• Archives of Reconstructive Microsurgery
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• v.1 no.1
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• pp.51-55
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• 1992

Problems of composite tissue transfer commonly arise when a single indispensable recipient vessel receives the graft vssel, and the graft vessel must be sutured in end-to-side fashion so as not todisturb the vascularity of the recipient vessel. The triangular flap in the recipient vessel wall gives an intact endothelial surface when the flow of blood stream is presented and may reduce the chance of anastomosis. We selected mature Wistar rats weighing over 450 grams to compare the conventional longitudinal slit from the triangular flap in the recipient carotid artery over bloood pressure and blood flow when the donor carotid artery was anastomosed in end-to-side fashion. In 30 minutes after anastomosis, maximum blood pressure measured in the donor carotid arterial side when the recipient arterial wall was fasioned with the longitudinal slit was recorded 114 mmHg and with the triangular flap 100mmHg. Minimum blood pressure with the longitudinal slit was 98mmHg and with the triangular flap 88mmHg. The amount of blood collected for 30 seconds in the conventional longitudinal slit was 1.18mg and in the triangular flap 0.78mg. Histology study in 30 minutes, the conventional longitudinal slit demonstrated the more hemorrhagic features around the suture material compared to that of the triangular. flap and, in the 7th day, the conventional longitudinal slit demonstrated the more prominent granulomatous reactions and vascular proliferations around the suture material compared to that of the triangular flap.

• Archives of design research
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• v.20 no.2 s.70
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• pp.41-52
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• 2007

Today, many pregnant women also advance up the business ladder and remain very active. They are consequently increasingly aware of the clothes they can wear. Despite these social changes, maternity wear has not been specially designed to satisfy the consumer's demands. From this, the purposes of this study are to investigate the current status of maternity wear and the apparent buying trends of pregnant women through a customers' opinion survey and interviews for the future maternity markets. In summary, the survey and interviews illustrate some important points which are that: Firstly, not all pregnant women buy maternity wear. Some pregnant women said they couldn't find enough difference in maternity wear prices even though they would like to buy some, commenting that maternity clothes were too expensive for such a short period of time. Also some already had maternity wear from a previous pregnancy, or had been passed on from friends and family. Secondly, on the other hand, many respondents were strongly concerned with style and quality rather than price because they agreed that there were not enough suitable maternity clothes for work and special occasions. Therefore some respondents would buy a maternity outfit for a special occasion. It also indicates that for a particular time, place or occasion like a party, wedding or other celebration, some respondents would buy a special outfit to make themselves feel good. Finally, according to the survey, the most important design concept is for wearable designs which change with the body during pregnancy; followed closely by designs which are able to be re-used when the pregnancy has finished. Nowadays, as recycling and saving resources are the biggest issues, if maternity manufacturers are encouraged to develop new products incorporating these new design concepts, more maternity markets will be developed to buy maternity wear.

• Archives of Pharmacal Research
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• v.21 no.6
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• pp.664-670
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• 1998

The role of intracellular $Ca^{2+}$, in the regulation of tumor cell proliferation by products of arachidonic acid (AA) metabolism was investigated using U-373 MG human as trocytoma cells. Treatment with nordihydroguaiaretic acid (NDGA), a lipoxygenase (LOX) inhibitor, or caffeic acid (CA), a specific 5-LOX inhibitor, suppressed proliferation of the tumor cells in a dose-dependent manner. However, indomethacin (indo), a cyclooxygenase (COX) inhibitor, did not significantly alter proliferation of the tumor cells. At anti-proliferative concentrations, NDGA and CA significantly inhibited intracellular $Ca^{2+}$ release induced by carbachol, a known intracelluar $Ca^{2+}$ agonist in the tumor cells. Exogenous administration of leukotriene $B_4(LTB_4)$, an AA metabolite of LOX pathway, enhanced proliferation of the tumor cells in a concentration-dependent fashion. In addition, $LTB_4$, induced intracelluar $Ca^{2+}$ release. Intracellular $Ca^{2+}$-inhibitors, such as an intracellular $Ca^{2+}$ chelator (BAPTA) and intracellular $Ca^{2+}$-release inhibitors (dantrolene and TMB-8), significantly blocked the LTB4-induced enhancement of cell proliferation and intracellular $Ca^{2+}$ release. These results suggest that LOX activity may be critical for cell proliferation of the human astrocytoma cells and that intracelluar $Ca^{2+}$ may play a major role in the mechanism of action of LOX.

• Archives of Pharmacal Research
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• v.25 no.6
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• pp.932-939
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• 2002

The aim of the present study was to determine the characteristics of cytisine on the secretion of catecholamines (CA) in isolated perfused rat adrenal glands, and to clarify its mechanism of action. The release of CA evoked by the continuous infusion of cytisine ($1.5{\times}10^{-5} M$) was time-dependently reduced from 15 min following the initiation of cytisine infusion. Furthermore, upon the repeated injection of cytisine ($5{\times}10^{-5}$), at 30 min intervals into an adrenal vein, the secretion of CA was rapidly decreased following the second injection. Tachyphylaxis to the release of CA was observed by the repeated administration of cytisine. The cytisine-induced secretion of CA was markedly inhibited by pretreatment with chlorisondamine, nicardipine, TMB-8, and the perfusion of $Ca^{2+}$-free Krebs solution, while it was not affected by pirenzepine or diphenhydramine. Moreover, the secretion of CA evoked by ACh was time-dependently inhibited by the prior perfusion of cytisine ($5{\times}10^{-6} M$). Taken together, these experimental data suggest that cytisine causes secretion of catecholamines from the perfused rat adrenal glands in a calcium-dependent fashion through the activation of neuronal nicotinic ACh receptors located in adrenomedullary chromaffin cells. It also seems that the cytisine-evoked release of catecholamine is not relevant to the activation of cholinergic M$_1$-muscarinic or histaminergic receptors.

• Archives of Plastic Surgery
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• v.34 no.5
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• pp.653-655
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• 2007

Purpose: The umbilicus is an important aesthetic component of the abdomen. Its absence is both cosmetically and psychologically distressing to the patient. Umbilical reconstruction should always be aimed at creating an umbilicus of sufficient depth and good morphology with less scarring. The C-V flap developed for nipple reconstruction was used in an inverted fashion in case of umbilical reconstruction. The aim of this article is to report our experience of scarred umbilical reconstruction using inverted C-V flap. Methods: A 22-year-old woman presented with contracted scar tissue in the umbilical region because she had undergone surgical correction of an umbilical hernia at 5 year of age. Pedicle of the inverted C-V flap was based cephalically. For enhancing depth of the umbilicus, three anchoring sutures to linea alba were done at both lateral and caudal aspects of the umbilical tube. Primary closures were done at donor sites of the V flaps and bolster sutures were done in the caudal direction of the inverted umbilical tube. Results: The patient was satisfied with the appearance of umbilicus. Major complications such as dehiscence, infection, and delayed healing did not occur. Conclusion: The inverted C-V flap is easy and simple technique, and it can produce a satisfactory reconstruction of umbilical structure.

• Archives of design research
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• v.20 no.3 s.71
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• pp.335-344
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• 2007

Hunminjeongeum. is. book. of. Hangul.. The. contents. is. all. about. philosophy. and. concept. of. Hangul. design.. It. is. world-valuable. design. text.. It. is. a. design. theory. book.. typographic. theory.. and. design. philosophy. book.. The. word. of. 'design'. is. Meotjit. in. Korean.. Design. is.'doing. or. making. with .Meot'. in. material,. non-material,. even. in. thinking.. Visual. communication. design. is.'Bom-Meotjit',. Fashion. design. is. 'Ot-Meotjit'.. Substance. of. Meot. is. Oullim,. the. great. harmony.. The. state. of. Meot. is. the. identity. of. Korean. design. spirit..

• Archives of design research
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• v.13
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• pp.139-150
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• 1996

This study is to develop brand renovation identities for kolon mode and 5 other brands: Arthur dixon, Arpeggio, Manstar, Just, Bella. Since those brands have their own identities for about 10 to 20 years, new images have to be made very carefully based on the examination of old identities whether they fit their concepts. lifestyle of their consumers, fasion trends and so on. The typical way of adopting a renovation identity for a existing brand is to consider a transition part which never needs to be considered for a new brand.

• Archives of design research
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• v.13
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• pp.55-64
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• 1996

Garment is not only a part of formative art that establishes a live shape by wearer but also space modeling which features the solidity based on human body. Hence, beyond the simple meaning of 'wearing clothes', modeling which makes a cubic shape in accordance with human body's movement, is an important element in garment design. This study examined puli-over-typed garment design that owns abundant space sense, taking complex shapes of geometrical diagrams with brief and simple features as a motive. The study aims at seeking after the combination of plane and cubic forms, and exploring formative garments which are further modern and different variance by approaching the natural section of geomentrical facets with tightfitting idea and composition of delicate colors and forms when plane pattern was put on human body.

• Archives of Plastic Surgery
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• v.37 no.2
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• pp.161-168
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• 2010

Purpose: Surgical approaches to the condylar neck and subcondyle area can cause some morbidity such as, facial nerve injury, time-consuming nature and external scar etc. So many surgeons hesitate using open reduction and internal fixation for the treatment of subcondylar fractures. We report open reduction and internal fixation of subcondylar fractures in 13 adult patients via transmasseteric approach. Methods: From 2007 to 2009, 13 adults with subcondylar fracture of mandible were treated with open reduction and internal fixation via transmasseteric approach. A preauricular incision was extended downwards in a curvilinear fashion in the cervicomastoid skin crease. Skin flap was elevated above the SMAS layer. Masseter muscle was splitted at the anteroinferior edge of the parotid gland. After the fracture was reduced, fixed with appropriate plates and screws. All operation were performed under general anesthesia. Results: Mean follow-up period was 13.3 months. There were no signs and symptoms of facial nerve injury, difficulty in mouth opening, or malocclusion. Dissection time was roughly within 30 minutes. Conclusion: Transmasseteric open reduction and internal fixation of mandible subcondylar fracture can be performed with excellent visualization, and inconspicuous scar. It also offers swift access to the subcondylar area while substatially reducing the risk to the facial nerve and eliminating the complications associated with transparotid approaches.

• Archives of Plastic Surgery
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• v.37 no.2
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• pp.169-174
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• 2010

Purpose: Reduction mammaplasty is a procedure with a relatively high patient satisfaction rate, however, associated scarring around the areola can be a serious problem. This study proposes a new modification of the breast reduction procedure by means of an inframammary incision alone. Methods: The breast is marked out preoperatively with standing position. Under the general anesthesia, an inframammary incision of approximately 7 - 8 cm is done. The subcutaneous plane is made in the lower pole of the breast, then the subglandular plane is entered and a sharp dissection is made up to 2 cm below the areola. The breast is mobilized from the chest wall and a cone-shaped parenchyme is removed in en-block except from the retroareolar central part. The remaining both pillars are gathered together with absorbable sutures and the base of the gland is narrowed to project the breast forward. The wound is closed in a layered fashion and taping of the breast mound is applied to redistribute the breast skin. Results: 21 patients (36 breasts) underwent this procedure from December 2004 to December 2009. Average follow up was 9 months (ranged from 6 months to 12 months). No major complication occurred. Most patients were pleased with the breast size, shape, and scars. However, 2 patients complained their hypertrophic scars which were corrected by revision. Conclusion: This technique is a simple approach to mild to moderate breast reduction through an inframammary incision alone. And, this technique provides an option with minimal complications and invisible scarring, which is especially important in the young patient group.