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Untold story of human cervical cancers: HPV-negative cervical cancer

  • Lee, Jae-Eun;Chung, Yein;Rhee, Siyeon;Kim, Tae-Hyung
    • BMB Reports
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    • v.55 no.9
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    • pp.429-438
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    • 2022
  • Cervical cancer is the fourth most common malignancy in women worldwide. Although infection from human papillomavirus (HPV) has been the leading cause of cervical cancer, HPV-negative cervical cancer accounts for approximately 3-8% of all cases. Previous research studies on cervical cancer have focused on HPV-positive cervical cancer due to its prevalence, resulting in HPV-negative cervical cancer receiving considerably less attention. As a result, HPV-negative cervical cancer is poorly understood. Its etiology remains elusive mainly due to limitations in research methodology such as lack of defined markers and model systems. Moreover, false HPV negativity can arise from inaccurate diagnostic methods, which also hinders the progress of research on HPV-negative cervical cancer. Since HPV-negative cervical cancer is associated with worse clinical features, greater attention is required to understand HPV-negative carcinoma. In this review, we provide a summary of knowledge gaps and current limitations of HPV-negative cervical cancer research based on current clinical statistics. We also discuss future directions for understanding the pathogenesis of HPV-independent cervical cancer.

Infodemic: The New Informational Reality of the Present Times

  • Araujo, Carlos Alberto Avila
    • Journal of Information Science Theory and Practice
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    • v.10 no.1
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    • pp.59-72
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    • 2022
  • This text discusses elements and characteristics of contemporary informational reality, that is, the ways of producing, circulating, organizing, using, and appropriating information in the current context. Initially, seven terms and concepts used to describe this reality are discussed: fake news, false testimonials, hate speech, scientific negationism, disinformation, post-truth, and infodemic. Next, an attempt is made to present a framework for such phenomena as an object of study in information science. Therefore, this scenario is characterized based on the three main models of information science study: physical, cognitive, and social. The contribution of each of them to the study of contemporary informational reality is analyzed, identifying aspects such as the bubble effect, clickbaits, confirmation bias, cults of amateurism, and post-truth culture. Finally, it presents the discussion of a possible veritistic turn in the field, in order to think about elements not covered so far by information science in its task and challenge of producing adequate understanding and diagnoses of current phenomena. In conclusion, it is argued that only accurate and comprehensive diagnoses of such phenomena will allow information science to develop services and systems capable of combating their harmful effects.

Comparison of Culture, Conventional and Real-time PCR Methods for Listeria monocytogenes in Foods

  • Kim, Dong-Hyeon;Chon, Jung-Whan;Kim, Hyunsook;Kim, Hong-Seok;Choi, Dasom;Kim, Young-Ji;Yim, Jin-Hyeok;Moon, Jin-San;Seo, Kun-Ho
    • Food Science of Animal Resources
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    • v.34 no.5
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    • pp.665-673
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    • 2014
  • We compared standard culture methods as well as conventional PCR and real-time PCR for the detection of Listeria monocytogenes (L. monocytogenes) in milk, cheese, fresh-cut vegetables, and raw beef that have different levels of background microflora. No statistical differences were observed in sensitivity between the two selective media in all foods. In total, real-time PCR assay exhibited statistically excellent detection sensitivity (p<0.05) and was less time consuming and laborious as compared with standard culture methods. Conventional culture methods showed poor performance in detecting L. monocytogenes in food with high levels of background microflora, generating numerous false negative results. While the detection of L. monocytogenes in fresh cut vegetable by culture methods was hindered only by L. innocua, various background microflora, such as L. innocua, L. welshimeri, L. grayi, and Enterococcus faecalis appeared on the two selective media as presumptive positive colonies in raw beef indicating the necessity of improvement of current selective media. It appears that real-time PCR is an effective and sensitive presumptive screening tool for L. monocytogenes in various types of foods, especially foods samples with high levels of background microflora, thus complementing standard culture methodologies.

The advantage of topographic prominence-adopted filter for the detection of short-latency spikes of retinal ganglion cells

  • Ahn, Jungryul;Choi, Myoung-Hwan;Kim, Kwangsoo;Senok, Solomon S.;Cho, Dong-il Dan;Koo, Kyo-in;Goo, Yongsook
    • The Korean Journal of Physiology and Pharmacology
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    • v.21 no.5
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    • pp.555-563
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    • 2017
  • Electrical stimulation through retinal prosthesis elicits both short and long-latency retinal ganglion cell (RGC) spikes. Because the short-latency RGC spike is usually obscured by electrical stimulus artifact, it is very important to isolate spike from stimulus artifact. Previously, we showed that topographic prominence (TP) discriminator based algorithm is valid and useful for artifact subtraction. In this study, we compared the performance of forward backward (FB) filter only vs. TP-adopted FB filter for artifact subtraction. From the extracted retinae of rd1 mice, we recorded RGC spikes with $8{\times}8$ multielectrode array (MEA). The recorded signals were classified into four groups by distances between the stimulation and recording electrodes on MEA (200-400, 400-600, 600-800, $800-1000{\mu}m$). Fifty cathodic phase-$1^{st}$ biphasic current pulses (duration $500{\mu}s$, intensity 5, 10, 20, 30, 40, 50, $60{\mu}A$) were applied at every 1 sec. We compared false positive error and false negative error in FB filter and TP-adopted FB filter. By implementing TP-adopted FB filter, short-latency spike can be detected better regarding sensitivity and specificity for detecting spikes regardless of the strength of stimulus and the distance between stimulus and recording electrodes.

Implementation of Multiple Sensor Data Fusion Algorithm for Fire Detection System

  • Park, Jung Kyu;Nam, Kihun
    • Journal of the Korea Society of Computer and Information
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    • v.25 no.7
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    • pp.9-16
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    • 2020
  • In this paper, we propose a prototype design and implementation of a fire detection algorithm using multiple sensors. The proposed topic detection system determines fire by applying rules based on data from multiple sensors. The fire takes about 3 to 5 minutes, which is the optimal time for fire detection. This means that timely identification of potential fires is important for fire management. However, current fire detection devices are very vulnerable to false alarms because they rely on a single sensor to detect smoke or heat. Recently, with the development of IoT technology, it is possible to integrate multiple sensors into a fire detector. In addition, the fire detector has been developed with a smart technology that can communicate with other objects and perform programmed tasks. The prototype was produced with a success rate of 90% and a false alarm rate of 10% based on 10 actual experiments.

Validity of Needle Aspiration Cytology and Frozen Section in Thyroid Tumor (갑상선 결절에서 세침흡인검사와 동결조직검사의 의의)

  • Kim Jae-Won;Lee Jang-Won;Bae Sung-Ho;Ko Kook-Jin;Yoon Suk-Young;Kim Young-Mo
    • Korean Journal of Head & Neck Oncology
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    • v.20 no.2
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    • pp.143-146
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    • 2004
  • Background and Object: The role of fine needle aspiration cytology (FNAC) and frozen section (FS) in management of thyroid neoplasms continues to generate considerable controversy. We reviewed our current experience to determine the clinical utility of FNAC and FS in our surgical management and investigated reliability of FNAC and FS in planning the extent of thyroid resection. Material and Method: 212 patients who had operations for thyroid disease from May 1996 to November 2003 were included our retrospective study. FNAC was undertaken in 175 patients and FS was done in 148 patients. Result: The sensitivity and specificity of FNAC were 72.1% and 100%, respectively, and those of FS were 67.2% and 100%. The results of FNAC were benign (n=72) , malignancy (n=31), indeterminate (n=9), and nondiagnostic (n=63). The results of FS were benign (n=95), and malignancy (n=53). The 9 indeterminate cases on FNAC were benign (n=6) and malignancy (n=3) on final pathology, and benign (n=7) and malignancy (n=2) on FS. The false negative of FNAC were micro papillary carcinoma (n=6) and follicular carcinoma (n=6). The false negative of FS were micropapillary carcinoma (n=10) and follicular carcinoma (n=2). Conclusion: When results of FNAC are interpreted as indeterminate, FS is a valuable tool. FS is helpful in determining the extent of thyroidectomy when results of FNAC were follicular neoplasm. However we always concerned about micropapillary carcinoma and follicular carcinoma although FNAC and FS were benign.

Plans to Integrate for the Polygraph Institution (거짓말탐지기 교육기관의 일원화 방안)

  • Kang, Dong Beom;Bae, Du Yeol
    • Convergence Security Journal
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    • v.15 no.1
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    • pp.49-57
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    • 2015
  • As the capitalist society was launched, false has been increasing day by day for the personal profit. Study after study since a long time ago has concluded that today's polygraph developed in order to determine these false. In Korea the polygraph has been used actively in current investigation agency, and passively in a private enterprise by a former polygraph examinant from the investigation agency. Each investigation agency is recruiting polygraph examinants through the strict qualifications, training education. Decisions of Supreme Court precedents about the polygraph test results are denying admissibility of evidence in reliability on the efficiency of a test equipment, way to ask, qualities of polygraph examinant, etc. The most fundamental cause of the issues mentioned in the precedents is that examinants of each investigation agency are being trained by dual education not centralized. Because of each investigation agency has its own training and polygraph examinant, each agency can occur variations every agency or every examinant, therefore ensuring the centralized educational system is needed. In this way, ensuring the centralized educational system will contribute to improve the reliability of polygraph test results and make a retrenchment in the educational budget in accordance with examinant training of each agency.

A New Deadlock Detection Mechanism in Wormhole Networks (웜홀 네트웍을 위한 새로운 교착상태 발견 기법)

  • Lee, Su-Jung
    • Journal of KIISE:Computer Systems and Theory
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    • v.30 no.5_6
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    • pp.280-289
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    • 2003
  • Deadlock recovery-based routing algorithms in wormhole networks have gained attraction due to low hardware complexity and high routing adaptability Progressive deadlock recovery techniques require a few dedicated resources to transmit deadlocked packets rather than killing them. Selection of deadlocked packets is primarily based on time-out value which should be carefully determined considering various traffic patterns or packet length. By its nature, current techniques using time-out accompany unignorable number of false deadlock detections especially in a heavy-loaded network or with long packet size. Moreover, when a deadlock occurs, more than one packet may be marked as deadlocked, which saturate the resources allocated for recovery. This paper proposes more accurate deadlock detection scheme which does not make use of time-out to declare deadlock. The proposed scheme reduces the probability to detect false deadlocks considerably. Furthermore, a single message is selected as deadlocked for each cycle of blocked messages, thereby eliminating recovery overheads.

Diagnosis of Inter Turn Short Circuit in 3-Phase Induction Motors Using Applied Clarke Transformation (Clarke 변환을 응용한 3상 유도전동기의 Inter Turn Short Circuit 진단)

  • Yeong-Jin Goh;Kyoung-Min Kim
    • Journal of IKEEE
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    • v.27 no.4
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    • pp.518-523
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    • 2023
  • The diagnosis of Inter Turn Short Circuits (ITSC) in induction motors is critical due to the escalating severity of faults resulting from even minor disruptions in the stator windings. However, diagnosing ITSC presents significant challenges due to similarities in noise and losses shared with 3-phase induction motors. Although artificial intelligence techniques have been explored for efficient diagnosis, practical applications heavily rely on model-based methods, necessitating further research to enhance diagnostic performance. This study proposed a diagnostic method applied the Clarke Transformation approach, focusing solely on current components while disregarding changes in rotating flux. Experimental results conducted over a 30-minute period, encompassing both normal and ITSC conditions, demonstrate the effectiveness of the proposed approach, with FAR(False Accept Rates) of 0.2% for normal-to-ITSC FRR(False Rejection Rates) and 0.26% for ITSC-to-normal FRR. These findings underscore the efficacy of the proposed approach.

Robust 2D Feature Tracking in Long Video Sequences (긴 비디오 프레임들에서의 강건한 2차원 특징점 추적)

  • Yoon, Jong-Hyun;Park, Jong-Seung
    • The KIPS Transactions:PartB
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    • v.14B no.7
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    • pp.473-480
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    • 2007
  • Feature tracking in video frame sequences has suffered from the instability and the frequent failure of feature matching between two successive frames. In this paper, we propose a robust 2D feature tracking method that is stable to long video sequences. To improve the stability of feature tracking, we predict the spatial movement in the current image frame using the state variables. The predicted current movement is used for the initialization of the search window. By computing the feature similarities in the search window, we refine the current feature positions. Then, the current feature states are updated. This tracking process is repeated for each input frame. To reduce false matches, the outlier rejection stage is also introduced. Experimental results from real video sequences showed that the proposed method performs stable feature tracking for long frame sequences.