• The Journal of the Korean dental association
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• v.51 no.9
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• pp.511-517
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• 2013

To assess the association between oral health and general health, this study examined the relationship between chewing difficulty and twelve chronic health conditions such as hypertension, hyperlipidemia, diabetes, cerebro- and cardiovascular disease, musculoskeletal disease, respiratory disease, eye/nose/throat disease, stomach/intestinal ulcer, renal dysfunction, thyroid disease, depression, and cancer in Korea. The study population was 3,066 elders aged 65 years old and more from the fourth Korean National Health and Nutrition Examination Survey. Chewing difficulty was measured on a 5-point Likert scale. Chronic conditions were assessed by self-reported questionnaire. Confounders were age, gender, education, income, smoking, drinking, and obesity. Chi-square test, general linear model, and multiple logistic regression model were done with complex sampling design. Musculoskeletal disease (adjusted odds ratio=1.33), respiratory disease (adjusted odds ratio=1.52), and cancer (adjusted odds ratio=1.58) were independently associated with chewing difficulty. Multiple chronic conditions with more than 4 chronic disease showed significant association with chewing difficulty (adjusted odds ratio=1.37).

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.3
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• pp.403-406
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• 2014

Purpose: In this study, we studied ocular disease by age in Ulsan. Methods: We checked medical record of 300 patients who visited eye clinic in Ulsan. Results: The main ocular disease on the age of 10 was keratitis, that of 20 was dry eye syndrome & keratitis, that of 30 was chalazion & conjunctivitis, that of 40~50 was conjunctivitis, that of 60 was conjunctivitis & cataract. Conclusions: The main cause of ocular disease of 10~20's are unsuitable wear of contact lenses & long-time use of smart phone as well as computer. That of 30~50's are allergic conjunctivitis and chemical material reaction as well as other several factors. Especially, attack rate of conjunctivitis of 30~50's is higher than city because of industrial area (Ulsan). The main cause of ocular disease in 50~60's is a kind of senility. Therefore, based on the results of this study, it could be used the basic data of education on ocular disease prevention in Ulsan.

• BMB Reports
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• v.48 no.3
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• pp.153-158
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• 2015

As FK506 binding proteins (FK506BPs) are known to play an important role in the regulation of a variety of biological processes related to cell survival, this study was designed to examined the protective effects of FK506 binding protein 12 (FK506BP) on low humidity air flow induced dry eye in a rat model using transduced PEP-1-FK506BP. After the topical application of PEP-1-FK506BP, tear volumes were markedly increased and significant prevention of cornea damage was observed compared with dry eye rats. Further, immunohistochemical analysis demonstrated that PEP-1-FK506BP markedly prevented damage to the cornea, the bulbar conjunctiva, and the palpebral conjunctiva epithelial lining compared with dry eye rats. In addition, caspase-3 and PARP expression levels were found to be decreased. These results demonstrated that topical application of PEP-1-FK506BP significantly ameliorates dry eye injury in an animal model. Thus, we suggest that PEP-1-FK506BP can be developed as a new ophthalmic drop to treat dry eye diseases.

• Korean Journal of Veterinary Research
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• v.41 no.1
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• pp.113-121
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• 2001

Beagle is one of the most popular laboratory animal in a dog. We investigated the incidence of spontaneous ophthalmic disease in Beagles in order to make basic data for quality control of Beagles in Korea. We surveyed 389 beagles from 3 different farms. The average prevalence rate of ophthalmic diseases was 19.3%. The prevalence rate of cataracts was higher than any other ophthalmic diseases, 7.5% and then in order of corneal scar(2.1%), retinal hemorrhage(1.5%), post-inflammatory retinal change(1.5%), cherry eye(1.0%), distichiasis(0.8%), entropion(0.8%), hypoplastic optic disc(0.8%), conjunctivitis(0.5%), retinal dysplasia(0.5%), asteroid hyalosis(0.3%), congenital eye anomaly(0.3%), corneal lipidosis(0.3%), conjunctival hemorrhage(0.3%), lens capsule pigmentation(0.3%), persistent hyperplastic primary vitreous (0.3%), posterior synechia(0.3%), eyelid tumor(0.3%) and uveal cyst(0.3%) were diagnosed. There was a slight difference between male(24.8%) and female(17.4%) in prevalence rate of ophthalmic disease. The incidence of spontaneous ophthalmic disease was increased with age. These data would be useful for using Beagles as laboratory animals and standard reference for quality control of dogs.

• Herbal Formula Science
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• v.12 no.2
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• pp.57-76
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• 2004

This report describes the remedial fields, symptoms, pathology, dosage, prescriptional constitution of 69 studies related to the use of Radix Asari main blended prescriptions from Dongeubogam. The following conclusions were reached through investigations on the prescriptions that use Radix Asari as a key ingredient. Radix Asari blended prescriptions are utilized for 14 therapeutic purposes, for example, in symptoms of tooth, eye, paralysis, ear-nose, skin infection and carbuncle. In particular, 14.49% of the prescriptions appear in the chapter of tooth, and 10.14% of those appear in the chapter of eye. Prescriptions that utilize Radix Asari as the main ingredient are used in the treatment of dental disease, othalmology, nose and ear disease, throat disease, common cold, dermothology, paralysis, musculoskeletal disease, disease of the head, asthma, genital disease, the injury of the cuts and they are also used for treating 50 different types of diseases. Radix Asari is used in Six pathogenic factors such as wind, wind-cold, wind-heat, wind-dampness heat, wind-dampness, dampness, paralysis, cold-chill, cold, dryness, in visceral pathogenic factors such as stomach, kidney, liver-kidney, liver and in chi-blood pathogenic factors such as chi-blood deficiency, chi-blood stagnation and in extravasated blood pathogenic factors such as impact injury, an injury such as cuts, blood accumulation as well as weakness-cold and parasites. The actual amount of Radix Asari blended has ranged at a wide variety of amounts from 2.5pun(about 0.94gram) to 3don(about 11.25gram). 26.09% of the prescriptions used 1don(about 3.75gram). The function of Radix Asari is to calm down, to get the consciousness back, to bore through, to warm up the meridians and to run it smoothly, to discharge of phlegm from the combination of drugs and prescriptions.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.11 no.1
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• pp.292-299
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• 1998

I examined 54 patients who had been diagnosed as dry eye or had experienced symptoms of dry eye such as foreign body sense, dry sense, sore sense, pain, etc. and had some results. The results were as follows; 1. In sex, there were more females than males. 2. The age was examined from 19 years to 70 years and 51-60 years was the most. 3. In duration of symptoms, 1-5 years was taken most of the patients. 4. In blood type, O type was dominant comparing other blood types. 5. In warm and cold preference cold was more than warm or tepid. 6. In associated ocular & systemic disease chronic gastritis was the most and the next was chronic conjunctivitis. 7. In main symptoms foreign body sense was the most of them 8. In prescription Gamisamultang(加味四物湯) was most frequently administered to the patients.

• 대한예방의학회:학술대회논문집
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• 1994.02b
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• pp.129-136
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• 1994

A model was developed for a simple clinical trial in which graders had defined probabilities of misclassifying pathologic material to disease present or absent. The authors compared Kappa between graders, and efficiency and bias in the clinical trial in the presence of misclassification. Though related to bias and efficiency, Kappa did not predict these two statistics well. These results pertain generally to evaluation of systems for encoding medical information, and the relevance of Kappa in determining whether such systems are ready for use in comparative studies. The authors conclude that, by itself, Kappa is not informative Enough to evaluate the appropriateness of a grading scheme for comparative studies. Additional, and perhaps difficult, questions must be addressed for such evaluation.

• Proceedings of the KOSOMBE Conference
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• v.1993 no.11
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• pp.27-30
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• 1993

Information about retinal blood vessels can be used in grading disease severity or as part of the process of automated diagnosis of diseases with ocular menifestations. In this paper, we address the problem of detecting retinal blood vessels and optic disk (papilla) in Eye-fundus images. We introduce an algorithm for feature extraction based on Fuzzy festering(FCM). The results ore compared to those obtained with other methods. The automatic detection of retinal blood vessels and optic disk in the Eye-fundus images could help physicians in diagnosing ocular diseases.

• Journal of Haehwa Medicine
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• v.13 no.2
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• pp.277-287
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• 2004

I have come to next conclusions in consequence of documentary study about medical books of many generations regarding venesection therapy. 1. Venesection therapy is much used for five sensory organ disease. Besides that internal disease, pain paralysis disease of muscle and joints, sugical disease, disease of woman and children, fever sunstroke CVA emergency case follow that in the order of frequency of use. 2. It is used for swollen tongue, eye pain, pharyngitis, swelling and pain in the throat, bleeding from the eye ear nose mouth or subcutaneous tissue, tonsillitis, aphthae and so on in the five sensory organ disease. Focus, sosang, jinjin yuye, taiyang, baihui are used for five sensory organ disease in the order of frequency of use. 3. It is used for malaria, headache, precordial pain, head-wind, abdominal colic, diseases characterized by acute diarrhea and vomiting, and so on in the Internal disease. Superficial venules and lymph vessesls, taiyang, quze are used for Internal disease in the order of frequency of use. 4. It is used for low back pain, hypochondriac pain, numbness, knee pain, tinea pedis, red swelling pain of hand and arm, flaccidity-syndrome, and so on in the pain paralysis disease of muscle and joints. Weizhong, superficial venules and lymph vessesls, Ashi point, zhigou are used for pain paralysis disease of muscle and joints in the order of frequency of use. 5. It is used for furuncle, tinea capitis, and so on in the sugical disease. Focus, weizhong are used for sugical disease in the order of frequency of use. 6. It is used for inflammatory disease with redness of skin, and so on in the disease of woman and children. Focus, weizhong, yanglingquan, yaoshu, sanyinjiao are used for disease of woman and children in the order of frequency of use. 7. It is used for fever, CVA, sunstroke, cadaverous coma, common cold, and so on in the fever sunstroke CVA emergency case. Sosang, weizhong, chize are used for fever sunstroke CVA emergency case in the order of frequency of use. 8. The urinary bladder channel of foot-taiyang is most used. Next there are the du channel, the stomach channel of foot-yangming, the lung channel of hand-taiyin, the gall baldder channel of foot-shaoyang, the triple-warmer channel of hand-shaoyang, the large intestine channel of hand-yangming, the spleen channel of foot-taiyin, the kidney channel of foot-shaoyin the pericardium channel of hand-jueyin the liver channel of foot-jueyin, the ren channel, the heart channel of hand-shaoyin, the small intestine channel of hand-taiyang in the order of frequency in use. 9. Superficial venules and lymph vessesls, focus, five shu points, extra-point, back point are used in the venesection therapy, those are characteristic of locating an acupuncture point.

• Journal of Korean Ophthalmic Optics Society
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• v.7 no.2
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• pp.229-234
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• 2002

The human eye and skin is exposed daily to solar energy. Expecially, the ultraviolet radiation (UVR) exposure has been damaged as an important causative factor in corneal disease. These damage of cornea was effected the retina. Therefore the eye function was effected very significant damage. As a results the protect of UVR in the eye is very important in ocular health. Therefore in living the intensive ultraviolet radiation environment by solar energy, human eye have protected the cornea and eyeball by the UV-blocking sunglass, eyeglass, goggles, and contact lens. Finally the specific UV-blocker lens devices available to the primary care for the subjects by optician. Of course, in the future these specific lenses have to development and study by fellowship.