• Molecules and Cells
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• v.44 no.5
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• pp.342-355
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• 2021

The microphthalmia-associated transcription factor family (MiT family) proteins are evolutionarily conserved transcription factors that perform many essential biological functions. In mammals, the MiT family consists of MITF (microphthalmia-associated transcription factor or melanocyte-inducing transcription factor), TFEB (transcription factor EB), TFE3 (transcription factor E3), and TFEC (transcription factor EC). These transcriptional factors belong to the basic helix-loop-helix-leucine zipper (bHLH-LZ) transcription factor family and bind the E-box DNA motifs in the promoter regions of target genes to enhance transcription. The best studied functions of MiT proteins include lysosome biogenesis and autophagy induction. In addition, they modulate cellular metabolism, mitochondria dynamics, and various stress responses. The control of nuclear localization via phosphorylation and dephosphorylation serves as the primary regulatory mechanism for MiT family proteins, and several kinases and phosphatases have been identified to directly determine the transcriptional activities of MiT proteins. In different immune cell types, each MiT family member is shown to play distinct or redundant roles and we expect that there is far more to learn about their functions and regulatory mechanisms in host defense and inflammatory responses.

• Journal of Families and Better Life
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• v.34 no.3
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• pp.147-163
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• 2016

Multicultural Family Support Centers (MFSC) have provided five program areas including family, gender equality, human rights, social integration, and counseling since 2015. It is important to examine the MFSC staff's perceptions of the family programs and program needs for multicultural families to improve the effectiveness of these programs. In this study, we aim to explore the staff's perceptions of the family programs and to assess multicultural family program needs based on the family life cycle. A total of 130 MFSC staff were recruited through 128 MFSCs across Korea. Descriptive statistics were conducted for data analysis. Our findings revealed that MFSC staff have increasingly recognized that their target audiences are not only marriage immigrants and their families but also foreign workers' families and families from North Korea. In addition, the MFSC staff identified the importance of family programs instead of only programs for individual family members and multicultural families' different program needs based on their family life cycle. Contrary to the positive perception of the family programs, they described challenges of the family programs including a shortage of funds, difficulty recruiting family member combinations (e.g., couples, parent-child) for family programs, a lack of a program manual, and a heavy workload. This study provides insights into the family programs including their development and delivery.

• Journal of Korean Academy of Nursing
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• v.28 no.1
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• pp.104-116
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• 1998

The purpose of this study was to analyze the trends of family nursing research in Korea. The subjects were 62 articles, 132 master theses and 20 doctoral theses published during the period between 1970-1997.7. The results are as follows. 1. The types of research that were analyzed were factor isolating. 34.1%, factor relating, 54.2%, situation relating. 6.1% and situation producing, 3.7%. 2. Research designs were experimental studies, 6. 1%, non-experimental studies, 89.7% and qualitative research, 4.2%. Survey research was the method used in 82.7% of the papers. 3. On the research subjects, 94 papers dealt with the family member of a patient or a single person, 59 papers dealt with a patient and 7 papers dealt with whole family. 4. On the places of studies, 64.0% of the studies were done in hospital rooms, 12.9% in the communities and community facilities. 12.0% in schools, 10.7% in the home, and 0.4% an occupational setting. 5. The most frequently used family concept in the title of the articles was "family support"(59 papers) followed by family function and family burden. 6. The most frequently used family assessment tool was Family Environment Scale(FES) developed by Moos & Insel. 7, According to family nursing domain described by Murphy' and Meister'study, the subdomain, relationship of the family and disease was found 83.2%. 8. Four papers built conceptual frameworks based on various theories of researchers. Eleven papers applied family theories and five papers applied nursing theories. Based on the above findings the following suggestions are made. 1. The various domains of family nursing research should be used including in the relationship of family and health, health policy and family. transcultural family research, and theoretical approach to family. 2. Qualitative research should be used for family nursing research. 3. Family assessment tools should be developed for the Korean family.

• The Korean Journal of Rehabilitation Nursing
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• v.2 no.2
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• pp.215-224
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• 1999

This study was designed to compare care needs of patients with cancer and family members in inpatient and outpatient settings. The questionnaire was a Likert type 5 point scale with 57 items on four need categories; informational, physical care emotional care and socioeconomic care. There were significant differences between inpatient and outpatient settings. Also, there were significant differences in degree of care need according to gender, religion, marital status, economic status, public insurance status, and the past regimen. In conclusion, emotional needs perceived by patients with cancer and family members were higher than the others. Based upon the result, it is recommended that the research to compare needs between cancer patients who have a same illness and family member are necessary.

• The Journal of Korean Medical History
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• v.26 no.1
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• pp.1-7
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• 2013

Jeonuigam(典醫監) is one of the Big Three of medical government office through the Joseon dynasty era. But Jeonuigam literature is extremely rare. This paper is to analyze 362 cadets of "Jeonham-saengdoan(前銜生徒案)" by writer of Jeonuigam origin. Jeonuigam filled cadet on a three-year cycle because the national examination for medical officials is conducted on same cycle. Most cadets came from a few meritorious family of medical career officials. Ratio of ten major family stand at 34.91 percent. 373 of the 392 cadets are confirmed as family member of medical bureaucrat. They have a very closed society. Wancheon(完薦) and cadet system strengthen the monopholy power of a few family. The analysis of study confirmed that in the 19th century Joseon(朝鮮) dynasty had monopolized the medical technicians.

• Journal of the Korean Home Economics Association
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• v.47 no.4
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• pp.11-24
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• 2009

This study aims to analyze families and the kinship concepts in Korean laws based on meanings, boundaries, and functions. Korean culture is in the process of changing from traditional familism to democratic individualism, yet this is not a simple transition. In recent times, many people have come to look at family life from both traditional and individual perspectives, so their family values are inconsistent with each other. Therefore, this creates many family conflicts. As a result of this problem, I have analyzed families and the kinship concepts in Korean laws based on meanings, boundaries, and functions. Because laws regulate and reflect our everyday life, it is meaningful to review these laws. The results are as follow: First, the meaning of family in Korean laws is to respect other family members, and democratic family relationships. Second, the family boundaries are very different depending on the laws. The core boundary is the nuclear family, but in addition to the nuclear family, the parents of the wife and husband, the family of origin and the kin living together are included in the family member regulations. Third, the functions of the family are caring, education, rules for the living place, child discipline, supporting each other, guardianship for the family members, succession of family assets, and legal accusation rights. Kinship plays an important role in determining child guardianship, permission of a minor to marry, and authority over legal incompetency. Therefore, there are some contradictions between individualism and patriarchy in Korean laws, and these can have an influence on the conflicts between family members in the everyday life.

• Journal of Korean Academy of Nursing
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• v.29 no.3
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• pp.467-484
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• 1999

The main objectives of this study were to investigate the concept of family function from the perspective of the contemporary Korean family, and to construct model of change of family function with chronic illness. The hybrid model approach was applied in which three phases(theoretical phase, empirical phase, and analytic phase) of concept development were explored for family functioning. The study was conducted from 1997 to 1998. In empirical phase, two groups of purposive samples were drawn : normal family group composed of six families without ill family member, and ill family group composed of seven families of which wives have rheumatoid arthritis. Only families with child(or children) in primary or secondary schools were included in the study. The results were as follows : In theoretical phase, six dimensions of family concept were emerged : affective, structural, control, cognitive, financial, and reproductive dimension. In order to analyse the Korean normal family function in middle class with middle-aged women, financial and reproductive dimension were not included. In empirical phase, five dimensions(affective, structural, control, cognitive, and external relationship) were found from the normal family data. External relationship dimension is very important factor as a resource of the support, especially when their parents or siblings had no help or support to them. In the affective dimension, Korean family emphasized harmony and balance rather than affective expression between couples and between parents and children. They also showed common goals of the families to solve their problems to control the family members. The priority of the goals was getting into the higher education of their children or helping their unhealthy parents or family members. Six dimensions (affective, structural, control, cognitive, external relationship, and financial) of family functions were emerged from the ill family data. From the analysis of ill family data, types of restructuring house chore after wives illness were developed : (a) negociated, (b) accomodated, and (c) isolated, enduring types. Although the dimensions of family functioning identified in this study are similar to the conceptualizations that exist in the western literature, there were distinct differences in the nature of major themes and subconcepts under these family function dimensions.

• Journal of Korean Academy of Nursing
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• v.28 no.3
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• pp.625-637
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• 1998

To determine factors affecting self-care behavior of diabetics, the relationships of hardiness, family support, demographic and medical variables to self-care behavior were investigated in 180 samples with non-insulin dependent diabetes mellitus. In stepwise multiple regression analysis, 26.76% of the variance in self-care behavior was accounted for by family support(15.52%), age(7.76%), and clinical history (2.07%). To compare the magnitude of predictor's significance by gender, stepwise multiple regression was conducted seperatively by gender group. In the male sample 25.22% of the variance in self-care behavior was accounted for by family support, age, and challenge. In the female sample family support, age, and committment were significant predictors in self-care behavior with 28.82% of the variance. The results highlight the value of family support in self-care behavior in diabetics regardless of gender difference. According to the finding of this study, family support is the most significant predictor of self-care behavior in NIDDM. This implicates that in future diabetic care, a family member should be encouraged to participate in the patient education process. Also as hardiness is not supported by a unidimensional construct, more empirical studies are recommended to differentiate the conceptual traits for the three subconcepts of hardiness.

• Korean Parent-Child Health Journal
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• v.19 no.1
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• pp.1-8
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• 2016

Purpose: This study was done to investigate the level of family support, job stress in clinical nurses end identify the participant's individual characteristics that influenced each of them. Methods: This study was a descriptive correlational study. The participants were 192 clinical nurses working in local middle range hospitals. The data were collected from May to June, 2013 and analyzed using descriptive statistics, t-test and Pearson's correlation by PASW statistics20. Results: The item mean score for family support was 21.01 and job stress was 98.89. There was a statistically significant negative correlation between family support and job stress (r=-.12). The level of job stress differed according to age (p=.014), duration of career (p=.013), department area (p<.001), position (p=.005), work duty form (p<.001), family member (p=.021), burden (p=.031), marital status (p=.001) and satisfaction (p<.001). Conclusion: Family support is needed to reduce job stress. Also, job satisfaction improvement programs and effective working systems should be developed to decrease the nurse's workplace stress.

• Journal of the Korean Home Economics Association
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• v.33 no.3
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• pp.85-99
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• 1995

The major purpose of this research was to investigate the causal relationships among working wives' work-family conflict, socialization of housework, and home management satisfaction. the double ABCX model of family stress and adaptation provided the theoretical framework for this study. the data were recruited from working wives who had more than one pre-school child. The respondents were asked to complete the self-administered questionnaires, and the responses of 536 working wives were used for the final analysis. basically Cronbach's α to the reliability of major variables, frequencies, percentages, means, standard deviation, pearson's correlation coefficients, and LISREL 7 program were performed to test the research model. The results of this study can be summarized as follows : 1. The frequency of work-family conflict was affected by the flexibility of work time and wives' income. 2. The severity of wok-family conflict was directly influenced by the frequency of the conflict, the flexibility of work-time, and wives' education level. 3. The variables influencing the degree of socialization of housework were found to be the frequency and the severity of work-family conflict, wives' education, and the degree of husband's participation in housework. 4. The higher degree of home management satisfaction was associated with the higher level of family member's health status, the greater degree of the flexibility of work-time, and the greater degree of husband's participation in household labor.