• Title/Summary/Keyword: fatigue

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Traditional Korean Medicine for Non-Small Cell Lung Cancer Patient Undergoing Pembrolizumab Immunotherapy: A Case Report (Pembrolizumab 면역치료를 시행 중인 비소세포성 폐암환자의 한방치료 증례보고)

  • Shim, So-hyun;Seo, Hee-jeong;Seo, Hyung-bum;Cho, Im-hak;Lee, Chan;Kim, So-yeon;Han, Chang-woo;Park, Seong-ha;Yun, Young-ju;Lee, In;Kwon, Jung-nam;Hong, Jin-woo;Choi, Jun-yong
    • The Journal of Internal Korean Medicine
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    • v.40 no.4
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    • pp.709-722
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    • 2019
  • Objective: The purpose of this study was to report the effect of traditional Korean medicine (TKM) in alleviating the side effects of lung cancer patient undergoing immunotherapy. Method: A 43-year-old man, who was diagnosed with non-small cell lung cancer, received pembrolizumab treatments. The patient was treated with acupuncture and herbal medicine (Geoeoyangpye-tang) to control various uncomfortable symptoms. The degree of pain was measured by the numeric rating scale (NRS). The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Core 30 (EORTC QLQ-C30) and the EORTC 13-item lung cancer-specific module (EORTC LC-13 questionnaire) were used to assess the change in the quality of life. Results: After the TKM treatment, the flank pain and arthralgia based on the NRS were significantly improved. Various uncomfortable symptoms such as fatigue, dyspnea, insomnia, and loss of appetite were also significantly improved, based on the EORTC QLQ-C30 and EORTC QLQ-LC13. The size of the primary tumor was decreased during treatment. The disease status was stable radiologically after two months from discharge.

Manufacture of 3D Textile Preform and Study on Mechanical Properties of Composites (3D Textile 프리폼 제조 및 복합재료 기계적 특성 연구)

  • Jo, Kwang-Hoon;Klapper, Vinzenz;Kim, Hyeon-Woo;Lee, Jeong-Woon;Han, Joong-Won;Byun, Joon-Hyung;Joe, Chee-Ryong
    • Composites Research
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    • v.32 no.1
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    • pp.65-70
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    • 2019
  • The aircraft composites wing parts are usually integrated with adhesive or fastener. These laminated composites have weak interlaminar strength, which can lead to delamination. In order to compensate the disadvantages of laminated composites, it is possible to improve the strength, durability, shock and fatigue resistance by reinforcing the fiber in the thickness direction. In addition, using a single structure near-net-shape saves the manufacturing time and the number of fasteners, thus can reduce the overall cost of the composite parts. In this study, compression test, tensile test and open-hole tensile test are carried out for three structural architecture of 3D (three-dimensional) textile preforms: orthogonal(ORT), layer-to-layer(LTL) and through-the-thickness(TTT) patterns. Among these, the orthogonal textile composite shows the highest Young's modulus and strength in tensile and compression. The notch sensitivity of the orthogonal textile composite was the smallest as compared with UD (unidirectional) and 2D (two-dimensional) fabric laminates.

A Structural Equation Model on Quality of Life in Hemodialysis Patients (혈액투석환자의 삶의 질 구조모형)

  • Kang, Seung-Ja;Seo, Nam-Sook
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.7
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    • pp.589-598
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    • 2019
  • This study was conducted to build a structural equation model explaining factors that affect hemodialysis patients' quality of life to test the goodness of fit of the model and identify directly and indirectly significant paths. To accomplish this, 230 patients receiving hemodialysis registered at study hospitals in G Metropolitan City and M City were randomly selected, and 201 were used in the final analysis. Data were collected using a self reporting questionnaire from February 1 to March 31, 2014. SPSS WIN 18.0 was used for descriptive statistics and correlation analysis of the general characteristics and for reliability analysis of the research tools. In addition, AMOS 18.0 was used for confirmatory factor analysis of latent variables, to determine the goodness of fit of the hypothetic model, and hypotheses testing. The results of this study were as follows: the fit of the modified model was 41.32, GFI = .96, AGFI = .92, RMR = .04, NFI = .96, CFI = .91 and TLI = .95. Twelve out of the 22 research hypotheses that were improved and improved were statistically significant. The results indicated that hemodialysis patients' quality of life was influenced directly by self-efficacy, depression, and self-care behavior, and indirectly by sleep disturbance, stress, fatigue, and family support. These variables explained 58.6% of the variation in quality of life. Overall, these findings suggest that nursing interventions for hemodialysis patients require strategies for managing patient depression and for increasing self-efficacy and self-care behavior to improve quality of life.

A Study on the Document viewer optimized for VR environment (VR 환경에 최적화 된 문서 뷰어에 관한 연구)

  • Joo, Yong-Ho;Kim, Sang-Mok;Cho, Ok-Hue
    • Journal of the Korea Convergence Society
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    • v.12 no.5
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    • pp.139-145
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    • 2021
  • Through this study, we intend to study user satisfaction in order to verify whether there is a need for full-scale research, development and commercialization of document viewers in a VR environment. VR content consists of realistic 3D graphics and 360-degree video, and provides a synesthesia experience and immersion. We developed and tested a VR document viewer prototype that can utilize this concept as a document viewing system. It can act as a viewer that provides an interactive viewing environment according to the user's body interaction and the direction of the field of view, and it can be said that the feature of VR document viewer is that it can draw the user's high level of immersion and concentration when using the viewer. The developed prototype was tested in a test group consisting of 100 VR experiences and device owners for about 1 hour and 3 days a day, and then a questionnaire survey in the form of a fixed selection question was conducted. This study is a prototype study of a document viewer suitable for a virtual reality environment, and can lead to a sense of immersion when reading a document, and suggest a new document viewer direction that is effective for visual fatigue and visual perception of the document.

Fibromyalgia from the Psychiatric Perspective (정신과적 관점에서의 섬유근통)

  • Lee, Yunna;Lee, Sang-Shin;Kim, Hyunseuk;Kim, Hochan
    • Korean Journal of Psychosomatic Medicine
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    • v.28 no.2
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    • pp.99-107
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    • 2020
  • Fibromyalgia is a disorder characterized by the core symptom of chronic widespread pain, along with fatigue, sleep disturbances, mood changes, and cognitive difficulties. The etiology of fibromyalgia involves a combination of biological factors, such as genetic vulnerability, alterations in pain processing and stress response system ; psychological factors, such as anxiety, depression, anger, and perceived stress ; environmental factors, such as infections, febrile diseases, and trauma. Central sensitization, which is amplified in the process of sensory stimulation, has been emphasized as a key etiological factor, as supported by enhanced wind-up, delayed aftersensation, decreased nociceptive flexion reflex threshold and functional imaging studies. Several guidelines recommend that a multimodal approach be used to treat fibromyalgia, including both pharmacological and non-pharmacological treatments, tailored to each individual, and that clinicians should provide an intellectual framework through sufficient education and emphasis on the importance of self-management. The prevalence of mood disorders, anxiety disorders, and other psychiatric problems is 7-9 times higher in patients with fibromyalgia than in the general population ; moreover, the association between fibromyalgia and certain psychopathologies or sleep problems has also been suggested. Since psychiatric problems, with shared vulnerabilities and risk factors, interact with fibromyalgia bidirectionally and also affect the disease course, an integrated management approach is needed to determine the risk of comorbidities.

Corrosion-Resistant High Strength S20C Element Riveted Al5052-SPFC980Y Steel Joints by Resistance Element Spot Welding (S20C 리벳된 Al5052와 SPFC980Y 강철 resistance-element 점용접 접합부의 미세조직 발달 및 고강도-부식 저항 특성)

  • Baek, Seung-Yeop;Song, Jong-Ho;Park, Seung-Youn;Song, Il-Jong;Lee, Hyun-Chul
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.2
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    • pp.794-801
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    • 2021
  • This study examined the mechanical strength and corrosion resistance of a dissimilar joint with an aluminum alloy and steel by resistance element spot welding. SPFC980 steels and Al5052 alloys were applied as the base materials. S20C steels were assembled on Al5052 for the riveting element before the electric resistance welding process. The SPFC980-S20C riveted Al5052 was welded at a 6.5 kA current and 250 kgf/㎠. As a result, the engraved S20C elements formed unstable nuggets after the spot welding processes. In contrast, in the embossed S20C elements, exceptional mechanical properties, such as robust corrosion resistance and fatigue resistance, were obtained by structurally sound joints. The correlation between the microstructure and mechanical properties were examined by microstructural investigations and FEM simulations. The corrosion reliability of element spot-welded SPFC980-Al5052 dissimilar joints was investigated systematically.

Analysis on the Changes in Muscle Function of the Leg Joint in Athletics Athletes Through by Whole Body Vibration Exercise Training (전신진동(Whole body vibration)운동훈련을 통한 육상 투척선수의 하지관절 근육 기능변화에 관한 분석)

  • Lee, Youngsun;Yoon, Changsun;Han, KiHoon;Kim, Jinhyun;Hah, Chongku;Park, Joonsung;Kim, Jongbin
    • Journal of Convergence for Information Technology
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    • v.11 no.3
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    • pp.250-260
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    • 2021
  • The purpose of this study is to investigate muscle function and symmetry index during whole body vibration exercise using lower extremity training posture for throwing athletes. For throwing athletes in their 20s(6 males, 4 females, age: 24.60±0.92years, height: 177.90±7.40cm, weight: 92.90±22.97kg), lower extremity training postures with squat, carphrase, and lunge movements. Whole body vibration exercise training was performed using. Tensiomyography(TMG) variables Time Delay(Td), Time Contraction(Tc), Time Sustain(Ts) Time Relaxation(Tr), and Displacement Maximumal(Dm) in the lower extremity joint muscles(biceps femoris(BF), gastrocnemius lateral(GL), gastrocnemius medial(GM), rectus femoris(RF), tibialis anterior(TA), lateral vastus(LV), medial latissimus(ML)), were measured to compare and analyze muscle activity, muscle fatigue, and left-right symmetry. The results of the study are left RF, VL, right VM (p<.05) in Td, VM (p<.05) in Tc, GM in Ts (p<.05), left RF in Tr, and right TA (p<. 05) showed a change. Therefore, it has been proven that various whole-body vibration training is an effective exercise with changes in muscle contraction, and stability of the core is secured by symmetry of the left and right muscles. For this reason, the whole body vibration exercise will have a positive effect on rehabilitation training, and it is believed that it will be able to improve performance.

An Analysis of the Trends of Aromatherapy Researches in Chinese Literatures

  • Sun, Jiao-Jing;Kim, Kyeong-Ran
    • Journal of the Korea Society of Computer and Information
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    • v.26 no.1
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    • pp.239-251
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    • 2021
  • Traditional Chinese medicine has treated diseases and improved health in nature-based experience. Advanced nations began to be interested in naturopathic therapy in the late 19th century and it led China to research aromatherapy. This study searched previous researches related with aromatherapy and generally analyzed aroma oil, applied body parts, methods of use, and period of use. For research contents, scientific and society journals from 2000 to 2019 related with aromatherapy were searched in CNKI(www.cnki.com) and WANFANG DATE(www.wanfang.com). Finally, 30 papers were selected through 5-step qualitative evaluation and expert review and analyzed. Frequency and percentage(%) were calculated by means of the Excel 2013 Program and represented by a chart. The results of analyzing aromatherapy trends are as follows. All 30 papers were researched in the medical society. The most common symptom was irritation and anxiety that appeared in 13 papers. Lavender oil and bergamot oil were commonly used aroma oil. Commonly applied part and method were nose and nasal inhalation. For aroma oil associated with symptoms, lavender oil was the best in irritative, anxious, and negative emotion, depression, labor pain, sleep disorder, migraine, tension, and vomiting, pain, and fatigue after operation. Lemon, ginger, and peppermint oil was good for nausea. Based on the findings, this study derived applied body parts, methods of use, and period of use in aromatherapy. However, most aromatherapy was used for patients in the nursing and medical fields in the simple form of inhalation and local massage. This study will suggest a standard ground that aromatherapy is good for pain, colic pain, and tension in a short period but needs a long period for the efficacy of psychological and neurological symptoms.

Multi-fidelity Data-fusion for Improving Strain accuracy using Optical Fiber Sensors (이종 광섬유 센서 데이터 융합을 통한 변형률 정확도 향상 기법)

  • Park, Young-Soo;Jin, Seung-Seop;Yoo, Chul-Hwan;Kim, Sungtae;Park, Young-Hwan
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.40 no.6
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    • pp.547-553
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    • 2020
  • As aging infrastructures increase along with time, the efficient maintenance becomes more significant and accurate responses from the sensors are pre-requisite. Among various responses, strain is commonly used to detect damage such as crack and fatigue. Optical fiber sensor is one of the promising sensing techniques to measure strains with high-durability, immunity for electrical noise, long transmission distance. Fiber Bragg Grating (FBG) is a point sensor to measure the strain based on reflected signals from the grating, while Brillouin Optic Correlation Domain Analysis (BOCDA) is a distributed sensor to measure the strain along with the optical fiber based on scattering signals. Although the FBG provides the signal with high accuracy and reproducibility, the number of sensing points is limited. On the other hand, the BOCDA can measure a quasi-continuous strain along with the optical fiber. However, the measured signals from BOCDA have low accuracy and reproducibility. This paper proposed a multi-fidelity data-fusion method based on Gaussian Process Regression to improve the fidelity of the strain distribution by fusing the advantages of both systems. The proposed method was evaluated by laboratory test. The result shows that the proposed method is promising to improve the fidelity of the strain.

Mixed-effects zero-inflated Poisson regression for analyzing the spread of COVID-19 in Daejeon (혼합효과 영과잉 포아송 회귀모형을 이용한 대전광역시 코로나 발생 동향 분석)

  • Kim, Gwanghee;Lee, Eunjee
    • The Korean Journal of Applied Statistics
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    • v.34 no.3
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    • pp.375-388
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    • 2021
  • This paper aims to help prevent the spread of COVID-19 by analyzing confirmed cases of COVID-19 in Daejeon. A high volume of visitors, downtown areas, and psychological fatigue with prolonged social distancing were considered as risk factors associated with the spread of COVID-19. We considered the weekly confirmed cases in each administrative district as a response variable. Explanatory variables were the number of passengers getting off at a bus station in each administrative district and the elapsed time since the Korean government had imposed distancing in daily life. We employed a mixed-effects zero-inflated Poisson regression model because the number of cases was repeatedly measured with excess zero-count data. We conducted k-means clustering to identify three groups of administrative districts having different characteristics in terms of the number of bars, the population size, and the distance to the closest college. Considering that the number of confirmed cases might vary depending on districts' characteristics, the clustering information was incorporated as a categorical explanatory variable. We found that Covid-19 was more prevalent as population size increased and a district is downtown. As the number of passengers getting off at a downtown district increased, the confirmed cases significantly increased.