• 비교문화연구
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• 제27권
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• pp.471-496
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• 2012

Since Takeo Toi's discussion in The Anatomy of Dependence (1973), the concept of amae has generated considerable interest in the fields of psychology, anthropology, communication and other fields. However, there have been few agreements on the definition and functions of amae (Behrens, 2004). Furthermore, it has rarely drawn interest from linguists in general and has rarely been discussed in the context of social interaction. This study aims to examine the concept of amae in Japanese and the corresponding phenomena in Korean, and attempts to explore the similarities and differences between them. The prototype of the amae relationship is the mother-infant relationship (Doi,1973). Even an adult can assume the role of a baby, showing his or her need for dependence on others and expecting to be accepted. It turns out that amae-like phenomena frequently occur in everyday life in Korea as well (Lee, 1982). There is no single term for the concept, but it can be translated in many different ways in Korean, for example, aykyo, ayang, ungsek, erikwang, etc. It can have either positive or negative connotations depending on the situation. It seems that the psychological system that causes dependent behaviors such as ungsek in Korea is cheong, one of the key terms characterizing the Korean culture. Cheong, like amae, starts in the mother-infant relationship extending to familial and to other relationships. A corpus-based analysis shows that cheong is conceptualized as gluing people together, growing over time, and also potentially fatal because it assumes illogical, uncalculated, and personal relationships. In conclusion, unlike some Japanese scholars' claim that amae is the Japanese concept that exists only in Japan, it seems that similar phenomena do exist in Korea as well, but that Korean has no single term corresponding to amae in Japanese. It seems that cheong can be posited in Korean as the inner emotional system that makes amae-like behaviors possible, and that there is not single term, but many, designating the behaviors, possibly because the behaviors have a negative connotation and are not encouraged in Korean society.

• Molecules and Cells
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• 제45권7호
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• pp.454-464
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• 2022

DJ-1 is one of the causative genes of early-onset familial Parkinson's disease (PD). As a result, DJ-1 influences the pathogenesis of sporadic PD. DJ-1 has various physiological functions that converge to control the levels of intracellular reactive oxygen species (ROS). Based on genetic analyses that sought to investigate novel antioxidant DJ-1 downstream genes, pyruvate dehydrogenase (PDH) kinase (PDK) was demonstrated to increase survival rates and decrease dopaminergic (DA) neuron loss in DJ-1 mutant flies under oxidative stress. PDK phosphorylates and inhibits the PDH complex (PDC), subsequently downregulating glucose metabolism in the mitochondria, which is a major source of intracellular ROS. A loss-of-function mutation in PDK was not found to have a significant effect on fly development and reproduction, but severely ameliorated oxidative stress resistance. Thus, PDK plays a critical role in the protection against oxidative stress. Loss of PDH phosphatase (PDP), which dephosphorylates and activates PDH, was also shown to protect DJ-1 mutants from oxidative stress, ultimately supporting our findings. Further genetic analyses suggested that DJ-1 controls PDK expression through hypoxia-inducible factor 1 (HIF-1), a transcriptional regulator of the adaptive response to hypoxia and oxidative stress. Furthermore, CPI-613, an inhibitor of PDH, protected DJ-1 null flies from oxidative stress, suggesting that the genetic and pharmacological inhibition of PDH may be a novel treatment strategy for PD associated with DJ-1 dysfunction.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2675-2680
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• 2014

Background: To investigate differentiated thyroid cancer risk factors in natives of French Polynesia is of interest because of the very high incidence of this cancer in the archipelago. Materials and Methods: To assess the role of various potential risk factors of thyroid cancer in the natives of French Polynesia we performed a case-control study. The study included almost all the French Polynesians diagnosed with differentiated thyroid carcinoma between 1981 and 2003 (n=229) and 373 French Polynesian control individuals from the general population without cancer. Results: Thyroid radiation dose received from nuclear fallout before the age of 15, a personal history of neck or/and head medical irradiation, obesity, tallness, large number of children, an artificial menopause, a familial history of thyroid cancer, a low dietary iodine intake, and having a spring as the main source of drinking water were found to be significant risk factors. No roles of smoking habits, alcohol consumption, iodine containing drugs, and exposure to pesticides were evidenced. Conclusions: Except for smoking, differentiated thyroid carcinoma risk factors in natives of French Polynesia are similar to those in other populations. Our finding on the role of having a spring as a drinking water origin is coherent with some other studies and could be due to geological factors.

• 한국경제지리학회지
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• 제16권3호
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• pp.408-422
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• 2013

논문은 최근의 학문적 성과들을 바탕으로 아시아 지역의 자본주의 다양성과 비즈니스 시스템에 대한 논의를 담고 있다. 본 논문의 목적은 참고 문헌들을 통해 국가의 역할과 경제 지리의 성격을 규명하여 라오스와 캄보디아의 자본주의적 다양성을 살펴보는 것이다. 따라서 영토가 경제 권력을 어떻게 재조직하는 요인으로 작용해왔는지에 대한 질문과 라오스와 캄보디아가 국가 자본주의와 베이징-서울-도쿄 합의에 의해 어떻게 변화하고 있는지에 대한 질문에 대답하고자 한다. 두 국가 간의 비교 분석은 라오스의 국가에 의해 조정되는 Frontier Capitalism과 캄보디아의 세습적 과두 체제 간의 차이를 규명한다. 라오스는 지역적으로 자본주의적 다양성이 발현된다. 공간적인 제약이 약한 캄보디아의 과두적 집권층은 상대적으로 시장의 기능에 주목하지만 기회의 균등이라는 면에서는 완전한 자유 시장을 지향하고 있지는 않다. 본 연구의 연구 결과들은 실증적, 이론적 두 가지 관점 모두에서 아시아의 자본주의에 대한 후속 연구의 가능성들을 제기한다. 향후의 연구는 중소 기업의 역할에 대해 고려해야 할 것이며 이론들은 과두제와 개인적, 가족적 자본주의를 통합하여야 한다.

• BMB Reports
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• 제42권3호
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• pp.136-141
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• 2009

Familial Amyotrophic lateral sclerosis (FALS) is a progressive neurodegenetative disorder induced by mutations of the SOD1 gene. Heat shock protein 27 (HSP27) is well-defined as a stress-inducible protein, however the its role in ALS protection has not yet been established. To investigate the role HSP27 may have in SOD1 mutant-mediated apoptosis, human SOD1 or HSP27 genes were fused with a PEP-1 peptide in a bacterial expression vector to produce a genetic in-frame fusion protein, which was then transduced into cells. We found the purified PEP-1-HSP27 fusion proteins can be transduced efficiently into neuronal cells and protect against cell death by enhancing mutant SOD1 activity. Moreover, transduced PEP-1-HSP27 efficiently prevents protein aggregation produced by oxidative stress. These results suggest that transduced HSP27 fusion protein may be explored as a potential therapeutic agent for FALS patients.

• 한국사회복지학
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• 제36권
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• pp.199-228
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• 1998

맞벌이 부인의 가족지원 서비스 필요도를 결정짓는 요인을 조사하기 위해, 맞벌이 부인의 스트레스와 역할과중을 증대시키는 직장과 가정의 상황 구조적 요인들을 나타내는 여섯 가지 스트레스원, 역할과중, 스트레스, 네 종류의 맞벌이가족 지원서비스 (보육비지원 서비스, 직장내 보육서비스, 휴직제도, 유동근무제도)에 대한 필요도 간의 상호 관계를 설명할 수 있는 포괄적인 이론모델을 개발하였다. 맞벌이가족 지원서비스 필요도를 결정짓는 요인에 있어서의 계층간 공통점과 차이점을 비교하기 위해, 전문직 맞벌이 부인과 생산직 맞벌이 부인의 모델을 별도로 개발하여 비교하였다. 본 연구에서 개발된 모델은 진주.사천지역에 거주하는 234명의 전문직 맞벌이 부인과 208명의 생산직 맞벌이 부인으로부터 수집된 설문조사 자료를 통하여 검증되었다. 공변량 구조분석을 이용하여, 변인들 간의 구조관계를 설명할 수 있는 최적의 이론구조모델이 선정되었다 (전문직 모델: df=141, GFI=0.928, CFI=0.965; 생산직 모델: df=141, GFI=0.902, CFI=0.912). 자료분석 결과, 현재 이용 중인 보육서비스에 대한 불만족도가 높을 수록, 근무시간이 길 수록, 맞벌이 부인들의 역할과중은 증가하며, 역할과중은 스트레스를 증가시키는 것으로 나타났다. 스트레스가 증가할 수록, 맞벌이 부인들은 휴직제도를 필요로 하는 것으로 나타났다. 한편, 자녀가 어릴 수록 보육비 지원서비스를 필요로 하고 있으며, 자녀의 나이가 증가될 수록 유동 근무제도를 필요로 하는 것으로 나타났다. 보육비지원 서비스에 대한 필요도가 높을 수록 직장내 보육서비스에 대한 필요도가 높으며, 직장내 보육서비스의 필요도가 높을 수록 휴직제도에 대한 필요도가 높게 나타났다. 또한 휴직제도에 대한 필요도가 높을 수록 유동근무제도에 대한 필요도도 높게 나타났다. 이와 같은 전문직과 생산직 맞벌이 부인 모두에게 일반화될 수 있는 9가지 공통적 인과관계를 제외하고는 전문직과 생산직 부인의 서비스 필요도 결정요인에 있어 상당한 차이점이 발견되었다. 두 집단의 공통적 요인과 차별적 요인에 대한 논의를 바탕으로, 각 직장의 환경과 개인의 필요에 따라 맞벌이 부인이 가장 필요로 하는 서비스를 차별적으로 제공할 수 있는 방안이 제시되었다.

• 대한한방내과학회지
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• 제21권4호
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• pp.565-573
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• 2000

Objective : This research was carried out to find out the general understanding of allergic diseases, the frequencies of allergic diseases and the attitude toward their oriental medical treatment(OMT) among common people. Methods : A total of 360 visitors at The 2nd International Exhibition on Oriental Medicine in 2000, participated in this research. We performed this survey with 22 items on the questionnaire. Results : Respondents knew the. fact that the allergic diseases were hereditary and could be affected by the living environment. 41.8% of the respondents had a past history of allergic diseases. Among the people who had allergic diseases, 63.5% had allergic rhinitis, which was the largest portion. Among them, 52.9% had a familial history. 81.5% of respondents with allergic diseases received western medical treatment for their allergies, 16.3% received both western and oriental medical treatment and 2.2% received OMT only. Among those who were treated for allergic disease, 62.0% were unsatisfied with the low effect of the treatment. To the point of excellence of OMT, 69.7%, which was the largest portion of respondents, believed that OMT could improve their constitutions. The problem with OMT was the high price of herbal medicine and this was the problem most frequently stated, by 51.4% of respondents. There was a positive attitude towards the effect of OMT, and respondents had a preference to receive OMT in the future(p<0.01). Conclusions : These days, it is a fact that the OMT for allergic diseases has a lower proportion to that of western treatment In order to increase the role of OMT, we think, oriental medical doctors need to develop an explanatory model of improving $people^{\circ}{\phi}s$ constitutions and should lower the cost of herbal medicine.

• Journal of Yeungnam Medical Science
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• 제24권1호
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• pp.1-10
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• 2007

만성 피로증후군은 인지능력 감소, 근골격 및 수면 장애증상을 가지며 심한 피로감을 특징으로 하는 증상군을 말한다. 아직 명확한 진단기법이나 확립된 표식자가 없으며, 타질환을 배제한 후 증상기준에 따라 진단하고 있다. 병태생리도 명확한 인과관계가 증명되지 않고 있으며 치료 역시 환자의 증상개선과 삶의 질 향상을 목표로 여러 방법을 동원하고 있는 실정이다. 그러나 대조군과 비교한 많은 연구들에서 중추신경계, 신경호르몬 조절 시스템 및 만성 면역 활성 등의 이상이 보고되고 있으며, 이러한 결과들을 근거로 현재 다양한 치료방법이 동원되고 있다. 또한 이 증후군은 가족력의 가능성이 크므로 향후 유전 및 환경적 요인에 관한 연구가 활발해질 것으로 보인다. 대부분의 환자들은 우울증이나 범불안 장애 등을 동반하고 있으며, 이들이 병태생리와 관련 있을 가능성도 크다고 볼 수 있다. 결론적으로 이 증후군은 개인의 유전적 요소에 생리학적, 정신적 요인과 더불어 영양, 생활습관, 스트레스, 호르몬 등의 다양한 요인들이 복합적으로 상호 작용하여 만성적인 피로감과 다양한 증상을 나타내는 것으로 볼 수 있다. 환자-의사간 긴밀한 관계를 바탕으로 약물 및 비약물요법과 인지요법, 단계적 운동요법 등 효과가 인정된 치료방법을 꾸준히 사용하면 증상개선과 삶의 질 향상에 도움이 될 것으로 생각한다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.3229-3235
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• 2013

Background: Many breast cancers are caused by certain rare and familial mutations in the high or moderate penetrance genes BRCA1, BRCA2 and CHEK2. The aim of this study was to examine the allele and genotype frequencies of seven mutations in BRCA1, BRCA2 and CHEK2 genes in breast cancer patients and to investigate their isolated and combined associations with breast cancer risk. Methods: We genotyped seven mutations in BRCA1, BRCA2 and CHEK2 genes and then analyzed single variations and haplotype associations in 106 breast cancer patients and 80 healthy controls. Results: We found significant associations in the analyses of CHEK2- 1100delC (p=0.001) and BRCA1-5382insC (p=0.021) mutations in breast cancer patients compared to controls. The highest risk was observed among breast cancer patients carrying both CHEK2-1100delC and BRCA2- Met784Val mutations (OR=0.093; 95%CI 0.021-0.423; p=0.001). We identified one previously undescribed BRCA2 and a CHEK2 four-marker haplotype of A-C-G-C which was overrepresented ($X^2$=7.655; p=0.0057) in the patient group compared to controls. Conclusion: In this study, we identified a previously undescribed BRCA2 and CHEK2 A-C-G-C haplotype in association with the breast cancer in our population. Our results further suggest that the CHEK2-1100delC mutation in combination with BRCA2-Met784Val may lead to an unexpected high risk which needs to be confirmed in larger cohorts in order to better understand their role in the development and prognosis of breast cancer.

• 가정과삶의질연구
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• 제2권1호
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• pp.131-150
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• 1984

The purpose of this study is to explore the family as an interaction system, concentrating on the mutual influences between communication and family development; (1) how Communication patterns affect family relationships, and (2) how relationships among family members affect communication. In order to do this Galvin, Brommel used the following frame work; family is a system in which communication regulates cohesion and adaptability by a flow of message patterns through a defined network of evolving interdependent relationships. A family system consists of members, the relationships among them, the family attributes, the members attributes and an environment in which family functions. Within the framework of common cultural communication patterns, each family has the capacity to develop its own communication code based on the experiences of individual members and the collective family experience. Most of us develop our communication skills within the family context learning both the general cultural language and the specific familial communication code. Communication may be viewed as a symbolic, transactional process as the process of creating and sharing meanings. To say that communication is a process implies a continuous interaction of an indefinite large numbers of variables with a concomitant,. continuous change in the values taken by these variables. Finally the process implies change, Family functions include the primary functions of cohesion and adaptability, and supporting functions of family images, themes, boundaries, and biosocial issues. The primary functions reveal concepts integrated family interaction and supporting function, along with those of cohesion and adaptability, give shape to family life. the characteristics of developed relationships of richness, uniqueness efficiency, substitutability, pacing , openness spontaneity, and evaluation are reflected in the verbal and nonverbal behaviors with which family members negotiated a set of common meanings and develop thier own unique message system. The message system is the major element of communication process and influences both the form and the content of thier relationship and in create and share meanings. Family systems need to provide order and predictability for thier members, specifically focusing on communication rules and the networks by which messages are transmitted. Most rules emerge as a result of multiful interactions. There are basic rules and rules about rules, or metarules. Perceiving the rules of family system is very difficult because often family members don't think about the basic rules, much less the metarules. Breaking the rule may result in the creation of a new set because the system may recalibrate itself to accept more variety of behavior. Families develop communication networks to deal with the general issue. Family adaptability may be seen through the degree of flexibility in forming and reforming networks and networks become a vital part of the decision- making process and relate to the power dynamics operating within the family. Networks also play an integral part in maintaining the roles and rules operating with the family system. Thus networks and rules have mutual influence. The family -of -origin issues influence all aspects of family communication and account for many of the communication patterns, rules and networks and the role of the family -of-origin influences as a primary force for communication on behavior of newly forming systems. Each family system develops its own communication meanings. There is not one right way to communicate within a family but may be indefinitly large change of family life and communication behavior. Study on functional family communication helps to gain a better understanding of dynamics of family communication and ability of a new insight into the family.