• 한국품질경영학회:학술대회논문집
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• 한국품질경영학회 1998년도 The 12th Asia Quality Management Symposium* Total Quality Management for Restoring Competitiveness
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• pp.217-224
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• 1998

A cost model, controlling multiple dependent subprocesses with minimum cost, is derived by renewal theory approach. The optimal multiple cause-selecting control chart and individual Y control chart are thus constructed to monitor the specific product quality and overall product quality contributed by the multiple dependent subprocesses. They may be used to maintain the process with minimum cost and effectively distinguish which component of the subprocesses is out of control. The optimal design parameters of the proposed control charts can be determined by minimizing the cost model using simple grid search method, An example is given to illustrate the application of the optimal multiple cause-selecting control chart and individual Y control chart.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5345-5351
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• 2012

Radiotherapy is an important part of modern cancer management for many malignancies, and enhancing the radiosensitivity of tumor cells is critical for effective cancer therapies. The Notch signaling pathway plays a key role in regulation of numerous fundamental cellular processes. Further, there is accumulating evidence that dysregulated Notch activity is involved in the genesis of many human cancers. As such, Notch inhibitors are attractive therapeutic agents, although as for other anticancer agents, they exhibit significant and potential side effects. Thus, Notch inhibitors may be best used in combination with other agents or therapy. Herein, we describe evidence supporting the use of Notch inhibitors as novel and potent radiosensitizers in cancer therapy.

• Mass Spectrometry Letters
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• 제8권1호
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• pp.8-13
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• 2017

Analysis of quinidine for fish tissues using single drop microextraction (SDME) coupled with atmospheric pressure matrix assisted laser desorption/ionization mass spectrometry (AP-MALDI-MS) are reported. Optimization conditions; such as extraction solvent, extraction time, pH of the aqueous solution, salt additions (NaCl), stirring rate, matrix type and concentration are investigated. Linear dynamic range (${\mu}M$), limit of detection, relative recovery%, and enrichment factor are 0.08-9.2, 0.05, $94.8{\pm}3.1-98.5{\pm}3.3%$, $4.34{\pm}0.28-4.40{\pm}0.30$, respectively. SDME-AP-MALDI-MS shows good intraday and interday reproducibility.

• Mass Spectrometry Letters
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• 제6권2호
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• pp.43-47
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• 2015

Detection of mefenamic acid (M, non-steroidal anti-inflammatory drug, NSAIDs) and its metallodrug was investigated using electrospray ionization mass spectrometry (ESI-MS) and fluorescence spectroscopy. ESI-MS data (500 µL, 1×10-3 M) revealed high detection sensitivity for the drug and metallodrug. ESI-MS spectra revealed peaks at 242, 580, and 777 Da corresponding to [M+H]+, [63Cu(M-H)2(H2O)2+H]+, and [56Fe(M-H)3+H]+, respectively. The metal:mefenamic ratios of ESIMS spectra are in complete agreement with the fluorescence spectroscopy results (1:2 for Cu(II) and 1:3 for Fe(III)). ESI is a soft ionization technique that can be used on labile metallo-mefenamic acids and is promising for the detection of these species in environmental samples and biological fluids.

• 대한한의학원전학회지
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• 제13권2호
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• pp.2-12
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• 2000

Zhang Jie Bin had a lot of influences on the oriental medical world to write Lei Jing(類經) and Lei Jing Tu Yi(類經圖翼). His oriental medicine is based on profound philosophy. In this thesis, he understand the thousand year of chinese philosophy of ancient times in the reign of Song, Yuan, and Ming dynasty and his view of the world which is revealed in Oriental Medicine is regarded as Qi(氣) and then Li(理) is considered not an object for a special purpose but an attribute of Qi(氣). The base which a debater is able to suggest like this is that because of his saying that Tai Ji(太極) is Yin and Yang(陰陽). The basis of his world is Qi Yi Yuan Lun(氣一元論) of Yin Yang Wei Fen(陰陽未分)

• 한국멀티미디어학회논문지
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• 제9권12호
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• pp.1572-1579
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• 2006

An usual acoustic emission(AE) event has two widely characterized parameters in time domain, peak amplitude and event duration. But noise in AE measuring may disturb the signals with its parameters and aggrandize the signal incertitude. Experiment activity of detection of the nick inside of porcelain with AE was made and study on AE signal processing with statistic be presented in this paper in order to pick-up information expected from the signal with noise. Effort is concentrated on developing a novel arithmetic to improve extraction of the characteristic from stochastic signal and to enhance the voracity of detection. The main purpose discussed in this paper is to treat with signals on amplitudes with statistic mutuality and power density spectrum in frequency domain, and farther more to select samples for neural networks training by means of least-squares algorithm between real measuring signal and deterministic signals under laboratory condition. By seeking optimization with the algorithm, the parameters representing characteristic of the porcelain object are selected, while the stochastic interfere be weakened, then study for detection on neural networks is developed based on processing above.

• Journal of Power Electronics
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• 제14권6호
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• pp.1263-1271
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• 2014

A novel hysteresis PWM control strategy for synchronous buck converter is proposed. The proposed control strategy is based on ampere-second balance of the modulate capacitor, which not only offers faster transient response to meet the challenges of the power supply requirements of fast dynamic load changes, but also provides better stability and solves the compensation problem of error amplifier in the conversional voltage PWM control. Finally, the steady-state and dynamic operation of the control method is analyzed and verified by simulation and experimental results.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1989년도 하계종합학술대회 논문집
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• pp.432-435
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• 1989

This paper presents an algorithm for electric field analysis which is essential to insulation design of extra-high voltage oil-filled cable accessories using finite element method. Governing equation is induced by electromagnetic equation. Variational method is adopted for FEN formulation. Automatic mesh generation which saves time and labor is introduced for the input data. The application results of proposed algorithms were used for insulation design to develop 345kV cable joint.

• BMB Reports
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• 제36권6호
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• pp.529-532
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• 2003

The potential physiological role and technological application of the premature termination of DNA polymerization through the off-switch of exo+ polymerases were studied using 3' phosphorothioate-modified or unmodified primers with single base mismatch distal to the 3' terminus. With exonuclease-digestible unmodified primers, a gradient premature termination of DNA polymerization was observed when amplified with exo+ polymerases. With 3' allele specific phosphorothioate-modified primers, an efficient off-switch effect occurred in the discrimination of a single nucleotide polymorphism when directly using genomic DNA. Clearly, the off-switch of exo+ polymerases is useful in biomedical research.

• 대한의생명과학회지
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• 제11권2호
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• pp.103-108
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• 2005

2-Deoxyribonolactone (dL) arises as a major DNA damage induced by a variety of agents, involving free radical attack and oxidation of C1'-deoxyribose in DNA. We investigated whether dL lesions can be repaired in mammalian cells and the mechanisms underlying the role of DNA polymerase $\beta$ in processing of dL lesions. Pol $\beta$ appeared to be trapped by dL residues, resulting in stable DNA-protein cross-links. However, repair DNA synthesis at site-specific dL sites occurred effectively in cell-free extracts, but predominantly accompanied by long-patch base excision repair (BER) pathway. Reconstitution of long-patch BER demonstrated that FEN1 was capable of removing the displaced flap DNA containing a 5'-dL residue. Cellular repair of dL lesions was largely dependent on the DNA polymerase activity of Pol $\beta$. Our observations reveal repair mechanisms of dL and define how mammalian cells prevent cytotoxic effects of oxidative DNA lesions that may threaten the genetic integrity of DNA.