• Journal of Preventive Medicine and Public Health
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• 제56권1호
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• pp.88-94
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• 2023

Objectives: This study examined how deprivation differed by region and the effect those differences had on suicidal ideation among the local population. Methods: Data collected over 10 years (2012-2021) in the Korea Welfare Panel Study were organized into 3 categories: metropolitan, city, and rural. A panel analysis was conducted on the impact of deprivation indices, socio-demographic characteristics, and life satisfaction on suicidal ideation in each category. Results: Income, divorce status, family relationship satisfaction, and medical deprivation had a significant impact on suicidal ideation in metropolitan areas, whereas these variables did not have significant effects in rural areas. In other words, income, family, and medical support were more impactful in city areas. Conclusions: Although the deprivation index was higher in rural areas than in city areas due to an aging population and reduced income levels, the mental health of rural residents was found to be generally better than that of city residents. The possibility that this is related to the strength of relationships within the respective communities should be considered in light of recent discussions on relational welfare.

• Genomics & Informatics
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• 제14권2호
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• pp.62-68
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• 2016

Osteoporosis is a medical condition of global concern, with increasing incidence in both sexes. Bone mineral density (BMD), a highly heritable trait, has been proven a useful diagnostic factor in predicting fracture. Because medical information is lacking about male osteoporotic genetics, we conducted a genome-wide association study of BMD in Korean men. With 1,176 participants, we analyzed 4,414,664 single nucleotide polymorphisms (SNPs) after genomic imputation, and identified five SNPs and three loci correlated with bone density and strength. Multivariate linear regression models were applied to adjust for age and body mass index interference. Rs17124500 ($p=6.42{\times}10^{-7}$), rs34594869 ($p=6.53{\times}10^{-7}$) and rs17124504 ($p=6.53{\times}10^{-7}$) in 14q31.3 and rs140155614 ($p=8.64{\times}10^{-7}$) in 15q25.1 were significantly associated with lumbar spine BMD (LS-BMD), while rs111822233 ($p=6.35{\times}10^{-7}$) was linked with the femur total BMD (FT-BMD). Additionally, we analyzed the relationship between BMD and five genes previously identified in Korean men. Rs61382873 (p = 0.0009) in LRP5, rs9567003 (p = 0.0033) in TNFSF11 and rs9935828 (p = 0.0248) in FOXL1 were observed for LS-BMD. Furthermore, rs33997547 (p = 0.0057) in ZBTB and rs1664496 (p = 0.0012) in MEF2C were found to influence FT-BMD and rs61769193 (p = 0.0114) in ZBTB to influence femur neck BMD. We identified five SNPs and three genomic regions, associated with BMD. The significance of our results lies in the discovery of new loci, while also affirming a previously significant locus, as potential osteoporotic factors in the Korean male population.

• 디지털융복합연구
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• 제14권8호
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• pp.93-104
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• 2016

본 연구의 목적은 제3문화 청소년의 가족건강성과 민족정체성의 관계에서 자아존중감의 매개효과를 검증해 보는 것이었다. 이를 위해 미국의 동부 버지니아 페어팩스(Fairfax) 카운티 지역과 서부 캘리포니아 얼바인(Irvine) 두 지역을 중심으로 한국인 청소년 혹은 미국시민권을 지니고 있지만 모국이 한국인인 청소년 86명을 대상으로 자료를 수집하여 분석하였다. 자료 분석은 SPSS 18.0 프로그램을 이용하여 기술통계, t-test와 일원분석분석, 상관분석, 회귀 분석을 실시하였고, 매개효과의 유의성을 검증하기 위해 Sobel test를 실시하였다. 본 연구의 주요결과는 첫째, 가족건강성, 자아존중감 그리고 민족정체성은 정적상관을 지니는 것으로 나타났다. 둘째, 가족건강성과 민족정체성의 관계에서 자아존중감은 부분매개효과를 지니는 것으로 나타났다. 셋째, 민족정체성 하위변인 중 민족정체성 탐색의 경우 가족건 강성과의 관계에서 자아존중감이 부분매개효과를 지니는 것으로 나타났으며, 민족소속감의 경우 자아존중감은 유의미한 영향력을 미치는 반면 가족건강성은 유의미한 영향력이 없는 것으로 나타났다. 이러한 연구결과를 바탕으로 건강한 민족정체성 형성을 위한 연구의 함의와 시사점 및 연구의 한계 그리고 후속연구를 위한 제언을 제시하였다.

• 한국재료학회지
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• 제21권12호
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• pp.685-689
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• 2011

The goal of this investigation was to produce a zirconia-family black ceramics that has enhanced functionality and reliability. Color zirconia ceramics have been produced by adding pigments. Pigments cause structural defects within zirconia and result in a drop in physical properties. Using environmentally friendly rice husk, we produced a black zirconia that is free of structural defects. In optimal firing conditions for black zirconia the calcining temperatures of the molding product are changed from $400^{\circ}C$ to $1200^{\circ}C$, and the firing temperatures are changed from $1400^{\circ}C$ to $1600^{\circ}C$. Color of testing the specimens was analyzed using Ultraviolet (UV) spectroscopy. Scanning Electron Microscope (SEM), EDAX (EDX), and Fourier transform infrared spectroscopy (FT-IR) analyses were carried out in order to examine impregnation properties and crystal phases. Universial Test Machine (UTM) was used to measure the flexual strength as well as the compressive strength. From experimental results, it was found that in optimal firing conditions the sample was calcined from $1000^{\circ}C$ to $1500^{\circ}C$. Commission internationalde I'Edairage (CIE) values of manufactured black zirconia color were $L^*$ = 29.73, $a^*$ = 0.23, $b^*$ = -2.68. The bending strength was 918 MPa and the compressive strength was 2676 MPa. These strength values are similar to typical strength values of zirconia, which confirms that carbon impregnation did not influence physical properties.

• 생명과학회지
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• 제31권10호
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• pp.944-953
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• 2021

리그닌은 식물의 세포벽에 풍부하게 존재하는 복잡한 phenylpropanoid 중합체이다. 주로 물 수송과 기계적 강도를 유지하는 조직에 존재하며 수분을 운반하거나, 기계적인 지지를 담당한다. 또한, 리그닌은 병원균의 감염이나 상처에 대한 물리적인 장벽으로 작용함으로써 방어 기작에 관여한다. 리그닌을 생성하는 모노리그놀 전구체는 cinnamyl alcohol dehydrogenase (CAD) 유전자에 의해 합성된다. CAD는 cinnamaldehyde를 cinnamyl alcohol(p-coumaryl, coniferyl, sinapyl alcohol)로 전환하는 효소이다. CAD는 속씨식물에서 multigenic family로 존재하며 여러 식물 종에서 다른 기능을 가진 CAD isoform이 밝혀졌다. CAD 유전자의 여러 isoform은 식물의 발달 및 환경 신호에 따라 다르게 발현되었다. 하나의 isoform이 발달 리그닌화에 관여하는 반면, 다른 isoform은 방어 리그닌 및 기타 세포벽에 결합된 페놀의 구성에 영향을 미칠 수 있음을 보여주었다. CAD isoform에 따라 기질 특이성이 다르게 나타나고, 이는 리그닌 합성을 조절하는 CAD 단백질의 생화학적 특성을 나타내는데 기여한다. 본 논문에서는 리그닌 생합성에서 CAD multigenic family 유전자의 발현과 조절에 대하여 설명하였다. CAD multigenic family의 isoform들은 유전적 조절이 복잡하고, 식물 발달 과정의 신호 경로와 스트레스 반응이 밀접하게 연동되어 있다. CAD 유전자에 의한 모노리그놀 합성은 발달 및 환경 신호에 의해 조절될 가능성이 높다.

• Journal of applied mathematics & informatics
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• 제41권6호
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• pp.1275-1301
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• 2023

This paper introduced the Weibull Marshall-Olkin Power Lomax (WMOPL) distribution. The statistical aspects of the proposed model are presented, such as the quantiles function, moments, mean residual life and mean deviations, variance, skewness, kurtosis, and reliability measures like the residual life function, and stress-strength reliability. The parameters of the new model are estimated using six different methods, and simulation research is illustrated to compare the six estimation methods. In the end, two real data sets show that the Weibull Marshall-Olkin Power Lomax distribution is flexible and suitable for modeling data.

• 가정과삶의질연구
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• 제15권1호
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• pp.71-82
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• 1997

This paper concerns with parent-child relationship program for the adolescents' parents(PCRP). The purpose of this paper is to develop a model for the strength of the relationship between parents and their children as well as to prevent adolescent's individual and social problems The contents of PCRP based on the theoretical background consist of our parts: understanding adolescent physical and psychological development understanding adolescent sexuality developing effective communication skills and developing conflict solving skills. Implicationsh for the program evaluation methods and further development of family life education are discussed.

• 한국가정과교육학회지
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• 제23권2호
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• pp.89-107
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• 2011

본 연구에서는 기혼자 22명을 대상으로 심층면접을 통하여 기혼자의 '결혼'에 대한 인식을 살펴보았다. 심층 면접 자료를 분석한 결과는 다음과 같다. 1. 기혼자들은 결혼을 통해 얻는 것이 있으면 잃는 것이 있다는 양면을 잘 인식하고 있었다. 즉 결혼을 하면서 잃어버린 자신의 세계에 대한 동경이 있고, 자유로웠던 싱글 시기를 그리워하고 아쉬워하지만, 반면에 결혼을 통해 안정감과 소속감을 얻게 되었고 외롭지 않다고 한다. 2. 기혼자들은 결혼은 경험하지 않으면 모르는 세계라고 인식한다. 싱글은 인생의 간만 보는 것이라면 결혼은 인생의 맛을 보는 것이라고 인식한다. 기혼자들이 결혼의 삶에서 찾아나가는 '맛'은 '가족과 자식의 힘', '인생 고비 뒤의 나를 찾아가는 길', '함께 하는 삶의 즐거움과 편안함', '넓어지는 삶의 폭, 높아지는 삶의 질'이다.

• 한국학교ㆍ지역보건교육학회지
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• 제12권1호
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• pp.1-20
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• 2011

Purpose: The purpose of this study is to analyze factors affecting suicidal ideation of athletes in middle and high school. Methods: The data in this study came from the survey which conducted to 500 students of physical education high school athletes and elite athletes in general school from the beginning of December 2009 to the end of January 2010 in Seoul and Kyunggi. Finally 436 cases was used. The dependant variable is suicidal ideation in this study. And the independent variables are socio-demographic factors, exercise-related factors, school and family environments, stress and depression factor. The analysis method is logistic regression analysis. Finally 436 cases was used. Results: First, the rate of suicidal ideation of athletes in middle and high school was 28.9%. Second, there were significant differences between stress and sex, grades, athletic career, kind of sport, sport skill level, the average exercise time per day, family circumstances, life satisfaction, future expectations. Third, there were significant differences between depression and sex, academic achievements, the average exercise time per day, family circumstances, life satisfaction, future expectations. Fourth, there were significant differences between suicidal ideation and sport skill level, academic achievements, the average exercise time per day, family circumstances, life satisfaction, future expectations. Fifth, the higher level of stress and degree of depression, the more increased the risk of suicidal ideation. Conclusions: Considering the close relationship between suicidal ideation and suicidal attempt, to reduce the suicidal ideation of athletes in middle and high school it is necessary to adjust exercising time properly and to promote life satisfaction. Also to overcome depression and stress support system should be established and to promote self-efficacy cognition strength program should be introduced in the school. So athletes in middle and high school should have confidence and self-confidence on the future.

• BMB Reports
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• 제54권3호
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• pp.176-181
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• 2021

Bcl-x, a member of the Bcl-2 family, plays a key role in apoptosis. Alternative splicing of Bcl-x pre-mRNA through alternative 5' splice-site selection produces an anti-apoptotic mRNA isoform that includes exon 2b and a pro-apoptotic Bcl-x mRNA isoform that excludes exon 2b. Here we used Bcl-x minigene and identified SRSF2 and SRSF6 as two regulatory factors of 5' splice-site selection of Bcl-x pre-mRNA. We selected binding clusters closer to 5' splice-sites from multiple potential binding sites of SRSF2 and SRSF6 to perform loss of functions analysis through site-directed mutagenesis. Our results demonstrated that these mutations did not abolish regulatory functions of SRSF2 or SRSF6, indicating that a single binding motif or a cluster was not a functional target of these proteins in Bcl-x pre-mRNA splicing. Random deletion mutagenesis did not disrupt the role of SRSF2 and SRSF6. Importantly, mutagenesis of 5' splice-site to a conserved or a weaker score demonstrated that the weaker strength of the target 5' splice-site or higher strength of the other 5' splice-site strength limited the role of SRSF2 and SRSF6 in 5' splice-site activation.