the necessity of information security field dealing with human factors are raised. The purpose of this study is to analyze the effectiveness of the aspect of information security on the cognitive process related to security policy. The research method consisted of the cross-design of the availability dimension and the culture dimension, and the information security process was measured with information security awareness, response efficacy, compliance behavioral intention, and information security behavior. As a result of the study, the dimension of availability had a significant effect on response efficacy, and it was found that the influence of the case-based condition was greater than that of the statistics-based condition. The cultural dimension had a significant effect on information security awareness, response efficacy, compliance behavioral intention, and information security behavior, and the influence of the homogeneity condition was found to be greater than that of the diversity condition. The proposed research model was verified as a multiple mediation model reconstructed with measurement variables. In addition, the discussion describes the necessity of an information security strategy in consideration of individual factors and organizational characteristics.

• Korean Journal of School Psychology
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• v.16 no.2
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• pp.129-157
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• 2019

The purpose of this study is to develop a group counseling program for adolescents with traumatic experiences and to verify the effect of the program. For this purpose, the posttraumatic growth program was developed in accordance with the group counseling program that based on the needs of field experts and the needs of the subjects. This program consisted of 10 sessions. To verify the effectiveness of the developed program, 20 characterization high school students were divided into experimental group and control group, and a total of 10 sessions were performed twice a week. After the program was conducted on the experimental group, quantitative analysis was conducted for comparison according to the lapse of time: before, after, and follow-up. independent sample t-analysis was used to examine homogeneity between two groups beforehand. Mixed ANOVA was also used to verify a hypothesis. In conclusion, the posttraumatic growth program has significant effects on posttraumatic growth and intentional rumination level with experienced adolescents. Findings and implications of this study were discussed.

• Progress in Medical Physics
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• v.25 no.2
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• pp.79-88
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• 2014

The dose distributions within the real volumes of tumor targets and critical organs during internal target volume-based intensity-modulated radiation therapy (ITV-IMRT) for liver cancer were recalculated by applying the effects of actual respiratory organ motion, and the dosimetric features were analyzed through comparison with gating IMRT (Gate-IMRT) plan results. The ITV was created using MIM software, and a moving phantom was used to simulate respiratory motion. The doses were recalculated with a 3 dose-volume histogram (3DVH) program based on the per-field data measured with a MapCHECK2 2-dimensional diode detector array. Although a sufficient prescription dose covered the PTV during ITV-IMRT delivery, the dose homogeneity in the PTV was inferior to that with the Gate-IMRT plan. We confirmed that there were higher doses to the organs-at-risk (OARs) with ITV-IMRT, as expected when using an enlarged field, but the increased dose to the spinal cord was not significant and the increased doses to the liver and kidney could be considered as minor when the reinforced constraints were applied during IMRT plan optimization. Because the Gate-IMRT method also has disadvantages such as unsuspected dosimetric variations when applying the gating system and an increased treatment time, it is better to perform a prior analysis of the patient's respiratory condition and the importance and fulfillment of the IMRT plan dose constraints in order to select an optimal IMRT method with which to correct the respiratory organ motional effect.

• The Journal of Korean Society for Radiation Therapy
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• v.18 no.1
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• pp.21-28
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• 2006

Purpose: The purpose of this study is to find a optimal beam spoiler condition on the dose distribution near the surface, when treating a squamous cell carcinoma of the head and neck and a lymphatic region with 10 MV photon beam. The use of a optimal spoiler allows elivering high dose to a superficial tumor volume, while maintaining the skin-sparing effect in the area between the surface to the depth of 0.4 cm. Materials and Methods: The lucite beam spoiler, which were a tissue equivalent, were made and placed between the surface and the photon collimators of linear accelerator. The surface-dose, the dose at the depth of 0.4 cm, and the maximum dose at the dmax were measured with a parallel-plate ionization chamber for $5{\times}5cm\;to\;30{\times}30cm^2$ field sizes using lucite spoilers with different thicknesses at varying skin-to-spoiler separation (SSS). In the same condition, the dose was measured with bolus and compared with beam spoiler. Results: The spoiler increased the surface and build-up dose and shifted the depth of maximum dose toward the surface. With a 10 MV x-ray beam and a optimal beam spoiler when treating a patient, a similer build-up dose with a 6 MV photon beam could be achieved, while maintaining a certain amount of skin spring. But it was provided higher surface dose under SSS of less than 5 cm, the spoiler thickness of more than 1.8 cm or more, and larger field size than $20{\times}20cm^2$ provided higher surface dose like bolus and obliterated the spin-sparing effect. the effects of the beam spoiler on beam profile was reduced with increasing depths. Conclusion: The lucite spoiler allowed using of a 10 MV photon beam for the radiation treatment of head and neck caner by yielding secondary scattered electron on the surface. The dose at superficial depth was increased and the depth of maximum dose was moved to near the skin surface. Spoiling the 10 MV x-ray beam resulted in treatment plans that maintained dose homogeneity without the consequence of increased skin reaction or treat volume underdose for regions near the skin surface. In this, the optimal spoiler thickeness of 1.2 cm and 1.8 cm were found at SSS of 7 cm for $10{\times}10cm^2$ field. The surface doses were measured 60% and 64% respectively. In addition, It showed so optimal that 94% and 94% at the depth of 0.4 cm and dmax respectively.

• The Journal of Korean Society for Radiation Therapy
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• v.27 no.1
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• pp.45-52
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• 2015

Purpose : The dose distribution of organ at risk (OAR) and normal tissue is affected by treatment technique in postoperative radiation therapy for prostate cancer. The aim of this study was to compare dose distribution characteristic and to evaluate treatment efficiency by devising VMAT plans according to applying differed number of arc and IMRT plan for postoperative patient of prostate cancer radiation therapy using a rectal balloon. Materials and Methods : Ten patients who received postoperative prostate radiation therapy in our hospital were compared. CT images of patients who inserted rectal balloon were acquired with 3 mm thickness and 10 MV energy of HD120MLC equipped Truebeam STx (Varian, Palo Alto, USA) was applied by using Eclipse (Version 11.0, Varian, Palo Alto, USA). 1 Arc, 2 Arc VMAT plans and 7-field IMRT plan were devised for each patient and same values were applied for dose volume constraint and plan normalization. To evaluate these plans, PTV coverage, conformity index (CI) and homogeneity index (HI) were compared and $R_{50%}$ was calculated to assess low dose spillage as per treatment plan. $D_{25%}$ of rectum and bladder Dmean were compared on OAR. And to evaluate the treatment efficiency, total monitor units(MU) and delivery time were considered. Each assessed result was analyzed by average value of 10 patients. Additionally, portal dosimetry was carried out for accuracy verification of beam delivery. Results : There was no significant difference on PTV coverage and HI among 3 plans. Especially CI and $R_{50%}$ on 7F-IMRT were the highest as 1.230, 3.991 respectively(p=0.00). Rectum $D_{25%}$ was similar between 1A-VMAT and 2A-VMAT. But approximately 7% higher value was observed on 7F-IMRT compare to the others(p=0.02) and bladder Dmean were similar among the all plan(P>0.05). Total MU were 494.7, 479.7, 757.9 respectively(P=0.00) for 1A-VMAT, 2A-VMAT, 7F-IMRT and at the most on 7F-IMRT. The delivery time were 65.2sec, 133.1sec, 145.5sec respectively(p=0.00). The obvious shortest time was observed on 1A-VMAT. All plans indicated over 99.5%(p=0.00) of gamma pass rate (2 mm, 2%) in portal dosimetry quality assurance. Conclusion : As a result of study, postoperative prostate cancer radiation therapy for patient using a rectal balloon, there was no significant difference of PTV coverage but 1A-VMAT and 2A-VMAT were more efficient for dose reduction of normal tissue and OARs. Between VMAT plans. $R_{50%}$ and MU were little lower in 2A-VMAT but 1A-VMAT has the shortest delivery time. So it is regarded to be an effective plan and it can reduce intra-fractional motion of patient also.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.36 no.3
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• pp.16-25
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• 2018

Initially from the Taoist scriptures, 'Dongcheon' is a term that can be regarded as a symbolic place in the real world for the enlightened ones who received relief and peace by restoring the human nature taught in the Confucian school. The long for an ideal world apart from the reality embodied as the labeling some places 'Dongcheon,' and the term was used to refer to a scenery where the ideal fairyland is reproduced. Besides, 'Dongcheon' was a term often used by Confucian scholars for various purposes including the attachment to the nearby landscapes, expressing homogeneity and superiority through placeness and the beautification of settlement spaces. This paper is the result of a field study on 'Dongcheon' in the Gyeongsang-Do. The research was conducted from March to August 2018, and we carried out firsthand location surveys on Dongcheons, of which some were lost, others were fairly preserved, and still others could not be located as only their existences were passed down orally. According to the field survey, there were total 111 inscriptions or engravings on the plates in Gyeongsang-Do that include the term 'Dongcheon.' There were 79 'Dongcheon' inscriptions confirmed in the Gyeongsangbuk-Do region: twenty in Yeongju-City, sixteen in Bonghwa-Gun, eleven in Andong-City and seven in Yeongyang-Gun and Ulgin-Gun. Among them, two were in the form of a wooden sign, and six were erected as rock signposts. Fourteen stops reported in the literature were lost or unidentified. Also, among the sixteen signs in Bonghwa-Gun, nine were cursive engravings. Meanwhile, there were 26 Dongcheon inscriptions in the Gyeongsangnam-Do region. Hamyang-Gun and Sancheong-Gun anf Hadong-Gun each housed three inscriptions, and seven places were in the form of rock signposts. 'Hwagaedongcheon' and 'Geumsandongcheon' could not be identified in inscriptions although they appear in Jibong Yuseol and Taengniji with stories of Choi Chiwon. The significance of this study is as a reference for future researches in traditional scenery, epigraphs, or as primary data that helps cultural exploration in the region.

• Korean Journal of Ecology and Environment
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• v.50 no.2
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• pp.216-237
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• 2017

Thermal effluent of the hot spring has long been a field of interest in the relationship between temperature gradient and freshwater algae in geology, limnology and aquatic ecology throughout the world. On the other hand, many artificial hot springs have been developed in Korea, but the research on them has not been still active. This study was performed every month from December 2015 to September 2016, to elucidate the spatiotemporal effects of thermal wastewater effluent (TWE) on the ecosystem of benthic algal assemblage in four stations(BSU (upstream), HSW (hot spring wastewater outlet), BSD1~2 (downstream)) of the upstream reach of the Buso Stream, a tributary located in the Hantan River basin. During the survey, the influencing distance of temperature on TWE was <1.0 km, and it was the main source of N P nutrients at the same time. The effects of TWE were dominant at low temperature and dry season (December~March), but it was weak at high temperature and wet season (July~September), reflecting some seasonal characteristics. Under these circumstances, the attached algal communities were identified to 59 genera and 143 species. Of these, the major phylum included 21 genera 83 species of diatoms(58.0%), 9 genera 21 species of blue-green algae (14.7%) and 25 genera 32 species of green algae (22.4%), respectively. The spatiotemporal distribution of them was closely related to water temperature ($5^{\circ}C$ and $15^{\circ}C$) and current ($0.2m\;s^{-1}$ and $0.8m\;s^{-1}$). In the basic environment maintaining a high water temperature throughout the year round, the flora favoring high affinity to $PO_4$ in the water body or preferring stream habitat of abundant $NO_3-PO_4$ was dominant. As a result, when compared with the outcomes of previous algal ecology studies conducted in Korea, the Buso Stream was evaluated as a serious polluted state due to persistent excess nutrient supply and high thermal pollution throughout the year round by TWE. It can be regarded as a dynamic ecosystem in which homogeneity (Summer~Autumn) and heterogeneity (Winter~Spring) are repeated between upstream and downstream.

• Journal of radiological science and technology
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• v.36 no.4
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• pp.291-297
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• 2013

This study is aimed to evaluate the effect of $T_{1/2}$ upon count rates in the analysis of dynamic scan using NaI (Tl) scintillation camera, and suggest a new quality control method with this effects. We producted a point source with $^{99m}TcO_4^-$ of 18.5 to 185 MBq in the 2 mL syringes, and acquired 30 frames of dynamic images with 10 to 60 seconds each using Infinia gamma camera (GE, USA). In the second experiment, 90 frames of dynamic images were acquired from 74 MBq point source by 5 gamma cameras (Infinia 2, Forte 2, Argus 1). There were not significant differences in average count rates of the sources with 18.5 to 92.5 MBq in the analysis of 10 to 60 seconds/frame with 10 seconds interval in the first experiment (p>0.05). But there were significantly low average count rates with the sources over 111 MBq activity at 60 seconds/frame (p<0.01). According to the second analysis results of linear regression by count rates of 5 gamma cameras those were acquired during 90 minutes, counting efficiency of fourth gamma camera was most low as 0.0064%, and gradient and coefficient of variation was high as 0.0042 and 0.229 each. We could not find abnormal fluctuation in $x^2$ test with count rates (p>0.02), and we could find the homogeneity of variance in Levene's F-test among the gamma cameras (p>0.05). At the correlation analysis, there was only correlation between counting efficiency and gradient as significant negative correlation (r=-0.90, p<0.05). Lastly, according to the results of calculation of $T_{1/2}$ error from change of gradient with -0.25% to +0.25%, if $T_{1/2}$ is relatively long, or gradient is high, the error increase relationally. When estimate the value of 4th camera which has highest gradient from the above mentioned result, we could not see $T_{1/2}$ error within 60 minutes at that value. In conclusion, it is necessary for the scintillation gamma camera in medical field to manage hard for the quality of radiation measurement. Especially, we found a tendency that count rate changes over time at this study, and we proved that it can effect $T_{1/2}$. And also, there is need of appropriate phantoms and the method of quality management like this study, because there are not any advice or limitation degrees for domestic medical purpose scintillation camera.