• The Korean Journal of Physiology
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• 제24권2호
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• pp.261-268
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• 1990

It has long been suggested that the cardiac atrium is a low pressure volume receptor controlling body fluid volume and blood pressure. Recently, the cardiac atrium has been found to contain a family of powerful peptides. To clarify the relationship between high blood pressure and the biologically active atrial peptides, experiments were done to define the characteristics of atrial natriuretic peptide secretion in the isolated perfused atria of renal hypertensive rats. Higher concentrations of plasma atrial natriuretic peptide and renin activity were observed in the two-kidney, one clip hypertensive rat compared to the normotensive rat. Atrial volume changes in response to pressure elevations were attenuated in hypertensive rats compared to normotensive rats. Incremental response to atrial volume changes in ANP secretion was accentuated in hypertensive rats. These date suggest that the accentuated atrial natriuretic peptide response to volume changes of hypertensive rats may be a physiological or pathphysiological adaptation to the high blood pressure and may be, at least in part, responsible for the elevated levels of plasma atrial natriuretic peptide observed in hypertensive rats.

• Journal of Obesity & Metabolic Syndrome
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• 제27권4호
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• pp.203-212
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• 2018

Dynamic energy balance can give clinicians important answers for why obesity is so resistant to control. When food intake is reduced for weight control, all components of energy expenditure change, including metabolic rate at rest (resting energy expenditure [REE]), metabolic rate of exercise, and adaptive thermogenesis. This means that a change in energy intake influences energy expenditure in a dynamic way. Mechanisms associated with reduction of total energy expenditure following weight loss are likely to be related to decreased body mass and enhanced metabolic efficiency. Reducing calorie intake results in a decrease in body weight, initially with a marked reduction in fat free mass and a decrease in REE, and this change is maintained for several years in a reduced state. Metabolic adaptation, which is not explained by changes in body composition, lasts for more than several years. These are powerful physiological adaptations that induce weight regain. To avoid a typically observed weight-loss and regain trajectory, realistic weight loss goals should be established and maintained for more than 1 year. Using a mathematical model can help clinicians formulate advice about diet control. It is important to emphasize steady efforts for several years to maintain reduced weight over efforts to lose weight. Because obesity is difficult to reverse, clinicians must prioritize obesity prevention. Obesity prevention strategies should have high feasibility, broad population reach, and relatively low cost, especially for young children who have the smallest energy gaps to change.

• 산업융합연구
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• 제3권2호
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• pp.51-71
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• 2005

As the living standards have been enhanced thanks to rapid to rapid economic growth following industrial progress, today the advancement of woman into specialized jobs keep expanding not only for economic purpose such as increasing family income but also due to changed perception on woman's role, i.e. self-realization. In the actual situations, however, women are generally placed in a inferior position compared with men in most jobs, despite existence of gender equality policy. Therefore, concern and study on female adaptation into job and their work attitude have become increasingly important, which can contribute to alleviating women's discontent in the work but to raising efficiency of job execution and improving work quality. In this treatise, I researched the job attitude of woman for the period of 1980 up to 2005, with interval of every 5 years. For empirical analysis, research has been done towards females teachers in elementary and middle schools as well as female works in financial institutions. Both job fields have comparatively high percentage of female employees and have less sexual discrimination. The purpose of this vertical research is (1) to find out how women workers perceive their job environment, (2) to analyze empirically the change in female job attitude and their flow of consciousness. Ultimately this treatise aimed at contributing to efficient management of female work force in our society.

• The Plant Pathology Journal
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• 제38권2호
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• pp.102-114
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• 2022

Pectobacterium carotovorum subsp. carotovorum (Pcc) is a gram-negative, broad host range bacterial pathogen which causes soft rot disease in potatoes as well as other vegetables worldwide. While Pectobacterium infection relies on the production of major cell wall degrading enzymes, other virulence factors and the mechanism of genetic adaptation of this pathogen is not yet clear. In the present study, we have performed an in-depth genome-wide characterization of Pcc strain ICMP5702 isolated from potato and compared it with other pathogenic bacteria from the Pectobacterium genus to identify key virulent determinants. The draft genome of Pcc ICMP5702 contains 4,774,457 bp with a G + C content of 51.90% and 4,520 open reading frames. Genome annotation revealed prominent genes encoding key virulence factors such as plant cell wall degrading enzymes, flagella-based motility, phage proteins, cell membrane structures, and secretion systems. Whereas, a majority of determinants were conserved among the Pectobacterium strains, few notable genes encoding AvrE-family type III secretion system effectors, pectate lyase and metalloprotease in addition to the CRISPR-Cas based adaptive immune system were uniquely represented. Overall, the information generated through this study will contribute to decipher the mechanism of infection and adaptive immunity in Pcc.

• Child Health Nursing Research
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• 제29권1호
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• pp.72-83
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• 2023

Purpose: North Korean refugee women struggle with the double burden of adaptation and parenting as mothers in a new environment. This study aimed to identify the knowledge, confidence, and educational needs regarding newborn care among North Korean refugees, and to determine differences between these variables according to participants' characteristics. Methods: Data were collected from September to October 2022, and 150 North Korean refugee women recruited using convenience sampling participated in the study. Descriptive statistics, the t-test, analysis of variance, and Pearson correlation analysis were used for data analysis. Results: The mean scores were as follows: parenting knowledge, 14.97 out of 25; infection prevention knowledge and confidence, 20.09 out of 33 and 51.37 out of 80, respectively; and educational needs, 245.86 out of 310. Significant differences were observed in newborn care, knowledge, and confidence according to maternal age, educational level, family structure, and pregnancy history. Significant positive correlations were observed between the participants' newborn care knowledge, confidence, and educational needs. Conclusion: Personalized educational programs should be implemented to enhance North Korean refugee women's confidence in newborn care, focusing on areas with low knowledge levels and high educational needs and enabling women to achieve healthy pregnancy and childbirth, and to parent well.

• Child Health Nursing Research
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• 제29권2호
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• pp.128-136
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• 2023

Purpose: This study aimed to identify the main keywords and research topics used in research on problematic smartphone use (PSU) among children (6-12 years old), including parental factors. Methods: The publication period for the literature was set from January 2007 to January 2022, as smartphones were first released in 2007. In total, 395 articles were identified, 230 of which were included in the final analysis. Text network analysis was performed using NetMiner 4.5. Results: Research on this topic has steadily increased since 2007, with 40 papers published in 2021. Eight main research topics were derived: group 1, parental attitudes; group 2, children's PSU behavior and parental support; group 3, family environment and behavioral addiction; group 4, social relationships; group 5, seeking solutions; group 6, parent-child relationships; group 7, children's mental health and school adaptation; and group 8, PSU in adolescents. Conclusion: Parental factors related to PSU have been studied in various aspects. However, more active research on school-age children's PSU needs to be conducted due to the paucity of research in this population compared to studies conducted among adolescents. The results of this study provide useful data for selecting research topics in the field of PSU.

• Molecules and Cells
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• 제46권7호
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• pp.399-413
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• 2023

cAMP responsive element-binding protein (CREB) is one of the most intensively studied phosphorylation-dependent transcription factors that provide evolutionarily conserved mechanisms of differential gene expression in vertebrates and invertebrates. Many cellular protein kinases that function downstream of distinct cell surface receptors are responsible for the activation of CREB. Upon functional dimerization of the activated CREB to cis-acting cAMP responsive elements within the promoters of target genes, it facilitates signal-dependent gene expression. From the discovery of CREB, which is ubiquitously expressed, it has been proven to be involved in a variety of cellular processes that include cell proliferation, adaptation, survival, differentiation, and physiology, through the control of target gene expression. In this review, we highlight the essential roles of CREB proteins in the nervous system, the immune system, cancer development, hepatic physiology, and cardiovascular function and further discuss a wide range of CREB-associated diseases and molecular mechanisms underlying the pathogenesis of these diseases.

• 사회복지연구
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• 제40권1호
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• pp.37-61
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• 2009

유방암은 진단과 치료과정에서 환자뿐만 아니라 배우자에게 심리사회적 디스트레스를 초래하게 된다. 이러한 배우자의 디스트레스는 다시 유방암환자의 적응, 삶의 질에 영향을 미치게 된다. 이에 따라 부부관계 맥락에서 유방암의 심리사회적 영향을 살펴보아야할 필요성이 제기된다. 이를 위해 유방암환자와 배우자를 대상으로 심리사회적 영향을 조사한 국외 연구 33편, 국내 연구 1편 총 34편을 방법론적 측면과 내용적 측면으로 분석하였다. 분석 결과를 토대로 후속 연구와 임상적 실천에 있어서의 제언점을 제시하였다.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2020년도 제62차 하계학술대회논문집 28권2호
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• pp.145-146
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• 2020

최근 급증하고 있는 다문화사회에서 다문화 가정의 가족 구성원의 안정적인 상태로의 정착과 특히 그 자녀들이 '건강하고 행복한 한국인'으로 동반 성장할 수 있는 방안 마련이 현재 주요 과제 중 하나라고 할 수 있다. 무엇보다도 한국의 저출산율은 사회를 구성하는 문제와 인구 노동력 감소로 이어져 국력까지 약화시킨다. 이를 해소할 방안 중 하나로 외국인들을 부족한 한국사회의 인구로 보충하는 것이다. 다문화 가정을 통한 자녀 출산과 그 자녀들로 하여금 성인인구를 늘리는가 하면 다문화가정의 자녀들이 사회의 구성원으로서 올바른 성장과 건강하고 행복한 한국인이 될 수 있도록 돕는 일이 우리 한국의 심각한 사회적 상황을 안정적으로 잘 지탱할 수 있는 길이다. 무엇보다도 감정의 기복이 심한 청소년기를 겪고 있는 다문화 가정의 청소년들의 학교생활적응과 관련된 연구의 필요성은 매우 중요한 역역이라고 볼 수 있다. 이에 본 연구는 학교생활적응에 중요한 작용을 하고 도움을 줄 수 있는 연구들의 필요성에 관한 방안들을 모색하고 향후 연구에 적용함으로써 학교생활에 대한 적응력을 높일 수 있는 기초적인 자료가 제공될 수 있도록 하는데 목적이 있다.

• 사회복지연구
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• 제40권2호
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• pp.123-143
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• 2009

암 환자를 돌보는 가족은 큰 생활의 변화와 부담을 겪으며, 그 안에서 긍정적 경험과 성장을 보고하기도 한다. 본 연구는 암 환자 가족을 대상으로 한국어판 외상 후 성장(K-PTGI) 척도를 사용하기 위하여 도구의 신뢰도와 타당도를 검증하였다. 도구의 신뢰도 검증을 위해 Cronbach α를 구하였으며, 수렴판별, 기준 타당도 검증을 위하여 긍정적 적응, 일상생활 방해, 돌봄부담감, 경제적 부담, 사회적지지, 종교여부와 상관관계를 분석하였다. 분석결과 K-PTGI는 암 환자 가족의 외상 후 성장을 평가하는 타당한 도구인 것으로 나타났으며 이 결과는 암 환자를 돌보는 가족을 이해하기 위한 임상적 연구의 기초로 활용할 수 있을 것이다.